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Psoralen-ultraviolet A-induced erythema: sensitivity correlates with the concentrations of psoralen in suction blister fluid.

Since the advent of psoralen-ultraviolet A (PUVA) therapy, the value of plasma 8-methoxypsoralen (8-MOP) concentrations to predict PUVA-indu … ith the degree of PUVA-induced erythema. 8-MOP concentrations in plasma and SBF were measured in 15 vitiligo patients and 11 volunteers. Blood and SBF samples were collected 2 h after taking 8-MOP, and 8-MOP concentrations in plasma and SBF were quantified using reverse-phase high-performance liquid chromatography. Eleven volunteers were phototested using …

The extent and nature of disability in different urticarial conditions.

Chronic forms of urticaria are common, often adversely impacting on quality of life. No formal studies have assessed the extent and nature o … -patients (60%) and higher than those seen in out-patients with psoriasis (29.7%), acne (24.3%) and vitiligo (16.1%).

Evidence for a retroviral trigger in Graves' disease.

An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious a … tients with one or more of the endocrine autoimmune complex disorders, including Addison's disease, vitiligo, myasthenia gravis and pernicious anemia. In addition we studied two individuals with Graves' disease from each of two families residing outside Louisiana, all of whom were positive for these antibodies.(ABSTRACT TRUNCATED AT 250 WORDS)

[Combined endocrine autoimmune syndrome--incidence, forms of manifestation and clinical significance].

UNLABELLED: In a retrospective case finding study we collected data from patients with polyglandular autoimmune syndrome type II (PGAS Type … type I) diabetes mellitus (IDDM) was seen in 11, Addison's disease in 7, primary hypogonadism in 5, vitiligo in 6 and pernicious anemia in 5 cases. The presence of antiparietal cell antibodies was demonstrated in 21 of 30 investigated patients. These patients also showed other evidence of autoimmune gastritis, such as increased gastrin (in 10 out of 13), d …

[Wallenberg's syndrome in a case of Vogt-Koyanagi-Harada disease].

A 45-year-old Japanese man, who had had bilateral visual disturbance due to Vogt-Koyanagi-Harada (VKH) disease 17 years before entry, was admitted to this hospital because of headache, vertigo and vomiting. On examination at entry, no abnormalities except for poliosis, patches of vitiligo on his left shin, sunset glow fundus, and positional nystagmus with Frenzel glasses were found. Laboratory data other than leukocytosis and elevated level of gamma-GTP were normal and the results of brain CT scan were within normal limits. On the following day, diplopia was developed and the neurological symp…

Long-term follow-up of autoimmune polyendocrine syndrome type 1 in Norway.

CONTEXT: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare yet severe multiorgan autoimmune disease caused by mutations in the auto … ns were chronic mucocutaneous candidiasis, enamel hypoplasia, and PAI, while for nonclassical APS-1 vitiligo, hypothyroidism, and PAI were most common. A broad proinflammatory cytokine signature was observed in classical APS-1, along with increased levels of the soluble form of the interferon (IFN)-α/β receptor. CONCLUSION: APS-1 should be considered in p …

Impact of Autoimmune Disease on Outcomes After Total Thyroidectomy for Thyrotoxicosis.

INTRODUCTION: Thyrotoxicosis with diffuse goiter is most commonly caused by Graves disease, which frequently coexists with other autoimmune … etween groups. Surgical site infection and hematoma were rare. In subgroup analyses by specific AD, vitiligo was associated with a higher risk of postoperative hypocalcemia (RR 1.54, 95% CI 1.04-2.29), whereas other autoimmune conditions demonstrated no statistically significant differences. CONCLUSIONS: Patients with coexisting ADs undergoing total thyro …

Effects of Phototherapy on Sleep, Fatigue and Quality of Life in Dermatology Patients: A Pilot Study.

OBJECTIVES: Sleep disturbances and fatigue are prevalent among dermatology patients. Owing to the growing evidence on the effects of light-b … e mean age was 48.2±12.9 years, and 63.3% of the patients were male. The most common diagnoses were vitiligo (40%), mycosis fungoides (26.7%), and psoriasis vulgaris (13.3%). The median PSQI score decreased from 8 at baseline to 5 at the one-month follow-up (p<0.001). The median PFS score decreased from 3.88 to 2.38 (p=0.019). DLQI showed no significant ch …

Organ-specific autoimmunity in primary Sjögren's disease.

