Результаты поиска

Non-venereal genital dermatoses and their impact on quality of life-A cross-sectional study.

BACKGROUND: Lesions on the external genitalia could be venereal or non-venereal. Non-venereal genital dermatoses are common and may cause co … udy group, 111(37.9%) patients had moderate and 133(45.4%) had large impact on the quality of life. Erectile dysfunction was seen in 48(19.8%) men and 9(3.7%) had premature ejaculation. A significant effect on dermatology life quality index was found with increasing age (P = 0.007), positive marital status (P = 0.006), history of unprotected sex (P < 0.001), history o …

Beyond Curvature: Prevalence and Characteristics of Penile Volume-Loss Deformities in Men With Peyronie's Disease.

INTRODUCTION: Non-curvature penile deformities associated with loss of erect penile volume are often overlooked and have not been thoroughly … esence or absence of axial instability, functional impairment, psychological distress, penile pain, erectile dysfunction, ejaculatory dysfunction, sexual dissatisfaction, decreased sexual activity, and decreased sexual desire. RESULTS: 128 patients met criteria for inclusion. 83 patients (65%) had volume-loss deformities. Unilateral indentations, hourglass deformitie …

Serum PSA as a predictor of testosterone deficiency.

INTRODUCTION: The relationship between serum prostate-specific antigen (PSA) and testosterone (T) levels is still controversial. According t … SURES: Several hormonal and biochemical parameters were studied, along with structured interview on erectile dysfunction (SIEDY), ANDROTEST, and PsychoANDROTEST. RESULTS: Receiver operating characteristic curve analysis for predicting severe hypogonadism (T<8 nmol/L) showed an accuracy of PSA=0.612±0.022 (P<0.0001), with the best sensitivity and specificity at PSA<0. …

Acupuncture versus paroxetine for the treatment of premature ejaculation: a randomized, placebo-controlled clinical trial.

BACKGROUND: Acupuncture therapy has been used by many researchers in both male and female sexual dysfunction studies. OBJECTIVE: To determi … ally active men aged between 28 and 50 yr were included. Men with other sexual disorders, including erectile dysfunction; with chronic psychiatric or systemic diseases; with alcohol or substance abuse; or who used any medications were excluded. INTERVENTION: The medicated group received paroxetine 20 mg/d; the acupuncture or sham-acupuncture (placebo) groups were tre …

Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat.

INTRODUCTION: Diabetes mellitus (DM) represents a major risk factor for erectile dysfunction (ED). Although the etiology of diabetes-induced ED is multifactorial and still unknown, reactive oxygen species are thought to be one of the key factors. AIM: The aim of this article is to investigate whether administration of edaravone, a free radical scavenger, could prevent type 1 diabetes-induced dysfunction of nitric oxide (NO)-induced relaxation in corpus cavernosum smooth muscle in the rat. METHODS: Six-week-old male Wistar rats were randomly divided into three groups. One group was treated wi…

Patient satisfaction after penile prosthesis implantation in men aged ≥80 years: a single-center retrospective descriptive study.

Penile prosthesis implantation is an established treatment for medically refractory erectile dysfunction, but patient-reported outcomes in men aged ≥80 years remain underexplored. This retrospective single-center study descriptively evaluated satisfaction, functional device use, and postoperative complications among men aged ≥80 years who underwent penile prosthesis implantation between January 2015 and September 2025. Patients aged 75-79 years were included only to provide clinical context rather than to establish comparative equivalence. Satisfaction was assessed during in-person follow-up u…

Exploring Intimacy in Amyotrophic Lateral Sclerosis: A Pilot Study of Educational Support in a Multidisciplinary Clinic.

OBJECTIVE: This pilot study explored the feasibility and perceived usefulness of an educational intervention on intimacy delivered within a … ufficient. Open-ended responses revealed diverse needs, including interest in tailored content (eg, erectile dysfunction) and a desire for providers to ask permission before discussing intimacy. Caregivers described shifting roles and emotional strain, indicating that written materials alone may not fully address intimacy-related challenges. CONCLUSIONS: Integrating …

Satisfaction of Sexual Partner After Vaginal Tightening Surgery: A Systematic Review.

