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Abdominal Pain and Vaginal Discharge: An Eye-Opening Simulation Case about Human Trafficking.

AUDIENCE: The aim of this simulation case is to educate medical students, interns, junior residents, senior residents, nurses, and faculty o … g a $150 billion-dollar industry and representing the second largest source of income for organized crime.1,2,3,4 Globally, an estimated 40.3 million people are victims of modern slavery, with more than 70% being women and girls, and one in four victims being children under the age of 18.3,4 While once perceived as a mostly international problem, preval …

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SUMMARYIn the last decade, our understanding of posttraumatic stress disorder (PTSD) has progressed from studies of war veterans and specifi … o socio-economic factors, such as less inequity between the wealthy and the poor and less violence, crime, and poverty in Chile than Mexico. These studies also suggest that traumatic events that occur in childhood are related to specific disorders rather than those that occurred later in life.Individuals with childhood interpersonal trauma exposure are …

Оценка и лечение агрессивного сексуального поведения: нынешние ограничения и потенциальные стратегии.

Несмотря на то, что в МКБ-11 была введена соответствующая классификация и симптоматика расстройства сексуального поведения (CSBD) по-прежнему противоречива. В этом обзоре мы изучили историю, эпидемиологический статус-кво, коморбиды, теории нейрофизики, текущие диагнозы и рекомендации по лечению для CSBD. Кроме того, мы подчеркнули недостатки текущих исследований и перспективы будущей работы. Селективные ингибиторы серотонина и налтрексон обычно используются в качестве "немаркированных" наркотиков. Диагностика и лечение пациентов, проходящих курс лечения, должны включать в себя биологические, п

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… If there are concerns about the risk of sexual crimes related to CSB, standardized risk assessment tools (such as STABLE-2007 or the Violence Risk Scale-Sexual Offender Version) can be used to evaluate this aspect ( 69 , 70 ). …

Питание N-6 Полиненасыщенное содержание жира в кислоте и здоровье мозга у взрослых людей среднего и старшего возраста.

ПАФА играет важную роль в возникновении и развитии нейродегенеративных заболеваний. С тех пор, как нейрозащитные эффекты n-3 ПУФА получил широкую поддержку, роль n-6 ПУФА по-прежнему обсуждается, а их основополагающие механизмы до сих пор не в полной мере понятны. В этом исследовании 169,295 Участники из Биобанка Соединенного Королевства были включены для анализа связей между питанием n-6 Поступление ПУФА и нейродегенеративные заболевания с использованием моделей коксовой регрессии с полной корректировкой для потенциальных сомнителей. Кроме того, для оценки воздействия различных моделей линейн

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… The IMD was utilized to assess social deprivation at the neighborhood level, encompassing seven distinct domains, which include health, education, income, employment, crime, barriers to housing and services, and living environment [ 21 ]. …

Prevalence and effect on survival of pre-treatment sarcopenia in patients with hematological malignancies: a meta-analysis.

Background & aimsEvidence regarding the prevalence of pre-treatment sarcopenia and its impact on survival in patients with hematological malignancies (HM) varies across studies. We conducted a systematic review and meta-analysis to summarize this discrepancy.MethodsPubMed, Embase and Cochrane library were systematically searched for relevant studies. Outcomes assessed were: prevalence of pre-treatment sarcopenia, overall survival (OS), progression-free survival (PFS) and complete response (CR). Weighted mean proportion, odds ratios (ORs) and hazard ratios (HRs) were estimated using a fixed-eff

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… Accessories to the crime: functions of cells recruited to the tumor microenvironment . Cancer Cell ( 2012 ) 21 ( 3 ): 309–22 . doi: 10.1016/j.ccr.2012.02.022 22439926 49 Tisdale MJ . Cancer cachexia . …

Действенность и безопасность цифрового таперинга для пациентов, которым предписывается опиоид после хирургической операции: протокол для перспективного исследования кохарта.

Предыстория 300 million Каждый год во всем мире проводятся хирургические операции, и опиоиды по-прежнему являются одним из основных методов борьбы с острой послеоперационной болью. Исследования показали, что значительное число пациентов не прекращают опиоидное лечение и продолжают использовать опиоиды в течение месяцев или даже лет после операции. Известная практика применения опиоидов рецептурного отпуска и управления ими является частью нынешних клинических руководящих принципов безопасного прописывания. Каждый пациент должен получать тщательный контроль, образование и план скрининга, когда

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… According to the World Health Organization and the United Nations Office on Drugs and Crime, the largest risk factor regarding misuse of addictive drugs is the lack of education and understanding of their adverse effects. …

Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation.

BackgroundCytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms.MethodsThis study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed correlations with JAK2 V617F status and clinical-hematological parameters.ResultsThe proinflammatory cytokine levels were increased in myeloproliferative neoplasm patients, and the presence of the JA

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… Accessories to the crime: functions of cells recruited to the tumor microenvironment Cancer Cell 21 3 2012 309 322 22439926 10.1016/j.ccr.2012.02.022 30 Kershaw M.H. Westwood J.A. Darcy P.K. …

Beyond Darwin: reactive heredity, burst-drift dynamics and eco‑evolutionary control of cancer.

