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Усовершенствованная последовательность транскриптомов и искусственный интеллект/машинное обучение (AI/ML) в имитируемом псориазом воспалении кератиноцитов человека.

ВВЕДЕНИЕ: Несмотря на то, что модель Keratinocyte HaCAT использовалась в предыдущих исследованиях для изучения воздействия антипсориатических агентов, по-прежнему отсутствует полное понимание механизма имитируемого имимодом распространения и трансдукции сигналов в псориазных кератиноцитах. ЦЕЛИ: Данное исследование было направлено на изучение молекулярных механизмов и путей, связанных с воспалением, подобным псориазу, в результате IMQ в кератиноцитах человека. МАТЕРИАЛЫ И МЕТОДЫ: Клетки HACAT подвергались воздействию различных концентраций IMQ, чтобы вызвать воспаление, аналогичное тому, котор

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… Immune dysregulation and inflammation causing hypopigmentation in post kala-azar dermal leishmaniasis: partners in crime? Trends Parasitol. 2023;39:822–36. doi: 10.1016/j.pt.2023.07.005. 74. Nunez R, Dona I, Cornejo-Garcia JA. …

Exposure to hate in online and traditional media: A systematic review and meta-analysis of the impact of this exposure on individuals and communities.

THE PROBLEM: People use social media platforms to chat, search, and share information, express their opinions, and connect with others. But … online comments (d = 0.51; 95% CI = 0.034-0.984; p < 0.05; n = 2) but does not seem to affect hate crimes directly. However, there is no evidence that exposure to hate fosters resistance behaviors among individuals who are frequently subjected to it (e.g. the intention to counter-argue factually). In terms of psychological consequences, this review dem …

Prognostic and functional role of the nuclear export receptor 1 (XPO1) in gastrointestinal cancers: a potential novel target?

In the last decades the survival of metastatic gastrointestinal (GI) cancer patients could have been significantly extended due to the introduction of targeted- and immunotherapy. However, only the minority of patients will experience long-lasting survival. Hence, novel therapeutics are clearly necessary for GI cancer patients. Molecular high-throughput profiling techniques have revealed potential novel targetable molecular alterations, emphasizing the necessity for tailored therapeutic approaches. Nuclear export proteins, particularly Exportin-1 (XPO1), have emerged as promising targets in ca

Выявление связанных с теплом диагнозов в ходе посещений чрезвычайных служб взрослыми в Чикаго: исследование по всей ассоциации.

Крайняя теплота - это растущая проблема здравоохранения. Несмотря на то, что в ходе предыдущих исследований были изучены ассоциации по вопросам теплоздоровья, их зависимость от ограниченных диагностических и диагностических категорий может упустить из виду или дезклассифицировать связанные с теплом заболевания. Здесь мы провели в Чикаго, штат Иллинойс, исследование теплообщности для оценки диагнозов острого лечения, связанных с экстремальным теплом. Использование 916,904 посещения в целях оказания неотложной медицинской помощи, включая экстренное отделение и встречи по оказанию неотложной меди

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… L., Temperature, crime, and violence: A systematic review and meta-analysis. Environ. Health Perspect. 132, 106001 (2024). 49. Anderson C. A., Temperature and aggression: Ubiquitous effects of heat on occurrence of human violence. Psychol. Bull. 106, 74–96 (1989). 50. …

Cannabidiol-from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer.

Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present in Cannabis sativa L., namely, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). Compared to THC, CBD has non-psychoactive effects, an advantage for clinical applications of anti-tumor benefits. The review is designed to provide an update regarding the multi-target effects of CBD in different

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… The decline in use was due to the association of cannabis with addiction, mental deterioration, and crime [ 11 ], and to the replacement of cannabis preparations with synthetic drugs. This led to an international prohibition of cannabis use [ 11 ]. …

Exportin 1 as a Therapeutic Target to Overcome Drug Resistance in Lung Cancer.

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality, with therapeutic resistance continuing to limit long-term responses. Among emerging resistance mechanisms, dysregulation of nucleocytoplasmic transport has gained attention for its ability to inactivate tumor suppressor pathways. Exportin 1 (XPO1), the primary nuclear export protein, is frequently overexpressed in NSCLC and promotes the cytoplasmic mislocalization of proteins involved in cell cycle control, apoptosis, and DNA repair. This includes key regulators such as p53, FOXO, and RB, whose inactivati

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… A Fraction of Crm1 Locates at Centrosomes by Its CRIME Domain and Regulates the Centrosomal Localization of Pericentrin. Biochem. Biophys. Res. Commun. 2009;384:383–388. doi: 10.1016/j.bbrc.2009.04.154. 47. …

Osteoclast Activation and Inflammatory Bone Diseases: Focusing on Receptors in Osteoclasts.

