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Cancer incidence and mortality in Quito: information to monitor cancer control policies.

IntroductionCancer represents a challenge for global public health, since it requires a comprehensive strategy for its control. In this context, the Population-Based Cancer Registries (PBCR) are key actors for the generation of public policies that guarantee their implementation.ObjectiveThis study analyses the trend in cancer incidence and mortality rates in the city of Quito during the period 1985-2017 and discusses them within the framework of the National Strategy against cancer proposed in 2017 for Ecuador.MethodsAge-standardized incidence and mortality rates are established using data fr

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… More than 70% of cases can be attributed to tobacco, so, without a doubt, tobacco control policies and the application of anti-smoking laws are key to reducing incidence and mortality rates. … In Ecuador, anti-smoking measures began in the 1980s and were deepened after the ratification of the WHO Framework Convention on Tobacco Control (WHO FCTC) in 2006 11 , 20 . …

Cancer management in the twenty-first century in India.

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… It is also important that every comprehensive cancer center offers cancer patients and also the community as a whole, a service of smoking / tobacco cessation and also promotes tobacco control in schools, working places, and public places. …

Evaluating Vaporized Cannabinoid Therapy in Multiple Sclerosis: Findings from a Prospective Single-Center Clinical Study.

Introduction: Multiple Sclerosis (MS) is associated with a wide range of debilitating symptoms, and conventional therapies often fail to adequately address the disease's multifaceted challenges. Cannabidiol (CBD) 13.0% + Delta9-tetrahydrocannabinol (THC) 9.0% (CBD13/THC9), a vaporized cannabis-based medicinal product, presents a novel therapeutic option for managing MS symptoms. Methods: This single-center longitudinal study followed 69 MS patients over a six-month period. Participants were assessed at treatment initiation and at three- and six-month intervals. Key measures included muscle spa

Cancer disparities: an extensive review.

Cancer disparities are persistently a significant public health burden worldwide and disproportionately impact the underserved populations. To effectively combat cancer disparities, a clear understanding of their causes and patterns is essential. Currently, government data and peer-reviewed research journals display a wide range of data to describe the extent of different cancer disparities. However, there are still gaps in understanding the scope and patterns of these disparities and in adopting practical approaches to eliminate them adequately. Accordingly, we examine essential topics that a

Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report.

BackgroundAdenoid cystic carcinoma of the trachea is a rare tumor, characterized by slow growth and low rate of local and distant metastasis. When achievable, complete surgical resection represents the optimal treatment approach, with the highest results in terms of overall survival. Radiation therapy is a reasonable alternative in cases of inoperable disease.Case presentationWe report a case of an 82-year-old white man affected by primary adenoid cystic carcinoma of the trachea, treated with debulking surgery and radiotherapy on the residual disease. A three-dimensional conformal radiation th

Using ncRNAs as Tools in Cancer Diagnosis and Treatment-The Way towards Personalized Medicine to Improve Patients' Health.

Although the first discovery of a non-coding RNA (ncRNA) dates back to 1958, only in recent years has the complexity of the transcriptome started to be elucidated. However, its components are still under investigation and their identification is one of the challenges that scientists are presently facing. In addition, their function is still far from being fully understood. The non-coding portion of the genome is indeed the largest, both quantitatively and qualitatively. A large fraction of these ncRNAs have a regulatory role either in coding mRNAs or in other ncRNAs, creating an intracellular

Личная профилактика нейродегенеративных заболеваний: обзор аналитического исследования и карта пробелов в данных.

