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Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… enalapril”, “ramipril”, “benazepril”, “fosinopril”, “moexipril”, “perindopril”, “quinapril”, “trandolapril” ARB | “losartan”, “valsartan”, “azilsartan”, “candesartan”, “eprosartan”, “irbesartan”, “olmesartan”, “telmisartan” | Antidepressants | “citalopram”, “escitalopram”, “paroxetine”, “fluoxetine”, “fluvoxamine …

Primed for global coronavirus pandemic: Emerging research and clinical outcome.

The global effort to combat and contain the coronavirus disease 2019 (COVID-19) caused by the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now proceeding on a war footing. The world was slow to react to the developing crisis, but once the contours of the impending calamity became evident, the different state and non-state actors have raced to put their act together. The COVID-19 pandemic has blatantly exposed the shortcomings of our healthcare system and the limitations of medical science, despite considerable advances in recent years. To effectively tack

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… Pharma AG , Switzerland | Phase-III, NCT04335032 ( ClinicalTrials.gov ) | Omega-3 fatty acid 53 | Fluvoxamine ( 57 ) | Washington University School of Medicine, USA | Phase-II, NCT04342663 ( ClinicalTrials.gov ) | Selective serotonin reuptake inhibitor (SSRI) 54 | Ibuprofen (58) | King’s College London … University of Medical Sciences, Iran | Phase-II/III IRCT20171122037571N2(ICTPR) | Protease inhibitor | IMU-838 (vidofludimus calcium) ( 100 ) | Immunic Therapeutics, USA | CALVID-1 trial, Phase-II, NCT04379271 . ( ClinicalTrials.gov ) | Inhibitor of dihydroorotate dehydrogenase (DHODH) enzyme 97 | Fluvoxamine …

Ixazomib, pomalidomide and dexamethasone in triple-class exposed multiple myeloma patients - a phase II study.

Multi-class upfront regimens for multiple myeloma (MM) have improved outcomes, yet many patients become either triple-class exposed (TCE) or refractory (TCR) early in their disease course. This is a phase II, investigator initiated, open-label, single-arm, prospective, multicenter study evaluating all-oral Ixazomib-pomalidomide- dexamethasone (IPd) regimen for TCE RRMM patients. Sixty-one patients were enrolled between March 1st 2021 and March 17th 2024. The median age was 74 (range: 53-89) years; 25 (41%) were ≥75 years old. Fiftyseven percent had high-risk cytogenetics (t(4;14), t(14;16), +1

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… Systemic treatment with strong inhibitors of CYP1A2 (fluvoxamine, enoxacin, ciprofloxacin), strong inhibitors of CYP3A (clarithromycin, telithromycin, itraconazole, voriconazole, ketoconazole, nefazodone, posaconazole) or strong CYP3A inducers (rifampin, rifapentine, rifabutin, carbamazepine, phenytoin …

Оценка и лечение агрессивного сексуального поведения: нынешние ограничения и потенциальные стратегии.

Несмотря на то, что в МКБ-11 была введена соответствующая классификация и симптоматика расстройства сексуального поведения (CSBD) по-прежнему противоречива. В этом обзоре мы изучили историю, эпидемиологический статус-кво, коморбиды, теории нейрофизики, текущие диагнозы и рекомендации по лечению для CSBD. Кроме того, мы подчеркнули недостатки текущих исследований и перспективы будущей работы. Селективные ингибиторы серотонина и налтрексон обычно используются в качестве "немаркированных" наркотиков. Диагностика и лечение пациентов, проходящих курс лечения, должны включать в себя биологические, п

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… Fluoxetine up to 80 mg/d; Clomipramine up to 400 mg/d; Fluvoxamine up to 300 mg/d; Fenfluramine up to 40 mg/d. There was no change in paraphilic fantasies or behaviors; non-sexual OCD symptoms decreased in 2 of 5 patients; and sexual OCD symptoms improved in 2 of 5 patients. …

Review of Paraneoplastic Syndromes in Children with Malignancy.

A paraneoplastic syndrome (PNS) is a set of symptoms and signs that can accompany the formation of a cancer but is not due to its direct infiltration or metastasis. PNS results from the secretion of peptides or hormones by tumor cells or from an immunological cross-reaction between the tumor antigens and host antigens. In the adult population, PNS affects up to 15% of patients with cancer, but data on pediatric patients remain lacking. The remarkable fact is that PNS can precede an oncology diagnosis, even by months or years. PNS can involve virtually any organ of the human body. In children,

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… Medications from the selective serotonin reuptake inhibitor group, such as paroxetine and fluvoxamine, have proven efficacy in the treatment of paraneoplastic pruritus. The effectiveness of tetracyclic antidepressants, opioid receptor antagonists, and aprepitant is also pointed out. …

From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases.

