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The Role of Injectables in the Treatment and Prevention of Cancer-Associated Thrombosis.

Cancer-associated thrombosis (CAT) is a leading cause of death among patients with cancer. CAT can manifest itself as venous thromboembolism (VTE), in the form of deep vein thrombosis or pulmonary embolism, or arterial thromboembolism. The pathophysiology of CAT is complex and depends on cancer-, patient-, treatment- and biomarkers-related factors. Treatment of VTE in patients with cancer is complex and includes three major classes of anticoagulant agents: heparin and its derivatives, e.g., low molecular weight heparins, direct oral anticoagulants (DOACs), and vitamin K inhibitors. Given the t

Изучение того, что имеет наибольшее значение для пациентов при повторном рефрактальном лечении нескольких миелом: канадский эксперимент по дискретному выбору пациентов, лиц, обеспечивающих уход, и врачей.

КОЛИЧЕСТВО: Возвращение/изъятие нескольких миелом (RRMM) оказывает значительное воздействие на качество жизни пациентов. В рамках этого исследования были изучены особенности лечения, характерные для RRMM в Канаде, при этом были сопоставлены параметры традиционных методов лечения с характеристиками химической антигенной рецепторной (CAR) T-клетокой терапии. Она была направлена на понимание предпочтений пациентов и того, каким образом те, кто ухаживает за больными, и специалисты в области здравоохранения (ХЦП) воспринимают эти предпочтения. МЕТОДЫ: Был проведен эксперимент по дискретному выбору

Seamless Navigation of Bispecific Therapies: Optimizing Management and Outpatient Access With a Focus on Coordination.

Bispecific antibodies (BsAbs) have emerged as crucial therapeutic agents for patients with relapsed/refractory diffuse large B-cell lymphoma, multiple myeloma, and most recently, lung cancer. These therapies have demonstrated remarkable efficacy in clinical trials; however, multidisciplinary collaboration is essential to ensure optimal patient outcomes amid the operational complexities associated with BsAb therapy. As BsAbs are being prepared for broader adoption, clinicians and treatment centers must navigate operational challenges, including financial considerations, patient selection, careg

Analysis of Skeletal-Related Events in a Liaison Treatment for Metastatic Spinal Tumors: A 10-Year Retrospective Study.

INTRODUCTION: Skeletal-related events (SREs), including pathological fractures and spinal cord compression, significantly reduce the quality of life and survival in patients with metastatic spinal tumors. Although multidisciplinary "liaison treatment" has been implemented at our institution to detect and manage all metastatic spinal lesions, some patients still develop SREs. This study aims to analyze the characteristics and circumstances of patients who experienced SREs despite this system, with particular focus on referrals from other hospitals. METHODS: We reviewed patients who developed S

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… Any case meeting this criterion is flagged, and the primary oncologist is contacted. We subsequently hold a monthly liaison conference―with a spine surgeon serving as the navigator―involving all relevant specialists to formulate a comprehensive treatment plan. … Reliability of the Spinal Instability Neoplastic Score (SINS) among radiation oncologists: an assessment of instability secondary to spinal metastases. Radiat Oncol. 2014;9:69. 11. Azam F, Latif MF, Farooq A, et al. …

Evaluation of prognostic preoperative factors in patients undergoing surgery for spinal metastases: Results in a consecutive series of 81 cases.

BackgroundSurgical treatment of spinal metastases should be tailored to provide pain control, neurological deficit improvement, and vertebral stability with low operative morbidity and mortality. The aim of this study was to analyze the predictive value of some preoperative factors on overall survival in patients undergoing surgery for spinal metastases.MethodsWe retrospectively analyzed a consecutive series of 81 patients who underwent surgery for spinal metastases from 2015 and 2021 in the Clinic of Neurosurgery of Ancona (Italy). Data regarding patients' baseline characteristics, preoperati

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… DISCUSSION The best treatment of spinal metastases requires an integrated approach with input from a multidisciplinary team comprised medical and radiation oncologists and neurosurgeons. … Oncologist. 2013;18:744–51. doi: 10.1634/theoncologist.2012-0293. 19. Lee BH, Kim TH, Chong HS, Moon ES, Park JO, Kim HS, et al. Prognostic factor analysis in patients with metastatic spine disease depending on surgery and conservative treatment: Review of 577 cases. …

Metastatic melanoma to the ovary in pregnancy: A case report.

