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Advanced multifunctional thermo- and electro-stimulative hydrogels for bone regeneration.

Bone defects caused by trauma, infection, tumors, osteoporosis, and diabetes disrupt skeletal integrity and impair regeneration. The healing process involves inflammatory hematoma formation, callus development, and remodeling, coordinated by diverse cells and signaling pathways. Conventional grafts and inorganic implants are limited by donor scarcity, immune rejection, and low bioactivity, necessitating more effective repair strategies. Recently, multifunctional smart hydrogels have emerged as a frontier in bone regeneration due to their biocompatibility, tunable structure, and ability to inte

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… promote BMSC osteogenesis | Balb/c nude mice, subcutaneous | Tumour-related bone defects and tumor | [ 138 ] CoFe 2 O 4 @MnFe 2 O 4 (MION)/RGD/Agarose(MRA) | MION | 1.35 kA m −1 | 5min | 41 °C | MION offers magnetothermal effect, boosts osteogenic differentiation and mineralization, and releases iron and cobalt … Additionally, elevated HSP90 expression, through p-Akt stabilization, upregulates hypoxia-inducible factor-1α (HIF-1α), which synergizes with iron and cobalt ion release from MION degradation to promote angiogenesis and improve local blood supply [ 139 ]. …

Genome-edited allogeneic CAR-T cells: the next generation of cancer immunotherapies.

Chimeric Antigen Receptor T (CAR-T) cell therapy has revolutionized cancer immunotherapy, particularly in hematological malignancies. However, the clinical application of autologous CAR-T cells faces significant high cost and manufacturing challenges. Universal allogeneic CAR-T cells, derived from healthy donors, represent a promising solution to these obstacles. These "off-the-shelf" therapies aim to reduce the complexity and cost of CAR-T production. Despite exciting advancements in genome-editing technologies and promising clinical trial data, significant challenges remain, including graft-

Drug-Induced Periocular and Ocular Surface Disorders: An EAACI Position Paper.

Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life-threatening complications. Drug-induced ocular adverse reactions are generally classified into two primary categories: toxic reactions and/or allergic hypersensitivity reactions, which can be IgE or non-IgE-mediated. Systemic antibiotics, antivirals, and anticonvulsants can trigger adverse reactions that may involve the OS. Drugs like antihistamines, beta-blockers, antipsychotics, antide

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… allergens | Functions | Main sources | Prevalence range contact allergy (%) | References Metals Nickel | Metallic colorants and glitter effect | Jewelry, makeup, makeup applicators, eye cosmetics (eyeshadow, eyeliner) metal nail files and eyelash curlers | 7.0–32.2 | [ 154 , 155 , 156 , 157 , 158 , 159 ] Cobalt …

Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast - A Novel Concept for Osteoporosis Treatment: Part 1.

PURPOSE: Osteoporosis results in a severe decrease in the life quality of many people worldwide. The latest data shows that the number of osteoporotic fractures is becoming an increasing international health service problem. Therefore, a new kind of controllable treatment methods for osteoporotic fractures is extensively desired. For that reason, we have manufactured and evaluated nanohydroxyapatite (nHAp)-based composite co-doped with iron oxide (IO) nanoparticles. The biomaterial was used as a matrix for the controlled delivery of miR-21-5p and miR-124-3p, which have a proven impact on bone

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… Development of multifunctional cobalt ferrite/hydroxyapatite nanocomposites by microwave assisted wet precipitation method: a promising platform for synergistic chemo-hyperthermia therapy . Ceram Int . 2019 ; 45 ( 10 ): 12860 – 12869 . doi: 10.1016/j.ceramint.2019.03.209 46. …

The Multifaceted Role of Annexin A1 in Colorectal Cancer: From Molecular Mechanisms to Predictive and Prognostic Implications.

Annexin A1 (ANXA1), a calcium-dependent phospholipid-binding protein, is considered a key modulator of cancer biology. Numerous pieces of evidence support its multifaceted involvement in tumor progression, metastatic dissemination, immune escape, and resistance to therapy in various malignancies, such as melanoma, along with liver, lung, and digestive tract tumors, including stomach and colorectal cancer (CRC). Although colon and rectal cancer (RC) exhibit overlapping characteristics, they are classified as separate clinical entities due to differences in tumor biology and therapy approaches.

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… Both hypoxia and exposure to the hypoxia-mimetic agent cobalt chloride (CoCl 2 ) may increase ANXA1 expression and hypoxia-inducible factor 1-alpha (HIF-1α) in breast cancer models [ 86 , 180 ]. …

What Is Precision Psychotherapy?

Precision medicine impacts virtually all medical specializations, including psychiatry. Although precision psychiatry, in general, is a flourishing area of research and debate, psychotherapy as one pillar of psychiatry receives little attention. Theoretical discussions about precision psychotherapy are rare; research on precision in psychotherapy is just evolving. In this paper, we provide a conceptualization of precision psychotherapy providing a common idea of what should be understood as precision in the context of psychotherapy and what kind of psychotherapy research is considered to contr

What Drives Innovation: The Canadian Touch on Liposomal Therapeutics.