OBJECTIVE: To assess the prevalence of organ-specific autoimmunity (OSA) among patients with primary Sjögren's disease (SjD), and its association with clinical and serological variables and disease activity. METHOD: We included 328 patients with SjD according to ACR/EULAR criteria. We recorded the following types of OSA: gastrointestinal [primary biliary cholangitis (PBC), autoimmune hepatitis (AH), coeliac disease], haematological (pernicious anaemia, haemolytic anaemia, idiopathic thrombocytopenia purpura), neurological (myasthenia gravis), dermatological (vitiligo, alopecia areata), and en…

Объединения между хулиганскими пемфигоидами и коморбидами: шведское общенациональное когортное исследование 5,738 Пациенты.

Бульварный пемфигоид (БП) связан с неврологическими и психиатрическими расстройствами, однако ни одно общенациональное исследование, основанное на народонаселении, не позволило в полной мере изучить связь различных коморбидов у пациентов BP в Швеции. ЦЕЛИ: Изучение связей между BP и различными совпадениями путем сопоставления этих условий до и после диагностирования BP с соответствующей контрольной группой. МЕТОДЫ: В Швеции было проведено общенациональное когортное исследование 2005 в адрес 2016, включая 5,738 Случаи BP и 17,167 :: соответствующие меры контроля в отношении возраста, пола и мес

Совпадение в аннотации оригинала
BACKGROUND: Bullous pemphigoid (BP) has been linked to neurological and psychiatric disorders, but no nationwide population-based study has … e, systemic lupus erythematosus, systemic sclerosis, psoriasis, lichen planus, alopecia areata, and vitiligo. After diagnosis, the overall hazard ratio (HR) for comorbidities was highest within the first year (HR 2.88, 95% CI: 2.68-3.10) and remained elevated beyond one year (HR 1.57, 95% CI: 1.44-1.71). Post-diagnosis associations remained elevated for de …

Comorbidities Associated With Lichen Planopilaris: A Systematic Review and Meta-Analysis.

Lichen planopilaris (LPP) is a primary cicatricial alopecia suggested to be associated with various comorbid medical conditions, including a … erythematosus (3.06 [2.29-4.09]; 1.8%), cutaneous squamous cell carcinoma (3.04 [1.64-5.66]; 4.8%), vitiligo (2.89 [1.60-5.24]; 2.0%), coronary artery disease (1.66 [1.46-1.88]; 7.6%), rheumatoid arthritis (1.50 [1.22-1.84]; 3.5%), hypothyroidism (1.48 [1.12-1.96]; 17.8%), thyroiditis (1.26 [1.08-1.48]; 3.9%), and iron deficiency anemia (1.18 [1.05-1.33]; …

PDE4 Inhibitors: Bridging Molecular Insights With Clinical Impact.

Phosphodiesterase-4 (PDE4) inhibitors are reshaping the treatment landscape for chronic inflammatory skin diseases by offering effective, no … ibility for refractory cases. As ongoing research explores its use in other skin conditions such as vitiligo and lichen planus, understanding the molecular differences among PDE4 inhibitors becomes increasingly relevant to the practicing dermatology provider. By connecting molecular pharmacology with therapeutic decision-making, this article supports derma …

Cold Atmospheric Plasma in the Treatment of Autoimmune Diseases: Mechanisms, Applications, and Prospects.

BACKGROUND: Autoimmune diseases, including rheumatoid arthritis (RA), are characterized by an aberrant immune responses that leads to chroni … ing autoimmune diseases, such as RA, atopic dermatitis, allergic contact dermatitis, psoriasis, and vitiligo is examined through current research findings. RESULTS: Studies have demonstrated that CAP can modulate fibroblast-like synoviocytes in RA, reducing their viability and inducing apoptosis. In skin diseases like atopic dermatitis, CAP has been shown …

Prevalence of anxiety, depression, sleeping problems, cognitive impairment, and suicidal ideation in people with autoimmune skin diseases.

