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Сравнительная активность диметилфумаратных производных IDMF в трех моделях, имеющих отношение к множественному склерозу и псориазу.

Диметилфумарат (DMF) — антивоспалительное и иммунорегулирующее лекарство, используемое для лечения множественных склерозов (MS) и псориаза. Его сенсационно-информационная собственность исключает его тематическое использование, что вызывает сожаление в связи с лечением псориаза. Изосорбид ди(метилфумарат) (ИДМФ) (новая производная ДМФ) был синтезирован для того, чтобы обойти эту негативную реакцию и раскрыть потенциал тематических родов, которые могли бы быть полезными для лечения псориаза в субпопуляции псориатических пациентов, страдающих МЗ, а также в целом. Здесь мы сравнили его терапевтиче

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… The filtrate was concentrated under vacuum to give 176 g crude product. This crude product was shaken in hexane (1 L), filtered and the solid again washed with hexane (500 mL). …

Editorial: Novel techniques of minimally invasive spine surgery for various pathologies.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Univariate and multifactorial logistic regression analyses identified depression ( P = 0.02), intravertebral vacuum cleft ( P = 0.01), no anti-osteoporosis treatment ( P < 0.001), cement volume <3 ml ( P = 0.02), and cement distribution ( P = 0.01) as independent risk factors for residual LBP. …

Развитие энцефалита рецептора против NMDA у пациента с множественным склерозом.

Энцефалит рецептора против N-метил-D (антиNMDA) является редким подтипом аутоиммунного энцефалита, который часто вызывает симптомы, характерные для ранней стадии заболевания. В данном случае речь идет о пациентке с повторным излучением множественных склерозов (RRMS), у которой появился энцефалит рецептора против NMDA, при этом она прошла курс лечения, позволяющий нейтрализовать болезни. У нее были нейрокогнитивные симптомы и нетипичные магнитные резонансные открытия. Клинические и лабораторные исследования, включая поясничные проколы, подтвердили наличие антител IgG против подблока GluN1 рецеп

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… Consequently, chest radiography was warranted owing to abrupt changes in the patient’s oxygen saturation and arterial blood gas, which revealed a ventilator-associated pneumothorax of the right lung that was successfully drained using a catheter with a vacuum bottle. …

Treatment of metastatic lesions localized in the acetabulum.

BackgroundMetastatic lesions localized in the periacetabular area cause troublesome pain and reduced mobility of the patients. Radiotherapy effectively decreases pain, yet it does not restore the ability to load the joint. Surgical treatment involving resection of metastatic lesions and joint reconstruction using bone grafts is burdened with a high rate of complications. Modular tumor prostheses are being increasingly used. In some cases, it is possible to strengthen the acetabular roof with bone cement using vertebroplasty kits. The aim of the study was to demonstrate various methods of treat

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… Two prostheses were implanted without cement, while four prostheses were implanted using vacuum-mixed bone cement injected with a positive pressure. Fig. 1 Anteroposterior radiogram ( a ) and transverse CT scan ( b ) in a kidney cancer patient with lytic bone loss in the right periacetabular area. …

Complications of percutaneous vertebroplasty: An analysis of 1100 procedures performed in 616 patients.

Percutaneous vertebroplasty (PVP) is a minimally invasive procedure widely used for the treatment of pain due to vertebral fractures of different origins-osteoporotic, traumatic, or neoplastic. PVP is minimally invasive, but the complications are not rare; however, they are in most cases not significant clinically. The most frequent is cement leakage, which can occur onto veins, paravertebral soft tissue, into the intervertebral disk, or to the spinal canal, affecting foraminal area or epidural space. We analyzed results of treatment and complications of vertebroplasty performed with the use o

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… Int Orthop 2014 ; 38 : 2309 – 12 . 25106669 10.1007/s00264-014-2470-3 [6] Wu AM Chi YL Ni WF Vertebral compression fracture with intervertebral vacuum cleft sign: pathogenesis, image, and surgical intervention . …

Evaluation of Different Regimens of Palliative Radiation Therapy for Symptomatic Bone Metastases: An Audit From a Tertiary Care Hospital in Jharkhand, India

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… Positioning and technique All patients were treated in a supine, reproducible position with adequate immobilization with a thermoplastic mask or vacuum lock. The target volumes were delineated on simulated CT scan images. …

Unforeseen Computed Tomography Resimulation for Initial Radiation Planning: Associated Factors and Clinical Impact.