Нейродегенеративные заболевания представляют собой серьезную проблему в области общественного здравоохранения в связи с их высокой распространенностью и низким прогнозом. Определение биомаркеров для стратификации людей в силу их риска развития этих заболеваний может помочь в определении новых индивидуализированных профилактических мер. Цель этого исследования заключалась в проведении аналитического обзора биомаркеров для первичной и вторичной индивидуализированной профилактики нейродегенеративных заболеваний. Поиск был нацелен на биомаркеры среди взрослых или групп повышенного риска в клиничес

Curcumin and Its Derivatives as Anticancer Agents in Head and Neck Cancer: Molecular Mechanisms and Preclinical Evidence

Head and neck cancer (HNC), particularly oral squamous cell carcinoma (OSCC), remains a major clinical challenge due to its aggressive behavior, high recurrence rates, and frequent resistance to conventional therapies. Natural compounds, especially curcumin and its derivatives, have gained increasing attention as potential anticancer agents due to their ability to target multiple molecular pathways involved in tumor progression. This review critically evaluates the current preclinical and translational evidence supporting curcumin and its derivatives as monotherapeutic agents in HNC, with part

От генов к окружающей среде: жизненный подход к профилактике педиатрических аутоиммунных заболеваний.

Аутоиммунные заболевания у детей, включая тип 1 Все более серьезной проблемой для здоровья людей во всем мире являются диабет, болезни селиака и детский артрит. Этот всплеск, слишком быстрый для того, чтобы его можно было объяснить только генетическими изменениями, подчеркивает важнейшую роль экологических факторов и подчеркивает настоятельную необходимость принятия активных превентивных мер. Этот обзор представляет собой комплексную, основанную на фактических данных основу для профилактики педиатрических аутоиммунных заболеваний по всему спектру услуг, начиная с первичной и заканчивая третичн

Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care.

BACKGROUND: Digital tracking on mobile devices, combined with clinical decision support systems and targeted client communication, can facilitate service delivery and potentially improve outcomes. OBJECTIVES: To assess the effects of using a mobile device to track service use when combined with clinical decision support (Tracking + CDSS), with targeted client communications (Tracking + TCC), or both (Tracking + CDSS + TCC). SEARCH METHODS: Cochrane CENTRAL, MEDLINE, Embase, Ovid Population Information Online (POPLINE), K4Health and WHO Global Health Library (2000 to November 2022). SELECTIO

Global epidemiological trend of cancer incidence and death in adults aged 60 years and older: a systematic analysis of data from GLOBOCAN 2022 and GBD2021.

BACKGROUND: Updated and comprehensive global assessments of cancer statistics specifically targeting adults aged ≥ 60 years have remained limited. To address this gap, we conducted a systematic epidemiological analysis of cancer burden in this rapidly growing demographic worldwide. METHODS: Population-based data from the Global Cancer Observatory (GLOBOCAN) 2022 and the Global Burden of Diseases (GBD) 2021 were used and analyzed in this study. The main outcomes of this study were age-standardised incidence (ASIR) or mortality rate (ASMR), and average annual percent change (AAPC). A Bayesian ag

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… Tobacco control policies and air quality improvement initiatives represent two cornerstone interventions for mitigating the global burden of TBL cancers. CRC, one of the digestive system cancers, had the highest ASIR and ASMR in adults aged over 90 in 2022. …

Analysis of the Mortality Trends of 23 Major Cancers in the Indian Population Between 2000 and 2019: A Joinpoint Regression Analysis.

PurposeCancer mortality trends have not been documented across the population of India. We, therefore, analyzed the overall and individual cancer mortality trends for 23 major cancers between 2000 and 2019 on the basis of Global Health Observatory (GHO) database.Materials and methodsThis study examined cancer mortality trends for 23 major cancer sites on the basis of 12.85 million cancer deaths obtained from the GHO of the WHO between 2000 and 2019. A joinpoint regression model was used to analyze the long-term trends of cancer mortality. Annual percentage change (APC) and average APC were est

Longevity leap: mind the healthspan gap.

Life expectancy has increased by three decades since the mid-twentieth century. Parallel healthspan expansion has however not followed, largely impeded by the pandemic of chronic diseases afflicting a growing older population. The lag in quality of life is a recognized challenge that calls for prioritization of disease-free longevity. Contemporary communal, clinical and research trends aspiring to extend the health horizon are here outlined in the context of an evolving epidemiology. A shared action integrating public and societal endeavors with emerging interventions that target age-related m

Coronary lesions in patients with COPD (Global Initiative for Obstructive Lung Disease stages I-III) and suspected or confirmed coronary arterial disease.