Liposomes are considered one of the most successful drug delivery systems (DDS) given their established utility and success in the clinic. In the past 40⁻50 years, Canadian scientists have made ground-breaking discoveries, many of which were successfully translated to the clinic, leading to the formation of biotech companies, the creation of research tools, such as the Lipex Extruder and the NanoAssemblr™, as well as contributing significantly to the development of pharmaceutical products, such as Abelcet®, MyoCet®, Marqibo®, Vyxeos®, and Onpattro™, which are making positive impacts on patient

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… Spectrophotometric determination of copper(II), nickel(II) and cobalt(II) as complexes with sodium diethyldithiocarbamate in cationic micellar medium of hexadecyltrimethylammonium salts Talanta 1994 41 179 185 10.1016/0039-9140(94)80105-3 18965905 80. Wehbe M. Anantha M. Shi M. Leung A.W. …

The Genetics and Epigenetics of 22q11.2 Deletion Syndrome.

Chromosome 22q11.2 deletion syndrome (22q11.2del) is a complex, multi-organ disorder noted for its varying severity and penetrance among those affected. The clinical problems comprise congenital malformations; cardiac problems including outflow tract defects, hypoplasia of the thymus, hypoparathyroidism, and/or dysmorphic facial features. Additional clinical issues that can appear over time are autoimmunity, renal insufficiency, developmental delay, malignancy and neurological manifestations such as schizophrenia. The majority of individuals with 22q11.2del have a 3 Mb deletion of DNA on chrom

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… Cobalt(III) Protoporphyrin activates the DGCR8 protein and can compensate microRNA processing deficiency. Chem. Biol. 22, 793–802. 10.1016/j.chembiol.2015.05.015 Bartel D. P. (2009). MicroRNAs: target recognition and regulatory functions. Cell 136. 10.1016/j.cell.2009.01.002 Bassett A. …

Фенотипический отбор высокоурожайной, водопродуктивной пшеницы (Triticum aestivum L.) с предполагаемыми мутантами при хорошо орошаемых и ограниченных условиях орошения.

Для устойчивого выращивания пшеницы в условиях ограниченных водных ресурсов в Египте жизненно важное значение имеет разработка высокоурожайных и водонепроницаемых сортов хлебной пшеницы с высокой производительностью воды. В этом исследовании в условиях как хорошо орошенной, так и ограниченной ирригации оценивались линии мутантов хлебной пшеницы из поколений М3, М4, М5 и их материнских сортов. three вегетационное время года2022-2024). Eight Согласно оценкам, агрономические характеристики и продуктивность водных ресурсов позволяют обнаружить высокоурожайные, устойчиво питающиеся водой пшеницы с

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… Seeds of each cultivar were irradiated with three doses of 100, 200, and 300 Gy of gamma rays (Cobalt-60) at the Egyptian Atomic Energy Authority, using a dose rate of 0.9 Gy s −1 . The corresponding exposure times were 111, 222, and 333 s, respectively. …

Advanced 3D Magnetic Scaffolds for Tumor-Related Bone Defects.

The need for bone substitutes is a major challenge as the incidence of serious bone disorders is massively increasing, mainly attributed to modern world problems, such as obesity, aging of the global population, and cancer incidence. Bone cancer represents one of the most significant causes of bone defects, with reserved prognosis regarding the effectiveness of treatments and survival rate. Modern therapies, such as hyperthermia, immunotherapy, targeted therapy, and magnetic therapy, seem to bring hope for cancer treatment in general, and bone cancer in particular. Mimicking the composition of

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… Magnetostrictive cobalt ferrites (CoFe 2 O 4 ) have also been successfully included in formulations of microsphere nanocomposites bioactive scaffolds. …

Reprogramming of nitrogen metabolism in tumors: mechanisms and therapeutic implications.

Nitrogen metabolism plays a key role in maintaining normal physiological functions of the organism and cell proliferation and differentiation. Nitrogen metabolism in normal human body maintains a dynamic balance to meet the body's demand for synthesis of biological macromolecules such as proteins and nucleic acids. However, in the process of tumor development, the nitrogen metabolism of tumor cells is reprogrammed to meet the demand of rapid proliferation, showing significantly different metabolic characteristics from normal cells. Key enzymes in the tumor microenvironment affect nitrogen meta

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… Agnello G, Alters SE, Rowlinson SW (2020) Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a pegylated, cobalt-substituted recombinant human arginase 1. …

Advances in nanotechnology-enabled adjuvants for peptide-based cancer vaccines.