PurposeRepeat computed tomography (CT) simulation is problematic because of additional expense of clinic resources, patient inconvenience, additional radiation exposure, and treatment delay. We investigated the factors and clinical impact of unplanned CT resimulations in our network.Methods and materialsWe used the billing records of 18,170 patients treated at 5 clinics. A total of 213 patients were resimulated before their first treatment. The disease site, location, use of 4-dimensional CT (4DCT), contrast, image fusion, and cause for resimulation were recorded. Odds ratios determined statis

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… in anatomy | 9.86% | 21 Rectal filling | 8.45% | 18 Immobilization devices | 6.57% | 14 Other | 6.57% | 14 Prone/supine | 4.69% | 10 CT scan length adjustment | 4.69% | 10 Change in RT plan | 4.69% | 10 Chemotherapy/lupron first | 4.22% | 9 Respiratory motion | 3.76% | 8 Bladder filling | 2.82% | 6 Vacuum …

Microwave ablation combined with cementoplasty under real-time temperature monitoring in the treatment of 82 patients with recurrent spinal metastases after radiotherapy.

BackgroundThe spine is the most frequently affected part of the skeletal system to metastatic tumors. External radiotherapy is considered the first-line standard of care for these patients with spine metastases. Recurrent spinal metastases after radiotherapy cannot be treated with further radiotherapy within a short period of time, making treatment difficult. We aimed to evaluate the effectiveness and safety of MWA combined with cementoplasty in the treatment of spinal metastases after radiotherapy under real-time temperature monitoring.MethodsIn this retrospective study, 82 patients with 115

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… The patients lay prone on the CT flatbed and were fixed with a vacuum negative pressure pad. The lateral position was an alternative if the patient could not lie prone. A positioning grid was placed on the skin surface, and a 5-mm slice CT was performed to choose the puncture path. …

Experience with indwelling pleural catheters in the treatment of recurrent pleural effusions.

Recurrent pleural effusions are frequently encountered in clinical practice. Whether malignant or nonmalignant, they often pose a challenge to the practicing clinician. When they recur, despite optimum medical therapy of the underlying condition and repeated thoracenteses, more invasive definitive approaches are usually required. Since its introduction in 1997, the PleurX catheter became the preferred method to treat recurrent malignant pleural effusions. Since then, a number of publications have documented its utility in managing recurrent nonmalignant pleural effusions. The purpose of this p

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… The pleural fluid is then drained daily, or every other day, using a special vacuum bottle that connects to the catheter [ Putnam et al. 2000 ; Warren et al. 2008]. …

When tissue is not the only issue: Poorly differentiated lung squamous-cell carcinoma with adrenal, costochondral, and cardiac metastases - case report.

Nonmelanoma skin cancer is the most common cancer in the world, and lung cancer is the leading cause of death from cancer. Histologically, squamous cell carcinoma (SCC) is the second most prevalent type of both skin and lung cancers. We report the case of a 38-year-old female with metastatic, poorly differentiated lung SCC detected on chest X-ray after she presented to the hospital with cough and dyspnea. She had had a 7.5 cm moderately differentiated well-circumscribed posterior scalp SCC completely excised eight years earlier. CT scan showed a large right lung mass, nodular filling defect in

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… Scans in June and July were consistent with continuously enlarging masses, as already mentioned, whose dimensions increased as follows: RML mass, 10 x 15 x 15-16.4 cm (including partial necrosis with vacuum phenomenon); right paratracheal node, 6.3 x 7.9 cm; left first rib, 6.4-7 x 5.7 cm; and bilateral …

Midwife continuity of care models versus other models of care for childbearing women.

BACKGROUND: Midwives are primary providers of care for childbearing women globally and there is a need to establish whether there are differ … models of care, midwife continuity of care models likely reduce instrumental vaginal birth (forceps/vacuum) from 14% to 13% (average RR 0.89, 95% CI 0.83 to 0.96; 14 studies, 17,769 participants; moderate-certainty evidence), and may reduceepisiotomy 23% to 19% (average RR 0.83, 95% CI 0.77 to 0.91; 15 studies, 17,839 participants; low-certainty evidence …

Tenckhoff tunneled peritoneal catheter placement in the palliative treatment of malignant ascites: technical results and overall clinical outcome.