BACKGROUND: Autoimmune skin diseases (ASDs) such as psoriasis and vitiligo, in addition to causing visible skin symptoms, are closely associated with psychological health issues. However, a comprehensive understanding of the prevalence of these psychological comorbidities in affected individuals is lacking. This study aims to identify the prevalence of anxiety, depression, sleeping problems, cognitive impairment, and suicidal ideation in people with ASDs. METHOD: PubMed, MEDLINE, Web of Science, and Cochrane Library searches were conducted from 1993 to May 2024. Observational studies reportin…

Variable clinical presentation of hypomorphic DCLRE1C deficiency from childhood to adulthood.

BACKGROUND: In this study, we aimed to report long-term follow-up of our pediatric and adult patients with DCLRE1C (DNA cross-link repair 1C … rrent infections (78%) and skin manifestations (61%) such as granulomatous skin lesions, warts, and vitiligo were the most common clinical findings. Autoimmune diseases were observed in 33% and malignancy in 17%. Most patients had low serum IgA and B- and T-cell lymphopenia at the first admission. Recent thymic emigrants (RTE), Tnaive, Bnaive, CD56dimCD16+ …

Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways.

Serotonin (5-HT), a neurotransmitter, is essential for normal and pathological pigmentation processing, and its receptors may be therapeutical targets. The effect and behavior of the 5-HT7 receptor (5-HT7R) in melanogenesis in high vertebrates remain unknown. Herein, we examine the role and molecular mechanism of 5-HT7R in the pigmentation of human skin cells, human tissue, mice, and zebrafish models. Firstly, 5-HT7R protein expression decreased significantly in stress-induced depigmentation skin and vitiligo epidermis. Stressed mice received transdermal serotonin 5-HT7R selective agonists (LP…

Immune-Related Disorders Associated With Ménière's Disease: A Systematic Review and Meta-analysis.

OBJECTIVE: To analyze evidence supporting an association between immune-related diseases and Ménière's disease (MD) since it has long been t … rbidities also showed a significant association with MD like chronic obstructive pulmonary disease, vitiligo, fibromyalgia, arthritis, and psoriasis. CONCLUSION: Epidemiological evidence supports an association between MD and immune-related disorders in European and Asian populations, with population-specific effects. The evaluation of thyroid diseases, a …

A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates.

INTRODUCTION: alpha-Interferon is associated with numerous cutaneous side effects, but the accurate incidence of these complications is not … 2 cases), pityriasis versicolor (1 case), worsening of recurrent buccal aphthous ulcer (1 case) and vitiligo (1 case). CONCLUSION: Cutaneous adverse events during adjuvant immunotherapy of melanoma with low-dose alpha-interferon seem to be frequent but do not result in treatment discontinuation. A good awareness of these side effects may be useful for a m …

Common Dermatologic Disorders in Down Syndrome: Systematic Review.

BACKGROUND: Down syndrome (DS) has been associated with cardiovascular, gastrointestinal, and immune-related abnormalities. Several dermatol … .7%), lichen nitidus (6, n=6; 1.1%), psoriasis (21, n=65; 4.8%), alopecia areata (27, n=253; 7.4%), vitiligo (8, n=40; 4.4%), onychomycosis (3, n=198; 24.7%), calcinosis cutis (14, n=15), connective tissue nevi (6, n=6), dermatofibroma (3, n=3), melanoma (3, n=3), syringomas (14, n=182; 21.2%), and elastosis perforans serpiginosa (19, n=24; 0.5%). CONCLUS …

A Study of Cutaneous Adverse Drug Reactions and their Association with Autoimmune Diseases at a Tertiary Centre in South-West Rajasthan, India.

BACKGROUND: Cutaneous adverse drug reactions (CADRs) comprise about 30% of all adverse drug reactions and observed in 2-3% of hospitalized p … form of diabetes (n = 27, 15.5%), hypothyroidism (n = 9, 5.1%), rheumatoid arthritis (n = 3, 1.7%), vitiligo (n = 2, 1.1%), and SLE (n = 1, 0.5%). CONCLUSION: Cutaneous ADR patterns and the drugs causing various reactions are changing every year, which may be because of the introduction of newer molecules and changing trends in the use of drugs. In our st …