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Efficacy of expressive helping in adult hematologic cancer patients undergoing stem cell transplant: protocol for the Writing for Insight, Strength, and Ease (WISE) study's two-arm randomized controlled trial.

BackgroundDuring, shortly after, and sometimes for years after hematopoietic stem cell transplant, a large proportion of hematological cancer patients undergoing transplant report significant physical and psychological symptoms and reduced health-related quality of life. To address these survivorship problems, we developed a low-burden, brief psychological intervention called expressive helping that includes two theory- and evidence-based components designed to work together synergistically: emotionally expressive writing and peer support writing. Building on evidence from a prior randomized c

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… Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–381. doi: 10.1016/j.jbi.2008.08.010. 47. Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle MT, Morrissey M, et al. …

Stakeholder perspectives and requirements to guide the development of digital technology for palliative cancer services: a multi-country, cross-sectional, qualitative study in Nigeria, Uganda and Zimbabwe.

IntroductionCoverage of palliative care in low and middle-income countries is very limited, and global projections suggest large increases in need. Novel approaches are needed to achieve the palliative care goals of Universal Health Coverage. This study aimed to identify stakeholders' data and information needs and the role of digital technologies to improve access to and delivery of palliative care for people with advanced cancer in Nigeria, Uganda and Zimbabwe.MethodsWe conducted a multi-country cross-sectional qualitative study in sub-Saharan Africa. In-depth qualitative stakeholder intervi

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… 11.13) Mean (SD) years’ palliative care experience | 9.70 (7.52) Country Nigeria | 19 (32.20%) Uganda | 20 (33.90%) Zimbabwe | 20 (33.90%) Policy Makers ( n = 26) Sex Male | 12 (46.15%) Female | 14 (53.85%) Professional background Doctor | 13 (50.00%) Nurse | 3 (11.54%) Pharmacist | 3 (11.54%) Health Informatics …

Тонаберсат усиливает цитотоксичность в глиобластоме с помощью темозоломида путем нарушения межклеточной связи через коннексин 43 ингибирование.

Клетки глиобластомы зависят от коннексина 43 (Cx43) на основе данных о разрыве (GJs) для межклеточной связи, позволяющей им интегрироваться в широко разветвленную злокачественную сеть. Несмотря на многообещающие перспективы новой целевой терапии, отсутствие клинически осуществимых ингибиторов GJ препятствует их внедрению в клинической практике. В настоящем исследовании мы изучили тонаберсат (ТО) — лекарство, вызывающее кровоизлияние в мозг и имеющее свойства GJ-ингиберия, с точки зрения его способности разобрать межклеточную связь в сетях глиобластомы. Для изучения функциональной межклеточной

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… Furthermore, we thank the Institute for Medical Biometry, Informatics and Epidemiology (IMBIE) at the University Bonn for their statistical advice. …

Pharmacomicrobiomics in Anticancer Therapies: Why the Gut Microbiota Should Be Pointed Out.

Anticancer treatments have shown a variable therapeutic outcome that may be partly attributable to the activity of the gut microbiota on the pathology and/or therapies. In recent years, microbiota-drug interactions have been extensively investigated, but most of the underlying molecular mechanisms still remain unclear. In this review, we discuss the relationship between the gut microbiota and some of the most commonly used drugs in oncological diseases. Different strategies for manipulating the gut microbiota layout (i.e., prebiotics, probiotics, antibiotics, and fecal microbiota transplantati

Abstracts From JADPRO Live at APSHO 2017.

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… Recommendations: Ongoing QA practices of OCM measures using AI, and RPM, improving data governance and clinical informatics, and implementing an information-based strategy to address the quality of oncology service delivery by the organization is essential. JL515. …

The impact of mHealth interventions on medication adherence in breast cancer: a systematic review of randomized controlled trials.

