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Exploiting artificial intelligence in precision oncology: an updated comprehensive review.

Precision oncology considers the genetic makeup of both the tumor and the cancer patient, medical history, clinical metadata, lifestyle and environmental factors. Thus, adoption of precision cancer medicine mandates sophisticated integrative analysis. Being a master in sorting and solving the puzzle pieces, artificial intelligence (AI)-powered frameworks emerged to fill the gap via executing multimodal analysis and generating meaningful outputs. Herein, we systematically discussed the opportunities and challenges of exploiting AI-assisted models in preclinical cancer research and in clinical o

Developing a patient portal for haematology patients requires involvement of all stakeholders and a customised design, tailored to the individual needs.

BackgroundElectronic patient portals are increasingly being implemented, also in (haemato) oncology. However, portal usage is low and depends on user and provider engagement. We explored wishes, expectations and thoughts of patients with a haematologic malignancy and their physicians with regard to the electronic patient portal.MethodsBased on insights from literature and a focus group discussion we built a 44-item questionnaire. This questionnaire was spread amongst patients with a haematologic malignancy at the outpatient clinic that was not yet exposed to patient portal facilities. Haematol

Искусственный интеллект, видоизменяющий парадигму гематологического диагноза и лечения злокачественных заболеваний: от статической оценки до динамического управления точностью.

Искусственный интеллект (ИИ) все чаще изучается в качестве инструмента содействия более точному и динамичному управлению диагностикой и лечением гематологов. В отличие от предыдущих обзоров, в которых основное внимание уделялось отдельным типам заболеваний или изолированным технологическим путям, в настоящем документе содержится всеобъемлющий обзор текущих прикладных программ АИШ и последних достижений в области диагностики, классификации, оценки прогнозов и принятия решений по лечению лейкемии, лимфомы, множественной миэломы и миэлодиспластических синдромов. Она охватывает ключевые технически

Convergence of mRNA technology and chimeric antigen receptor therapy: targeted technology optimizing targeted therapy.

Engineering cells to express chimeric antigen receptors (CARs) represents a novel approach in cancer immunotherapy, demonstrating remarkable efficacy in the treatment of hematologic malignancies while also encountering numerous challenges. Against the backdrop of the widespread application of COVID-19 mRNA vaccines, the integration of mRNA technology to produce CAR cells and enhance CAR therapies marks the cutting edge of cancer treatment innovation, offering potential solutions to the challenges faced by traditional CAR therapies. This convergence offers distinct advantages. It enables the ge

Judicialization of health: profile of demands for oncological medicines in a state in the central region of Brazil.

BACKGROUND: The significant increase in access to oncological medicines through court cases suggests that constitutional guarantees of integral and universal care in the Brazilian public health system are uncertain. METHODS: A retrospective observational study was conducted to analyze data from lawsuits requesting oncological medicines from 2014 to 2020 in the State of Goiás, Brazil, in state and federal courts. Sociodemographic, medical, and legal variables were statistically examined using descriptive, association, and correlation methods. RESULTS: Women brought more than half (54%) of the

Современный подход к диагностике диабетической ретинопатии

В этой статье рассматриваются инновационные методы диагностики диабетической ретинопатии, поскольку распространение сахарного диабета и его осложнений продолжает расти. Новые методы сосредоточены на раннем обнаружении заболеваний. Технологические новшества, такие как телеофтальмология, смартфонная фотография, искусственный интеллект с глубоким обучением или широкополосная фотография, могут повысить диагностическую точность и ускорить лечение. В ходе обзора в качестве перспективных решений для дистанционного офтальмологического обслуживания рассматриваются телеоптальмология и ручная фотография.

Применение непрерывного мониторинга глюкозы в когнитивных исследованиях диабета: обзор скопирования.

ЦЕЛЬ ОБЗОРА: Непрерывный мониторинг глюкозы (КГМ) все чаще включается в исследования по изучению когнитивных функций у больных диабетом. В этом аналитическом обзоре систематически картируется, каким образом КГМ применяется в когнитивных исследованиях среди лиц, страдающих диабетом, для характеристики нынешних методологических подходов, выявления ключевых пробелов в знаниях и информирования о будущих исследованиях. ПОСЛЕДНИЕ ВЫВОДЫ: Обзор аналитического исследования был проведен в соответствии с принципами Аркси и О'Мэлли. Систематический поиск five Были созданы электронные базы данных (PubMed,

Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review.

Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis affecting 5 million adults in the United States, with an age-adjusted prevalence of 4% to 15% and increasing up to 30% with age and the presence of cardiovascular risk factors. In this article we focus on lower extremity PAD and specifically on the superficial femoral and proximal popliteal artery (SFPA), which are the most common anatomic locations of lower extremity atherosclerosis. We summarize current evidence and perform a systematic review on the diagnostic evaluation as well as the medical, endovascular and s

Дифференциальные когнитивные траектории в зависимости от степени нарушения.

Несмотря на то, что когнитивное расстройство (CI) является распространенным явлением при множественном склерозе (MS), традиционная когнитивная реабилитация часто ограничивается проблемами доступности и присоединения. Телеабилитация представляет собой доступную альтернативу, однако ее эффективность при различных уровнях жесткости CI остается неясной. Нынешнее перспективное, одноцентральное, одностороннее вмешательство с многократными мерами, направленными на выявление изменений в когнитивных и психосоциальных результатах после осуществления на дому программы познавательной телереабилитации с еж

Exploring Barriers and Facilitators to Engagement of an Online Acceptance and Commitment Therapy Intervention for Cancer Survivors With Chronic Painful Chemotherapy-Induced Peripheral Neuropathy: Qualitative Interview Study.

BackgroundOnline self-management interventions for cancer survivors are increasingly being used, but engagement is often difficult for patients. Given the importance of engagement for intervention effectiveness, identifying patient-reported barriers and facilitators is essential.ObjectiveThe aim of this study was to qualitatively examine barriers and facilitators influencing engagement with an online self-management intervention, offered with or without guidance, for cancer survivors experiencing chronic painful chemotherapy-induced peripheral neuropathy (CIPN).MethodsPatients who took part in

The acceptability of using wearable electronic devices to monitor physical activity of patients with Multiple Myeloma undergoing treatment: a systematic review.

INTRODUCTION: Multiple myeloma (MM) is diagnosed in 6,000 people in the UK yearly. A performance status measure, based on the patients' reported level of physical activity, is used to assess patients' fitness for treatment. This systematic review aims to explore the current evidence for the acceptability of using wearable devices in patients treated for MM to measure physical activity directly. METHODS: Three databases were searched (MEDLINE, EMBASE and CINAHL) up until 7th September 2023. Prospective studies using wearable devices to monitor physical activity in patients on treatment for MM

Artificial intelligence for risk assessment and outcome prediction in malignant haematology.

Risk stratification is the backbone of clinical decision-making for patients with haematological malignancies. Models currently used in routine clinical practice often rely on static rules, conventional statistics and expert consensus. While pragmatic and accessible, these models fail to capture the complex biological interactions and patient heterogeneity, especially as data dimensionality grows given the availability of more comprehensive molecular analysis. Artificial intelligence (AI), particularly machine learning (ML), offers the potential to process such high-dimensional data, uncover l

Use of Software as a Medical Device to Improve Therapeutic Adherence in Patients With Hematological Malignancies: Prospective Interventional MargheRITA Study.

BackgroundHematological malignancies are a global health challenge, with a substantial number of deaths each year. Treatment adherence is crucial for improving patient outcomes in patients with hematological malignancies, but resource limitations and logistical challenges hinder optimal outpatient management. Digital health solutions such as the Remote Intelligence for Therapeutic Adherence (RITA) software as a medical device (SaMD) offer potential solutions by facilitating telemedicine visits and supporting patients in managing their treatment.ObjectiveThe aim of this study was to evaluate th

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… Given that patients with hematological malignancies often must adhere to strenuous medication regimens, manage symptoms associated with treatment, and, eventually, experience late effects associated with survivorship, they would benefit greatly from digital technology aimed at decreasing these burdens …

Advances in the assessment of minimal residual disease in mantle cell lymphoma.

The clinical impact of minimal residual disease detection at early time points or during follow-ups has been shown to accurately predict relapses among patients with lymphomas, mainly in follicular and diffuse large B cell lymphoma. The field of minimal residual disease testing in mantle cell lymphoma is still evolving but has great impact in determining the prognosis. Flow cytometry and polymerase chain reaction-based testing are most commonly used methods in practice; however, these methods are not sensitive enough to detect the dynamic changes that underline lymphoma progression. Newer meth

:: воздействие респираторной подготовки по вопросам респираторной функции, утомления, качества жизни и функциональной способности пациентов с множественным склерозом.