INTRODUCTION AND HYPOTHESIS: The vaginal tightening surgery is on the rise all over the world, with improved sexual function being one of the benefits proposed for this surgery. This study aims to investigate the satisfaction of sexual partner with vaginal tightening surgery. METHODS: Electronic databases were systematically searched for related articles published between January 2000 and April 2025. The selection criteria included original English articles evaluating partner's satisfaction after any type of vaginal tightening surgeries in healthy women. After removing duplicates, a total of

Acute Paraplegia in the Emergency Department: Acute Leriche Syndrome as a Vascular Mimic of a Spinal Cord Emergency.

Acute paraplegia is a neurological emergency requiring prompt diagnosis to prevent irreversible neurological deficits and permanent disability. Although traumatic causes of acute paraplegia are well-characterized, non-traumatic acute paraplegia poses a diagnostic challenge because of its diverse etiologies. Leriche syndrome, also known as aortoiliac occlusive disease, typically presents with chronic lower-extremity claudication, diminished femoral pulses, and erectile dysfunction; however, it can rarely present with acute paraplegia and mimic a spinal cord emergency. We report the case of a 58…

Spinal H-Sign in Syphilitic Myelitis Mimicking MOGAD.

INTRODUCTION: Longitudinally extensive transverse myelitis (LETM) is classically associated with aquaporin-4 antibody-mediated neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). The "H-sign," reflecting gray matter involvement, is considered suggestive of MOGAD. However, infectious etiologies, including neurosyphilis, may rarely mimic autoimmune inflammatory myelopathies radiologically. CASE REPORT: A 50-year-old man presented with 6 months of erectile dysfunction and urinary retention, followed by progressive gait instability. …

Prevalence of sexual dysfunction in relapsing-remitting multiple sclerosis and its association with brain and cervical cord MRI findings.

Sexual dysfunction (SD), a prevalent yet underreported complication in multiple sclerosis (MS), significantly impacts quality of life. This cross-sectional study at Imam Reza Clinic, Shiraz University of Medical Sciences, evaluated SD prevalence in 80 relapsing-remitting MS (RRMS) patients (65 females and 15 males; mean age 38.7 years) compared to 80 demographically matched controls (61 females and 19 males; mean age 39.1 years). SD was assessed using the Female Sexual Function Index (FSFI) for females and the International Index of Erectile Function (IIEF) for males, alongside brain-focused M

Tadalafil Use in Cardiovascular Disease.

Tadalafil is a phosphodiesterase inhibitor currently approved for use in erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). While tadalafil's benefits in ED and BPH have been well-established for years, its benefits in PAH were identified only recently in major clinical trials, resulting in the recent approval of a single-tablet, combination therapy of tadalafil with an endothelin receptor antagonist for PAH. With Tadalafil's cardiovascular benefits in ED, BPH, and PAH, clinical researchers have begun investigating whether tadalafil's use …

Penile Fracture Management at Trauma Centers in the United States.

INTRODUCTION: Current AUA urological trauma guidelines recommend prompt surgical intervention for patients presenting with acute penile fracture to minimize potential risks of erectile dysfunction and penile curvature. Given its relatively rare occurrence, there have been few large population-based studies evaluating real-world management of penile fracture. We hypothesized that there is variability in intervention for patients presenting with penile fracture associated with patients' clinical and demographic characteristics and hospital characteristics. METHODS: The Trauma Quality Improvemen…

Lived experiences of the sexual and reproductive health consequences of parkinson's disease and their impact on health-related quality of life in Ethiopia.

BACKGROUND: Despite being a vital component of daily life and a significant determinant of health-related quality of life (HRQoL), sexual an … age range from 37 to 80 years. Poor sexual intimacy, lack of sexual desire, sexual dissatisfaction, erectile dysfunction, premature ejaculation, penile size decrement and seminal fluid leakage were identified as sexual health consequences of PD. Reproductive health consequences are less children than desired, abortion, and perceived infertility. Experiencing SRH conse …

Prostate Biopsy and Malpractice: Analysis of a National Legal Database from 1995 to 2025.