BackgroundNon-adherence to medication can reduce therapeutic effectiveness in breast cancer patients, thereby increasing the risk of disease progression or recurrence. This study aimed to systematically review the existing scientific literature on the impact of mHealth interventions on medication adherence among breast cancer patients.MethodsThis systematic review was conducted following PRISMA guidelines and focused on randomised clinical trials published in English. The review evaluated the effectiveness of mHealth interventions in improving medication adherence in breast cancer patients fro

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… BMC Medical Informatics and Decision Making , 15(1), 46. 10.1186/s12911-015-0171-5 Hariton, E., & Locascio, J. J. (2018). Randomised controlled trials – The gold standard for effectiveness research. …

Olive Leaf Extract (OLE) Anti-Tumor Activities Against Hematologic Tumors: Potential Therapeutic Implications for Pediatric Patients with B-Acute Lymphoblastic Leukemia.

Background/Objectives: Several studies reported that olive leaf extract (OLE) may exert potent anti-cancer activities against human solid and hematological tumors. Such effects are mostly related to the polyphenol oleuropein and its derivatives, which are highly concentrated in OLE. Here, we investigated the anti-tumor effects of OLE in vitro against human acute leukemia and lymphoma cells. Methods: Cell proliferation and apoptosis have been evaluated by flow cytometry (using CFSE and Annexin-V/7AAD, respectively) in the presence or absence of OLE at different concentrations and in combination

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… Informatics Approaches for Predicting, Understanding, and Testing Cancer Drug Combinations Kinase Signaling Networks Methods in Molecular Biology Humana Press New York, NY, USA 2017 1636 485 506 10.1007/978-1-4939-7154-1_30 PMC6322649 28730498 20. Yadav B. Wennerberg K. Aittokallio T. Tang J. …

Predicting which patients with cancer will see a psychiatrist or counsellor from their initial oncology consultation document using natural language processing.

BackgroundPatients with cancer often have unmet psychosocial needs. Early detection of who requires referral to a counsellor or psychiatrist may improve their care. This work used natural language processing to predict which patients will see a counsellor or psychiatrist from a patient's initial oncology consultation document. We believe this is the first use of artificial intelligence to predict psychiatric outcomes from non-psychiatric medical documents.MethodsThis retrospective prognostic study used data from 47,625 patients at BC Cancer. We analyzed initial oncology consultation documents

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… Convolutional neural networks for biomedical text classification: application in indexing biomedical articles. in Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics 258–267 10.1145/2808719.2808746 (ACM, 2015). 47. Rios A, Kavuluru R. …

Using Wearable Inertial Sensors to Assess Mobility of Patients With Hematologic Cancer and Associations With Chemotherapy-Related Symptoms Before Autologous Hematopoietic Stem Cell Transplant: Cross-sectional Study.

BackgroundWearable sensors could be a simple way to quantify and characterize mobility in patients with hematologic cancer scheduled to receive autologous hematopoietic stem cell transplant (autoHSCT) and how they may be related to common treatment-related symptoms and side effects of induction chemotherapy.ObjectiveWe aimed to conduct a cross-sectional study comparing mobility in patients scheduled to receive autoHSCT with that in healthy, age-matched adult controls and determine the relationships between patient mobility and chemotherapy-related symptoms.MethodsPatients scheduled to receive

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… Parkinson's disease Physiol Meas 2019 09 30 40 9 095003 10.1088/1361-6579/ab4023 31470423 31470423 PMC8072263 40 Harris PA Taylor R Thielke R Payne J Gonzalez N Conde JG Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics …

Combination of the PI3K inhibitor Idelalisib with the conventional cytostatics cytarabine and dexamethasone leads to changes in pathway activation that induce anti-proliferative effects in B lymphoblastic leukaemia cell lines.

BackgroundThe introduction of combined conventional cytostatics and pathway-specific inhibitors has opened new treatment options for several cancer types including hematologic neoplasia such as leukaemias. As the detailed understanding of the combination-induced molecular effects is often lacking, the identification of combination-induced molecular mechanisms bears significant value for the further development of interventional approaches.MethodsCombined application of conventional cytostatic agents (cytarabine and dexamethasone) with the PI3K-inhibitor Idelalisib was analysed on cell-biologic

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… Institute for Biostatistics and Informatics in Medicine and Ageing, Rostock University Medical Center, Rostock, Germany. Yvonne Saara Gladbach, Mathias Ernst, Mohamed Hamed, Sarah Fischer, Stephan Struckmann, Georg Fuellen. Faculty of Biosciences, Heidelberg University, Heidelberg, Germany. …

Upcoming Revolutionary Paths in Preclinical Modeling of Pancreatic Adenocarcinoma.