Предыстория и цели: Телеабилитация (TR) предлагает новаторский подход к решению проблем доступности при управлении множественным склерозом (МС). В этом исследовании была дана оценка эффективности интеграции упражнений по дыханию в программы TR, направленные на улучшение дыхательной функции, усталости и качества жизни. Материалы и методы: Было проведено выборочное контролируемое испытание с участием 48 пациентов из числа НР, которые были произвольно включены в состав групп TR и контроля. Обе группы проводили упражнение дыхательных путей в течение восьми недель. До и после вмешательства была про

A Rapid Systematic Review on the Experiences of Cancer Survivors Residing in Rural Areas during the COVID-19 Pandemic.

The COVID-19 pandemic has caused considerable disruption to cancer care and may have exacerbated existing challenges already faced by cancer survivors from rural areas. This has created a need for a rapid evidence synthesis to inform the development of tailored interventions that address the specific needs of rural cancer survivors who continue to be affected by the pandemic. The review was conducted following guidance from the Cochrane Rapid Review Methods Group. Database searches were performed via the EBSCOHost interface (includes MEDLINE, CINAHL, PsycINFO) on 25 May 2022 and supplemented w

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… The increased use of telehealth and digital technologies were not without their challenges and these included access and support issues as well as communication and connectivity difficulties due to sensory impairment, rurality and inadequate equipment [ 52 ]. … This review has shown that access to digital technology and connectivity issues are still prominent within rural settings and so investment as well as education is required [ 69 ] to ensure that digital inequalities do not widen as telemedicine models of care continue to be rolled out in a post-pandemic …

Разработка интерактивной прикладной программы биоразведки для оценки декстерности пальцев.

ЦЕЛЬ: Точная оценка функции пальца имеет решающее значение для контроля за ежедневной деятельностью рук. Однако для оценки различных задач, связанных с использованием пальцев, не хватает специализированных цифровых приложений. Цель этого исследования заключается в разработке индивидуального прикладного программного обеспечения цифрового биоразведки для оценки декситеритности пальцев. МЕТОДЫ: Мы разработали цифровую программу биоразведки, совместимую с смартфонами и таблетками, которая позволяет 3-min испытание на декстерминацию пальцев, измерение скорости и точности для каждого пальца и каждог

Usability testing of an electronic patient-reported outcome system linked to an electronic chemotherapy prescribing and patient management system for patients with cancer.

BackgroundPeople affected by cancer experience a wide range of symptoms which have a major impact on their functioning and health-related quality of life (HRQoL). One way to measure the impact of cancer symptoms is through the use of patient-reported outcomes.MethodsAn electronic patient-reported outcome (ePRO) application (ChemoPRO®) was designed to be used by cancer patients to report their symptoms and communicate with their clinical team. Usability testing sessions were conducted with people with lived experience of cancer to understand how real users interact with the ChemoPRO® system. On

A qualitative study of cancer survivors' exercise behaviour 4 months after a telerehabilitation program.

PURPOSE: Although telerehabilitation can improve access to exercise programs for cancer survivors, it is not known if these programs lead to ongoing change in exercise habits. This study explored participant experiences of exercise 4 months after finishing specialized cancer exercise-based telerehabilitation. METHOD: A qualitative study embedded in a randomized controlled trial evaluated exercise-based cancer telerehabilitation delivered in groups. Data were collected via semistructured interviews that were audio-recorded and transcribed verbatim. Seventeen adult cancer survivors (age 21 to 8

Convenient Access to Expert-Reviewed Health Information via an Alexa Voice Assistant Skill for Patients With Multiple Myeloma: Development Study.

BackgroundPatients with multiple myeloma (MM) have high information needs due to the complexity of the disease and variety of treatments. Digital voice assistants provide support in daily life and can be a convenient tool that even older patients can use to access health information. Voice assistants may therefore be useful in providing digital health services to meet the information needs of patients with MM.ObjectiveWe aim to describe and report on the development, content, and functionality of the first Amazon Alexa voice assistant skill for patients with MM in Germany with the goal of empo