Результаты поиска

Is Prophylaxis the Only Way Out for Cytokine Release Syndrome Associated With Chimeric Antigen T-cell Therapy?

Chimeric antigen receptor T-cell (CAR-T) therapy is a new advancement in hematology and oncology with its use in treating many refractory malignancies. Cytokine release syndrome (CRS) is CAR-T's clinically hazardous side effect, ranging from mild to life-threatening events. It was one of the first side effects detected with CAR-T. We conducted a literature review using PubMed (MeSH) to study CRS incidence after the administration of CAR-T to reflect its clinical importance. Nine studies are mentioned, with a total of 1357 patients enrolled for different types of refractory/relapsed cancers, an

Совпадение в полном тексте источника
… Management of CRS is a multimodality approach with integrated care through intensive care unit (ICU) staff and oncologists [ 13 ]. Grading systems help compartmentalize CRS and help focus on the respective treatment modalities [ 14 ]. … a single-arm, multicentre, phase 1-2 trial Lancet Oncol Locke FL Ghobadi A Jacobson CA 31 42 20 2019 30518502 10.1016/S1470-2045(18)30864-7 PMC6733402 32 FDA approval summary: tocilizumab for treatment of chimeric antigen receptor T cell-induced severe or life-threatening cytokine release syndrome Oncologist …

Clinical Usefulness of Bronchoalveolar Lavage in the Management of Pulmonary Infiltrates in Adults with Hematological Malignancies and Stem Cell Transplantation.

IntroductionPulmonary complications are frequent in patients with hematologic malignancies and stem cell transplantation. Regardless of the microbiological usefulness of bronchoalveolar lavage (BAL), little information exists on both its benefits as a guide for therapeutic decisions and its impact on patients' clinical outcome.MethodsA prospective observational single-center study was performed between July 2011 and July 2016. Consecutive episodes of pulmonary infiltrates were analyzed in subjects over 18 years of age who presented hematologic malignancies and underwent chemotherapy or stem ce

Совпадение в полном тексте источника
… The multidisciplinary approach to the management of these patients (including internists, oncologists, pneumologists, and infectious diseases specialists) leads to discrepancies in the usefulness of BAL in this setting. 41 In a recent study, Marchesi et al. observed that a BAL-driven antimicrobial approach … Survey of academic pulmonologists, oncologists, and infectious disease physicians on the role of bronchoscopy in managing hematopoietic stem cell transplantation patients with pulmonary infiltrates. J Bronchology Interv Pulmonol. 2014;21(1):32–39. doi: 10.1097/LBR.0000000000000042. …

Understanding mortality in multiple myeloma: Findings of a European retrospective chart review.

OBJECTIVES: This study aimed to provide real-world data on the characteristics and treatment of patients with multiple myeloma (MM) at the time of death. METHODS: The study was a retrospective patient chart review across France, Germany, Italy, Spain and the UK during 2016, and included patients who had died in the 3 months before the index date. RESULTS: Data from 786 patients were reviewed. At the time of death, 37% of patients were receiving active treatment, 12% were in a treatment-free interval and 51% were receiving only supportive care. Death before and during active first-line treatm

Совпадение в полном тексте источника
… Physicians, including oncologists, haematologists and onco‐haematologists, and internists in Germany were solicited to participate in the study. … Almost all physicians (99.5%) were oncologists or haematologists. The charts of 786 deceased patients were reviewed (France, 139; Germany, 171; Italy, 171; Spain, 138; UK, 167). …

Pathologic fracture and healthcare resource utilisation: A retrospective study in eight European countries.

BackgroundSkeletal-related events (SREs; pathologic fracture [PF], spinal cord compression and radiation or surgery to bone) are common complications of bone metastases or bone lesions and can impose a considerable burden on patients and healthcare systems. In this study, the healthcare resource utilisation (HRU) associated with PFs in patients with bone metastases or lesions secondary to solid tumours or multiple myeloma was estimated in eight European countries.MethodsEligible patients were identified in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland.

Совпадение в полном тексте источника
… The largest changes in the mean number of outpatient visits per PF from baseline were in visits to radiation oncologists/radiotherapists (long bones 1.0 [SD 2.5]; other bones 1.5 [SD 3.8]) and oncologists (long bones 0.5 [SD 1.9]; other bones 0.8 [SD 2.3]). …

How do we estimate survival? External validation of a tool for survival estimation in patients with metastatic bone disease-decision analysis and comparison of three international patient populations.