BackgroundTo assess the technical and clinical outcome of percutaneous insertion of tunneled peritoneal catheters in the palliative treatment of refractory malignant ascites and to determine the safety and feasibility of intraperitoneal administration of cytotoxic drugs through the tunneled catheter.Materials and methodsConsecutive patients palliatively treated with a tunneled peritoneal catheter to drain the malignant ascites were identified. Patients' medical history, procedural and clinical follow-up data, including complications and estimated survival, were reviewed. Additionally, a sub an

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… described with the PleurX catheter; this monocuffed catheter was initially designed for drainage of malignant pleural effusions but it can also be used for drainage of malignant peritoneal fluid. 3 , 9 – 11 Additionally, if this type of indwelling tunneled catheter is used, it is recommended to use vacuum …

Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients.

ObjectiveThis study aimed to examine the association between different inflammatory markers and specific clinical endpoints in patients with febrile neutropenia.MethodWe prospectively evaluated the expression of procalcitonin (PCT), interleukin 8 (IL-8), induced protein-10, tumor necrosis factor alpha (TNF-α), two soluble TNF-α receptors (sTNF-R I and sTNF-R II), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 alpha, and eotaxin in 37 episodes of febrile neutropenia occurring in 31 hospitalized adult onco-hematologic patients. Peripheral blood samples were collected i

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… Peripheral blood samples were collected using vacuum tubes (BD Vacutainer SST II Plus plastic tubes; Becton Dickinson Diagnostic Systems, São Paulo, Brazil) in the morning on the initial day of fever (inclusion or day 0) and subsequently on days 1, 3, and 7. …

Clinical values of serum Semaphorin 4D (Sema4D) in medication‑related osteonecrosis of the jaw.

BACKGROUND: Bisphosphonates (BPs) are widely used in clinical practice to prevent and treat bone metabolism-related diseases. Medication-related osteonecrosis of the jaw (MRONJ) is one of the major sequelae of BPs use. Early prediction and intervention of MRONJ are of great significance. METHODS: Ninety-seven patients currently on treatment with BPs or with a history of BPs usage and 45 healthy volunteers undergoing dentoalveolar surgery were included in this study. Participants' serum Semaphorin 4D (Sema4D) levels were measured and analyzed before participants underwent surgery (T0) and afte

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… The blood collection process was completed by experienced nurses using vacuum blood collection tubes according to the hospital's blood collection procedures. Each patient was required to have two tubes of blood collected at each blood draw for research and storage. …

A Systematic Review of Sildenafil Mortality Through the Years.

Sildenafil is a medication used for the treatment of erectile dysfunction. It was approved by the U.S. Food and Drug Administration (FDA) in 1998. Several articles have raised concerns regarding the use of sildenafil and the occurrence of serious adverse events, such as myocardial ischemia, stroke, and even death. Our aim is to systematically review the existing literature on mortality associated with sildenafil use. The method used for this systematic review was completed by searching three databases: PubMed, Scopus, and Web of Science. Articles were screened and assessed for eligibility. Thi

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… Moreover, patients who are prescribed drugs that are proven to have interactions with sildenafil should receive education regularly at their follow-up visits and offered alternatives to be used such as vacuum pump, alprostadil intraurethral pellet (suppository), intrapenile injections of alprostadil …

Cost Analysis With Use of Expandable Cage or Cement in Single level Thoracic Vertebrectomy in Metastasis.

STUDY DESIGN: Retrospective case series. OBJECTIVE: Patient with metastatic cancer frequently require spinal operations for neural decompression and stabilization, most commonly thoracic vertebrectomy with reconstruction. Objective of the study was to assess economic aspects associated with use of cement versus expandable cage in patients with single level thoracic metastatic disease. We also looked at the differences in the clinical, radiological, complications and survival differences to assess non-inferiority of PMMA over cages. METHODS: The electronic medical records of patients undergoi

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… This is contrary to pure vacuum mixed PMMA which shrinks by around 6% to 7% in volume during the curing process. In most clinical setting and in our cases as well, hand mixed cement is used which results in entrapment of air within the cement mix. …

Human Amniotic Membrane Dressing as a Non-Surgical Alternative for Extensive Chronic Ulcers: A Comparative Case Study.