Peptide-based vaccines only contain peptide epitopes and exclude unnecessary biological materials, which greatly reduces the risk of causing an undesired immune response and further improves the safety profile, garnering considerable interest in vaccine development. However, the immunogenicity induced by these peptides alone is not potent enough to elicit an effective immune response. Recently, combining the adjuvants with peptide antigens has shown promising effects to realize a satisfying immune response. In this review, we discuss the development of immunoadjuvants to enhance the safety and

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… To address the incapability of short MHC-I-restricted peptides generating sufficient and continuous potent antigen-specific T cell response, liposomes containing cobalt porphyrin–phospholipid (CoPoP) binding with short MHC-I-restricted peptides, along with PHAD (synthetic monophosphoryl lipid A), and …

Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells.

Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of a lethal cancer recurrence after standard first-line treatment (reductive surgery and chemotherapy). New treatments and adjunct therapies are needed. In ovarian cancer, as in other cancers, the immune response, particularly cytotoxic (CD8+) T cells are correlated with a decreased risk of recurrence. As well as completely new antigen targets resulting from DNA mutations (ne

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… Curcumin complexed with different metal ions has been tested for antibacterial inhibition activity, though only curcumin complexed with cobalt displayed antibacterial properties against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus [ 155 ]. …

Interstitial Lung Disease and Pulmonary Fibrosis: A Practical Approach for General Medicine Physicians with Focus on the Medical History.

Interstitial lung disease (ILD) and pulmonary fibrosis comprise a wide array of inflammatory and fibrotic lung diseases which are often confusing to general medicine and pulmonary physicians alike. In addition to the myriad of clinical and radiologic nomenclature used in ILD, histopathologic descriptors may be particularly confusing, and are often extrapolated to radiologic imaging patterns which may further add to the confusion. We propose that rather than focusing on precise histologic findings, focus should be on identifying an accurate etiology of ILD through a comprehensive and detailed m

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… Over the past several decades, many other occupations and substances have been grouped under occupation-related lung disease, and include exposures to beryllium, cobalt, tungsten, aluminum, and other chemicals [ 136 , 137 ]. …

Rapid Fire Presentations

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Precision Reprogramming in CAR-T Cell Therapy: Innovations, Challenges, and Future Directions of Advanced Gene Editing.

Chimeric antigen receptor (CAR)-T cell therapy represents a breakthrough in cancer immunotherapy, demonstrating impressive clinical outcomes, particularly for hematologic malignancies. However, its broader therapeutic application, especially against solid tumors, remains limited. Key challenges include T cell exhaustion, limited persistence, cytokine-mediated toxicities, and logistical hurdles associated with manufacturing autologous products. Emerging gene editing technologies, such as CRISPR/Cas systems, base editing, and prime editing, offer novel approaches to optimize CAR-T cells, aiming

Е-постеры.

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… Results : We found decreasing material stiffness from cobalt-chrome (CoCr) and stainless steel (SS) via titanium (Ti) to PEEK. Surprising differences of up to 10% were found between Ti rods from different manufacturers. … Although rod material could be one of the factors, few articles have mentioned the difference in screw backout between cobalt chrome rods (CoCr) and titanium alloy rods (Ti). The purpose of this study is to evaluate screw backout and sagittal alignment of the spine using CoCr rod or Ti rod. …

Устные доклады

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The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease.

The well-orchestrated turnover of proteins in cross-striated muscles is one of the fundamental processes required for muscle cell function and survival. Dysfunction of the intricate protein degradation machinery is often associated with development of cardiac and skeletal muscle myopathies. Most muscle proteins are degraded by the ubiquitin-proteasome system (UPS). The UPS involves a number of enzymes, including E3-ligases, which tightly control which protein substrates are marked for degradation by the proteasome. Recent data reveal that E3-ligases of the cullin family play more diverse and c

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… Functional activity of cullin-2-based E3-ligase complexes can be inhibited by the divalent metal ions cobalt and nickel ( Table 1 ), which bind to three different regions in the cullin protein. …

Токсичность тяжелых металлов в клиническом и экологическом здравоохранении: источники, механизмы, диагностика и научно обоснованное управление ртутью, свинцом, кадмием и арсеником.

Тяжелые металлы, включая ртуть (Hg), свинец (Pb), кадмий (Cd) и мышьяк (As), по-прежнему остаются значительными глобальными токсинами в силу их экологической стойкости, широкомасштабного антропогенного высвобождения и серьезного биологического воздействия. Этот обзор укрепляет нынешнее понимание их природных и промышленных источников, круговорота окружающей среды, маршрутов воздействия на человека и факторов уязвимости на уровне населения. Она охватывает их токсикокинетику и токсикодинамику, делая акцент на специфических для каждого вида механизмах поглощения, распределения и травмирования, вк

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… Unlike essential trace elements such as iron, zinc, copper, manganese, molybdenum, cobalt, and selenium, these toxic metals and metalloids have no known beneficial physiologic role at environmentally relevant exposure levels. …