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Biosecurity implementation in indoor and outdoor-access broiler production systems in the Netherlands.

Good biosecurity practices on poultry farms can improve animal health, welfare, and productivity, but implementation varies considerably between farms. Recurrent highly pathogenic avian influenza (HPAI) outbreaks and the expansion of higher-welfare systems with outdoor access have raised concerns about potential differences in exposure risk. However, it remains unclear to what extent biosecurity implementation differs between production systems. A cross-sectional comparative study was conducted to assess HPAI-related biosecurity practices and risk factors in Dutch broiler farms, comparing inte

Development of a Basic Robotic Training Course for Residents in General Surgery in the Netherlands.

INTRODUCTION: The continued adoption of robotic-assisted surgery (RAS) in digestive surgery has created an increasing demand for structured training of surgical residents. However, standardized basic RAS training programs specifically designed for residents remain limited, resulting in variable exposure and skill acquisition. This study describes the development and evaluation of a structured basic RAS training course, to standardize education and improve residents' robotic surgery skills. METHODS: A 2-day, on-site basic RAS training course was developed by the Dutch Robotic Surgery Working G

Polyneuropathy in kidney transplant recipients: a cross-sectional study in Groningen, the Netherlands.

OBJECTIVES: To determine the prevalence and clinical characteristics associated with polyneuropathy in kidney transplant recipients (KTRs). DESIGN: Cross-sectional study. SETTING: SENS study at the University Medical Center Groningen, the Netherlands, December 2021-May 2023. PARTICIPANTS: KTR, participating in the ongoing TransplantLines Biobank and Cohort Study, ≥12 months post-transplantation. MAIN OUTCOME MEASURES: Participants underwent a structured neurological assessment including history taking, neurological examination, quantitative sensory testing and nerve conduction studies. An …

Sedative Antipsychotic Use by Children and Adolescents in The Netherlands: Dosages, Duration, and Prescribers.

BACKGROUND: Increasing dispensing of sedative antipsychotics in children and adolescents has been reported in several countries, including the Netherlands, raising concerns about appropriate prescribing and safety. While previous studies have described antipsychotic use in Dutch youth, detailed information on dispensing patterns, dosages, treatment duration, and prescribers of sedative antipsychotics remains limited. This study therefore examined the dispensing patterns of quetiapine, olanzapine, and pipamperone and compared them with aripiprazole and risperidone, using data from the IADB.nl d…

A paradigm shift in fertility care? Discourses on AI for IVF in the Netherlands and the UK.

Artificial intelligence (AI) is increasingly promoted as a transformative innovation in in vitro fertilization (IVF), particularly for embryo selection. This article examines how discourses surrounding AI in IVF reflect broader shifts in medical paradigms and market logics. Drawing on a comparative critical discourse analysis of clinic websites, media texts and professional publications in the Netherlands and the United Kingdom, we explore how stakeholders frame the promise and potential of AI-enabled embryo selection. Our findings reveal three interconnected dynamics. First, UK discourses pre…

Acceptability of screening for celiac disease at Youth Health Care Centers in The Netherlands.

A novel evaluation of the acceptability of screening and mass screening for celiac disease (CD) in young children at the Preventive Youth Health Care Centres (YHCCs) in the Netherlands. Children aged 1-4 years attending the YHCC Kennemerland region were screened for CD-related symptoms. Symptomatic children were offered a point-of-care (POC) test for CD antibodies. Parents of both symptomatic and asymptomatic children received tailored questionnaires assessing opinions on case finding and mass screening and about distress and anxiety. Parents of POC-positive children received follow-up questio…

Source attribution of foodborne pathogens in the Netherlands using structured expert elicitation.