To date, PDAC remains the cancer having the worst prognosis with mortality rates constantly on the rise. Efficient cures are still absent, despite all attempts to understand the aggressive physiopathology underlying this disease. A major stumbling block is the outdated preclinical modeling strategies applied in assessing effectiveness of novel anticancer therapeutics. Current in vitro preclinical models have a low fidelity to mimic the exact architectural and functional complexity of PDAC tumor found in human set, due to the lack of major components such as immune system and tumor microenviron

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… This process starts with target identification through chemo-informatics tools such as chemical structure similarity searching ( 113 ), data mining/machine learning ( 114 ), panel docking ( 115 ), and bioactivity spectra based algorithms ( 116 ). …

Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside.

Despite impressive efforts invested in epigenetic research in the last 50 years, clinical applications are still lacking. Only a few university hospital centers currently use epigenetic biomarkers at the bedside. Moreover, the overall concept of precision medicine is not widely recognized in routine medical practice and the reductionist approach remains predominant in treating patients affected by major diseases such as cancer and cardiovascular diseases. By its' very nature, epigenetics is integrative of genetic networks. The study of epigenetic biomarkers has led to the identification of num

Integrating Artificial Intelligence, Circulating Tumor DNA, and Real-World Evidence to Optimize Hematologic Clinical Trials: Toward Adaptive and Learning Trial Designs.

The integration of emerging technologies and real-world data is transforming the landscape of hematologic clinical trials. Artificial intelligence (AI) offers remarkable capabilities for predictive modeling, patient stratification, and adaptive trial design, while circulating tumor DNA (ctDNA) provides a minimally invasive biomarker for disease monitoring, the early detection of relapse, and treatment response assessment. Concurrently, real-world evidence (RWE) complements traditional clinical trial data by capturing treatment effectiveness, safety, and patient outcomes in broader, heterogeneo

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… Informatics 2025 206 106141 10.1016/j.ijmedinf.2025.106141 41075423 62. Chopra H. Annu Shin D.K. Munjal K. Priyanka Dhama K. Emran T.B. Revolutionizing clinical trials: The role of AI in accelerating medical breakthroughs Int. J. …

Машинное обучение выявляет микробиомы и клинические прогнозы устойчивой потери веса после продолжительного поста.

Длительное постирование может улучшить метаболическое здоровье, однако контролируемые данные по здоровым взрослым с более длительным последующим наблюдением и многомерным профилированием ограничены. Мы расследовали немедленное и 12-week ПОСЛЕДУЮЩИЕ ПОСЛЕДУЮЩИЕ ПОСЛЕДСТВИЯ 5-day Быстрое вмешательство в состав тела, кишечный микробиом и циркулирующие и фекальные метаболиты, а также оценка того, прогнозируют ли базовые характеристики индивидуальные реакции на потерю веса. В ходе случайного, контролируемого списка ожидания, 38 здоровые взрослые 5-day быстрого вмешательства с помощью 12-week :: пос

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… Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inf. 2009;42:377–81. 10.1016/j.jbi.2008.08.010. 24. Hopewell S, et al. …

Decoding Immunodeficiencies with Artificial Intelligence: A New Era of Precision Medicine.

Primary and secondary immunodeficiencies comprise a wide array of illnesses marked by immune system abnormalities, resulting in heightened vulnerability to infections, autoimmunity, and cancers. Notwithstanding progress in diagnostic instruments and an enhanced comprehension of the underlying pathophysiology, delayed diagnosis and underreporting persist as considerable obstacles. The implementation of artificial intelligence into clinical practice has surfaced as a viable method to enhance early detection, risk assessment, and management of immunodeficiencies. Recent advancements illustrate ho

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… A Framework for Augmented Intelligence in Allergy and Immunology Practice and Research-A Work Group Report of the AAAAI Health Informatics, Technology, and Education Committee J. Allergy Clin. Immunol. Pract. 2022 10 1178 1188 10.1016/j.jaip.2022.01.047 35300959 PMC9205719 114. You Y. Lai X. …

Психометрическая оценка шкалы соответствия лекарствам ПРОМИСШ среди пациентов предписывала пероральное противораковое лекарство для множественных миелом.

