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TEMPO oxidized cellulose nanofibers from electrospun regenerated cellulose: Processing feasibility and application potentials.

2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) oxidized cellulose nanofiber (TOCN) as an ecofriendly 1D nano-unit has been endowed with infinite possibilities to prepare a variety of functional materials. However, its wide applications have been significantly restricted due to complicated preparation processes from natural wood precursor with low production yield and severe contamination. Herein, we propose to mass produce regenerated TOCN (rTOCN) using electrospun cellulose acetate nanofiber (CANF) as precursor. It was illustrated that regenerated cellulose nanofibers (rCNF) obtained from deace

Comparison of the effect of isoflurane and propofol on liver regeneration after donor hepatectomy - A randomized controlled trial.

BACKGROUND: The biotransformation of inhalational anesthetic agents can result in production of hepatotoxic metabolites, which may potentially impair liver regeneration. Thus, isoflurane and propofol may have differential impacts on liver regeneration after donor hepatectomy. STUDY OBJECTIVE: To compare the regeneration liver volume (RgLV) via computed tomography (CT) volumetry on post-operative day (POD) 14 in isoflurane and propofol groups. DESIGN: Randomized controlled pilot trial. PATIENTS: Sixty donors, who underwent donor hepatectomy. INTERVENTIONS: Patients were randomized into isof…

Regenerating island-derived protein 3E concentrations in healthy dogs and dogs with various inflammatory processes.

BACKGROUND: Blood concentrations of regenerating island-derived proteins (REG) are high in humans with sepsis, acute pancreatitis, and gastrointestinal diseases. REG3E was recently identified in canine pancreas and blood, but concentrations in dogs with various diseases are unknown. OBJECTIVES: To measure and compare REG3E concentrations in dogs with sepsis, acute pancreatitis, gastrointestinal diseases, and healthy dogs. METHODS: Cross-sectional study measuring plasma REG3E concentrations using an in-house developed ELISA in stored convenience samples from client-owned dogs with naturally o

Safety and effectiveness of Merizelle oxidised regenerated cellulose in achieving haemostasis in surgical procedures: a surveillance study.

OBJECTIVE: Topical haemostatic materials applied to bleeding sites during surgery play an important role in intraoperative haemostasis. This study aimed to evaluate the clinical safety and efficacy of Merizelle oxidised regenerated cellulose (ORC) (Meril Life Sciences Pvt. Ltd., India) in achieving haemostasis across various surgical procedures. METHOD: This was a prospective, multicentre, single-arm, observational, post-marketing surveillance study. The primary endpoint was the proportion of patients achieving haemostasis within 10 minutes of application of ORC at target bleeding sites. The

Analysis of the prognostic efficacy of syndecan-1 for patients with ACLF and its functional role in liver regeneration.

BACKGROUND: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by systemic inflammation with a high short-term mortality rate … nd sulodexide could increase the expression of SDC-1 and attenuate liver injury, by promoting liver regeneration and inhibiting cell apoptosis through the activation of JAK1/STAT3 signalling. CONCLUSIONS: Collectively, our findings suggest that SDC-1 represents a potential prognostic and therapeutic target for ACLF and should be further investigated.

Engineered Magnetic-Functionalized Carbon Xerogels for Sustainable Arsenic Removal: Bridging Adsorption Efficiency with Regenerability.

This study developed iron-oxide-functionalized carbon xerogels for enhanced arsenic adsorption to mitigate global water contamination. The c … imal conditions: 1.0 M KOH, 160 rpm agitation, and 90 min contact time. The adsorbent retained >88% regeneration efficiency over four cycles, demonstrating robust reusability. Synergistic effects of magnetite incorporation, tailored pyrolysis, and H2O2 modification significantly improved arsenic selectivity and capacity in complex matrices, while enabling magn …

[Establishment and application of key technologies for periodontal tissue regeneration based on microenvironment and stem cell regulation].

The prevalence of periodontitis in China is as high as 74.2%, making it the leading cause of tooth loss in adults and severely impacting both oral and overall health. The treatment of periodontitis and periodontal tissue regeneration are global challenges of significant concern. GE Shaohua' s group at School and Hospital of Stomatology, Shandong University has focused on the key scientific issue of "remodeling the periodontal inflammatory microenvironment and optimizing tissue repair and regeneration". They have elucidated the mechanisms underlying the persistence of periodontitis, developed b…

Comparing Small Buccal Dehiscence Defects Treated With or Without Guided Bone Regeneration: A Subanalysis of an RCT.

