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Comprehensive machine learning analysis of PANoptosis signatures in multiple myeloma identifies prognostic and immunotherapy biomarkers.

PANoptosis is closely associated with tumorigenesis and therapeutic response, yet its role in multiple myeloma (MM) remains unclear. This study analyzed bulk transcriptomic and clinical data from the TCGA and GEO databases to identify seven PANoptosis-related genes (PRGs) using machine learning (LASSO regression and random forest models) and univariate Cox analysis, and constructed a prognostic risk model. The model demonstrated robust predictive performance across three external validation cohorts. High-risk patients exhibited higher tumor purity, increased tumor mutational burden, and distin

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… Reverse transcription was performed with the Reverse Transcription Kit (Lanjeke Biotech, Beijing, China; Cat. … Chromogenic development was carried out using a diaminobenzidine (DAB) peroxidase substrate kit(Zhong Shan Golden Bridge Biotech, Beijing, China; Cat. #ZLI-9018), with the reaction duration optimized through microscopic monitoring. …

Cold atmospheric plasma sensitizes head and neck cancer to chemotherapy and immune checkpoint blockade therapy.

Head and neck cancer (HNC) is the seventh most prevalent cancer globally, often characterized by chemo-resistance and immunosuppression, which significantly hampers treatment efficacy. Cold atmospheric plasma (CAP) has recently emerged as a promising adjuvant oncotherapy with substantial potential and advantages. In this study, Piezobrush® PZ2, a handheld CAP unit based on the piezoelectric direct discharge technology, was used to generate and deliver non-thermal plasma. We aimed to investigate the effects of CAPPZ2 on various types of HNC cells and elucidate the underlying mechanisms. In addi

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… The HNC cells were collected and washed with ice-cold PBS solution, then lysed in RIPA cell lysis buffer (Solaibao, Beijing, China) containing complete™ Protease Inhibitor Cocktail. … Following PBS washing, the sections were then incubated with appropriate biotinylated secondary antibodies provided in the ABC kit (PV-6000D, Beijing Zhongshan Jinqiao Biotechnology Co., Ltd, Beijing, China), and visualized using the diaminobenzidine substrate. …

Emerging advances in drug delivery systems (DDSs) for optimizing cancer complications.

The management and treatment of tumor complications pose continuous challenges due to the inherent complexity. However, the advent of drug delivery systems (DDSs) brings promising opportunities to address the tumor complications using innovative technological approaches. This review focuses on common oncological complications, including cancer thrombosis, malignant serous effusion, tumor-associated infections, cancer pain, and treatment-related complications. Emphasis was placed on the application and potential of DDSs in mitigating and treating these tumor complications, and we delved into th

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… , Beijing, China (2) | Peking University First Hospital NCT06160323 | Recruiting | Pancreatic Cancer Non-resectable | EUS-guided celiac ganglion neurolysis/celiac Plexus neurolysis | NA | Hong Kong, Hong Kong | Chinese University of Hong Kong NCT06017895 | Recruiting | Nasopharyngeal carcinoma | Doxepin … Torres, MD NCT05288569 | Recruiting | Lung Cancer | ICIs | anti-PD-1/anti-PD-L1 immunotherapy | NA | Beijing, China | Peking Union Medical College Hospital NCT04552704 | Terminated | Advanced Malignant Solid Neoplasm | Cytokine therapy | Immunomodulators | I/II | Sacramento, California, United States …

Challenges and strategies associated with CAR-T cell therapy in blood malignancies.

Cellular immunotherapy, particularly CAR-T cells, has shown potential in the improvement of outcomes in patients with refractory and recurrent malignancies of the blood. However, achieving sustainable long-term complete remission for blood cancer remains a challenge, with resistance and relapse being expected outcomes for many patients. Although many studies have attempted to clarify the mechanisms of CAR-T cell therapy failure, the mechanism remains unclear. In this article, we discuss and describe the current state of knowledge regarding these factors, which include elements that influence t

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… NCT05381662 | phase I/II | ALL | CD19 | Recruiting | Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd NCT04840875 | Phase I | Acute T-cell leukemia / lymphoma | CD7 | Recruiting | Beijing Boren Hospital NCT04340167 | phase II | R/R B-ALL | CD22 | Recruiting | Beijing Boren Hospital NCT04778579 … NCT04219163 | Phase 1 | R/R AML | CLL-1 | Recruiting | Baylor College of Medicine NCT04835519 | Phase I/​II | R/R AML | CD33 | Recruiting | Beijing Boren Hospital NCT04803929 | Early Phase 1 | R/​R AML(M4/​M5) | ILT3 | Recruiting | Carbiogene Therapeutics Co. Ltd. …

Icariin as a potential anticancer agent: a review of its biological effects on various cancers.