Foodborne pathogens represent a significant public health burden. Quantifying the relative importance of various potential sources of foodborne infection is challenging due to data scarcity and uncertainty in empirical studies. Structured expert judgment (SEJ) provides a valuable methodological alternative to gain insights into source attribution of foodborne pathogens. We conducted a SEJ study to attribute human cases of 26 foodborne pathogens in the Netherlands to seven major transmission pathways, 20 food groups, and two animal groups, in a typical post-COVID19 year, using Cooke's classical…

Labor Market Outcomes of People with HIV Pre- and Post-Diagnosis in the Netherlands.

In the current era of effective antiretroviral therapy, HIV has become a manageable chronic condition. Little is known about the consequences of HIV on individuals' labor market outcomes. We study the impact of an HIV diagnosis using linked clinical data (the Dutch ATHENA cohort) and administrative data. A causal effect is estimated by comparing outcomes of people with HIV diagnosed between 2010 and 2022 (n = 5960) to a matched control group (n = 59,600) in a difference-in-difference design. We find that people with HIV are less likely to be employed, work fewer hours, earn less income, and ar

The participants' perspective on facioscapulohumeral muscular dystrophy trials in The Netherlands - A qualitative study.

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary muscle disease without an available cure. The first trials with po … ation, expectations, concerns, and experiences of FSHD patients in the first clinical trials in the Netherlands resulting in recommendations for future trials. METHODS: Semi-structured interviews with participants of phase II and III losmapimod trials were conducted. The interview guide was based on previous conducted literature reviews and consultation of a …

Resource use and in-hospital costs after aneurysmal subarachnoid hemorrhage in the Netherlands.

INTRODUCTION: Aneurysmal Subarachnoid Hemorrhage (aSAH) is a severe condition requiring advanced interventions and intensive in-hospital care. The associated financial burden challenges resource allocation and healthcare sustainability. RESEARCH QUESTION: This study aimed to evaluate the in-hospital healthcare consumption and costs for patients hospitalised with aSAH. MATERIAL AND METHODS: A bottom-up approach was used to assess in-hospital healthcare consumption and costs for aSAH patients at a Dutch referral centre (November 2021-April 2024). Costs were calculated by multiplying resource c

Increased recreational ketamine use and subsequent outbreak of urological complications in The Netherlands.

INTRODUCTION: Recreational ketamine use has increased in the last decades with incidental reports of urological complications. This study aimed to explore trends in the number of acute intoxications and urological complications from recreational ketamine use in the Netherlands. METHODS: We retrospectively studied data from 2018 to 2024 from inquiries on ketamine toxicity to the Dutch Poisons Information Centre and data from the first outpatient clinic dedicated to ketamine-induced uropathy in the Netherlands at Jeroen Bosch Hospital, 's-Hertogenbosch. RESULTS: An increase was observed in the…

Revision of nitrogen critical loads for Natura 2000 Habitat types in The Netherlands.

Critical loads for atmospheric deposition of nitrogen are increasingly used as official standards in national legislation. This requires unique values (i.e., not ranges) based on state-of-the-art scientific knowledge. In The Netherlands such values have been derived in the past by combining the empirical critical load ranges for Europe with local simulated values. We describe this method in detail, resulting in a unique critical load value for each Habitat type of the European Habitats Directive that occurs in The Netherlands. As the empirical values have been adjusted downward several times i…

Non-medical barriers and facilitators of ageing in place: a cohort study in the Netherlands.

Most western countries lack the capacity to maintain institutional care levels for the ageing baby boom generation. To date, the non-medical drivers of the decision to "age in place" versus using expensive institutional long-term care (LTC) have not been comprehensively studied. This study, based on data from the Longitudinal Aging Study Amsterdam, aims to better understand why some individuals, with comparable medical needs, decide or are able to remain living independently longer than others.The sample included a representative cohort of Dutch adults aged 58 and older (n = 1,792), followed f

Timely integration of palliative care into oncology in hospitals in the Netherlands: a feasibility study.

