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Ferric derisomaltose augments intrinsic skeletal muscle electron transport chain activity in heart failure: A FERRIC-HF II molecular substudy.

AIMS: Skeletal muscle energetic augmentation might be a mechanism via which intravenous iron improves symptoms in heart failure, but no dire … te generation, were calculated by subtracting non-phosphorylating LEAK respiration. Complex I-V and myoglobin protein levels, and skeletal muscle fibre type composition were assayed. Patients randomised to FDI (n = 21) or placebo (n = 19) were similar (age 66 ± 13 years, 73% men, left ventricular ejection fraction 37 ± 8%, 48% New York Heart Association cla …

The Effect of an American Football Practice on Physical and Cognitive Performance and Recovery.

Frank, E, Ben-Zeev, T, Weissman, I, Binman, L, Ostfeld, I, Harel, N, and Hoffman, JR. The effect of an American football practice on physica … , 24 hours postpractice (D1), and 36 hours postpractice (D2). Blood samples were obtained to assess myoglobin, and brain-derived neurotrophic factor (BDNF), testosterone (T), and cortisol (C). T and C measures were obtained at PRE only to provide an indication of the baseline anabolic/catabolic ratio on the recovery response. Results revealed that physical …

Different circulating biomarkers in women and men with paroxysmal atrial fibrillation: results from the AF-RISK and RACE V studies.

AIMS: The clinical risk profile of atrial fibrillation (AF) patients is different in men and women. Our aim was to identify sex differences … BP-4) were higher. In men, matrix metalloproteinase-3 (MMP-3), C-C motif chemokine-16 (CCL-16), and myoglobin were higher. In the validation cohort, four out of five biomarkers could be confirmed: levels of ALCAM (P = 1.73 × 10-4) and FABP-4 (P = 2.46 × 10-7) and adhesion biological pathways [false discovery rate (FDR) = 1.23 × 10-8] were higher in women. I …

Muscular heat shock protein response and muscle damage after semi-professional football match.

PURPOSE: A typical football match leads to neuromuscular fatigue and physical performance impairments up to 72-96 h post-match. While muscle … tivity were analyzed with immunohistochemistry. Blood samples were analyzed for creatine kinase and myoglobin. RESULTS: Within 24 h post-match, a 2.7- and 9.9-fold increase in creatine kinase and myoglobin were observed, countermovement jump performance decreased by -9.7% and muscle soreness increased by 0.68 units. αB-crystallin and HSP70 accumulated in c …

Diazoxide preserves myocardial function in a swine model of hypothermic cardioplegic arrest and prolonged global ischemia.

OBJECTIVE: Adenosine triphosphate potassium sensitive channels provide endogenous myocardial protection via coupling of cell membrane potent … ar developed pressure, left ventricular ejection fraction, diastolic function, myocardial troponin, myoglobin, markers of apoptosis, and left ventricular infarct size were compared. RESULTS: Four pigs in the cardioplegia alone group could not be weaned from cardiopulmonary bypass. There were no differences in myoglobin, troponin, or apoptosis between group …

The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis.

BACKGROUND: Evidence about COVID-19 on cardiac injury is inconsistent. OBJECTIVES: We aimed to summarize available data on severity differences in acute cardiac injury and acute cardiac injury with mortality during the COVID-19 outbreak. METHODS: We performed a systematic literature search across Pubmed, Embase and pre-print from December 1, 2019 to March 27, 2020, to identify all observational studies that reported cardiac specific biomarkers (troponin, creatine kinase-MB fraction, myoglobin, or NT-proBNP) during COVID-19 infection. We extracted data on patient demographics, infection sever…

Complement activation in acute myocardial infarction: An early marker of inflammation and tissue injury?

BACKGROUND: Acute myocardial infarction (AMI) is a potentially fatal condition, being a major cause of death worldwide. Ischemia suffered du … n (AGP), and classical markers of myocardial necrosis (creatine kinase, creatine kinase-MB isoform, myoglobin and troponin-I) in a longitudinal study of patients with AMI (from admission, 6 h and 12 h post admission, and at discharge from hospital). Individuals undergoing cardiac catheterization (CC) with normal coronary arteries and asymptomatics with no h …

Using blood lactate concentration to predict muscle damage and jump performance response to maximal stretch-shortening cycle exercise.