Numerous chemical compounds used in cancer treatment have been isolated from natural herbs to address the ever-increasing cancer incidence worldwide. Therein is icariin, which has been extensively studied for its therapeutic potential due to its anti-inflammatory, antioxidant, antidepressant, and aphrodisiac properties. However, there is a lack of comprehensive and detailed review of studies on icariin in cancer treatment. Given this, this study reviews and examines the relevant literature on the chemopreventive and therapeutic potentials of icariin in cancer treatment and describes its mechan

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… In recent years, Shenogen Pharma (Beijing, China) has developed icaritin either as a monotherapeutic drug or a combo-drug combined with an oncolytic virus, primarily for the treatment of liver cancer ( Bailly, 2020 ). Their icaritin-derived drugs have undergone several clinical trials. … Beijing, China : Beijing University of Traditional Chinese Medicine . Zhao L. M. Pan X. M. Song H. Q. ( 2011 ). Experimental study on icariin enhancing the killing sensitivity of CIK cells to B-MD-C1 (ADR +/+) . J. Immunol. 27 ( 2 ), 114 – 118 . 10.13431/j.cnki.immunol.j.20110026 Zhao Q. Cao L. …

Role of CCR1/5/7 in hepatocellular carcinoma: a study on prognostic evaluation, molecular subtyping, and association with immune infiltration.

This study aims to assess the prognostic value of the C-C motif chemokine receptor (CCR) gene family in hepatocellular carcinoma (HCC) and its relationship with immune infiltration and molecular subtypes of HCC. The evaluation of the GSE14520 dataset and TCGA database confirmed the prognostic significance of CCR. Building upon the correlation between CCR1, CCR5, and CCR7 and favorable prognosis, we further validated the prognostic importance of CCR1, CCR5, and CCR7 in ICGC database and an independent cohort from Guangxi autonomous region. Then, we constructed a risk prognosis model. Additional

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… The liver tissues (paired HCC and para-carcinoma tissues) of 49 HCC patients at the First Affiliated Hospital of Guangxi Medical University were collected and then immersed in RNAstore Reagent (Tiangen, Beijing, China) within 30 minutes of collection. … IHC assay was performed using a universal two-step IHC kit (PV-9000, ZSGB-BIO, Biotech, Beijing, China) following the manufacturer’s protocols. …

Роль NLRP3 инфламасома в множестве склероза: патогенез и фармакологическое применение.

Множественный склероз (MS) широко признается в качестве хронического провокационного аутоиммунного расстройства, характеризующегося демиэлизацией центральной нервной системы (КНС) и нейродегенерацией. Гиперактивация иммунной и подстрекательской реакции признается в качестве ключевого фактора, способствующего патогенезу и прогрессированию MS. Среди различных иммунных и подстрекательских реакций исследователи все больше концентрируют внимание на воспалении — комплексе белков. Запуск и активация воспламенения неразрывно связаны с началом НР. В частности, NLRP3 воспаляет, наиболее широко изучавший

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… This work was supported by grants from Beijing Natural Science Foundation Program (No. 7244297 and 7234412) and National Natural Science Foundation of China (No. 82204483). Author contributions W-GZ: Writing – original draft. X-RZ: Writing – original draft. YY: Writing – original draft. …

A genetic variant study of bortezomib-induced peripheral neuropathy in Chinese multiple myeloma patients.

BackgroundBortezomib results in peripheral neuropathy (PN) in approximately 50% of patients, during multiple myeloma (MM) treatment, a complication known as Bortezomib-induced peripheral neuropathy (BIPN). The drug response varies among individuals. Genetic factor may play an important role in BIPN.MethodsA next-generation sequencing (NGS) panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib therapy. mRNA expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative

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… Genotyping was performed using MultipSeq® Custom Panel Kit (IGMU228XV1) (iGeneTech, Beijing, China). Protocols were carried out according to the manufacturer’s recommendations. … High-quality sequencing reads were specifically captured using the amplicon sequencing method (E-Seq Mecidal, Beijing, China) and sequenced using an Illumina HiSeq X ten (Illumina, Inc., CA, USA) at high depth with 150 bp paired-end reads. …

Анализ ассоциации геномов показывает новый QTL CsPC1 для перикарпового цвета в огурце.