Drug repurposing, the process of identifying new therapeutic uses for existing drugs, has emerged as a cost-effective and time-saving alternative to traditional drug development. This strategy leverages the known pharmacological and safety profiles of approved or investigational drugs to accelerate their clinical application for other diseases. In recent years, repurposed drugs have played a crucial role in addressing treatment gaps in complex and multifactorial diseases such as cancer, neurodegenerative disorders and infectious diseases. This review highlights prominent examples where repurpo

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… Methylphenidate | ADHD | Enhancing cognitive function and reducing apathy in conditions such as AD and traumatic brain injury | [ 105 ] Fluvoxamine | SSRI | Managing COVID‐19 | [ 106 ] Cardiovascular medications for metabolic disorders | Metformin | Diabetes | Anticancer | [ 107 ] Probenecid | Gout … For example, fluvoxamine, an SSRI, has demonstrated effectiveness in managing COVID‐19, and ongoing research is exploring its potential advantages in AD [ 106 ]. …

Computational proteomics to enhance personalized treatment of COVID-19 and Long COVID.

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to significant global health burden, including both acute infections and persistent post-acute sequelae, also known as Long COVID (LC) in survivors. While clinical management has reduced case-fatality rates, a substantial proportion of patients develop LC, a heterogeneous syndrome with long-term symptoms. This complex continuum requires therapeutic strategies for both the acute and chronic phases. Plasma proteomics has emerged as a powerful tool in precision medicin

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… support; not standard of care | Not applicable | Not applicable | [ 243 , 244 ] Remdesivir | Antiviral (for Ebola, Hepatitis C) | Viral RNA-dependent RNA polymerase | Repurposed: Inhibits viral replication | FDA-approved for hospitalized COVID-19 patients | Not applicable | Not applicable | [ 245 ] Fluvoxamine …

Терапевтический потенциал моделей Purmorphamine через болезни.

Purmorphamine (PUR) — тройная субституция пурина, которая выборочно активирует сгущенный рецептор, тем самым инициируя Sonic Hedgehog (Shhh) сигнализирующий путь, имеющий решающее значение для эмбриональной модели, нейронной спецификации и регенерации тканей в различных системах различных органов. Регулирование сигнала " Шш " причастно к дегенеративным заболеваниям, однако терапевтические меры, направленные на этот путь, по-прежнему ограничены. PUR демонстрирует широкую терапевтическую эффективность различных моделей предклинических заболеваний путем активации как транскрипции с помо

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… . | ↓ Compulsive behaviours; synergy with fluvoxamine | [ 9 ] Multiple sclerosis | 2024 | Rat, EB‐ICP induced MS | 5 & 10 mg/kg | i.p. | ↑ Locomotion, cognitive & spatial memory; ↓ TNF‐α, IL‐1β, NEFL; enhanced remyelination | [ 11 ] Blood–brain barrier disruption | 2014 | MBEC4 endothelial monolayer …

[Alpha-interferon and mental disorders].

UNLABELLED: The interferon alpha stands as a reference both in oncology and virology. But its efficiency is limited by frequent somatic as w … treatments for the other disorders are conventional: haloperidol and lithium for bipolar disorders, fluvoxamine for obsessive compulsive disorders and neuroleptics for psychotic disorders. CONCLUSION: The appearance of neuropsychiatric side effects during a chemotherapy using the interferon-alpha molecule is a frequent complication, the consequences of which …

Каннабидиол как иммунный модулятор: всеобъемлющий обзор.

Каннабидиол (КБР), непсихоактивный фитоканнабиноид, полученный из сативы Каннабиса, стал многообещающим терапевтическим агентом в силу его разнообразных фармакологических свойств, включая сильные антивоспалительные, нейрозащитные и иммунодуляторные эффекты. КБР модифицирует иммунную реакцию, включая регулирование активности клеток Т, введение апоптоза макрофага, подавление провоспалительных цитокинов и модуляцию сигнальных путей воспаления и иммунной гомеостазии. Был проведен всеобъемлющий поиск литературы с использованием баз данных PubMed, Scopus и Web of Science в целях выявления соответств

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… Carbamazepine, topiramate, phenobarbital, rifampicin, efavirenz, pioglitazone Protease inhibitors, ketoconazole, nefazodone, loperamide CYP2C19  Substrates Inducers Inhibitors  Antidepressants, proton pump inhibitors, clopidogrel, propranolol, warfarin Rifampin, carbamazepine, phenobarbital, phenytoin Fluvoxamine …

Expert panel consensus statement on the optimal use of pomalidomide in relapsed and refractory multiple myeloma.