Metastatic melanoma to the ovary is an uncommon presentation. We report a case of metastatic melanoma to the ovary that presented as a growing left adnexal mass during pregnancy and was thought to be benign by imaging and frozen section pathology. Here we discuss the challenges in radiologic and pathologic diagnosis, as well as considerations for the mother and newborn.

Radiotherapy in COVID-19 patient affected by multiple myeloma: a case report.

In COVID-19 pandemic, cancer patients may be vulnerable for their immunological status and need of immunosuppressive anti-neoplastic treatments. Choosing the best treatment option in COVID-19 positive cancer patients is still a challenging issue. We report the case of a 62-year-old woman diagnosed with multiple myeloma and affected by COVID-19. After the diagnosis of multiple myeloma in January 2019, the patient underwent first line therapy followed by bone marrow autologous stem cell transplantation, achieving a complete response in September 2019. In March 2020, the patient showed intrathora

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… Therefore, the case was discussed in a multidisciplinary meeting among Hematologists, Internists and Radiation Oncologists, focusing the attention on the elevated risk of infection, comorbidity, and death in case of systemic myeloma treatment (with proteasome inhibitors, monoclonal antibody or immunomodulatory … Two radiation technologists and a radiation oncologist wore single-use personal protective equipment (PPE): surgical-cap, eye-protection, filtering facepiece respirator FFP2, gown, 2 pairs of gloves and closed shoes. Furthermore, a personal timetable and itinerary were identified. …

Characteristics and Outcomes of Patients with Hematological Malignancies Admitted for Intensive Care - a Single Centre Experience

Background and Purpose: Patients with hematological malignancies admitted to an intensive care unit (ICU) generally have a high mortality rate. The aim of our study was to assess the characteristics and outcomes of such patients and to identify factors predicting ICU mortality. Material and Methods: This retrospective chart review was conducted in the intensive care unit (ICU) of Shaukat Khanum Memorial Cancer Hospital and Research Centre over a period of 5 years, from January 2010 to January 2015. Results: Characteristics :A total of 213 patients were included in this study. There were 150 (7

Bisphosphonate induced osteonecrosis of jaw in breast cancer patients: A systematic review.

BackgroundBisphosphonate therapy is widely used for the treatment of bone metastasis in breast cancer patients.AimThe aim of this study is to estimate the overall prevalence of bisphosphonate induced osteonecrosis of jaw (BONJ) in breast cancer patients with bone metastasis.Materials and methodsA literature review was conducted to search and evaluate all the articles that contained original data on the prevalence of BONJ in breast cancer patients from the year 2003-2009. Pubmed search terms used were bisphosphonate, osteonecrosis, breast cancer and jaw. Eleven publications that fulfilled the i

Acupuncture in the treatment of chemotherapy-induced peripheral neuropathy: a meta-analysis and data mining.

BackgroundThe efficacy and acupoint selection of acupuncture in treating chemotherapy-induced peripheral neuropathy (CIPN) remain controversial. This study aims to explore the specific efficacy and acupoint selection of acupuncture in treating CIPN through a meta-analysis and data mining.MethodsSearching for clinical trials on acupuncture treatment for CIPN in 8 databases, evaluating its efficacy and safety through a meta-analysis, and exploring its acupoint selection through data mining.ResultsThe meta-analysis included 21 studies and 2,121 patients, showing that compared with the control gro

Systemic therapy and radiotherapy related complications and subsequent hospitalisation rates: a systematic review.