BACKGROUND: It is well known that eccentric muscle contractions induce delayed onset muscle soreness (DOMS) and exertional rhabdomyolysis (ERB), both of which are related to high blood levels of muscle damage markers after exercise. Creatine kinase (CK) is, together with some other markers (i.e. myoglobin, α-actin, skeletal troponin), widely used in determination of muscle damage. Moreover, DOMS after eccentric exercise has been shown to be associated with altered blood lactate concentration after subsequent submaximal or maximal cycling exercise. However, it is unknown whether blood lactate c…

A multi-marker approach for the prediction of adverse events in patients with acute coronary syndromes.

BACKGROUND: Cardiac troponin T (cTnT), high sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP … the ED with symptoms of acute coronary syndrome (ACS) and subsequently tested for cTnT, NT-proBNP, myoglobin, CK-MB, and hs-CRP. Adverse events (AEs) occurring within 30 days (death, myocardial infarction, unstable angina and the need for revascularization procedures) were recorded and ROC curves were constructed. RESULTS: AEs occurred in 42 patients (10% …

Heme protein-induced tubular cytoresistance: expression at the plasma membrane level.

Following experimental rhabdomyolysis, animals become resistant to heme protein-induced acute renal failure (ARF). The goals of this study w … ered protein effect, or a result of endotoxin cascade activation), rats were injected with purified myoglobin, non-heme containing filterable proteins, or endotoxin. Only myoglobin induced cytoresistance. In vivo heme oxygenase inhibition (tin-protoporphyrin) did not block the emergence of cytoresistance and it was expressed despite Na,K-ATPase inhibition ( …

A case of paraneoplastic myositis induced rhabdomyolysis due to pancreatic adenocarcinoma.

Rhabdomyolysis is a clinical syndrome characterized by the breakdown of skeletal muscle tissue, leading to the release of myoglobin and creatine kinase (CK) into the bloodstream. The condition clinically presents with myalgia, weakness, and dark urine. It can lead to kidney failure and can be life threatening. Various factors and conditions, including trauma, prolonged immobilization, strenuous exercise, infections, alcohol consumption, medications, and malignancies are potential causes. A rare cause of pancreatic cancer-induced paraneoplastic myositis has been observed. Herein, we present the…

Fatal case of West Nile encephalitis associated with acute anteroseptal ST elevation myocardial infarction (STEMI): a case report.

Cardiac involvement has rarely been reported in West Nile (WNV) infection. We report a fatal case of WNV encephalitis associated with an acute anteroseptal ST elevation myocardial infarction. The patient was hospitalized with a fever, headache, nausea and vomiting. The physical examination revealed positive meningeal signs and an altered level of consciousness. High levels of cardiac enzymes (creatine phosphokinase/MB fraction, lactate dehydrogenase, myoglobin and cardiac troponin I) and ST elevation on electrocardiogram were found. Both CSF and urine samples were positive for WNV RNA. This ca…

Severe catatonia and neuroleptic malignant syndrome: report of 3 cases.

Catatonia is a syndrome characterized by motor rigidity or stupor, negativism, mutism and inappropriate or bizarre posture. Without proper management, patients may have significant morbidity and mortality from stupor, coma and death (lethal or malignant catatonia). Neuroleptic malignant syndrome (NMS) is characterized by a sudden appearance of motor rigidity, fever, autonomic effect, increased white blood cell count, serum creatinine phosphokinase, liver enzymes, and myoglobin. The mortality rate is 15 per cent to 25 per cent or even higher when depot form of neuroleptic is used. We report a p…

The management and diagnosis of rhabdomyolysis-induced acute kidney injury: a case study.

Rhabdomyolysis is characterised by a rapid dissolution of damaged or injured skeletal muscle that can be the result of a multitude of mechanisms. It can range in severity from mild to severe, leading to multi-organ failure and death. Rhabdomyolysis causes muscular cellular breakdown, which can cause fatal electrolyte imbalances and metabolic acidosis, as myoglobin, creatine phosphokinase, lactate dehydrogenase and other electrolytes move into the circulation; acute kidney injury can follow as a severe complication. This article reflects on the case of a person who was diagnosed with rhabdomyol…

Laryngeal rhabdomyosarcoma in adults.