This analysis aimed to assess clinical and radiographic outcomes of single-tooth posterior implants with a dehiscence defect treated with or without guided bone regeneration (GBR). In a randomized clinical trial of 59 patients, single-tooth posterior implants were placed. For the subanalysis of 16 patients with a buccal dehiscence defect (≤ 5 mm), the implants were randomly assigned to GBR or spontaneous healing (SH). In 8 patients, the implants were surrounded by native bone. A transmucosal healing approach was chosen for all sites. Patients were examined at restoration delivery (RD) and at 1…

Regeneration-Associated Factors in the Regulation of Adult and Post-Traumatic Neurogenesis in the Forebrain of Fish and Other Vertebrates.

This review summarizes a growing collection of data on adult neurogenesis in various vertebrate species, with a focus on teleost fish and mammals. Teleost fish serve as exceptional models for studying the dynamics of the cell cycle and the functions of adult neural stem progenitor cells (aNSPCs) throughout the central nervous system (CNS). New information about the characteristics of cells in various areas of the telencephalon of non-model objects-juvenile masu salmon Oncorhynchus masou and chum salmon Oncorhynchus keta-during postembryonic ontogenesis and after traumatic injury expands the cu

The effects of benzimidazole and electrical stimulation on peripheral nerve regeneration after short- and long-term injury.

This research investigated the effects of benzimidazole (BZ) and electrical stimulation (ES) on peripheral nerve regeneration after short- and long-term injury and assessed functional recovery by means of stereological, histological, and electrophysiological analyses. Fifty-four male albino Wistar rats were divided into nine groups of six animals each. No treatment or surgery was applied to the control (CONT) group. The sciatic nerve was crushed for 5 s in the short-term injury (STI) and for 60 s in the long-term injury (LTI) groups. In the STI + BZ group and the LTI + BZ group, the rats recei…

A glial cell derived pathway directs regenerating optic nerve axons toward the optic chiasm.

After optic nerve injury, several retinal ganglion cell (RGC) intrinsic signaling pathways have been shown to enhance RGC survival and RGC a … referred to as Plod3) to be required to direct regrowing RGC axons toward the midline during active regeneration. Moreover, we show that transgenic lh3 expression in sox10+ presumptive olig2+ oligodendrocytes located near the optic chiasm restores directed axonal growth in lh3 mutants. Finally, we find that mutants in collagen 18a1 (col18a1), a putative Lh3 su …

The role of the glutathione pathway in tracheal regeneration with aortic allografts through antioxidant-driven tissue integration.

Tracheal regeneration remains a major challenge due to the lack of efficient graft integration and functional restoration. Current approaches fail to address oxidative stress-induced tissue remodeling. Here, we show that the glutathione pathway plays a pivotal role in tracheal regeneration with aortic allografts by modulating redox homeostasis and promoting host-graft integration. Through transcriptomic profiling, histological analyses, and functional assessment, we demonstrate that antioxidant-driven tissue remodeling enhances epithelialization, neovascularization, and extracellular matrix or…

Оптогенетические подходы к регенерации нейронных тканей: обзор базовых принципов оптогенетики и целевых клеток для лечения.

Оптогенетика произвела революцию в области нейрофизики, позволив точно контролировать нейронную активность с помощью светочувствительных белков, известных как опсины. В этой обзорной статье рассматриваются основополагающие принципы оптогенетики, включая активацию как изоляционных, так и ингибиционных осью, а также разработку моделей оптогенетики, в которых используются рекомбинантные вирусные векторы. Значительная часть этой статьи посвящена ограничениям, связанным с оптогенетическими инструментами, и изучает стратегии преодоления этих трудностей. Эти стратегии включают использование вирусов а

Совпадение в аннотации оригинала
Optogenetics has revolutionized the field of neuroscience by enabling precise control of neural activity through light-sensitive proteins kn … onal neurobiological methods. Evidence has shown that optogenetic modulation can enhance motor axon regeneration, achieve complete sensory reinnervation, and accelerate the recovery of neuromuscular function. This approach also induces complex patterns of coordinated motor neuron activity and promotes neural reorganization. Optogenetic approaches hold immense …

Mitigation of BMP-induced inflammation in craniofacial bone regeneration and improvement of bone parameters by dietary hesperidin.