BackgroundWe recently developed a clinical decision support tool, capable of estimating the likelihood of survival at 3 and 12 months following surgery for patients with operable skeletal metastases. After making it publicly available on www.PATHFx.org , we attempted to externally validate it using independent, international data.MethodsWe collected data from patients treated at 13 Italian orthopaedic oncology referral centers between 2010 and 2013, then applied to PATHFx, which generated a probability of survival at three and 12-months for each patient. We assessed accuracy using the area und

Совпадение в полном тексте источника
… Italian oncologists typically refer patients with excellent prognoses for orthopaedic consultation. In patients with more extensive disease and less favorable prognoses, however, surgery may be deemed unsuitable in the eyes of the oncologist, which obviates the need for an orthopaedic opinion. …

Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients.

BACKGROUND: Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is an adverse effect of bisphosphonate treatment with varying reported incidence rates. METHODS: In two neighboring German cities, prevalence and additional factors of the development of BP-ONJ in multiple myeloma patients with bisphosphonates therapy were recorded using a retrospective (RS) and cross-sectional study (CSS) design. For the RS, all patients treated from Jan. 2000--Feb. 2006 were contacted by letter. In the CSS, all patients treated from Oct. 2006--Mar. 2008 had a physical and dental examination. Additional

Experimental Drugs for Chemotherapy- and Cancer-Related Anemia.

Anemia in cancer patients is a relevant condition complicating the course of the neoplastic disease. Overall, we distinguish the anemia which arises under chemotherapy as pure adverse event of the toxic effects of the drugs used, and the anemia induced by the tumour-associated inflammation, oxidative stress, and systemic metabolic changes, which can be worsened by the concomitant anticancer treatments. This more properly cancer-related anemia depends on several overlapping mechanism, including impaired erythropoiesis and functional iron deficiency, which make its treatment more difficult. Stan

Vaccination in Oncology Patients: Evidence, Clinical Challenges, and Future Directions.

This narrative review provides a comprehensive synthesis of patients with cancer disproportionately affected by vaccine-preventable infectious diseases due to malignancy-related immune dysfunction and treatment-induced immunosuppression. Vaccination represents a cornerstone of supportive care in oncology; however, vaccine uptake remains suboptimal and immune responses are frequently attenuated, particularly in patients with hematological malignancies and those receiving highly immunosuppressive therapies. This review provides a comprehensive synthesis of current evidence on vaccine immunogenic

Совпадение в полном тексте источника
… Oncologists and cancer care teams are therefore encouraged to proactively anticipate common misconceptions during consultations, rather than waiting for patients to raise concerns. … Patients who receive clear, personalized recommendations from their oncologist or members of the cancer care team are far more likely to accept vaccination than those who do not receive such guidance or receive ambiguous messages. …

Prognostic value of nutritional and functional screening instruments for mortality in patients with hematologic malignancies.

PurposeFunctional and nutritional impairments adversely affect outcomes in hematologic malignancies; however, the comparative prognostic value of widely available screening instruments remains insufficiently explored. The present study aimed to examine the association between nutritional and functional screening instruments and 12-month mortality in hospitalized patients with hematologic malignancies.MethodsIn this prospective cohort of 91 patients (median age 53 years [IQR, 35-61]), nutritional screening and assessment tools (PG-SGA, GLIM criteria) and functional screening instruments (SARC-F

Early Palliative Care in Advanced Hematologic Malignancies: A Systematic Review of Patient-Centered Outcomes.

Background: Patients with hematologic malignancy (HM) experience high symptom burden (SB) and diminished quality of life (QOL). While early palliative care (EPC) benefits solid tumors, its impact in HM remains uncertain. Objectives: To systematically review the effects of EPC on patient-centered outcomes in individuals with HM. Methods: MEDLINE, Web of Science, Cochrane Library, and Scopus were searched for English-language articles published between 2020 and 2024. Eligible studies included adults with advanced HM receiving EPC compared with usual care, reporting outcomes on SB, QOL, place of

Совпадение в полном тексте источника
… Salins et al. similarly emphasized the importance of renaming PC as “supportive care” as a key recommendation from oncologists [ 56 ]. … Attitudes and Beliefs Toward Supportive and Palliative Care Referral Among Hematologic and Solid Tumor Oncology Specialists Oncologist 2015 20 1326 1332 10.1634/theoncologist.2015-0240 26417037 PMC4718432 56. Salins N. Ghoshal A. Hughes S. Preston N. …

A Review on Curability of Cancers: More Efforts for Novel Therapeutic Options Are Needed.