Darwinian clonal evolution provides a necessary framework for understanding tumour progression, yet emerging evidence shows that some cancers depart from a strictly gradualist tempo through episodic "macroevolutionary" leaps. We propose a unifying Burst-Drift-Control (BDC) model in which short-lived genomic reconfigurations ("bursts") that transiently alter heritable genomic states ("reactive heredity") precede longer intervals of constrained expansion, creating time-bounded vulnerabilities that clinicians may strategically steer ("control"). In this usage, the Drift component refers specifica

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… Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21:309–22. 60. Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012;196:395–406. 10.1083/jcb.201102147. 61. …

The Endosteal Niche in Breast Cancer Bone Metastasis.

The establishment of bone metastasis remains one of the most frequent complications of patients suffering from advanced breast cancer. Patients with bone metastases experience high morbidity and mortality caused by excessive, tumor-induced and osteoclast-mediated bone resorption. Anti-resorptive treatments, such as bisphosphonates, are available to ease skeletal related events including pain, increased fracture risk, and hypercalcemia. However, the disease remains incurable and 5-year survival rates for these patients are below 25%. Within the bone, disseminated breast cancer cells localize in

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… Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. (2012) 21:309–22. 10.1016/j.ccr.2012.02.022 …

Healthcare workload associated with transition onto kidney replacement therapy: a retrospective cohort study.

BACKGROUND AND HYPOTHESIS: Transition onto kidney replacement therapy (KRT) is a complex, intensive phase for patients with advanced chronic kidney disease (CKD), characterised by high healthcare utilisation. Frequent outpatient visits, surgical and radiological procedures, hospitalisations and haemodialysis (HD) sessions impose a significant time burden on patients. The concept of time toxicity is widely described in oncology, and captures the disruption to patients' lives due to treatment-related demands. We aimed to quantify time- based healthcare workload during the transition onto KRT and

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… The SIMD is a Scotland-specific composite area-level measure of deprivation that combines data on education, employment, household income, health, access to services, crime and housing to determine a deprivation quintile score from 1 (most deprived) to 5 (least deprived) [ 22 ]. …

Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer.

Pancreatic ductal adenocarcinomas (PDAs) are notoriously aggressive and resistant to treatment. They distinguish themselves further by their robust fibroinflammatory, or desmoplastic, stromal reaction and degree of hypovascularity. Recent findings have revealed multiple mechanisms of stromal complicity in disease pathogenesis and resistance. In this review, we focus on altered physicomechanics as one mechanism of what we term as 'stromal resistance' in PDA. Extremely high interstitial fluid pressures and a dense extracellular matrix combine to limit the delivery and distribution of therapeutic

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… J Clin Oncol 29 (34): 4548 –4554 21969517 10.1200/JCO.2011.36.5742 PMC3565012 Vonlaufen A, Joshi S, Qu C, Phillips PA, Xu Z, Parker NR, Toi CS, Pirola RC, Wilson JS, Goldstein D, Apte MV ( 2008 ) Pancreatic stellate cells: partners in crime with pancreatic cancer cells . …

Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide.

Current standard adjuvant therapy of glioblastoma multiforme (GBM) using temozolomide (TMZ) frequently fails due to therapy resistance. Thus, novel therapeutic approaches are highly demanded. We tested the therapeutic efficacy of the second-generation XPO1 inhibitor Eltanexor using assays for cell viability and apoptosis in GBM cell lines and GBM stem-like cells. For most GBM-derived cells, IC50 concentrations for Eltanexor were below 100 nM. In correlation with reduced cell viability, apoptosis rates were significantly increased. GBM stem-like cells presented a combinatorial effect of Eltanex

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… A fraction of Crm1 locates at centrosomes by its CRIME domain and regulates the centrosomal localization of pericentrin Biochem. Biophys. Res. Commun. 2009 384 383 388 10.1016/j.bbrc.2009.04.154 19422798 42. Rosen J.C. Weiss J. Pham N.A. Li Q. Martins-Filho S.N. Wang Y. Tsao M.S. Moghal N. …

Anakoinosis: Communicative Reprogramming of Tumor Systems - for Rescuing from Chemorefractory Neoplasia.

Disruptive technologies, such as communicative reprogramming (anakoinosis) with cellular therapies in situ for treating refractory metastatic cancer allow patient care to accelerate along a totally new trajectory and highlight what may well become the next sea change in the care of patients with many types of advanced neoplasia. Cellular therapy in situ consisted of repurposed drugs, pioglitazone plus all-trans retinoic acid or dexamethasone or interferon-alpha (dual transcriptional modulation) combined with metronomic low-dose chemotherapy or low-dose 5-azacytidine, plus/minus classic targete

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… Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21:309–322. doi: 10.1016/j.ccr.2012.02.022. 7. Kallinowski F, Schlenger KH, Runkel S, et al. Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts. …

Surveillance for Violent Deaths - National Violent Death Reporting System, 50 States, the District of Columbia, and Puerto Rico, 2022.