BackgroundHospitalisation resulting from complications of systemic therapy and radiotherapy places a substantial burden on the patient, society, and healthcare system. To formulate preventive strategies and enhance patient care, it is crucial to understand the connection between complications and the need for subsequent hospitalisation. This review aimed to assess the existing literature on complications related to systemic and radiotherapy treatments for cancer, and their impact on hospitalisation rates.MethodsData was obtained via electronic searches of the PubMed, Scopus, Embase and Google

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… The findings also suggest the importance of a multidisciplinary approach to cancer care, involving oncologists, nurses, or other health professionals to minimise the adverse events and reduce hospitalisation rates. … Hassett MJ Rao SR Brozovic S Stahl JE Schwartz JH Maloney B Chemotherapy-related hospitalization among community cancer center patients Oncologist 2011 16 378 387 10.1634/theoncologist.2010-0354 21349949 PMC3228109 47. …

Interventional radiology in the elderly.

Interventional radiological percutaneous procedures are becoming all the more important in the curative or palliative management of elderly frail patients with multiple underlying comorbidities. They may serve either as alternative primary minimally invasive therapies or adjuncts to traditional surgical treatments. The present report provides a concise review of the most important interventional radiological procedures with a special focus on the treatment of the primary debilitating pathologies of the elderly population. The authors elaborate on the scientific evidence and latest developments

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… Given the limited life expectancy and poor performance status of these patients, urgent airway stenting is a sufficient and effective palliative therapy. 53 , 54 The procedure generally involves mutidisciplinary evaluation and execution from a team of oncologists, surgeons and interventional radiologists … Oncologist. 2008;13(3):309–319. doi: 10.1634/theoncologist.2007-0195. 23. Mercadante S. Malignant bone pain: pathophysiology and treatment. Pain. 1997;69(1–2):1–18. doi: 10.1016/s0304-3959(96)03267-8. 24. Callstrom MR, Charboneau JW. …

Informational needs assessment of non-Hodgkin lymphoma survivors and their physicians.

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… Challenge in collaboration for family physicians and oncologists. Canadian family physician Medecin de famille canadien 1996; 42: 899–904;907–910. 14. Short PF,Vargo MM. Responding to employment concerns of cancer survivors. J Clin Oncol 2006; 24: 5138–5141. 15. …

Occult cirrhosis presenting as progressive tremor: acquired hepatocerebral degeneration induced by traditional Chinese medicine and natural health products, aggravated by manganese supplements: A case report.

RATIONALE: Acquired hepatocerebral degeneration (AHD) is a rare neurological complication of chronic liver disease or portosystemic shunting, typically characterized by extrapyramidal symptoms and manganese accumulation in the basal ganglia. Its diagnosis is particularly challenging in patients with occult cirrhosis and complex exposure histories, especially when traditional Chinese medicines (TCM) and natural health products (NHPs) contribute to hepatotoxicity. PATIENT CONCERNS: A 66-year-old woman presented with a 2-year history of progressive postural and intention tremor, with marked wors

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… For oncologists, these steps are particularly important because supplement-related liver injury may compromise the hepatic reserve and alter the metabolism, tolerability, and safety of anticancer therapies. … Fundamentally, in regions or communities with a long tradition of herbal or alternative medicine use, multidisciplinary management involving neurologists, hepatologists, oncologists, and pharmacologists or toxicologists should be actively involved to ensure early recognition and prevention of such complications …

People Living with HIV Eligibility in Canadian Cancer Clinical Trials.

Background: People living with HIV (PLWH) have historically been excluded from cancer clinical trials, prompting the 2017 ASCO-Friends of Cancer Research recommendations to limit unjustified exclusions and promote equitable access. This study evaluated how Canadian Cancer Trials Group (CCTG) protocols align with these recommendations. Methods: We conducted a cross-sectional review of CCTG active trial protocols, abstracting HIV eligibility language and trial characteristics, and assessing associations using Chi-square tests. Results: Of 136 trials activated between 1999 and 2025, 81.6% involve

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… In a survey of United States (US)-based medical and radiation oncologists, 69% of the 500 respondents felt that available cancer management guidelines were insufficient for the care of PLWH [ 6 ]. … Cancer Treatment in Patients with HIV Infection and Non–AIDS-Defining Cancers: A Survey of US Oncologists J. Oncol. Pract. 2015 11 e380 e387 10.1200/JOP.2014.002709 25873060 PMC5706142 7. Venturelli S. Pria A.D. Stegmann K. Smith P. Bower M. …

Последствия осуществления программы реабилитации пациента с множественной миеломой до пересадки на спинарном коре: тематическое исследование.

Введение: Множественная миелома представляет собой приблизительно 12% Гематологическое обледенение и главным образом затрагивает пожилых людей, что существенно снижает качество их жизни. Несмотря на то, что практические занятия показали преимущества в онкологии, данные, характерные для ММ, по-прежнему являются ограниченными и маловероятными. Наличие сложных коморбидов у пациентов из числа ММ требует весьма индивидуализированных подходов. Предварительная абилитация стала перспективной стратегией укрепления функциональных возможностей до аналоговой трансплантации стволовых клеток. В этом тематич

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… Diagnostic Evaluation The initial diagnostic evaluation was performed by an oncologist on 23 September 2024. Currently, the WHO in the IEC-10 classifies MM as a malignant hematological disease. … However, the effectiveness of such interventions depends on appropriate patient selection, comprehensive risk assessment, and sustained multidisciplinary collaboration involving physiotherapists, oncologists, and mental health professionals [ 40 ]. …

Efficacy and safety of selinexor-based regimens as first-line treatments for elderly patients with diffuse large B-cell lymphoma: a real-world study.

PURPOSE: This study aimed to evaluate the efficacy and safety of selinexor-based regimens as first-line treatments for elderly patients with diffuse large B-cell lymphoma (DLBCL). METHODS: A retrospective analysis of 16 elderly patients with DLBCL who received selinexor-based regimens as first-line treatments at Sun Yat-sen University Cancer Center from November 2021 to September 2023 was conducted. The primary endpoint was the objective response rate (ORR), while the secondary endpoints included progression-free survival (PFS), duration of response (DOR), and safety. RESULTS: Among the 16 e

Assessment of patient perceptions of counselling on oral antineoplastic agents by a dedicated cancer services pharmacist in an outpatient cancer clinic.

BackgroundOral antineoplastic agents have caused a paradigm shift in cancer treatment, however, they produce many unique challenges. Although oral antineoplastics can have complex administration regimes, low adherence rates and high possibilities of drug-drug interactions, they are administered unsupervised at home. Cancer services pharmacists have the required skillsets to improve patient outcomes associated with oral antineoplastic treatment by increasing patient health literacy, improving concordance and optimising administration protocols.AimTo evaluate patients' perceptions, experiences a

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… Oncologists are increasingly prioritising patient preference and quality of life by choosing treatments that maximise convenience and flexibility, as well as clinical outcomes [ 3 ]. … The oncologist . 2001 ; 6 ( S4 ): 12 – 16 . doi: 10.1634/theoncologist.6-suppl_4-12 11585969 5 Pourroy B , Tournamille JF , Bardin C , et al . …

RR Myelo POINT: A Retrospective Single-Center Study Assessing the Role of Radiotherapy in the Management of Multiple Myeloma and Possible Interactions with Concurrent Systemic Treatment.

Background and purpose: Although chemotherapy, biological agents, and radiotherapy (RT) are cornerstones of the treatment of multiple myeloma (MM), the literature regarding the possible interactions of concurrent systemic treatment (CST) and RT is limited, and the optimal RT dose is still unclear. Materials and methods: We retrospectively analyzed the records of patients who underwent RT for MM at our institution from 1 January 2005 to 30 June 2020. The data of 312 patients and 577 lesions (treated in 411 accesses) were retrieved. Results: Most of the treated lesions involved the vertebrae (60

Tumor Type Agnostic Therapy Carrying BRAF Mutation: Case Reports and Review of Literature.

BackgroundPrecision medicine is based on molecular and genotypic patient characterization to define specific target treatment. BRAF mutation is an oncogenic driver, and the Cancer Genome Atlas has identified BRAF mutations in different cancer types. Tumor type agnostic therapy is based on targeting genomic alterations, regardless of tumor origin. In this context, novel therapeutic agents including BRAF and MEK inhibitors based on the molecular landscape in solid tumors have been investigated. Case presentation, Case 1: The first case is chemotherapy-refractory, BRAF V600E mutated intrahepaticc