BackgroundTimely integration of palliative care has numerous benefits for patients with incurable cancer. Based on a recent national Delphi study on the timely integration of palliative care in oncology, three recommendations were formulated regarding 1) advance care planning (ACP), 2) routine symptom monitoring during the last year of life, and 3) involving the Specialist Palliative Care Team (SPCT) during the last three months of life. This pilot study aimed to assess the feasibility of these recommendations in the Dutch context.MethodsFour Dutch hospitals implemented these recommendations f

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… Netherlands Comprehensive Cancer Center (IKNL). Palliatieve Zorg in Nederlandse ziekenhuizen: resultaten 2023. 2024. 30. van Velzen N, Brom L, van der Vorst ML, Kiers M, Wagemans M, Kazimier H, et al. … Specialist palliative care teams and characteristics related to referral rate: a national cross-sectional survey among hospitals in the Netherlands. BMC Palliat Care. 2021;20(1):175. 32. Guccione L, Fullerton S, Gough K, Hyatt A, Tew M, Aranda S, et al. …

Vaginal NOTES adnexal surgery: Results of a retrospective cohort study in The Netherlands.

OBJECTIVE: Vaginal natural orifice transluminal endoscopy (vNOTES) is a minimally invasive technique gaining popularity for several gynaecological procedures. This study presents the first 81 adnexal cases, performed in The Netherlands. DESIGN SETTING PARTICIPANTS AND INTERVENTION: This retrospective cohort study included patients who underwent vNOTES adnexal surgery for benign indications at Zuyderland Medical Centre between March 2020 and August 2024. Baseline characteristics, surgical outcomes, and per- and postoperative outcomes were analysed. Two expert vaginal and endoscopic gynaecologi…

Seasonal patterns of preterm birth in the Netherlands: A population-based cohort study.

INTRODUCTION: Preterm birth is subject to seasonal periodicity, dependent on geographical, meteorological, and environmental factors. This study aims to assess whether preterm birth in the Netherlands is subject to seasonal periodicity. MATERIAL AND METHODS: We performed a population-based cohort including singleton births between January 1, 2010 and December 31, 2019 between 24 + 0 and 42 + 6 weeks of gestation in the Netherlands. The primary outcome was the incidence of preterm birth <37 weeks. Secondary outcomes were total, spontaneous, and iatrogenic preterm birth <28, <32, and <37 weeks …

Genomic epidemiology of Salmonella Enteritidis human infections in the Netherlands, 2019 to 2023.

Salmonella enterica serotype Enteritidis (SE) is a common foodborne pathogen that can cause human salmonellosis. Identifying closely related cases is essential to control the pathogen through, e.g. outbreak investigation, but it is often challenging due to the low genetic diversity of SE, particularly with traditional typing methods. This study aimed to investigate the population structure of SE genomes collected during routine surveillance in the Netherlands using whole-genome sequencing (WGS), their clustering, temporal distribution and the association between epidemiological and phenotypic …

Monitoring Pathogens in Free-Living Large Herbivores in a Nature Reserve in the Netherlands.

Monitoring and surveillance of pathogens are crucial for safeguarding animal and public health. While passive surveillance is more common for wild and free-living animals, active monitoring improves the detection and characterisation of specific pathogens relevant to animal and public health. In the Oostvaardersplassen (OVP) nature reserve in the Netherlands, an active monitoring system for Heck cattle (Bos taurus), Konik horses (Equus caballus) and red deer (Cervus elaphus) has been in place since 1997. This study utilised the data generated from the monitoring system to estimate pathogen pre…

Incidence and prevalence of primary biliary cholangitis in the Netherlands - A nationwide cohort study.

BACKGROUND & AIMS: Although primary biliary cholangitis (PBC) is considered a rare disorder, accurate determination of its incidence and prevalence remains challenging due to limited comprehensive population-based registries. We aimed to assess the incidence and prevalence of PBC in the Netherlands over time through the nationwide Dutch PBC Cohort Study (DPCS). METHODS: DPCS retrospectively included every identifiable patient with PBC in the Netherlands from 1990 onwards in all 71 Dutch hospitals. Incidence and prevalence were assessed between 2008-2018 by Poisson regression between sex and a…