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Individualized Hospital to Home, Exercise-Nutrition Self-Managed Intervention for Pre-Frail and Frail Hospitalized Older Adults: The INDEPENDENCE Randomized Controlled Pilot Trial.

PurposePre-frailty and frailty in older adults are associated with poor health outcomes and increase health-care costs, and further worsening during hospitalization. This study aimed to examine the effect of an individualized hospital to home, exercise-nutrition self-managed intervention for pre-frail and frail hospitalized older adults.Patients and methodsOlder adults admitted to an acute medical unit of a tertiary hospital in South Australia who were pre-frail or frail were recruited from September 2020 to June 2021, randomized to either control or intervention group and followed up at 3 and

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… Fundamentals of Biostatistics . 7th ed. Boston, MA: Brooks/Cole; 2011. 23. Pedersen MM, Petersen J, Beyer N, Damkjaer L, Bandholm T. …

Drug Conjugates for Targeting Eph Receptors in Glioblastoma.

Glioblastoma (GBM) is a complex and heterogeneous tumor that warrants a comprehensive therapeutic approach for treatment. Tumor-associated antigens offer an opportunity to selectively target various components of the GBM microenvironment while sparing the normal cells within the central nervous system. In this study, we conjugated a multivalent vector protein, QUAD 3.0, that can target four receptors: EphA3, EphA2, EphB2, and also IL-13RA2, spanning virtually 100% of the GBM microenvironment, to doxorubicin derivatives. The conjugates effectively bound to all four receptors, although to varyin

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… We wish to acknowledge the support of the Wake Forest Baptist Comprehensive Cancer Center: Proteomics and Metabolomics Shared Resource, Cellular Imaging Shared Resource, Tumor Tissue and Pathology Shared Resource, Cell Engineering Shared Resource, Clinical and Translational Science Institute, and Biostatistics …

Systematic review of defibrotide studies in the treatment of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS).

Veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT) conditioning or high-dose nontransplant chemotherapy. VOD/SOS with multi-organ dysfunction (MOD) is associated with a mortality rate of > 80%. Defibrotide (25 mg/kg/day) is approved to treat hepatic VOD/SOS with renal or pulmonary dysfunction post HSCT in the United States and to treat severe hepatic VOD/SOS in patients > 1 month of age in the European Union. A random effects model was used for pooling data from 17 sys

Condition-specific or generic preference-based measures in oncology? A comparison of the EORTC-8D and the EQ-5D-3L.

PurposeIt has been argued that generic health-related quality of life measures are not sensitive to certain disease-specific improvements; condition-specific preference-based measures may offer a better alternative. This paper assesses the validity, responsiveness and sensitivity of a cancer-specific preference-based measure, the EORTC-8D, relative to the EQ-5D-3L.MethodsA longitudinal prospective population-based cancer genomic cohort, Cancer 2015, was utilised in the analysis. EQ-5D-3L and the EORTC QLQ-C30 (which gives EORTC-8D values) were asked at baseline (diagnosis) and at various follo

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… Rosner (Ed.), Fundamentals of biostatistics. Pacific Grove. 30. Cicchetti DV. Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instruments in psychology. Psychological Assessment. 1994;6(4):284. doi: 10.1037/1040-3590.6.4.284. 31. …

General population norms for the EQ-5D-3 L in Norway: comparison of postal and web surveys.

BackgroundThe EQ-5D-3 L instrument is a standardized questionnaire which was developed as a simple, generic measure of health for clinical and economic appraisal. To aid in the interpretation, scores are often compared with a normative group. The objectives of this study were 1) to provide population norms for the EQ-5D-3 L for Norway, and 2) to compare scores from postal and web surveys.MethodsWe conducted two surveys in samples that were aimed to be representative of the Norwegian general population: 1) a postal survey (n = 5000) and 2) a panel study with electronic data collection (n = 1936

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… Epidemiol Biostatistics Public Health. 2015;12. 10.2427/11457. 13. Golicki D Niewada M General population reference values for 3-level EQ-5D (EQ-5D-3L) questionnaire in Poland Pol Arch Med Wewn 2015 125 18 26 25578383 10.20452/pamw.2638 14. …

Abstracts of the Cell Therapy Transplant Canada 2024 Annual Conference.