Bone homeostasis depends on the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption. An increasing number of studies have revealed that under inflammatory conditions, osteoclast overactivation is responsible for bone loss in relevant bone diseases. Multiple signaling pathways such as receptor activator of nuclear factor-kappa B ligand (RANKL) signaling are involved in osteoclast activation. These signaling pathways rely on various receptors expressed on the surface of osteoclast progenitor cells (OPCs) or osteoclasts, which are activated by their correspo

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… Do they act as partners in crime? Rheumatology . 2019;58(8):1331–1343. doi: 10.1093/rheumatology/kez218 75. Jantaboon S, Sakunrangsit N, Toejing P, et al. Lipopolysaccharide impedes bone repair in FcγRIIB-deficient mice. Int J mol Sci . 2023;24(23):16944. doi: 10.3390/ijms242316944 76. …

The indignities of shielding during the COVID-19 pandemic for people with sickle cell disorders: an interpretative phenomenological analysis.

This article seeks to understand the first-hand experiences of people with sickle cell, a recessively inherited blood disorder, who were identified as clinically extremely vulnerable during the COVID-19 pandemic. Part of a larger sequential mixed-methods study, this article uses a selective sample of eight qualitative semi-structured interviews, which were analysed using interpretative phenomenological analysis (IPA). The first stage of IPA focused on practical concerns participants had correlated to understanding shielding and their feelings about being identified as clinically extremely vuln

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… Crime Justice Soc. Democr. 10, 140–155. doi: 10.5204/ijcjsd.1743 Tremain S. L. (Ed.) (2023). “Disaster ableism: epistemologies of crisis” in The Bloomsbury Guide to Philosophy of Disability. …

The Deadly Duo of COVID-19 and Cancer!

As of September 19, 2020, about 30 million people have been infected with the novel corona virus disease 2019 (COVID-19) globally, and the numbers are increasing at an alarming rate. The disease has a tremendous impact on every aspect of life, but one of the biggest, related to human health and medical sciences, is its effect on cancer. Nearly 2% of the total COVID-19 patients prior to May 2020 had cancer, and the statistics are quite frightening as the patient can be referred to as "doubly unfortunate" to suffer from cancer with the added misery of infection with COVID-19. Data regarding the

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… SARS-CoV-2 and cancer: are they really partners in crime? Cancer Treat. Rev. 89:02068. 10.1016/j.ctrv.2020.102068 Wang J., Hajizadeh N., Moore E. E., McIntyre R. C., Moore P. K., Veress L. V., et al. (2020). …

Efficacy and safety of venous angioplasty of the extracranial veins for multiple sclerosis. Brave dreams study (brain venous drainage exploited against multiple sclerosis): study protocol for a randomized controlled trial.

BackgroundMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with a disabling progressive course. Chronic cerebrospinal venous insufficiency (CCSVI) has recently been described as a vascular condition characterized by restricted venous outflow from the brain, mainly due to blockages of the internal jugular and azygos veins. Despite a wide variability among studies, it has been found to be associated with MS. Data from a few small case series suggest possible improvement of the clinical course and quality of life by performing percutaneous ball

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… The perfect crime? Chronic cerebrospinal venous insufficiency not leaving a trace in MS. J Neurol Neurosurg Psychiatry. 2011;82:436–440. doi: 10.1136/jnnp.2010.231613. Mehrpour M, Najimi N, Fereshtehnejad SM, Safa FN, Mirzaeizadeh S, Motamed MR, Nabavi M, Sahraeian MA. …

Evidence for reciprocal network interactions between injured hearts and cancer.

Heart failure (HF) and cancer are responsible for 50% of all deaths in middle-aged people. These diseases are tightly linked, which is supported by recent epidemiological studies and case control studies, demonstrating that HF patients have a higher risk to develop cancer such as lung and breast cancer. For HF patients, a one-size-fits-all clinical management strategy is not effective and patient management represents a major economical and clinical burden. Anti-cancer treatments-mediated cardiotoxicity, leading to HF have been extensively studied. However, recent studies showed that even befo

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… Endothelial cells and cancer cells: metabolic partners in crime? Curr Opin Hematol. ( 2015 ) 22 : 234 – 42 . 10.1097/MOH.0000000000000138 25767953 55. …

Interpretability and fairness evaluation of deep learning models on MIMIC-IV dataset.

The recent release of large-scale healthcare datasets has greatly propelled the research of data-driven deep learning models for healthcare applications. However, due to the nature of such deep black-boxed models, concerns about interpretability, fairness, and biases in healthcare scenarios where human lives are at stake call for a careful and thorough examination of both datasets and models. In this work, we focus on MIMIC-IV (Medical Information Mart for Intensive Care, version IV), the largest publicly available healthcare dataset, and conduct comprehensive analyses of interpretability as w

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… One well-known example is the software COMPAS (Correctional Offender Management Profiling for Alternative Sanctions), which was found a bias against African-Americans to assign a higher risk score of recommitting another crime than to Caucasians with the same profile 39 . …

Viewing the US presidential electoral map through the lens of public health.

Health, disease, and mortality vary greatly at the county level, and there are strong geographical trends of disease in the United States. Healthcare is and has been a top priority for voters in the U.S., and an important political issue. Consequently, it is important to determine what relationship voting patterns have with health, disease, and mortality, as doing so may help guide appropriate policy. We performed a comprehensive analysis of the relationship between voting patterns and over 150 different public health and wellbeing variables at the county level, comparing all states, including

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… This earlier research focused on the following variables: physically unhealthy days, mentally unhealthy days, percent food insecure, the teen birth rate, the primary care physician visit rate, the age-adjusted mortality rate, the violent crime rate, average health care costs, the percent diabetic, and …

The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme.

Glioblastoma multiforme (GBM) represents the most common and aggressive malignant form of brain tumour in adults and is characterized by an extremely poor prognosis with dismal survival rates. Currently, expanding concepts concerning the pathophysiology of GBM are inextricably linked with neuroinflammatory phenomena. On account of this fact, the identification of novel pathomechanisms targeting neuroinflammation seems to be crucial in terms of yielding successful individual therapeutic strategies. In recent years, the pleiotropic growth factor progranulin (PGRN) has attracted significant atten

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… Progranulin and the receptor tyrosine kinase EphA2, partners in crime? J. Cell Biol. 2016;215:603–605. doi: 10.1083/jcb.201610097. 67. Park B., Buti L., Lee S., Matsuwaki T., Spooner E., Brinkmann M.M., Nishihara M., Ploegh H.L. Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling. …

Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets.

Resveratrol (3,4',5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory and anti-cancer. Many studies have given special attention to different aspects of resveratrol anti-cancer properties and proved its high efficiency in targeting multiple cancer hallmarks. Tumor microenvironment has a critical role in cancer development and progression. Tumor cells coordinate with a cast of normal cells to aid the malignant behavior of cancer. Many cancer supporting players were detected in tum

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… Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment Cancer Cell 2012 21 309 322 10.1016/j.ccr.2012.02.022 22439926 53. Bissell M.J. Hall H.G. Parry G. How does the extracellular matrix direct gene expression? J. Theor. …

Interpreting Randomized Controlled Trials.

This article describes rationales and limitations for making inferences based on data from randomized controlled trials (RCTs). We argue that obtaining a representative random sample from a patient population is impossible for a clinical trial because patients are accrued sequentially over time and thus comprise a convenience sample, subject only to protocol entry criteria. Consequently, the trial's sample is unlikely to represent a definable patient population. We use causal diagrams to illustrate the difference between random allocation of interventions within a clinical trial sample and tru

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… Because Bayesian reasoning is probabilistic, it is different from logical conclusive verifications or refutations, such as exculpatory evidence that a suspect of a crime has an alibi, implying that it is certain the suspect could not have committed the crime [ 27 , 28 ]. …

Последствия злоупотребления наркотиками для путей ферроптоза: потенциальные терапевтические цели для расстройств, связанных с потреблением психоактивных веществ.

Серьезными проблемами в области здравоохранения во всем мире, особенно в развитых странах, по-прежнему являются расстройства, связанные с потреблением психоактивных веществ. Для ОСВ характерна устойчивая нейроинфламмация и синаптическая дисфункция мозга. Несмотря на десятилетия интенсивного расследования, детальные механизмы, лежащие в основе ВСГ, по-прежнему остаются иллюзорными. Ферроптоз — это высокорегулируемый процесс смерти клеток, на который сильно влияют метаболизм железа, пероксидация липидов, производство реактивных видов кислорода (РОС) и антиоксидантные системы. Он был связан с мно

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… Beyond their health effects, SUDs exert profound societal impacts, including increased unemployment, crime, family instability, and homelessness, resulting in substantial economic burden ( Daley, 2013 ). …

The application, safety, and future of ex vivo immune cell therapies and prognosis in different malignancies.

IntroductionImmunotherapy has revolutionized how cancer is treated. Many of these immunotherapies rely on ex vivo expansion of immune cells, classically T cells. Still, several immunological obstacles remain, including tumor impermeability by immune cells and the immunosuppressive nature of the tumor microenvironment (TME). Logistically, high costs of treatment and variable clinical responses have also plagued traditional T cell-based immunotherapies.MethodsTo review the existing literature on cellular immunotherapy, the PubMed database was searched for publications using variations of the phr

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… Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21:309–22. doi: 10.1016/j.ccr.2012.02.022. 139. Zhang E, Gu J, Xu H. Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors. …

Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2.

Osteolytic bone lesions are one of the central features of multiple myeloma (MM) and lead to bone pain, fractures, decreased quality of life, and decreased survival. Dysfunction of the osteoclast (OC)/osteoblast (OB) axis plays a key role in the development of myeloma-associated osteolytic lesions. Many signaling pathways and factors are associated with myeloma bone diseases (MBDs), including the RANKL/OPG and NF-κB pathways. NRF2, a master regulator of inflammatory signaling, might play a role in the regulation of bone metabolism via anti-inflammatory signaling and decreased reactive oxygen s

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… MM-induced osteolysis: Partners in crime. Blood. 2008;112:3–4. doi: 10.1182/blood-2008-03-144097. 49. Teitelbaum S.L., Ross F.P. Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 2003;4:638–649. doi: 10.1038/nrg1122. 50. Boyle W.J., Simonet W.S., Lacey D.L. …

Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

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