Лекарства от оральных противораковых заболеваний являются стандартными средствами лечения рака. Соблюдение лекарств влияет на результаты медицинского обслуживания, однако действительные и надежные меры по оценке саморегистрируемого соответствия лекарствам ограничены. Психометрические свойства шкалы соблюдения лекарственных средств ПРОМИСС (PMAS) были оценены у пациентов, которым были предписаны пероральные противораковые препараты для множественных миелом. МЕТОДОЛОГИЯ: Это был вторичный анализ, проведенный в ходе продольного наблюдения, в ходе которого были исследованы соответствие лекарствам,

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… Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG (2009) Research electronic data capture (REDCap) - A metadata-driven methodology and workflow process for providing translational research informatics support. …

Artificial intelligence across the cancer care continuum.

Artificial intelligence (AI) holds significant potential to enhance various aspects of oncology, spanning the cancer care continuum. This review provides an overview of current and emerging AI applications, from risk assessment and early detection to treatment and supportive care. AI-driven tools are being developed to integrate diverse data sources, including multi-omics and electronic health records, to improve cancer risk stratification and personalize prevention strategies. In screening and diagnosis, AI algorithms show promise in augmenting the accuracy and efficiency of medical image ana

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… Informatics‐enabled behavioral medicine in oncology . Cancer J . 2011 ; 17 ( 4 ): 222 ‐ 230 . doi: 10.1097/ppo.0b013e318227c811 21799329 PMC3148812 96 Wei Y , Guo X . Revolutionizing clinical experimental protocol design through the ChatGPT technology . …

Exploring the characteristics of conversational agents in chronic disease management interventions: A scoping review.

ObjectiveWith the increasing global burden of chronic diseases, there is the potential for conversational agents (CAs) to assist people in actively managing their conditions. This paper reviews different types of CAs used for chronic condition management, delving into their characteristics and the chosen study designs. This paper also discusses the potential of these CAs to enhance the health and well-being of people with chronic conditions.MethodsA search was performed in February 2023 on PubMed, ACM Digital Library, Scopus, and IEEE Xplore. Studies were included if they focused on chronic di

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… Transforming consumer health informatics through a patient work framework: connecting patients to context. J Am Med Inform Assoc JAMIA 2015; 22: 2–10. 5. Corbin J, Strauss A. Managing chronic illness at home: three lines of work. Qual Sociol 1985; 8: 224–247. 6. …

Use of active video games with or without videoconferencing on health outcomes in adolescent and young adult cancer survivors: a systematic review.

PurposeAdolescent and young adult (AYA) cancer survivors experience greater functional deficits compared to non-cancer peers or older survivors with a similar diagnosis. Physical activity (PA) is a key strategy for mitigating functional decline, and motivation and peer support are critical PA facilitators in AYA cancer survivors. Active video games (AVGs) may be a "gateway" method to promote PA. Further, integrating AVGs into group videoconferencing, a medium used by AYAs to socialize, can capitalize on peer support needed for PA motivation. Thus, we examined the use of AVGs and/or videoconfer

Efficacy and Safety of Filgrastim and Its Biosimilars to Prevent Febrile Neutropenia in Cancer Patients: A Prospective Study and Meta-Analysis.

Background: The aim of this review and meta-analysis was to identify, assess, meta-analyze and summarize the comparative effectiveness and safety of filgrastim in head-to-head trials with placebo/no treatment, pegfilgrastim (and biosimilar filgrastim to update advances in the field. Methods: The preferred reporting items for systematic reviews and meta-analyses PRISMA statement were applied, and a random-effect model was used. Primary endpoints were the rate and duration of grade 3 or 4 neutropenia, and an incidence rate of febrile neutropenia. Secondary endpoints were time to absolute neutrop

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… IMS Institute for Healthcare Informatics; Singapore: 2016. 92. Aapro M., Cornes P., Abraham I. …