Chronic wound management remains a significant clinical challenge, requiring adaptive therapeutic approaches to achieve wound closure that nonetheless frequently prove fruitless. Balancing the initial pro-inflammatory response with debris removal and tissue rebuilding remains elusive in most cases, leading to pain, drastic quality-of-life deterioration, and, eventually, amputation. Meanwhile, patient adherence is an overarching theme. Furthermore, non-surgical alternatives that effectively promote tissue rebuilding are essential for patients seeking to avoid further invasive procedures. We rep

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… Beta IL-8 Interleukin 8 MMP-1 Matrix Metalloproteinase-1 MMP-2 Matrix Metalloproteinase-2 RNA Ribonucleic Acid ROI Region of Interest qPCR Quantitative Polymerase Chain Reaction TGF-β Transforming Growth Factor Beta TIMP-1 Tissue Inhibitor of Metalloproteinases-1 TNF-α Tumor Necrosis Factor Alpha VAC Vacuum-Assisted …

Бремя наследственного транстиретинового амилоида на качество жизни.

ВВЕДЕНИЕ: амилоидоз наследственного транстиретина (ХАТТР) является прогрессивным, дегенеративным заболеванием с периферической нейропатией, кардиомиопатией и другими клиническими проявлениями. В этом исследовании рассматривается воздействие амилоидоз hATTR на качество жизни (QOL). МЕТОДЫ: Удельный QOL, измеряемый с помощью Norfolk QOL-Diabetic Neuropathy, сопоставлялся между пациентами с амилоидозом HATTR и пациентами с типом 2 диабет, в то время как общий QOL, измеряемый с помощью 36-item Вариант обследования состояния здоровья в краткой форме 2 (В тыс.SF-36v2), были сопоставлены между пациен

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… lot” when compared with patients in the other chronic condition samples on 6 of 10 items, including the ability to engage in vigorous activities (such as running, lifting heavy objects, or participating in strenuous sports), ability to engage in moderate activities (such as moving a table, pushing a vacuum …

Гибридные эндосомные пальто содержат различные классы сортирующих нексинов.

Эндосомы представляют собой станции по сортировке белков, где многочисленные мембранные халаты образуют тюбуловодикулярные носители, экспортирующие белки в Голги, плазменную мембрану или эндолизосомальные отсеки. Предполагается, что отдельные классы сортировки нексинов образуют отдельные однородные халаты, определяющие эндосомные пути сортировки и их грузы. Snx3 и белки SNX-BAR Vps5-Vps17 принадлежат к различным классам сортировки-нексина. Они могут образовывать однородные, зависящие от ретромера пальто, которые различаются по конструкции и способам их соединения с мембраной и распознавания гр

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… Coverslips were then silanized with 3-glycidyloxypropyltrimethoxysilane (Catalogue no. 440167, Sigma) for 5 h under vacuum, rinsed with acetone and dried. Polyethylene glycol coating was performed by placing the coverslips in a beaker containing PEG400 (Sigma) at 90 °C for 60 h. … Lipids were then spotted (typically 1 µL, corresponding to about 1 nmol) on the coverslips and dried for 30 min under vacuum. The coverslip was mounted on an IBIDI 6-channel µ-slide (µ-Slide VI 0.4. IBIDI, Cat. No: 80606). …

Количественный T1 чувствителен к кортикальной ремиилизации при множестве склерозов: посмертное исследование МРТ.

Было продемонстрировано, что ремиилизация корковых повреждений у людей с множественным склерозом (pwMS) является обширной. В этой работе мы стремились оценить, может ли посмертная количественная МРТ (qMRI) помочь в обнаружении этих районов. Мы сняли шесть стационарных целых мозгов умершего PSMS на 3T-MRI с использованием коэффициента переноса магнитизации (MTR, 570 мкм изотроп), миелиновой водной фракции (MWF, 1000 мкм изотроп), количественного Т1 (qT1, 670 мкм изотроп), количественного картирования уязвимости (QSM, 330 мкм изотроп) и радиальной диффузии (RD, 1300 или 1400 мкм изотроп). Иммуно

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… As an additional step prior to imaging, we removed air bubbles from the holder using a vacuum pump, to avoid sources of undesired susceptibility artifacts. …