BackgroundSystemic inflammation is the pathophysiological link between coronary artery disease (CAD) and COPD. However, the influence of subclinical COPD on patients with suspected or diagnosed CAD is largely unknown. Thus, this study was designed to evaluate the degree of coronary involvement in patients with COPD and suspected or confirmed CAD.MethodsIn this cross-sectional study, carried out between March 2015 and June 2017, 210 outpatients with suspected or confirmed CAD were examined by both spirometry and coronary angiography or multidetector computed tomography. These patients were divi

Dental management before radiotherapy of the head and neck region: 4-year single-center experience.

OBJECTIVE: To review our experience with a standardized dental management approach in patients with planned radiotherapy of the head and neck region based on preradiation and follow-up data. MATERIAL AND METHODS: Records of patients who underwent radiotherapy between June 2016 and November 2020 were reviewed. Data on dental findings and therapeutic recommendations were extracted from a prospectively managed database. Hospital records were used to obtain follow-up data. RESULTS: Two hundred eighty-one patient records were identified. After the exclusion of 81 patients because of incomplete da

Fecal occult blood test for colorectal cancer screening: an evidence-based analysis.

UNLABELLED: The colorectal cancer (CRC) screening project was undertaken by the Medical Advisory Secretariat (MAS) in collaboration with the Cancer Care Ontario (CCO).In November 2007, the Ontario Health Technology Advisory Committee (OHTAC) MAS to conduct an evidence-based analysis of the available data with respect to colorectal cancer diagnosis and prevention. The general purpose of the project was to investigate the effectiveness, cost effectiveness, and safety of the various methods and techniques used for colorectal cancer screening in average risk people, 50 years of age and older.The o

Life's essential 8 and specific cancer risk and mortality in men and women: a population-based cohort analysis of 332,417 United Kingdom participants.

BackgroundThis study aimed to explore the association between Life's Essential 8 (LE8) and the risk of cancer occurrence and cancer-associated mortality across 24 cancer types. The cardiovascular health (CVH) score is constructed based on the overall LE8 score, providing a more direct measure of CVH and its potential relationship with cancer risk.MethodsThis cohort enrolled participants from a prospective cohort of the United Kingdom Biobank, including individuals aged 37-73 years, with 332,417 cancer-free participants. CVH scores were assessed using the LE8 metrics. The primary outcome of thi

Взаимосвязь между историей аутоиммунной болезни и развитием рака поджелудочной железы: тематическое исследование 32,640 Пациенты.

Рак поджелудочной железы - это очень смертельный рак с ростом заболеваемости и плохим прогнозом из-за позднего диагноза. Хотя известно несколько факторов риска, данные о потенциальной роли аутоиммунных заболеваний остаются ограниченными. С учетом растущей распространенности аутоиммунных заболеваний и их связи с различными вредителями цель этого исследования заключается в изучении их потенциальной связи с раком поджелудочной железы. МЕТОДЫ: 5,440 у пациентов с первым диагнозом рака поджелудочной железы и 27,200 В базе данных " Analyzer " (IQVIA) были выявлены лица, не страдающие раком

Plasma Heat Shock Protein 90 Alpha: A Valuable Predictor of Early Chemotherapy Effectiveness in Advanced Non-Small-Cell Lung Cancer.

BACKGROUND Heat shock protein-90 alpha (HSP90a) is more abundant in non-small-cell lung cancer (NSCLC) patients than in control individuals. However, whether it can reflect chemotherapy efficacy remains unknown. This study aimed to investigate the association of HSP90a with chemotherapy in advanced NSCLC. MATERIAL AND METHODS We retrospectively evaluated data from patients admitted to the Department of Respiratory Medicine, Shaoxing People's Hospital, from September 2016 to September 2018 with stage IIIB or IV NSCLC and administered 4 cycles of third-generation platinum-based combination chemo

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien