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[Epidemiological dynamics of Dengue on Easter Island].

Dengue is considered an emerging disease with an increasing prevalence especially in South America. In 2002, an epidemic of classic Dengue (DENV-1) occurred unexpectedly on Easter Island, where it had never been detected before. It reappeared in 2006-2007 and 2008, 2009 and 2011. The aim of this study was to estimate the most relevant parameters of the epidemiological dynamics of transmission of Dengue on Easter Island and to model the dynamics since 2002, comparing the predictions with the actual situation observed. Of the total cases, 52.27% were females and 47.73% men. The average age of in…

Dengue viral infection in children: a perspective.

Dengue is a vector-borne viral infection of global importance. Several pathogenetic mechanisms such as immune enhancement and selection pressure have been proposed and febrile, critical and recovery phases have been identified. A new classification proposed by WHO has recently been introduced where definitions have been changed to 'probable dengue', 'dengue with warning signs' and 'severe dengue'. The majority of dengue viral infections are self-limiting, but complications have high morbidity and mortality. The diagnosis of dengue viral infection is essentially clinical, although confirmation …

Dengue and chikungunya in travelers: recent updates.

PURPOSE OF REVIEW: Dengue virus (DENV) and chikungunya virus (CHIKV) cause significant morbidity in many world regions and their epidemiology, pathogenesis, vector issues, and control and prevention continue to fascinate researchers. This review focuses on the progress in these areas in the past 2 years. RECENT FINDINGS: Recent studies have highlighted the features of the epidemiology of DENV and CHIKV in Africa, some places of transmission being detected through travelers as sentinels. Autochthonous transmission of both viruses has been documented in France, raising concern regarding the pot…

[Neonatal dengue in Peru: a case report].

We present the case of a full-term female newborn, whose mother died seven days postpartum from multi-organ failure due to severe dengue confirmed by NS1 antigen detection and positive IgM. The newborn did not have any complication, but at the fourth day of life she developed fever, jaundice, signs of plasma leakage, thrombocytopenia, hepatomegaly, ascitis, and others signs of systemic inflammation response syndrome. She fully recovered with supportive treatment. The RT-PCR test of a peripheral blood sample revealed a positive result for the dengue virus serotype 2, confirming the first case o…

Dengue fever in the Indian Subcontinent: an overview.

The Indian Subcontinent has emerged as a scene of many mosquito-borne infectious diseases, including malaria and dengue fever. After the 1990s, the rate of malaria declined owing largely to preventive measures, but at the same time dengue fever (DF) and dengue hemorrhagic fever (DHF) were increasing in the region. Outbreaks were recorded in all countries of the Indian Subcontinent with India, Pakistan, Bangladesh and Sri Lanka on the forefront and suffering from the largest number of cases and deaths. We discuss annual cases of DF/DHF in these four countries and possible factors involved in DF…

Сопутствующий Денге и малярия в регионе Амазонки.

ВВЕДЕНИЕ: Амазонский регион имеет обширные лесные районы и природные экосистемы, что создает благоприятные условия для существования бесчисленных арбовирусов. Более 200 арбовирусов были изолированы в Бразилии, и около 40 из них связаны с человеческими заболеваниями. Четыре из 40 считаются имеющими важное значение для здоровья населения в Бразилии: вирусы Денге (1-4), Оропуша, Майаро и Желтая лихорадка. Наряду с этими вирусами около 98% случаев заболевания малярией приходится на регион Амазонки.МЕТОДЫ: Данное исследование было направлено на изучение присутствия арбовирусов в 111 образцах клинич

Совпадение в аннотации оригинала
INTRODUCTION: The Amazon region has extensive forested areas and natural ecosystems, providing favorable conditions for the existence of innumerous arboviruses. Over 200 arboviruses have been isolated in Brazil and about 40 are associated with human disease. Four out of 40 are considered to be of public health importance in Brazil: Dengue viruses (1-4), Orop…

Клетки вируса денге в vivo.

Денге был признан одним из наиболее важных в мире новых инфекционных заболеваний, передающихся через переносчиками болезней. Несмотря на то, что денге обычно вызывают самоограничивающуюся инфекцию, у некоторых пациентов может возникнуть опасное для жизни заболевание - геморрагическая лихорадка денге (ГФД)/синдром шока денге. Причина, по которой ДГФ/ДСО происходит у некоторых лиц, не ясна. Исследования в эндемических регионах показывают, что ранее существовавшие антитела являются фактором риска для ДХФ/ДСР. Виремия и тромбоцитопенсия являются ключевыми клиническими особенностями вируса денге у

Совпадение в аннотации оригинала
Dengue has been recognized as one of the most important vector-borne emerging infectious diseases globally. Though dengue normally causes a self-limiting infection, some patients may develop a life-threatening illness, dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). The reason why DHF/DSS occurs in certain individuals is unclear. Studies in the e…

Encephalitis in the clinical spectrum of dengue infection.

Dengue viral infections are common worldwide. Clinical manifestations form a broad spectrum, and include uncomplicated dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Encephalopathy has been well reported and has classically been thought to result from the multisystem derangement that occurs in severe dengue infection; with liver failure, shock, and coagulopathy causing cerebral insult. However, there is increasing evidence for dengue viral neurotropism, suggesting that, in a proportion of cases, there may be an element of direct viral encephalitis. Understanding the pathoph…

[Paediatric features of Dengue and Chikungunya fevers].

Dengue (Df) and Chikungunya fever (Cf) arbovirosis are booming in the world, because of the plasticity of their pathogens, mutant RNA viruses making the acquisition of sustainable herd immunity and vaccination difficult in humans, and the plasticity of their vectors, the female mosquitoes of the genus Aedes (Stegomya), capable of adapting to different environments. This review summarizes the viral life cycle and epidemiology of these arboviruses, pathogenesis and pediatric aspects of their clinical forms and the basic principles of their treatment and prevention.

[Future prospects in developing of dengue vaccines].

Dengue is a viral, febrile and acute disease that causes more morbility than any other infection for Arbovirus. It becomes necessary to implement a safe and effective vaccine that will contribute to the eradication of this disease, especially in endemic areas with very low socio-economic conditions. The only option that exists at the present to control the transmission of the disease is through vector control. So far, there are no effective antiviral drugs for flavivirus such as dengue. Candidates for vaccines for this disease, who are currently in advanced stages of development, are live atte…

Gastrointestinal manifestations of dengue infection in adults.

This is a retrospective study of the gastrointestinal symptoms, signs and laboratory parameters in adult dengue patients admitted to Kuala Lumpur Hospital from 1st December 2004 to 31st December 2004. Clinical and laboratory parameters that may predict the need for intensive care were investigated. Six hundred sixty-six patients with clinical and biochemical features consistent with dengue infection were identified. Patients were stratified into those who required intensive care and those who were managed in non high dependency wards. Serum alanine aminotransaminase (ALT) levels were normal in…

Vascular endothelium: the battlefield of dengue viruses.

Increased vascular permeability without morphological damage to the capillary endothelium is the cardinal feature of dengue haemorrhagic fever (DHF)/dengue shock syndrome (DSS). Extensive plasma leakage in various tissue spaces and serous cavities of the body, including the pleural, pericardial and peritoneal cavities in patients with DHF, may result in profound shock. Among various mechanisms that have been considered include immune complex disease, T-cell-mediated, antibodies cross-reacting with vascular endothelium, enhancing antibodies, complement and its products, various soluble mediator…

[Early indicators of dengue infection in children].

OBJECTIVE: To identify clinical manifestations and laboratory findings useful for the early diagnosis of dengue in children. MATERIALS AND METHODS: We prospectively evaluated 125 children (aged 5 to 12 years old) with acute febrile syndrome with no apparent etiology. Paired serologic tests and/or viral culture were performed and dengue infection was confirmed in 40 patients and ruled out in 68 (17 indefinite cases). Early clinical manifestations (within the first 4 days of the disease) in the groups with dengue and other causes of febrile syndrome were compared. Independent indicators of deng…

Is dengue severity related to nutritional status?

A retrospective review of dengue patients admitted to Queen Sirikit National Institute of Child Health (previously known as Children's Hospital) from 1995 to 1999 revealed 4,532 confirmed cases of dengue infection; 80.9% were dengue hemorrhagic fever (DHF) and 19.1% were dengue fever cases (DF). Among the DHF patients; 30.6% had shock. The majority of them, 66.6%, had a normal nutritional status, while 9.3% were malnourished and 24.2% had obesity as classified by weight for age. Compared with control patients with other diagnoses (excluding HIV/AIDS patients), malnourished children had a lower…

[Critical aspects of dengue control in Brazil].

Dengue is now the main reemerging disease in the world. In the absence of an efficacious preventive vaccine and effective etiologic treatment and chemoprophylaxis, the only vulnerable link for reducing dengue transmission is the mosquito Aedes aegypti, its principal vector. There are many difficulties in combating this mosquito in large and medium-sized cities. The complexity of contemporary urban life generates factors that facilitate the mosquito's proliferation and constraints on the reduction of its infestation rates. The objectives of dengue control should be based on available scientific…