PROBLEM/CONDITION: In 2022, approximately 24,000 persons died of homicide and approximately 49,000 persons died of suicide in the United Sta … micide most often was precipitated by an argument or conflict, occurred in conjunction with another crime, or, for female victims, was related to intimate partner violence. Nearly all legal intervention deaths were among males, and the legal intervention death rate was highest among males aged 30-34 years. The legal intervention death rate was highest a …

Surveillance for Violent Deaths - National Violent Death Reporting System, 48 States, the District of Columbia, and Puerto Rico, 2021.

PROBLEM/CONDITION: In 2021, approximately 75,000 persons died of violence-related injuries in the United States. This report summarizes data … micide most often was precipitated by an argument or conflict, occurred in conjunction with another crime, or, for female victims, was related to intimate partner violence. Nearly all victims of legal intervention deaths were male, and the legal intervention death rate was highest among men aged 30-34 years. The legal intervention death rate was highest …

NLRP3 inflammasome: a key driver of neuroinflammation and a novel therapeutic target for neuropathic pain.

Neuropathic pain represents a serious complication arising from a spectrum of disorders that precipitate lesions within the central and peripheral nervous systems. This disabling pain can persist for years, severely diminishing the quality of life of the affected individuals. The treatment options available for neuropathic pain at present have limited efficacy. Moreover, the adverse effects associated with these options restrict their application. The exact etiological mechanisms underlying the pathogenesis of neuropathic pain remain unclear. However, neuroinflammatory processes mediated by th

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… P2X7 receptor and the NLRP3 inflammasome: Partners in crime. Biochem Pharmacol. 2021;187:114385. doi: 10.1016/j.bcp.2020.114385. 36. Starobova H, Vetter I. Pathophysiology of chemotherapy-induced peripheral neuropathy. Front Mol Neurosci. 2017;10:174. doi: 10.3389/fnmol.2017.00174. 37. …

TGF-β: an active participant in the immune and metabolic microenvironment of multiple myeloma : TGF-β in the microenvironment of multiple myeloma.

Although substantial quantities of potent therapies for multiple myeloma (MM) have been established, MM remains an incurable disease. In recent years, our understanding of the initiation, development, and metastasis of cancers has made a qualitative leap. Cancers attain the abilities to maintain proliferation signals, escape growth inhibitors, resist cell death, induce angiogenesis, and more importantly, escape anti-tumor immunity and reprogram metabolism, which are the hallmarks of cancers. Besides, different cancers have different tumor microenvironments (TME), thus, we pay more attention to

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… Hanahan D, Coussens LM (2012) Accessories to the crime: functions of cells recruited to the tumor microenvironment [J]. Cancer Cell 21(3):309–322. 10.1016/j.ccr.2012.02.022 68. …

Multidisciplinary Progress in Obesity Research.

Obesity is a chronic disease that endangers human health. In recent years, the phenomenon of obesity has become more and more common, and it has become a global epidemic. Obesity is closely associated with many adverse metabolic changes and diseases, such as insulin resistance, type 2 diabetes mellitus, coronary heart disease, nervous system diseases and some malignant tumors, which have caused a huge burden on the country's medical finance. In most countries of the world, the incidence of cancer caused by obesity is increasing year on year. Diabetes associated with obesity can lead to seconda

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… Accessories to the crime: Functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21:309–322. doi: 10.1016/j.ccr.2012.02.022. 24. Rueda-Clausen C.F., Ogunleye A.A., Sharma A.M. Health benefits of long-term weight-loss maintenance. Annu. Rev. …

Rare disease patients protection: theoretical discussion and institutional construction of orphan drug designation in China.

Orphan drugs play a vital role, often described as the "public goods of public goods." As a result, they demand robust policy support. Among these, the designation of orphan drugs serves as the pivotal and core element of the national incentive mechanism for such drugs. The designation of orphan drugs is a prerequisite and a key system to determine whether pharmaceutical enterprises are eligible to access policy support, which directly determines the effective output of orphan drugs and the fairness of public policies. However, there is still an urgent need to explore this system in China theo

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… From a political point of view, if the survival and physical and mental health of vulnerable groups are not guaranteed for a long period of time, it may trigger social group conflicts and an increase in the crime rate, which are issues related to social stability [ 18 ]. …

Suicide Risk Among Patients With Cancer by Sex in Japan: A Population-based Study.

BackgroundIn Japan, few studies have examined suicide risk for 5-year relative survival rates for cancer sites. Since 5-year relative survival rates differ by sex, we aim to examine suicide risk for patients with cancer separately for men and women.MethodsWe estimated the risk of suicide among patients with cancer by sex in Japan compared to the general population, using standardized mortality ratios (SMRs). Patients with cancer diagnosed between January 1, 1985-December 31, 2013 and registered in the Osaka Cancer Registry were followed for up to 10 years. The outcome was suicide death. In add

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… In contrast, suicide has historically been a crime or stigma in some countries, which requires consideration and response in accordance with national culture and norms. Our study had some limitations. …