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Clinicopathological and Prognostic Value of Neutrophil-Lymphocyte Infiltration in Oral Squamous Cell Carcinoma.

This study aims to explore the influence of CD66b+ and CD8+ tumor infiltration, along with the tumoral neutrophil-lymphocyte ratio (tNLR) an … ve front) and compartments (parenchyma and stroma). Prognostic impacts on overall survival (OS) and progression-free survival (PFS) were assessed using Kaplan-Meier survival curves. Smoking history correlated with higher bNLR. Blood lymphocyte counts were significantly higher in surviving patients (P=0.014). TNM stage I/II tumors exhibited better OS and lower CD66b+ cell c …

Nationwide Brain Tumor Registry-based Study of Adult Intracranial Ependymoma in Japan.

Ependymoma, a rare neuroepithelial malignancy of the central nervous system, affects both children and adults and may occur anywhere along t … ox proportional hazards analyses identified key prognostic factors influencing overall survival and progression-free survival. Gross total resection and near-total resection were associated with better outcomes, while EOR less than 95% and preoperative Karnofsky performance status score below 70 were significantly correlated with poorer OS. WHO grade 2 tumors were more pre …

Extramedullary disease in multiple myeloma at diagnosis and over the course of the disease.

Extramedullary disease (EMD) is an aggressive manifestation of multiple myeloma (MM) and is categorized into two distinct types: extramedull … in situ hybridization abnormalities compared to EM-B. Patients with EM-E had significantly shorter progression-free survival and overall survival than those with EM-B. Anemia, hypercalcemia, high LDH, EMD at relapse, ≥ 2 involved sites, and not receiving autologous stem cell transplantation were independent poor risk factors for survival. In conclusion, EMD is a heterogen …

Treatment Outcomes of Multiple Myeloma in Developing Countries: A Systematic Review and Meta-Analysis.

Multiple myeloma (MM) treatment outcomes in developing countries may be impacted by resource constraints. This systematic review and meta-an … st follow-up (2.5-12.5 years) was 62% (95% CI: 48-75%), with high heterogeneity (I²=92%), while the progression-free survival rate at longest follow-up (3-8 years) was 44% (95% CI: 23-67%). Comparative analyses demonstrated ASCT was associated with significantly superior 5-year survival compared to conventional chemotherapy (RR: 1.59; 95% CI: 1.38-1.82). Bortezomib-based r …

Prognostic value of 18F-FDG PET/CT in patients with relapsed multiple myeloma.

This study aimed to assess the prognostic value of 18F-fluorodeoxyglucose positron emission tomography/computer tomography (18F-FDG PET/CT) in patients with relapsed multiple myeloma (MM). Fifty-one consecutive patients with relapsed MM were enrolled in this retrospective study. 18F-FDG parameters based on the Italian Myeloma Criteria for PET Use (IMPeTUs) and clinical data were analyzed for overall survival (OS) and progression-free survival (PFS). The Cox proportional risk model was used for univariate and multivariate analysis, and Kaplan-Meier survival curves were used for survival analysi…

Podoplanin expression in salivary gland carcinomas and its clinical significance. An immunohistochemical study.

Podoplanin (D2-40) is a lymphatic endothelial marker that is considered as a specific marker for lymphatic endothelial cells and lymphangiog … tumour type (p = 0.03), prognosis (p ≤ 0.001), and mortality (p ≤ 0.001). The overall survival and progression-free survival differed significantly in cases with high and low expression (p ≤ 0.001). Podoplanin overexpression might be a significant prognostic indicator for patients with SGCs, implicating that it is a potential therapeutic target to improve survival in thes …

Reappraisal of the prognostic value of Epstein-Barr virus status in monomorphic post-transplantation lymphoproliferative disorders-diffuse large B-cell lymphoma.

The role of the Epstein-Barr virus (EBV) status in the blood for predicting survival in post-transplantation lymphoproliferative disorders-d … se (60.0% vs. 94.4%, P = 0.043) and complete response (40.0% vs. 88.9%, P = 0.019) as well as worse progression-free survival (PFS) (P = 0.035) and overall survival (OS) (P = 0.039) compared with patients with negative plasma EBV DNA. In multivariate analysis, plasma EBV DNA positivity was a significantly unfavorable prognostic factor for PFS [hazard ratio (HR) 4.92, 95% c …

Assessment of Resectability of Mediastinal Germ Cell Tumor Using Preoperative Computed Tomography.