Огурчик - это важная дыня в мире с разными перикарными цветами. Однако потенциальные гены и основополагающий генетический механизм для такой важной черты огурца неизвестны. В этом исследовании на хромосоме был найден цвет колокольчика, контролирующего перикарп 3 генома огурцов. Результаты: В этом исследовании светло-зеленая линия G35 и темно-зеленая линия Q51 были пересечены для производства one Население F2. Таким образом, мы определили крупное цокольное поле CsPC1 (Перикарный цвет) 1). Далее мы нарисовали строку CsPC1 94-kb районная хромосома 3 который содержит 15 Гены. Среди этих генов Csa3

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… Total RNA was extracted using the Quick RNA Isolation Kit (Huayueyang Biotechnology (Beijing) Co., Beijing, China) following the manufacturer’s instructions. The concentration of total RNA was quantified using a Nanodrop 2000 spectrophotometer (Thermo Fisher Scientific, Delaware, USA). …

Prescription and use of psychoactive medications among cancer patients and associated factors in lower and upper middle-income countries: systematic review.

PURPOSE: To describe the prescription and use of psychoactive medications among cancer patients in low- and middle-income countries (LMICs) and explore the factors influencing their prescription and use. METHODS: This systematic review was conducted following the PRISMA guidelines. Six electronic databases were searched. We included observational studies that investigated the prescription and use of psychoactive medications among adult cancer patients in low- and middle-income countries (LMICs) according to the 2024 World Bank's classification. Eligible studies specifically focused on the use

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… antidepressant treatment 53.3% (8 of 15 depressed patients) Beck Depression Inventory-II (BDI-II), for assessment of depressive symptoms cutoff point of 20 points was chosen Zhao et al., 2014 China n = 460 (Patients hospitalized for cancer were recruited from the oncology department of a university hospital in Beijing … treatment 53.3% (8 of 15 depressed patients) | Beck Depression Inventory-II (BDI-II), for assessment of depressive symptoms cutoff point of 20 points was chosen Zhao et al., 2014 China | n = 460 (Patients hospitalized for cancer were recruited from the oncology department of a university hospital in Beijing …

Astragaloside II, природный садонин, облегчает ремимиэлирование в демиэлинговых неврологических заболеваниях с помощью рецептора P75NTR, опосредованного осью сигнала β-катенина/Id2/MBP в клетках-прекурсорах олигодендроцитов.

КОЛИЧЕСТВО: Демиелинация является отличительной чертой неврологических расстройств, таких, как множественный склероз и оптика нейромиелита, что приводит к неврологическим расстройствам. Существующая терапия в первую очередь модифицирует иммунную реакцию, но не позволяет напрямую содействовать ремонту миелина. Расширение дифференциации олигодендроцитов и производства олигодендроцитов (ООП) имеет решающее значение для восстановления целостности миелина.ЦЕЛИ: В рамках этого исследования изучался терапевтический потенциал астрагалосида II (AS-II), биоактивного садонина с нейрозащитными и продиффер

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… sh-p75NTR stable knockdown cell line were inoculated into a 24-well plate at a density of 5 × 10 4 cells/mL, and were then transfected with the pEnCMV-p75NTR-3 × FLAG overexpression plasmid (Miaoling Co., Ltd., Wuhan, China) using Neofect TM DNA transfection reagent (TF201201, Neofect biotech Co., Ltd., Beijing … The protein samples were then prepared for SDS-PAGE, followed by Coomassie Blue staining (P1300, Solarbio Science & Technology Co., Ltd., Beijing, China). Finally, the protein bands were excised for mass spectrometry sequencing and data analysis [ 34 ]. …

Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells.

Tyrosine kinase inhibitors (TKIs) are mostly used in non-small cell lung cancer (NSCLC) treatment. Unfortunately, treatment with Gefitinib for a period of time will result in drug resistance and cause treatment failure in clinic. Therefore, exploring novel compounds to overcome this resistance is urgently required. Here we investigated the antitumor effect of homoharringtonine (HHT), a natural compound extracted from Cephalotaxus harringtonia, on Gefitinib-resistant NSCLC cell lines in vitro and in vivo. NCI-H1975 cells with EGFR T790M mutation are more sensitive to HHT treatment compared with

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… Docetaxel was provided by Beijing InnoChem Science & Technology Co., Ltd (Beijing, PR China). The 3-(4,5-dimethylthiahiazozy1)-3,5-di-phenytetrazoliumromide (MTT), Trypan Blue and Hoechst 33258 were purchased from Sigma-Aldrich. …