Laryngeal rhabdomyosarcoma is a rare disease. Only nine of these tumours have been adequately described in world literature in the adult population. Adult patients with laryngeal rhabdomyosarcoma often present at a later stage than other laryngeal tumours, including squamous cell carcinoma. Diagnosis is made by identification of cross-striations histochemically or cytoplasmic myoglobin by immunohistological methods. We present a 66-year-old woman with pleomorphic rhabdomyosarcoma of her larynx. This is the first female in the adult age group to be presented. Surgical treatment with adjuvant ra…

Effects of rapid weight loss and rapid weight regain on oxidant status and muscle damage in judo athletes.

BACKGROUND: Athletes in weight-class sports frequently use rapid weight loss (RWL) before the official weigh-in to compete in a lower weight … , total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidative stress index (OSI), and myoglobin (Mb) concentrations were measured at each time point. RESULTS: Body weight decreased by 6% following RWL and remained 4% below baseline after RWG (p<0.001). TAC increased by 20% after RWL and remained 11% above baseline following RWG, whereas TOC a …

Acute Biochemical Muscle Damage Responses to a Single Session of Whole-Body Electromyostimulation.

PURPOSE: This study aimed to investigate the acute effects of whole-body electromyostimulation (WB-EMS) on markers of skeletal muscle damage … ed at baseline and at 24, 48, and 72 h postexercise. Key biomarkers were measured: creatine kinase, myoglobin, alanine and aspartate aminotransferases, urinary cystatin C, and urinary potassium. Ratings of perceived exertion were also recorded. RESULTS: Despite low perceived exertion (<13), WB-EMS induced statistically significant elevations in serum creat …

High-sensitivity Cardiac Troponin I Changes Following Subcutaneous Needle Puncture, Restraint, and Venipuncture in Cynomolgus Monkeys.

BACKGROUND/AIM: Cardiac troponin I (cTnI) is a sensitive biomarker of myocardial injury in which procedure-related stress may cause mild, no … LDH4, LDH5), aspartate aminotransferase (AST), heart-type fatty acid-binding protein (H-FABP), and myoglobin were measured. Post-procedure values were compared with the baseline. RESULTS: With SMC, cTnI was below the LLOQ at baseline in all animals, increased significantly at 2 and 4 h (peak at 4 h: mean approximately 16 pg/ml), and returned to near basel …

Кассетная нефропатия в СИС: Раннее признание и экстракорпоральные стратегии улучшения результатов.

Острая почечная травма (АКИ), вызванная кастами, является частой, но недостаточно признанной причиной дисфункции почек в отделении интенсивной терапии. Она возникает, когда фильтрованные белки или пигменты - свободные световые цепи (ФЛК) в множестве миеломы, миоглобин в хабдомиолизе, билирубин в тяжелом холестазе или гемоглобин в внутриваскулярном гемолизе - возникают внутри почечных трубок, образуя обструктивные касты и вызывая окислительные и подстрекательские травмы. Раннее распознавание имеет важное значение, поскольку традиционные маркеры (кротинин, мочи) задерживаются. Формирующиеся биом

Совпадение в аннотации оригинала
Cast-induced acute kidney injury (AKI) is a frequent yet under-recognized cause of kidney dysfunction in the intensive care unit. It arises when filtered proteins or pigments - free light chains (FLCs) in multiple myeloma, myoglobin in rhabdomyolysis, bilirubin in severe cholestasis, or hemoglobin in intravascular hemolysis - precipitate within kidney tubule…

Acute kidney injury induced by exertional rhabdomyolysis in military personnel.

BACKGROUND: Exertional rhabdomyolysis is a relatively common condition among military personnel and athletes, potentially leading to acute k … 60 highly trained personnel. Exertional rhabdomyolysis was evaluated through serum creatine kinase, myoglobin, and lactate dehydrogenase. Kidney function was assessed using serum creatinine, urea and phosphate. Acute kidney injury was defined according to Acute Kidney Injury Network criteria. The diagnosis of pre-renal or intrinsic acute kidney injury was b …