On behalf of Cell Therapy Transplant Canada (CTTC), we are pleased to present the Abstracts of the CTTC 2024 Annual Conference. The conference was held on 1-3 May 2024 in beautiful Victoria, British Columbia, at the Victoria Conference Centre, and attracted 293 in-person delegates and five virtual attendees. Several plenary sessions were held on topics such as gene therapy for hemoglobin disorders, optimizing donor selection, graft-versus-host disease (GvHD) strategies, collaborative care, survivorship, graft failure, and CAR-T therapy. Poster authors presented their work during a lively and e

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… Lazo-Langner 1,2,4 Department of Medicine, Division of Hematology, Western University, London, ON, Canada Schulich School of Medicine & Dentistry, Western University, London, ON, Canada Blood and Marrow Transplant Program, London Health Sciences Centre, London, ON, Canada Department of Epidemiology and Biostatistics … Michelis 1 , Jonas Mattsson 1 , and Rajat Kumar 1 Hans Messner Allogeneic Transplant Program, Princess Margaret Cancer Centre, Toronto, ON, Canada Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, ON, Canada Department of Pathology, Princess Margaret Cancer Centre, Toronto, ON …

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2018

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… Azad 6 , Theo Moraes 7,8 , Malcom Sears 9,10 , Padmaja Subbarao 7,8,9 , Qingling Duan 1,2 1 Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, Canada; 2 School of Computing, Queen’s University, Kingston, Ontario, Canada; 3 Department of Clinical Epidemiology and Biostatistics … , Manitoba, Canada; 7 The Hospital for Sick Children, Toronto, Ontario, Canada; 8 Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada; 9 Division of Respirology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada; 10 Department of Clinical Epidemiology and Biostatistics …

Характеристики и результаты вторичных гематологических магнатов после аутологической трансплантации стволовых клеток в случае множественной миеломы.

Автологическая трансплантация стволовых клеток (auto-SCT) по-прежнему является важной основой в многократной терапии миэломы (MM); вместе с тем существует повышенный риск развития второй первичной халатности, включая вторую гематологическую халатность (SHM). Мы провели ретроспективное исследование пациентов с MM, которые прошли авто-SCT в нашем учреждении между 1990 и 2022 и впоследствии разработан SHM. Среди 3401 пациентов с MM, которые прошли авто-SCT, 110 (В тыс.3.2%) разработан SHM [терапия, связанная с опухолью миэлоида (t-MN) = 98; острая лимфоболическая лейкемия в клетке B (t-B-ALL) = 1

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… Acknowledgements Research reported in this publication was supported by NIH grant P30CA077598 utilizing the Biostatistics and Bioinformatics Core shared resource of the Masonic Cancer Center, University of Minnesota and by the National Center for Advancing Translational Sciences of the National Institutes …

Геномика определяет злонамеренную трансформацию в условиях Миеломы.

Множественной миеломе (ММ) последовательно предшествует моноклонная гаммопатия неопределённого значения (МГУС) и множественная миелома (ШМ). Хотя эти прекурсоры являются асимптоматическими, они не являются полностью доброкачественными и сопряжены с риском продвижения к MM на протяжении всей жизни. В отличие от других раковых заболеваний, определяемых патологией, злокачественная трансформация от MGUS или SMM до MM до сих пор основывалась на демонстрации клинического ущерба конечной организации, поскольку морфология и цитогенетика не могут надежно их отличить. В настоящем исследовании используют

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… was made possible through the Oncology Research Information Exchange Network (ORIEN) Avatar Project in collaboration with Aster Insights (formerly known as M2Gen), the Total Cancer Care protocol, and supported by the NTRO, Tissue Core, Molecular Genomics, Cancer Pharmacokinetics and Pharmacodynamics, Biostatistics …

Information-Seeking Patterns and Communication Preferences Among Japanese Survivors With Cancer: Cross-Sectional Analysis.