Cancer remains a major cause of death globally. Given its relapsing and fatal features, curing cancer seems to be something hardly possible for the majority of patients. In view of the development in cancer therapies, this article summarizes currently available cancer therapeutics and cure potential by cancer type and stage at diagnosis, based on literature and database reviews. Currently common cancer therapeutics include surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy. However, treatment with curative intent by these methods are mainly eligible for patients with loca

The Future of Oncology in Psychiatric Medications.

Recent years have provided numerous reports on the mechanisms of action of psychiatric medications (antidepressants, antipsychotics, mood stabilizers, and antidementia drugs) that directly inhibit the growth of cancer cells, as well as on their indirect effects on the psyche and immune system, and their supportive effects on chemotherapeutic agents. The mechanisms of the anticancer activity of psychiatric drugs include inhibition of dopamine and N-methyl-D-aspartate receptors that work via signaling pathways (PI3K/AKT/mTOR/NF-κB, ERK, Wnt/ß-catenin, and bcl2), metabolic pathways (ornithine dec

Exploring social determinants of health on chemotherapy-induced peripheral neuropathy severity in ovarian cancer: An integrative review.

Ovarian cancer remains a significant public health concern for women despite advancements in cancer management. Despite comprising only 2.5 % of cancers in women, ovarian cancer ranks as the fifth leading cause of cancer-related deaths among women, with patients frequently receiving late diagnoses. Chemotherapy, a primary treatment, frequently causes chemotherapy-induced peripheral neuropathy (CIPN), affecting over 60 % of patients and leading to severe sensory, motor, and autonomic nerve impairments. This often necessitates dosage reduction or discontinuation of treatment, thereby increasing

Identification of germline cancer predisposition variants in pediatric sarcoma patients from somatic tumor testing.

Genetic predisposition is an important risk factor for cancer in children and adolescents but detailed associations of individual genetic mutations to childhood cancer are still under intense investigation. Among pediatric cancers, sarcomas can arise in the setting of cancer predisposition syndromes. The association of sarcomas with these syndromes is often missed, due to the rarity and heterogeneity of sarcomas and the limited search of cancer genetic syndromes. This study included 43 pediatric and young adult patients with different sarcoma subtypes. Tumor profiling was undertaken using the

Совпадение в полном тексте источника
… In the case of the centers involved in this study, there are genetic counseling units with geneticists and cancer oncologists, where the relevant tests are requested from family members and, once the results are known, genetic counseling is provided. … Oncologist. 2014;19:193–201. doi: 10.1634/theoncologist.2013-0328. 41. Biotteau M, et al. Sporadic and familial variants in NF1: An explanation of the wide variability in neurocognitive phenotype? Front. Neurol. 2020;11:368. doi: 10.3389/fneur.2020.00368. 42. Kratz CP, et al. …

Rehabilitation after Allogeneic Haematopoietic Stem Cell Transplantation: A Special Challenge.

The general population is getting older and suffer more haematological malignancies despite being physically fit. These malignancies are mainly only curable via an alloHCT, and they are now carried out more frequently. Patients benefit from intensive rehabilitation earlier and may need it repeatedly in cases of severe side effects (e.g., graft-versus-host disease). They can suffer many problems that other cancer patients do not experience, such as severe infections, continued immunosuppression, nutritional restrictions, acute or chronic GvHD, or organ impairments (e.g., lung, eyes). They may a

Совпадение в полном тексте источника
… The rehabilitation of patients after alloHCT differs from “standard” rehabilitation, and it demands a lot of specialised experience on the part of physicians and nursing staff; physiotherapists, dietitians, and psycho-oncologists may also be confronted with extraordinary situations [ 5 ]. … These problems also require experienced psycho-oncologists because their treatment differs from the follow-up care of “normal” oncology patients. With longer and more frequent support during a 3–4-week rehabilitation programme, these discomforts can be dealt with effectively. …

Effects of Physical Exercise Intervention on Psychological and Physical Fitness in Lymphoma Patients.

Background and objectives: Lymphoma patients experience a psychological and physiological decline that could be reversed by exercise. However, little is known about the effects of the exercise on psychological and physical fitness variables. Therefore, the purpose of this longitudinal study was to assess self-efficacy, fatigue and physical fitness before and after an eight-week exercise intervention. Materials and Methods: Thirty-six participants (54.4 ± 19.1 years) performed a supervised exercise program (~60 min, 2d·wk-1). Each session included a combined progressive training of cardiorespir

Совпадение в полном тексте источника
… After the corresponding oncologist gave consent, the participants were considered suitable for the study if they met the inclusion criteria and did not present contraindications to physical exercise for patients with cancer. … Cancer–related fatigue: Can exercise physiology assist oncologists? Lancet Oncol. 2003 4 616 625 10.1016/S1470-2045(03)01221-X 14554239 5. Miller K.D. Siegel R.L. Lin C.C. Mariotto A.B. Kramer J.L. Rowland J.H. Stein K.D. Alteri R. Jemal A. …

Chemotherapy-induced neuropathies-a growing problem for patients and health care providers.

IntroductionChemotherapy-induced neuropathies are one of the most common side effects of cancer treatment, surpassing bone marrow suppression and kidney dysfunction. Chemotherapy effects on the nervous system vary between different classes of drugs and depend on specific chemical and physical properties of the drug used. The three most neurotoxic classes of anti-cancer drugs are: platinum-based drugs, taxanes, and thalidomide and its analogs; other, less neurotoxic but also commonly used drugs are: bortezomib, ixabepilone, and vinca alkaloids.MethodsHere, in this paper, based on our experience

Targeted treatments of bone metastases in patients with lung cancer.

Until now ~30-40% of patients with advanced lung cancer develop bone metastases, but as the newer therapies are extending survival, the chance of developing bone metastases increases. Bone metastases cause skeletal-related events (SREs) such as pathologic fractures, spinal cord compression, radiation therapy or surgery to bone, or hypercalcemia, which can have debilitating consequences affecting patients' health-related quality of life (HR-QOL) and performance status (PS). Poor PS then prevents the patients to receive further lines of treatments, which are available today. SREs are associated

Spinal cord Compression Outcomes Of Treatment (SCOOT) Delphi study.

BackgroundEarlier diagnosis, advances in medical oncology and radiation modalities continue to improve cancer patients' survival length, leading to a rise in metastatic disease and metastatic spinal cord compression (MSCC). Treatment approaches need a high level of individualisation, making management decisions for these patients challenging.MethodsA modified Delphi study with quantitative and qualitative analysis to identify thresholds for surgical intervention for MSCC patients and the factors underpinning those thresholds. A predefined expert panel was sent rounds of decision-making questio

Совпадение в полном тексте источника
… Primary | Age | Duration of symptoms | Functional status | Mets at time of diagnosis | Neurological function at presentation | Number of spinal lesions | Pain | Oncologists’ predicted life expectancy | Primary tumour | Site of spinal lesions | Type of spinal lesion | Visceral mets Prostate | 7 [75] ¶ … Good interactions with oncologists are vital to achieving this. The time from onset of symptoms to presentation, response to previous treatment, time from primary diagnosis to presentation and potential for future treatments or disease control dictate when and if to intervene surgically. …

Subspecialty Second-Opinion in Multiple Myeloma CT: Emphasis on Clinically Significant Lytic Lesions.

Background and objectives: In order to increase the accuracy of lytic lesion detection in multiple myeloma, a dedicated second-opinion interpretation of medical images performed by subspecialty musculoskeletal radiologists could increase accuracy. Therefore, the purpose of this study is to evaluate the added value (increased accuracy) of subspecialty second-opinion (SSO) consultations for Computed Tomography (CT) examinations in Multiple Myeloma (MM) patients undergoing stem cell transplantation on standard computed tomography with a focus on focal lesion detection. Materials and Methods: Appr