BACKGROUND AND OBJECTIVES: Mediastinal germ cell tumor (MGCT) is a relatively rare tumor. Complete resection after chemotherapy is a standar … ors for incomplete resection. RESULTS: A total of 56 patients underwent resection of MGCT. The 5-y progression-free survival (PFS) and overall survival (OS) were 79% and 83%. In multivariate analysis, complete resection was the only significant prognostic factor for better PFS (hazard ratio (HR) = 9.083, P= 0.00021) and OS (HR = 5.519, P= 0.0445). The preoperative CT find …

[Analysis of Clinical Characteristics and Prognosis of 46 Elderly Patients with Peripheral T Cell Lymphoma (PTCL)].

OBJECTIVE: To investigate the clinical characteristics and prognostic factors of patients with peripheral T cell lymphoma (PTCL). METHODS: The clinical data of 46 elderly PTCL patients admitted in Tianjin Medical University Cancer Hospital from April 2008 to August 2014 were collected, the clinical features, prognostic factors and treatments, as well as followed-up outcome were analyzed retrospectively. Survival analysis was performed by Kaplan-Meier method, and the COX proportional hazard model was used to perform multivariate analysis. RESULTS: The median survival time was 11 months, and t

Liver-directed surgery of neuroendocrine metastases: What is the optimal strategy?

INTRODUCTION: Neuroendocrine tumors (NETs) frequently metastasize to the liver. Operative debulking offers symptomatic relief and improved survival; however, the frequent presence of multifocal, bilobar disease and high recurrence rates introduces doubt regarding their optimal management. Parenchyma-sparing debulking (PSD) procedures (ablation, enucleation, wedge resections) may offer similar survival improvements as resection while minimizing morbidity and preserving functional liver tissue. METHODS: Clinicopathologic variables from 228 patients with small bowel or pancreatic NETs managed op

Outcomes of surgical treatment of primary signet ring cell carcinoma of the colon and rectum: 22 cases reviewed with literature.

Colorectal primary signet ring cell carcinoma (PSRCCR) is a rare entity with a dismal prognosis, mainly because of delayed diagnosis. The ob … he rates of curative and palliative resections performed were equal. Mean overall survival and mean progression-free survival times were found to be 33.3 ± 7.1 months (95% confidence interval, 19.4-47.2 months) and 11.8 ± 3.5 months (95% confidence interval, 4.9-18.7 months), respectively. It was concluded that site of the tumor, presence of bowel obstruction, peritoneum a …

Early rejection episodes.

1. Early rejection episodes had an overriding effect on graft survival. One-year graft survival decreased by 18% in LRD transplants and by 27% in cadaver-donor transplants when rejection occurred. Early rejection-free patients had 96% (LRD) and 87% (cadaver-donor) 1-year graft survival. 2. Among rejection-free recipients of first cadaver transplants, 1-year graft survival decreased by 5% when function was delayed for 8-14 days and by 10% when function was delayed more than 14 days, suggesting some rejections were masked by early nonfunction. 3. Rejections occurred in 30% of first cadaver donor

Association of Intratumoral Microbiota With Prognosis in Patients With Nasopharyngeal Carcinoma From 2 Hospitals in China.

IMPORTANCE: Microbiota-tumor interactions have qualified microbiota as a promising prognostic biomarker in various types of cancers. Although the nasopharynx acts as a crucial niche of the upper respiratory tract microbiome, whether the intratumoral microbiota exists and its clinical significance in nasopharyngeal carcinoma (NPC) remain uncertain. OBJECTIVE: To evaluate the clinical significance of intratumoral microbiota for individual prognostication in patients with NPC. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study included NPC biopsy samples from 2 hospitals: Sun Ya

Survival Impact of Supramarginal Resection According to MGMT Promoter Methylation Status in Glioblastoma: A Systematic Review and Meta-analysis.

OBJECTIVES: To evaluate the association between supramarginal resection (SMR) and survival in IDH-wildtype glioblastoma and determine whethe … ere included. Random-effects meta-analysis pooled hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS). Risk of bias was assessed using the Newcastle-Ottawa Scale and RoB2. RESULTS: Fifteen studies (34,006 patients) met the inclusion criteria, and 13 studies (32,780 patients) were metaanalyzed. SMR was associated with improved OS (HR 0.62, 95% …

Long-Term Results of Hematopoietic Cell Transplantation (HCT) for Adults with Blood Disorders- A Systematic Review.