Резюме научных материалов, представленных ГКОМ 2019 : Берлин, Германия. 27 - 30 Март 2019

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… P9 Anti-calreticulin antibody – A Novel Autoantibody in Patients with Idiopathic Inflammatory Myopathies and Its Association with Malignancy He Chen, Yong-Peng Ge, Guo-Chun Wang, Han-Bao Yang, Qing-Lin Peng, Ya-Mei Zhang, Xin Lu China Japan Friendship Hospital, Beijing, China Correspondence: He Chen … P11 Increased serum Galectin-9 (Gal-9) in patients with idiopathic inflammatory myopathies Lin Liang, Qinglin Peng, He Chen, Yamei Zhang, Xin Lu, Guochun Wang China-Japan Friendship Hospital; Beijing, China Correspondence: Lin Liang Objective: To investigate the levels of serum galectin9(Gal-9) in …

Oral Presentations

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Е-постеры.

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Lenalidomide-associated pure red cell aplasia during the treatment of POEMS syndrome: A case report and brief review of the literature.

Lenalidomide is widely used in the treatment of hematological malignancies, with bone marrow suppression being one of the most common hematological adverse effects associated with its use. However, lenalidomide-associated pure red cell aplasia (PRCA) remains exceptionally rare. The present study describes a case of PRCA secondary to lenalidomide therapy in a patient with POEMS syndrome. A 61-year-old woman diagnosed with POEMS syndrome received lenalidomide (25 mg/day) in combination with dexamethasone. Following 3 months of treatment, she developed severe anemia accompanied by a markedly redu

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… Bone marrow aspirate smears were air-dried and fixed in absolute methanol for 10 min at room temperature, followed by staining with Wright-Giemsa solution (Beijing Solarbio Science & Technology Co., Ltd.) for 15 min and rinsing in distilled water. …

Analyzing Comorbidity Patterns in Patients With Thyroid Disease Using Large-Scale Electronic Medical Records: Network-Based Retrospective Observational Study.

BackgroundThyroid disease (TD) is a prominent endocrine disorder that raises global health concerns; however, its comorbidity patterns remain unclear.ObjectiveThis study aims to apply a network-based method to comprehensively analyze the comorbidity patterns of TD using large-scale real-world health data.MethodsIn this retrospective observational study, we extracted the comorbidities of adult patients with TD from both private and public data sets. All comorbidities were identified using ICD-10 (International Classification of Diseases, 10th Revision) codes at the 3-digit level, and those with

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… We are grateful to Professor Hui Chen (The Capital Medical University, Beijing, China) for her methodological suggestions on our study. … Association of adiposity with thyroid nodules: a cross-sectional study of a healthy population in Beijing, China. BMC Endocr Disord. 2019 Oct 16;19(1):102. doi: 10.1186/s12902-019-0430-z. https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-019-0430-z .10.1186/s12902-019-0430-z 26. …

Baseline immunonutritional status drives CAR T-cell efficacy, survival, and safety in R/R lymphoma: validation of a pre-lymphodepletion PNI threshold.

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape for relapsed/refractory (R/R) lymphoma. However, heterogeneous responses and treatment-related toxicities remain significant challenges. The prognostic nutritional index (PNI), reflecting both nutritional status and systemic immune competence, has emerged as a potential biomarker in various malignancies. This study aimed to evaluate the predictive value of the PNI assessed specifically prior to lymphodepletion in patients with R/R lymphoma receiving CAR T-cell therapy. We retrospectively analyzed 449 pati

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… The study was approved by the Institutional Review Committee of Beijing GoBroad Hospital (ChiCTR-1900020980, ChiCTR-2200058972). All procedures adhered to the principles of the Declaration of Helsinki, and written informed consent was obtained from all participants prior to enrollment. … Declarations Institutional review board statement The study was approved by the Institutional Review Committee of Beijing GoBroad HospitalApproval No.RP2025-033.approval date:June 25, 2025.and conducted according to the Declaration of Helsinki. …

Электронные постеры

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γδ T cells: origin and fate, subsets, diseases and immunotherapy.

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering the use of allogeneic Vδ2+ γδ T cells for treating late-stage solid tumors and tuberculosis patients. However, we recognize untapped potential and optimization opportunities to fully harness γδ T cell effector functions in immunotherapy. This review aims to thoroughly examine γδ T cell im