In this report, a panel of European myeloma experts discuss the role of pomalidomide in the treatment of relapsed and refractory multiple myeloma (RRMM). Based on the available evidence, the combination of pomalidomide and low-dose dexamethasone is a well-tolerated and effective treatment option for patients with RRMM who have exhausted treatment with lenalidomide and bortezomib. The optimal starting dose of pomalidomide is 4 mg given on days 1-21 of each 28-day cycle, whereas dexamethasone is administered at a dose of 40 mg weekly (reduced to 20 mg for patients aged >75 years). The treatment

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… properties of lenalidomide and pomalidomide 17 , 88 Abbreviations: CYP, cytochrome P 450; P-gp, P-glycoprotein. a Common P-gp inhibitors include cyclosporine, clarithromycin, itraconazole, ketoconazole, quinidine and verapamil. b Common strong inhibitors of CYP1A2 include ciprofloxacin, enoxacin and fluvoxamine …

Paroxetine : a review of its pharmacology and therapeutic potential in the management of panic disorder.

SYNOPSIS: Paroxetine is the first selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor (SSRI) to be approved for the treatment … inhibitor of serotonin uptake than the selective serotonin reuptake inhibitors (SSRIs) Citalopram, fluvoxamine and fluoxetine. Paroxetine was more potent than sertraline in one study that compared mean inhibition constants for serotonin uptake, but not in another study that compared the concentrations required to inhibit serotonin uptake by 50%. In contrast …

FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy.

In December 2019, a novel SARS-CoV-2 coronavirus emerged, causing an outbreak of life-threatening pneumonia in the Hubei province, China, and has now spread worldwide, causing a pandemic. The urgent need to control the disease, combined with the lack of specific and effective treatment modalities, call for the use of FDA-approved agents that have shown efficacy against similar pathogens. Chloroquine, remdesivir, lopinavir/ritonavir or ribavirin have all been successful in inhibiting SARS-CoV-2 in vitro. The initial results of a number of clinical trials involving various protocols of administr

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… | JPRN jRCTs041190120 | 86 | - Favipiravir | NCT04273763 | 60 | combined with bromohexine, IFN α-2b and umifenovir Favipiravir | NCT04310228 | 150 | compared to tocilizumab; combined with tocilizumab Favipiravir | NCT04336904 | 100 | - Fingolimod | NCT04280588 | 30 | compared to standard treatment Fluvoxamine …

Evaluation of Proteasome Inhibitors in the Treatment of Idiopathic Pulmonary Fibrosis.

Idiopathic pulmonary fibrosis (IPF) is the most common form of idiopathic interstitial pneumonia, and it has a worse prognosis than non-small cell lung cancer. The pathomechanism of IPF is not fully understood, but it has been suggested that repeated microinjuries of epithelial cells induce a wound healing response, during which fibroblasts differentiate into myofibroblasts. These activated myofibroblasts express α smooth muscle actin and release extracellular matrix to promote matrix deposition and tissue remodeling. Under physiological conditions, the remodeling process stops once wound heal

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… Because pirfenidone is mainly metabolized by cytochrome P450 1A2 (CYP1A2) enzymes, patients should avoid the concomitant use of other CYP1A2 inhibitors (e.g., fluvoxamine and ciprofloxacin) or inducers (e.g., tobacco, omeprazole, and rifampicin) [ 93 ]. …

Cancer cachexia--pathophysiology and management.

About half of all cancer patients show a syndrome of cachexia, characterized by anorexia and loss of adipose tissue and skeletal muscle mass. Cachexia can have a profound impact on quality of life, symptom burden, and a patient's sense of dignity. It is a very serious complication, as weight loss during cancer treatment is associated with more chemotherapy-related side effects, fewer completed cycles of chemotherapy, and decreased survival rates. Numerous cytokines have been postulated to play a role in the etiology of cancer cachexia. Cytokines can elicit effects that mimic leptin signaling a

Abstracts of the 5(th) Cachexia Conference, Barcelona, Spain, December 5-8, 2009.

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Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision Oncology.

Oleocanthal (OC), a secoiridoid phenolic compound exclusive to extra virgin olive oil (EVOO), has emerged as a promising nutraceutical with multifaceted anti-cancer properties. Despite its well-characterized anti-inflammatory and antioxidant effects, the mechanistic breadth and translational potential of OC in oncology remain underexplored and fragmented across the literature. This comprehensive review synthesizes and critically analyzes recent advances in the molecular, pharmacological, and translational landscape of OC's anti-cancer activities, providing an integrative framework to bridge pr

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… Co-delivery with CYP inhibitors, such as fluvoxamine, could prolong systemic exposure, while lymphatic targeting using nanoemulsions (<100 nm) with OC and medium-chain triglycerides (MCTs) could enhance intestinal lymphatic uptake, bypassing portal circulation. …

DNA Damaging Drugs

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… Drug Interactions Because the active bendamustine metabolites, γ-hydroxy bendamustine and N-desmethyl-bendamustine, are formed via Cytochrome P450 CYP1A2, the concomitant intake of CYP1A2 inhibitors (such as fluvoxamine <Luvox> or ciprofloxacin <Cipro>) has the potential to increase the exposure to …

15th Конгресс Европейской ассоциации клинической фармакологии и терапии (ЕАКПТ)

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Emergency Care

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