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Cardiovascular Concerns, Cancer Treatment, and Biological and Chronological Aging in Cancer: JACC Family Series.

Cardiovascular disease (CVD) and cancer are leading causes of death globally, particularly among the rapidly growing population of older adults (OAs). CVD is a leading cause of mortality among cancer survivors, often accelerated by cancer treatments associated with short- or long-term cardiotoxicity. Moreover, there is a dynamic relationship among CVD, cancer, and aging, characterized by shared risk factors and biological hallmarks, that plays an important role in caring for OAs, optimizing treatment approaches, and developing preventive strategies. Assessment of geriatric domains (eg, functio

Cardiovascular health: an important component of cancer survivorship.

Advances in the detection and treatment of cancer have translated into improved cancer survival rates and a growing population of cancer survivors. These include those living with cancer and individuals free of the disease following treatment. Epidemiological studies demonstrate that cancer survivors are at an increased risk of cardiovascular disease (CVD), with cardiovascular (CV) mortality overtaking cancer mortality in some tumour types. Cancer and CVD share common aetiological risk factors, for example, age, tobacco use and obesity, as well as a shared inflammatory pathogenesis. The CV ris

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… (ESMO) and American Society of Clinical Oncologists (ASCO) 81 118 119 * High risk: High and very-high baseline CV toxicity risk based on HFA-ICOS assessment; receipt of doxorubicin ≥ 250 mg/m 2 , RT > 15 Gy MHD; doxorubicin ≥ 100 mg/m 2 and RT 5–15 Gy MHD; high risk haematopoietic stem cell transplant … We also searched relevant clinical guidelines produced by the European Society for Medical Oncologists (ESMO), American Society of Clinical Oncology (ASCO), European Society of Cardiology (ESC), and National Comprehensive Cancer Network. The reference lists of retrieved articles were also searched. …

Abstracts From JADPRO Live at APSHO 2017.

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… Although many rural facilities have infusion centers that administer chemotherapy, those facilities do not have direct oversight by an oncologist or oncology-trained advanced practice professional (APP). … Results: A significant amount of ambulatory cancer care was provided by NPs and PAs, 6.9% of the workforce was NPs and PAs, compared with medical oncologists, hematologists or double boarded hematology/oncology physicians who comprised 9.5% of the workforce. …

Orthopaedic Oncology in Contemporary Practice: A Comprehensive Review of Primary Bone Tumours, Metastatic Pathways, and Evolving Surgical Techniques.

Orthopaedic oncology encompasses the diagnosis and management of primary bone sarcomas and metastatic skeletal disease, requiring integration of oncologic principles with complex musculoskeletal reconstruction. Advances in molecular classification, cross-sectional imaging, systemic therapy, and surgical technology have substantially transformed contemporary clinical practice. This comprehensive review synthesises current evidence across epidemiology, tumour biology, diagnostic strategies, staging systems, multidisciplinary management, reconstructive techniques, complication profiles, and survi

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… A comprehensive assessment done by different specialists, like orthopaedic surgeons, radiologists, pathologists, and medical oncologists, can help reduce delays in the definitive management of the disease [ 42 ]. … Coordination between the orthopaedic surgeons, radiation oncologists, and medical oncologists helps in aligning the local and systemic treatment goals. …

Role of muscle glucometabolism derived from 18F-FDG PET/CT in sarcopenia of elderly patients with newly diagnosed malignancies.

BackgroundOur previous studies have found that certain cancer patients with sarcopenia tend to present with lower glucometabolism within skeletal muscles. This study aimed to investigate the association between sarcopenia and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) along with clinicopathological factors in elderly patients with treatment-naïve malignant tumors.MethodsClinicopathological and 18F-FDG PET/CT characteristics of 1,024 elderly patients with newly diagnosed malignancies [638 men, 386 women; median age: 68 years (range, 60-99 years)] we

Obstacles to Early Diagnosis of Gaucher Disease.

Gaucher disease (GD) is a rare lysosomal storage disorder resulting from a deficiency of the lysosomal enzyme glucocerebrosidase caused by biallelic variants in the GBA1 gene. Patients may present with a wide spectrum of disease manifestations, including hepatosplenomegaly, thrombocytopenia, bone manifestations, and in the case of GD types 2 and 3, neurodegeneration, cognitive delay, and/or oculomotor abnormalities. While there is no treatment for neuronopathic GD, non-neuronopathic manifestations can be efficiently managed with enzyme replacement therapy or substrate reduction therapy. Howeve

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… Patients are often misdiagnosed or referred to multiple different specialists, most often hematologist-oncologists, before receiving a diagnosis. 35 , 36 Among hematologists, there remains a lack of awareness of GD, as a study across seven countries found that only 20% of 406 surveyed hematologist oncologists … Consequences of diagnostic delays in type 1 Gaucher disease: the need for greater awareness among hematologists-oncologists and an opportunity for early diagnosis and intervention . Am J Hematol . 2007 ; 82 ( 8 ): 697 – 701 . doi: 10.1002/ajh.20908 17492645 10. Koto Y , Narita A , Noto S , et al. …

Assessment of a Systematic Screening of Occupational Exposures in Malignant Hemopathies in the Rhone-Alpes Area: Prolymphome Study.

BACKGROUND: Several studies have highlighted the role of environmental exposures in malignant hemopathies etiology. Some patients with malignant hemopathies can be compensated as occupational diseases. The Prolymphome research aimed to assess a systematic screening of occupational exposures in patients with lymphoma or myeloma treated in three hospitals in the Rhône-Alpes region. METHODS: Patients received a self-administered questionnaire to fill in at home to collect their job history and potential occupational exposures to carcinogens. A physician assessed the questionnaire to determine if

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… Numerous barriers to the recognition of occupational cancers have been identified in the literature, including oncologists’ lack of time to gather patients’ occupational histories, multiple exposures, and a lack of knowledge and expertise, due partly to the long latency period between the exposure and … However, this approach necessitated oncologist involvement before identifying occupational exposures, and limited time from oncologists was frequently noted as a barrier to identifying occupational cancers [ 28 ]. …

Prevalence, classifications and factors associated with sexual dysfunction among adult cancer patients on chemotherapy at the Uganda Cancer Institute, Mbarara.

BACKGROUND: Sexual dysfunction is a social challenge that devastates many people, including cancer patients. However, among the numerous reported side effects of chemotherapy sexual dysfunction is the least studied and reported. The chemotherapeutics used among cancer patients are potential risk factors for the development of sexual dysfunction, and such an understanding of these risk factors can lead to numerous interventions to bypass their effects on sexual activity. OBJECTIVE: The goal of this study was to determine the prevalence, classification and factors associated with sexual dysfunc

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… The UCIMRRH also has two [ 2 ] oncologists, one [ 1 ] oncology pharmacist, one [ 1 ] pharmacist, and 5 nurses. Study population All male and female adult cancer patients who visited the UCIMRRH and met the inclusion criteria were included in the study. … Sexual and fertility-related adverse effects of medicinal treatment for cancer; a national evaluation among medical oncologists. Support Care Cancer. 2022;30(5):4035–47. 35064326 10.1007/s00520-021-06721-9 39. …

The Role of Minimal Access Surgery in the Treatment of Spinal Metastatic Tumors.

Study designLiterature review.ObjectiveTo provide an overview of the recent advances in minimal access surgery (MAS) for spinal metastases.MethodsLiterature review.ResultsExperience gained from MAS in the trauma, degenerative and deformity settings has paved the road for MAS techniques for spinal cancer. Current MAS techniques for the treatment of spinal metastases include percutaneous instrumentation, mini-open approaches for decompression and tumor resection with or without tubular/expandable retractors and thoracoscopy/endoscopy. Cancer care requires a multidisciplinary effort and adherence

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… Treatment Algorithms For treatment of spinal tumors, patients benefit from an evaluation by a multidisciplinary team, including neurosurgeons, radiation and medical oncologists, interventional radiologists, and pain specialists. 8 The NOMS framework assesses 4 key factors to facilitate the decision … Oncologist . 2013 ; 18 : 744 – 751 . doi:10.1634/theoncologist.2012-0293 23709750 10.1634/theoncologist.2012-0293 PMC4063402 10 Bilsky MH Laufer I Fourney DR , et al. Reliability analysis of the epidural spinal cord compression scale . …

Bone metastases from head and neck malignancies: Prognostic factors and skeletal-related events.

BackgroundWe conducted a multicenter retrospective analysis to describe the characteristics, frequency of skeletal-related events (SREs), and prognosis of head and neck cancer (HNC) in patients with bone metastases (BM).Patients and methodsThe data of 192 HNC patients with BMs were collected. Analyses were conducted separately in 64 nasopharyngeal cancer (NPC) patients and in 128 non-NPC patients.ResultsSREs occurred in 34 (27%) non-NPC and in 6 (9%) NPC patients, respectively. Median overall survival (OS) was 25 and 6 months in NPC and non-NPC patients, respectively. Locoregional recurrence (

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… The management of patients with bone metastases requires a multidisciplinary team involving medical oncologists and radiation oncologists, as well as orthopedic surgeons, neurosurgeons, and interventional radiologists to provide the best treatment strategy, appropriate preventive measures, and treatment … Oncologist. 2015; 20: 291–298. 10.1634/theoncologist.2014-0206 6. Bhandari V, Jain RK. A retrospective study of incidence of bone metastasis in head and neck cancer. J Cancer Res Ther. 2013; 9: 90–93. 10.4103/0973-1482.110385 7. Pietropaoli MP, Damron TA, Vermont AI. …

Use of percutaneous microwave ablation for the treatment of bone tumors: a retrospective study of clinical outcomes in 47 patients.

ObjectiveThe present study aimed to evaluate the short-term clinical performance and safety of percutaneous microwave ablation (MWA) techniques for the treatment of bone tumors.MethodsThis single-institution retrospective study investigated 47 cases of bone tumors treated by MWA from June 2015 to June 2018. The study included 26 patients (55.3%) with benign bone tumors and 21 patients (44.7%) with malignant bone tumors. The tumors were located in the spine or sacrum (15, 31.9%), the upper extremities (6, 12.8%), the lower extremities (17, 36.2%) and the pelvis (9, 19.1%). Outcomes regarding cl

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… Additionally, a truly multidisciplinary approach involving orthopedic oncologists, radiation oncologists, and interventional radiologists is usually ignored, but is essential for diagnostic guidance and treatment evaluation. … 12.8% Lower extremity | 17 | 36.2% Pelvis | 9 | 19.1% Surgical management | MWA | 14 | 29.8% MWA+BC | 18 | 38.3% Endoscopic MWA+IAB/BC | 15 | 31.9% Follow-up (months) | Mean±SD (months) | 4.8±1.6 Range | 2–9 Before undergoing MWA, we usually conduct a multidisciplinary meeting with our experienced oncologists …

The Challenges of Prognosticating Persistent Critical Illness: A Qualitative Study.

BackgroundMedical decision-making in the ICU is influenced by a patient's anticipated clinical course. However, intensivists struggle to identify accurately which patients will experience within-ICU events-such as new late-onset shock or acute hypoxic respiratory failure (AHRF)-that contribute to the development of persistent critical illness (PerCI). Given the uniqueness of patients who experience PerCI, understanding how intensivists process and incorporate evolving clinical information into their prognostication remains unknown for this population.Research questionWhat processes do intensiv

Comparative Outcomes in Metastatic Spinal Cord Compression and Femoral Metastatic Disease: Distinct Clinical Entities with Divergent Prognoses?

Background and Objectives: Acute metastatic cord compression (AMSCC) and femoral impending/pathological fracture negatively impact a patient's quality of life, morbidity and survival, and are considered significant life events. This study aims to compare AMSCC and FMD as distinct yet overlapping metastatic orthopedic emergencies, addressing whether they represent sequential disease stages or distinct patient subpopulations-an analysis critical for prognosis and treatment planning. Materials and Methods: Records of all patients who underwent surgery for a femoral metastatic disease (FMD) over a

Cardiotoxicity in people undergoing cancer treatment - the role of the oncology nurse.

Cardiotoxicity is a significant complication of cancer treatment, and this review describes the cardiovascular risks associated with various therapies and emphasizes the crucial role of oncology nurses in managing these risks. Many cancer treatments, including cytotoxic therapies, radiation, targeted therapies, and immune-modulatory drugs, have been shown to increase the likelihood of cardiovascular toxicity, leading to conditions such as acute coronary syndrome, heart failure, and atrial fibrillation. Guidelines are now available to reduce treatment-related cardiovascular toxicity (CTR-CVT) a

Proteasome inhibitors in medullary thyroid carcinoma: time to restart with clinical trials?

IntroductionMedullary thyroid cancer (MTC) is a rare thyroid tumour whose management in advanced stages is challenging, despite effective therapeutic options having expanded in recent years. Proteasome inhibitors (PrIn) have shown the ability to improve patient outcomes, including survival and quality of life, in several malignancies, due to their ability to impair cell proliferation and cause apoptosis through the inhibition of the proteasome activity. Consequently, these drugs could represent a useful tool, alone or in combination with other treatments, in MTC patients.Aim of the studyThis r

Development of an evidence-based educational resource in oncology: 'Living safely with bone metastases'.

OBJECTIVE: To create an evidence-based patient education resource to better support cancer patients with bone metastases in carrying out safe movements during activities of daily living, to maintain their bone health and reduce the risk of fractures. METHODS: A quality improvement project was conducted in three phases: Development of the Resource, Preliminary Feedback and Revision, and French Canadian Translation. RESULTS: The educational resource Living Safely with Bone Metastases focuses on safe movement, activities of daily living, and exercise, organized within the sections Move with car

Ultrasound-guided central venous catheterization in cancer patients improves the success rate of cannulation and reduces mechanical complications: a prospective observational study of 1,978 consecutive catheterizations.

BackgroundA central venous catheter (CVC) currently represents the most frequently adopted intravenous line for patients undergoing infusional chemotherapy and/or high-dose chemotherapy with hematopoietic stem-cell transplantation and parenteral nutrition. CVC insertion represents a risk for pneumothorax, nerve or arterial punctures. The aim of this prospective observational study was to explore the safety and efficacy of CVC insertion under ultrasound (US) guidance and to confirm its utility in clinical practice in cancer patients.MethodsConsecutive adult patients attending the oncology-hemat

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… Since in our department oncologists and hematologists have performed ultrasound imaging procedures as well as interventional ultrasound in clinical practice for patient management (diagnosis, staging, restaging and follow-up) for almost 25 years [ 21 - 27 ], this procedure was early applied as a guidance … In the present study, ultrasound-guided CVC procedures were performed by our own specifically experienced oncologists and hematologists, and we agree with a recent report [ 28 ] that ultrasound is an easily learned technique that not only enhances the physical examination, but has the distinct advantage …

Глобальное бремя множественной миеломы1990-2021) и прогнозы на период 2035:: методический анализ с учетом глобального бремени болезней; 2021 исследование и менделианская случайность.

ЦЕЛЬ: Множественная миелома (ММ), являющаяся второй по частотности гематологической злокачественностью, подвергается всесторонней оценке с точки зрения ее глобального бремени заболеваний и факторов риска с использованием базы данных о глобальном бремени болезней (ГБЗ) и менделианского ронтомизации (МВ). МЕТОДЫ: В рамках этого исследования использовались данные GBD 2021 :: база данных для широкого изучения стандартизированных по возрасту показателей заболеваемости, смертности, а также лет жизни с поправкой на инвалидность (DALY) в увязке с MM. Мы провели оценку воздействия различных географичес

The role of the PD-1/PD-L1 immune checkpoint pathway in myocardial infarction: a review from pathophysiological mechanisms to therapeutic strategies.

Programmed cell death protein 1 (PD-1) and its ligand, programmed death-ligand 1 (PD-L1), are vital molecules in immune checkpoints, significantly impacting cancer treatment. Recent studies have increasingly highlighted the complex roles of the PD-1/PD-L1 pathway in cardiovascular diseases, particularly in myocardial infarction (MI). In addition to being involved in immune modulation and the inflammatory response post-myocardial ischemia, this pathway is also crucial for myocardial repair and regeneration. Additionally, the clinical application of PD-1/PD-L1 immune checkpoint inhibitors has le

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… For example, patients receiving ICIs may experience immune-related adverse events, including myocarditis or myocardial infarction, which necessitate close monitoring and timely intervention by both cardiologists and oncologists ( 28 , 29 ). … Furthermore, ongoing communication between cardiologists and oncologists is essential for monitoring treatment responses and adjusting therapeutic strategies as needed. …

Cancer burden in Europe: a systematic analysis of the GLOBOCAN database (2022).

BackgroundCancer remains a significant public health challenge in Europe, with substantial regional disparities in incidence, mortality, and access to healthcare. This study analyses cancer patterns across Eastern, Northern, Southern, and Western Europe in 2022, highlighting key public health implications and gaps in prevention and treatment.MethodsUsing data from GLOBOCAN 2022, this study assessed total new cancer cases, age-standardized incidence and mortality rates (ASRs) per 100,000, and cumulative cancer risk at age 75. The top three cancers by sex and region were also analysed to identif