BackgroundWith increasing numbers of survivors with cancer, the importance of patient-centered information provision and communication to alleviate psychological burdens, such as anxiety and depression, is growing. However, substantial individual differences exist in patients with cancer information-seeking behaviors and use of support services, and few studies have comprehensively examined cognitive and psychological factors such as treatment status, sex, trust in information sources, and patient-provider relationships.ObjectiveThis study aimed to integrate the theory of planned behavior and

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… Norman GR Streiner DL Biostatistics: The Bare Essentials 4th People’s Medical Publishing House 2014 ISBN ‎ 9781607951780 42. …

Prognostic utility of Palliative Prognostic Index in advanced cancer: A systematic review and meta-analysis.

ObjectivesTo evaluate the prognostic utility of Palliative Prognostic Index (PPI) scores in predicting the death of adults with advanced cancer.MethodsA systematic review and meta-analysis were conducted. Six databases were searched for articles published from inception till 16 February 2024. Observational studies reporting time-to-event outcomes of PPI scores used in any setting, timing and score cutoffs were eligible. Participants were adults with advanced cancer residing in any setting. Random effects meta-analysis was used to pool hazard, risk, or odds ratios. Findings were narratively syn

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… Journal of Pain and Symptom Management 53(5), 962–970.e10. doi: 10.1016/j.jpainsymman.2016.12.330 Simms L, Barraclough H and Govindan R (2013) Biostatistics primer: What a clinician ought to know—prognostic and predictive factors. …

Developing the Breast Utility Instrument to Measure Health-Related Quality-of-Life Preferences in Patients with Breast Cancer: Selecting the Item for Each Dimension.

Introduction. Generic preference-based instruments inadequately measure breast cancer (BrC) health-related quality-of-life preferences given advances in therapy. Our overall purpose is to develop the Breast Utility Instrument (BUI), a BrC-specific preference-based instrument. This study describes the selection of the BUI items. Methods. A total of 408 patients from diverse BrC health states completed the EORTC QLQ-C30 and BR45 (breast module). For each of 10 dimensions previously assessed with confirmatory factor analysis, we evaluated data fit to the Rasch model based on global model and item

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… Items meeting the a priori criteria were reviewed by the multidisciplinary research team with expertise in patient outcome measurement, biostatistics, health economics, general internal medicine, and breast medical oncology. …

Exploring the impact of a decision support algorithm to improve clinicians' chemotherapy-induced peripheral neuropathy assessment and management practices: a two-phase, longitudinal study.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) negatively affects physical function and chemotherapy dosing, yet, clinicians infrequently document CIPN assessment and/or adhere to evidence-based CIPN management in practice. The primary aims of this two-phase, pre-posttest study were to explore the impact of a CIPN clinician decision support algorithm on clinicians' frequency of CIPN assessment documentation and adherence to evidence-based management. METHODS: One hundred sixty-two patients receiving neurotoxic chemotherapy (e.g., taxanes, platinums, or bortezomib) answered pati

Combination of the PI3K inhibitor Idelalisib with the conventional cytostatics cytarabine and dexamethasone leads to changes in pathway activation that induce anti-proliferative effects in B lymphoblastic leukaemia cell lines.

BackgroundThe introduction of combined conventional cytostatics and pathway-specific inhibitors has opened new treatment options for several cancer types including hematologic neoplasia such as leukaemias. As the detailed understanding of the combination-induced molecular effects is often lacking, the identification of combination-induced molecular mechanisms bears significant value for the further development of interventional approaches.MethodsCombined application of conventional cytostatic agents (cytarabine and dexamethasone) with the PI3K-inhibitor Idelalisib was analysed on cell-biologic

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… Institute for Biostatistics and Informatics in Medicine and Ageing, Rostock University Medical Center, Rostock, Germany. Yvonne Saara Gladbach, Mathias Ernst, Mohamed Hamed, Sarah Fischer, Stephan Struckmann, Georg Fuellen. Faculty of Biosciences, Heidelberg University, Heidelberg, Germany. …

A Web-Based Lifestyle-Related Course for People Living With Multiple Sclerosis: Quantitative Evaluation of Course Completion, Satisfaction, and Lifestyle Changes Among Participants Enrolled in a Randomized Controlled Trial.