OBJECTIVE: To evaluate the current evidence on prostate biopsy litigation risks, we analyzed malpractice litigations related to prostate bio … juries named, the most common were infection (9/47), acute or chronic pain after biopsy (6/47), and erectile dysfunction (4/47), LUTS (4/47), and bleeding (4/47). Eighteen cases (75.0%) resulted in defendant verdict, while one (4%) resulted in plaintiff verdict with an award of $226,795.00. One case (4%) resulted in private settlement of unknown amount. Two lawsuits ( …

Gonadal efficacy of Thymus quinquecostatus Celakovski: Regulation of testosterone levels in aging mouse models.

Late-onset hypogonadism (LOH) is an age-related disease in men characterized by decreased testosterone levels with symptoms such as decreased libido, erectile dysfunction, and depression. Thymus quinquecostatus Celakovski (TQC) is a plant used as a volatile oil in traditional medicine, and its bioactive compounds have anti-inflammatory potential. Based on this knowledge, the present study aimed to investigate the effects of TQC extract (TE) on LOH in TM3 Leydig cells and in an in vivo aging mouse model. The aqueous extract of T. quinquecostatus Celakovski (12.5, 25, and 50 µg/mL concentrations…

Possible retinotoxicity of long-term vardenafil treatment.

Phosphodiesterase (PDE) inhibitors - such as vardenafil - are used primarily for treating erectile dysfunction via increasing cyclic guanosine monophosphate (cGMP) levels. Recent studies have also demonstrated their significant cardioprotective effects in several diseases, including diabetes, upon long-term, continuous application. However, PDE inhibitors are not specific for PDE5 and also inhibit the retinal isoform. A sustained rise in cGMP in photoreceptors is known to be toxic; therefore, we hypothesized that long-term vardenafil treatment might result in retinotoxicity. The hypothesis was…

Трекеты (Trk-Targeting Drugs): Новинная терапия различных заболеваний.

Многие маршруты могут привести к переходу от здорового к больному фенотипу. Однако не так уж много путей, чтобы двигаться в противоположном направлении, т.е. Таким образом, остается следующий насущный вопрос: каковы патогенные пути и как можно противодействовать им в терапевтических целях? Человеческие клетки содержат >500 белковые киназы и почти 200 белковые фосфаты, действующие на тысячи белков, включая факторы роста клеток. Здесь мы обсуждаем нейтрофины с патогенными или метаботрофными способностями, в частности нейротрофический фактор, полученный из мозга, фактор нервного роста (НГФ), про-

Совпадение в аннотации оригинала
Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposi … ers (hypertension, atherosclerosis, type 2 diabetes mellitus, metabolic syndrome, obesity, diabetic erectile dysfunction and atrial fibrillation) and (1b) neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, and multiple sclerosis), and (2) antagonistic trackins, particularly TrkANGF inhibitors for prostate and breast cancer, pain, and arrhythmogenic …

The Complexity of Bariatric Patient's Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass.

Postbariatric altered gastrointestinal (GI) anatomy/physiology may significantly harm oral drug absorption and overall bioavailability. In this work, sildenafil, the first phosphodiesterase-5 (PDE5) inhibitor, was investigated for impaired postbariatric solubility/dissolution and absorption; this research question is of particular relevance since erectile dysfunction (ED) is associated with higher body mass index (BMI). Sildenafil solubility was determined both in vitro and ex vivo, using pre- vs. postsurgery gastric contents aspirated from patients. Dissolution tests were done in conditions m…

Comparison of Postoperative Outcomes of Trans-urethral Resection of the Prostate, Laser Vaporization, and Laser Enucleation: A Double Propensity Score Matched Analysis.

OBJECTIVE: To compare postoperative outcomes of 3 types of endourologic surgeries (trans-urethral resection of the prostate [TURP], laser va … n of follow-up and patient-specific urologic outcomes, such as prostate size, urinary incontinence, erectile dysfunction, and retrograde ejaculation.