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Patterns of multimorbidity in older adults with multiple myeloma: An analysis of SEER-Medicare.

OBJECTIVE: Multimorbidity influences the management of symptoms, treatment, and health outcomes for older adults with multiple myeloma. Our study characterized patient profiles defined by discrete chronic condition patterns and examined the distribution of their sociodemographic factors in older adults at time of diagnosis with multiple myeloma. METHODS: Using the Surveillance, Epidemiology and End Results (SEER) Program database linked with Medicare insurance claims (2007-2017), we examined 11,926 individuals diagnosed with multiple myeloma at age ≥ 65 years. Hierarchical cluster analysis wa

Temporal Trends in Cancer Burden and 27 Subtypes Among Women of Childbearing Age Globally from 1990 to 2021.

BackgroundCancer among women of childbearing age (WCBA, 15-49 years) has distinct clinical and public health implications. Using modeled estimates from the Global Burden of Disease Study (GBD) 2021, we assessed temporal and spatial patterns of total cancer and 27 cancer subtypes among WCBA from 1990 to 2021.MethodsWe extracted incidence and mortality estimates for WCBA globally, across five socio-demographic index (SDI) regions, 21 GBD regions, and 204 countries and territories. Age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) were calculated. Temporal tren

Случай критической дигит-изхимии у пациента с предполагаемой Серонегативной Склеродермой диагностирован через "Найлфолд" "Кастероскопия".

Системный склероз (scleroderma) может проявляться с помощью современных симптомов ишемической васкулопатии, включая развитие цифровой язвы. Эти язвы могут быть невосприимчивыми и вредными для качества жизни пациента, поэтому быстрый диагноз, дифференциация с другими сосудистыми этиологиями и лечение имеют важное значение для спасения этой ткани. Однако диагностика склеродермы может быть трудной при возникновении серонгегирующего заболевания. Капиллероскопия с капильероскопией Nailwold является жизненно важным инструментом, который может помочь с диагностикой в серонегативных случаях. Склеродер

Factors That Predict Persistent Smoking of Cancer Survivors.

We conducted this cross-sectional study to elucidate factors that predict persistent smoking of the Korean cancer survivors. The subjects were 130 adult (≥19 yr old) cancer survivors who were smokers at the diagnosis of cancer and have participated in the Korean National Health and Nutrition Examination Surveys conducted from 2007 to 2011. We categorized them into the persistent smokers and the quitters, according to change in smoking status between the time of cancer diagnosis and the time of the survey. Factors associated with persistent smoking were evaluated using the multiple logistic reg

Nicotine receptor partial agonists for smoking cessation.

BACKGROUND: Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). This is an update of a Cochrane Review first published in 2007. OBJECTIVES: To assess the effectiveness of nicotine receptor partial agonists, including varenicline and cytisine, for smoking cessation. SEARCH METHODS: We searched the Cochrane Tobacco Addiction Group's Specialised Register in April 2022 for trials, using relevant terms in t

Effectiveness of psychosocial interventions for reducing parental substance misuse.

BACKGROUND: Parental substance use is a substantial public health and safeguarding concern. There have been a number of trials of interventions relating to substance-using parents that have sought to address this risk factor, with potential outcomes for parent and child. OBJECTIVES: To assess the effectiveness of psychosocial interventions in reducing parental substance use (alcohol and/or illicit drugs, excluding tobacco). SEARCH METHODS: We searched the following databases from their inception to July 2020: the Cochrane Drugs and Alcohol Group Specialised Register; CENTRAL; MEDLINE; Embase

Global inequalities in tracheal, bronchus, and lung cancer care quality from 1990 to 2021.

Tracheal, bronchus, and lung cancer remains a major global cancer burden, but cross-national comparisons using composite proxy indicators are limited. Using Global Burden of Disease 1990-2021 estimates, we constructed a quality-of-care index (QCI) from incidence, mortality, prevalence, and disability outcomes; assessed temporal and geographic patterns; modeled associations with linear mixed models; and compared older adults with the overall population. Age-standardized incidence and death rates declined globally, but QCI remained highly unequal across 204 countries. QCI was higher in high-deve

Совпадение в полном тексте источника
… associated disease burden. 16 For instance, without tobacco control measures, US per capita cigarette consumption in 2011 would have been five times higher. 17 By 2022, tobacco control efforts had averted over 3.85 million lung cancer deaths globally, 18 thus underscoring the pivotal role of such policies … While tobacco control had led to reduced TBLC incidence and mortality, regional environmental factors may drive high TBLC prevalence in some areas. …

Genetic Association between NFKBIA and NFKB1 Gene Polymorphisms and the Susceptibility to Head and Neck Cancer: A Meta-Analysis.

BackgroundThe role of the NFKB1 gene rs28362491 polymorphism and NFKBIA gene rs2233406 polymorphism in the development of head and neck cancer (HNC) remains controversial. This meta-analysis was performed to assess the relationship between the gene polymorphisms and HNC quantitatively.MethodsPubMed, Embase, Web of Science, WanFang Data, and China National Knowledge databases were used to search for eligible articles. The relationship was evaluated by STATA 11.0.ResultsEight eligible articles were included in our study. Nine case-control studies from the eight included articles were correlated

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study.

IMPORTANCE: The increasing burden due to cancer and other noncommunicable diseases poses a threat to human development, which has resulted in global political commitments reflected in the Sustainable Development Goals as well as the World Health Organization (WHO) Global Action Plan on Non-Communicable Diseases. To determine if these commitments have resulted in improved cancer control, quantitative assessments of the cancer burden are required. OBJECTIVE: To assess the burden for 29 cancer groups over time to provide a framework for policy discussion, resource allocation, and research focus.

Совпадение в полном тексте источника
… This highlights the importance of focusing tobacco control efforts on lower SDI countries, to avoid these countries’ having to experience the same tragedy of unnecessary tobacco-related deaths that many high SDI countries have had to face. … with tobacco control. …

Interstitial Lung Disease and Pulmonary Fibrosis: A Practical Approach for General Medicine Physicians with Focus on the Medical History.

Interstitial lung disease (ILD) and pulmonary fibrosis comprise a wide array of inflammatory and fibrotic lung diseases which are often confusing to general medicine and pulmonary physicians alike. In addition to the myriad of clinical and radiologic nomenclature used in ILD, histopathologic descriptors may be particularly confusing, and are often extrapolated to radiologic imaging patterns which may further add to the confusion. We propose that rather than focusing on precise histologic findings, focus should be on identifying an accurate etiology of ILD through a comprehensive and detailed m

Comparative study of early onset cancer burden between China and the United States from 1990 to 2021.

China and the United States face a mounting burden associated with early-onset cancers. Comparing the burden and trends of early-onset cancers between the two countries, analyzing attributable risk factors, drawing on the successful experience of the US in cancer research, prevention, and care can provide valuable insights to inform China's prevention and control strategies. A comparative study based on the 2021 Global Burden of Disease repository was conducted to assess the average annual percentage change in the burden of early-onset cancers. Linear regression analysis was performed using th

Environmental Factors, Lifestyle Risk Factors, and Host Characteristics Associated With Philadelphia Negative Myeloproliferative Neoplasm: A Systematic Review.

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by the overproduction of mature myeloid cells and are often associated with an acquired genetic mutation of Janus Kinase2V617F. Various epidemiological studies have indicated associations between environmental factors, lifestyle factors, and host characteristics with developing MPNs. This review aims to collect and summarize the existing information on these risk factors and establish their association with pathogenesis MPNs. Medline, Embase, PubMed, and grey literature were systematically searched u

Морфологические изменения в сетчатке при расстройствах, связанных с употреблением алкоголя: систематический обзор и метаанализ исследований с использованием технологии оптической согласованности.

Цель обзора - использование чреонического алкоголя связано с различными структурными и функциональными изменениями в мозге. Скринальная морфология, оцениваемая с помощью оптической последовательности томографии (OCT), неинвазивно выявляет повреждения мозга, связанные с алкоголем, и может быть маркером болезней. 15/ Апрель/2025). Метаанализы случайного воздействия проводились по толщине параметров сетчатки как на диске, так и на макуле: слой волокна сетчатки (RNFL), слой ячеек ганглиона (GCL), внутренний плексиформный слой (IPL), плексиформальный слой с ганглионными клетками (GCIPL), толщина хо

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. METHODS: We used the comparative risk assessment framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years

Интеллектуальные расстройства и расстройства в развитии диагностируются в Калифорнии и неблагоприятно сказываются на материнском здоровье.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Женщины, страдающие умственными расстройствами и расстройствами в области развития, относятся к категории населения, результаты деятельности по охране материнского здоровья которого по-прежнему плохо задокументированы. Мы провели оценку связей между диагностикой ИПД у матерей в Калифорнии и неблагоприятными последствиями для матерей, а также проанализировали, способствуют ли эти отношения дородовые клинические характеристики. МЕТОДЫ: Это ретроспективное исследование групп населения охватывало все роды ≥22 Неделя беременности в Калифорнии между 2007 и 2021, с использовани

Summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation.

The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as access to transplantation, patient demographic and health status factors, immunological and psychosocial assessment. The roles of various risk factors and comorbid conditions governing an individual's suitability for transpla

Risk Factors for Mucosal Redness in the Duodenal Bulb as Detected via Linked Color Imaging.

Linked color imaging (LCI) for image-enhanced endoscopy (IEE) highlights mucosal color differences. We investigated risk factors associated with mucosal redness of the duodenal bulb using LCI. Consecutive patients were retrospectively selected after their duodenal bulbs were observed via LCI. A symptom questionnaire (Izumo scale) was completed. The LCI of the duodenal bulb was subjectively evaluated on whether redness was present and objectively evaluated based on L* a* b* color values. The clinical characteristics of the 302 study participants were: male/female, 120/182; mean age, 70.9 years.

Neoplasm related mortality risk in Systemic Sclerosis: a nationwide study.

BackgroundThe higher mortality rates in patients with Systemic sclerosis (SSc) are related to SSc activity, cardiovascular disease, and neoplasms, among other factors. Our objective was to assess the impact of solid organ neoplasms (SON) and hematological neoplasms (HN) on mortality among SSc patients.MethodsA retrospective, observational comparison of SON and HN-related deaths in SSc patients with those in the general Spanish population was conducted using data from the Spanish Hospital Discharge Database. Binary logistic regression was used to analyze the impact of SSc on mortality risk from

The ISHLT chronic lung allograft dysfunction consensus criteria are applicable to pulmonary chronic graft-versus-host disease.

Pulmonary chronic graft-versus-host disease (PcGVHD) is a devastating complication of allogeneic hematopoietic stem cell transplant (HCT). The 2014 National Institutes of Health cGVHD consensus criteria (NIH criteria) only captures bronchiolitis obliterans syndrome (BOS). In this study, we adapted the 2019 International Society for Heart and Lung Transplantation (ISHLT) criteria of chronic lung allograft dysfunction (CLAD) to define novel phenotypes of PcGVHD and compared the performance of this criteria with the NIH criteria to identify patients with high-risk PcGVHD. We reviewed consecutive

Increased risk of bisphosphonate-related osteonecrosis of the jaw in patients with Sjögren's syndrome: nationwide population-based cohort study.

OBJECTIVE: The aim of this study was to explore whether patients with Sjögren's syndrome (SS) were susceptible to bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) after tooth extraction in the entire population of Taiwan. DESIGN: A nationwide population-based retrospective cohort study. SETTING: Data were extracted from Taiwan's National Health Insurance Research Database (NHIRD). METHODOLOGY: Medical conditions for both the study and control group were categorised using the International Classification of Diseases, 9th Revision. ORs and 95% CIs for associations between SS and o