BACKGROUND: Web-based health courses providing lifestyle-related information can potentially increase knowledge, facilitate behavior change, and improve health outcomes for people living with multiple sclerosis (MS). Despite the low engagement with web-based programs by this population, few studies have evaluated factors influencing engagement. This study evaluated engagement with our 6-week lifestyle-related course (Multiple Sclerosis Online Course; MSOC) by participants enrolled in a large, international randomized controlled trial, as well as preliminary outcomes. OBJECTIVE: This study aim

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… This study was administered and conducted solely by the Neuroepidemiology Unit at the Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, the University of Melbourne. …

MICAL1 promotes the proliferation in acute myeloid leukemia and is associated with clinical prognosis and immune infiltration.

Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies that has a poor prognosis and a high rate of relapse. Dysregulated metabolism plays an important role in AML progression. This study aimed to conduct a comprehensive analysis of MRGs using TCGA and GEO datasets and further explore the potential function of critical MRGs in AML progression. In this study, we identified 17 survival-related differentially expressed MRGs in AML using TCGA and GEO datasets. The 150 AML samples were divided into three molecular subtypes using 17 MRGs, and we found that three molecular

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… ClusterProfiler is an R package used in bioinformatics and biostatistics for functional enrichment analysis and visualization. …

Mapping oncogenic protein interactions for precision medicine.

Normal protein-protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in oncogenic protein-protein interactions (oncoPPIs). OncoPPIs, which can result from genomic alterations, are a hallmark of many types of cancers. Recent technological advances in the field of mass spectrometry (MS)-based interactomics, structural biology and drug discovery have prompted scientists to identify and characterise oncoPPIs. Disruption of oncoPPI inte

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… EXISTING CHALLENGES FOR ONCOGENIC PROTEIN INTERACTION STUDIES Genomics, 36 , 37 transcriptomics 45 and proteomics 77 , 78 initiatives coupled with bioinformatics and biostatistics have extracted vast collections of biological data from comparatively small amount of patient material obtained at biopsy …

A Novel Intravesical Dextrose Injection Improves Lower Urinary Tract Symptoms on Interstitial Cystitis/Bladder Pain Syndrome.

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a painful recurrent condition characterized by the discomfort of the bladder, and current treatment options have limited effectiveness. Prolotherapy is a well-known treatment that involves the injection of non-biologic solutions to reduce pain and/or promote proliferation of soft tissue, and dextrose is the most common injectate. This study investigated the effects of dextrose prolotherapy in a rat model of IC/BPS and patients with IC/BPS. We used cyclophosphamide to induce IC/BPS in rats, and intravesical instillation of 10% dextrose sol

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… Regression Methods in Biostatistics: Linear, Logistic, Survival, and Repeated Measures Models . New York : Springer Publishing Co. , 266 – 289 . Vora A. Borg-Stein J. Nguyen R. T. ( 2012 ). Regenerative Injection Therapy for Osteoarthritis: Fundamental Concepts and Evidence-Based Review . …

Canine cancer immunotherapy studies: linking mouse and human.

Despite recent major clinical breakthroughs in human cancer immunotherapy including the use of checkpoint inhibitors and engineered T cells, important challenges remain, including determining the sub-populations of patients who will respond and who will experience at times significant toxicities. Although advances in cancer immunotherapy depend on preclinical testing, the majority of in-vivo testing currently relies on genetically identical inbred mouse models which, while offering critical insights regarding efficacy and mechanism of action, also vastly underrepresent the heterogeneity and co

SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocols.

Transparent and accurate reporting in early phase dose-finding (EPDF) clinical trials is crucial for informing subsequent larger trials. The SPIRIT statement, designed for trial protocol content, does not adequately cover the distinctive features of EPDF trials. Recent findings indicate that the protocol contents in past EPDF trials frequently lacked completeness and clarity. To address this gap, the international consensus-driven SPIRIT-DEFINE checklist was developed through a robust methodological framework for guideline development, with the aim to improve completeness and clarity in EPDF t