Based on anti-inflammatory and osteogenic properties of hesperidin (HE), we hypothesized its systemic administration could be a cost-effective method of improving BMP-induced bone regeneration. Sprague-Dawley rats were allocated into 4 groups (n = 10/group): a 5-mm critical-sized mandible defect + collagen scaffold or, scaffold + 1 µg of BMP2 with and without dietary HE at 100 mg/kg. HE was administered by oral gavage 4 weeks prior to surgeries until euthanasia at day 7 or 14 post-surgery. The healing tissue within the defect collected at day 7 was subjected to gene expression analysis. Mandib…

The efficacy of adipose stem cell-derived exosomes in hair regeneration based on a preclinical and clinical study.

BACKGROUND: Androgenetic alopecia (AGA) is a prevalent hair loss disorder with psychological repercussions. Traditional treatments have limi … ASC-Exosomes also promoted hair shaft elongation and ALP activity, suggesting a potential for hair regeneration. Thirty participants with AGA enrolled and treated over 24 weeks. The subjects experienced a significant increase in total hair density, improved global photographic assessments, and reported higher subjective satisfaction without severe adverse rea …

Minimally invasive periodontal regeneration with the buccal approach: a systematic review and meta-analysis of clinical studies.

OBJECTIVE: The aim of this study was to investigate clinical periodontal parameters after treatment using the Minimally Invasive Surgical Technique (MIST), Modified Minimally Invasive Surgical Technique (M-MIST), and/or any technique for papilla preservation, such as Entire Papilla Preservation (EPP), modified-papilla preservation technique (M-PPT), or simplified-papilla preservation technique (SPPT). METHODS: The focus question was "For patients with periodontal intrabony defects (P), what is the best minimally invasive regenerative approach (I), comparing MIST, M-MIST, and papilla preservat

Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle.

Vestibular hair cells are mechanoreceptors critical for detecting head position and motion. In mammals, hair cell loss causes vestibular dysfunction as spontaneous regeneration is nearly absent. Constitutive expression of exogenous ATOH1, a hair cell transcription factor, increases hair cell regeneration, however, these cells fail to fully mature. Here, we profiled mouse utricles at 14 time points, and defined transcriptomes of developing and mature vestibular hair cells. To mimic native hair cells which downregulate endogenous ATOH1 as they mature, we engineered viral vectors carrying the sup…

Enhancing the porosity of biphasic calcium phosphate using polyethylene glycol as the porogen for bone regeneration applications.

Biphasic calcium phosphate (BCP) has been used as a material to support bone grafting, repair, recovery, and regeneration over the past decades. However, the inherent weakness of BCP is its low porosity, which limits the infiltration, differentiation, and proliferation of bone cells. To address this issue, porous BCP was synthesized using polyethylene glycol (PEG) 1000 with weight ratio ranging from 20%-60% in BCP as the porogen through the powder-forming method. Analytical methods such as Fourier transform infrared spectroscopy, x-ray diffraction, scanning electron microscopy were used to dem…

Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration.

Zebrafish have a remarkable ability to regenerate injured hearts. Altered hemodynamic forces after larval ventricle ablation activate the endocardial Klf2a-Notch signaling cascade to direct zebrafish cardiac regeneration. However, how the heart perceives blood flow changes and initiates signaling pathways promoting regeneration is not fully understood. The present study demonstrated that the mechanosensitive channel Trpv4 sensed the altered hemodynamic forces in injured hearts and its expression was regulated by blood flow. In addition to mediating the endocardial Klf2a-Notch signal cascade ar…

Construction of an interface interaction in a g-C3N4/CdS/NiS for photoreforming of plastic and clean hydrogen regeneration.

Converting plastics into organic matter by photoreforming is an emerging way to deal with plastic pollution and produce valuable organic matter. Water shortage can be alleviated by using seawater resources. To solve these problems, we synthesize a ternary heterostructure composite g-C3N4/CdS/NiS. Heterojunctions are formed between graphitized carbon nitride (g-C3N4), cadmium sulfide (CdS) and nickel sulfide (NiS), which effectively improve the problem of fast charge recombination of pure g-C3N4 and CdS. The results of the g-C3N4/CdS/NiS photocatalytic tests show that the hydrogen production ra