Both autologous and allogeneic stem cell transplantations are widely used as a standard of care or significant clinical option in treating various malignant and non-malignant diseases of the hematopoietic system. The value of these treatment methods would be better assessed through the review of long-term progression-free and overall survival (PFS and OS) rates, which are highly dependent on the primary diagnosis and stage of disease at the time of transplantation as well as on the specific type of used transplantation procedure. While the best (over 90%) 5-, 10- and 15-year survival rates are

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… Table 1 Long-term results of autologous transplantation for the diseases, where at least 5-year progression-free survival (PFS) and/or overall survival (OS) rates are available Abbreviations: ALCL – anaplastic large T-cell lymphoma, AML – acute myeloid leukemia, CML – chroni myeloid leukemia, DLBCL – … Table 2 Long-term results of allogeneic transplantation for the diseases, where at least 5-year progression-free survival (PFS) and/or overall survival (OS) rates are available Abbreviations: ALL – acute lymphoblastic leukemia, AML – acute myeloid leukemia, CMML – chronic myelomonocytic leukemia, CML …

Prognosis of patients with advanced bile tract carcinoma: assessment using the modified-Gustave Roussy Immune Score (mGRIm-s) as a clinico-immunological tool.

BACKGROUND: The emergence of immune checkpoint inhibitors (ICIs) has enhanced survival outcomes for certain patients with advanced biliary t … TS: Survival outcomes post-immunotherapy favored the low mGRIm-s group, with significantly improved progression-free survival (PFS) and overall survival (OS) (8.50 months vs. 3.70 months and 21.60 months vs. 8.00 months). COX regression confirmed an elevated risk in the high mGRIm-s group. Subgroup analysis highlighted a notable survival advantage for low mGRIm-s patients …

Adjuvant radiotherapy after salvage surgery for melanoma recurrence in a node field following a previous lymph node dissection.

BACKGROUND AND OBJECTIVES: Adjuvant radiotherapy (RT) can be given to melanoma patients following salvage surgery for node field recurrence after a previous regional node dissection, but the value of this treatment strategy is poorly documented. This study evaluated long-term node field control and survival of patients treated in this way in an era before effective adjuvant systemic therapy became available. METHODS: Data for 76 patients treated between 1990 and 2011 were extracted from an institutional database. Baseline patient characteristics, treatment details and oncological outcomes wer

Prognostic Value of Peritoneal Cytology in Stage I Serous and Clear Cell Carcinoma of the Endometrium.

(1) Background: To investigate the relation between malignant peritoneal cytology and survival outcomes in patients who underwent primary st … s with negative cytology. In univariate analysis, malignant cytology and serous histology had worse progression-free survival (PFS) and overall survival (OS) (all, p < 0.05). In sensitive analysis, the detrimental effects of malignant cytology on survival were more prominent in patients over 60 years old, those with serous histology, stage IB disease, and those who receive …

The prognostıc significance of blood counts in patients with hodgkin lymphoma.

BACKGROUND AND AIM: The aim of the study was to examine the demographic, clinical features, treatment responses, and outcomes of Hodgkin lymphoma (HL) patients and to investigate the factors affecting their survival. PATIENTS AND METHODS: A retrospective analysis was made of patients diagnosed with HL in our department between 2009 and 2019. Treatment regimen, treatment response, and follow-up times were recorded for all patients. Using these data, complete response (CR) rates, overall survival (OS), and progression-free survival (PFS) were calculated. The effects of parameters on survival we…

Long-term outcome after allogeneic stem cell transplantation in multiple myeloma.

The role of allogeneic hematopoietic stem cell transplantation (allo-SCT) in multiple myeloma is controversial. We analyzed the results of 205 patients transplanted in one center during 2000-2017. Transplantation was performed on 75 patients without a previous autologous SCT (upfront-allo), on 74 as tandem transplant (auto-allo), and on 56 patients after relapse. Median overall survival (OS) was 9.9 years for upfront-allo, 11.2 years for auto-allo, and 3.9 years for the relapse group (p = 0.015). Progression-free survival (PFS) was 2.4, 2.4, and 0.9 years, respectively (p < 0.001). Non-relapse…