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Pathophysiological Roles of the CX3CL1-CX3CR1 Axis in Renal Disease, Cardiovascular Disease, and Cancer.

CX3CL1 and its unique receptor, CX3CR1, are leukocyte migration factors and are involved in the pathogenesis and progression of many inflammatory diseases and malignancies. The CX3CL1-CX3CR1 axis induces a variety of responses, including cell proliferation, migration, invasion, and apoptosis resistance. CX3CL1 is a transmembrane protein, and proteolysis generates a soluble form. The membrane and soluble forms of CX3CL1 exhibit different functions, but both bind to the chemokine receptor CX3CR1. The CX3CL1-CX3CR1 axis is a chemokine system that has attracted attention not only as a therapeutic

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… Arthritis Rheum. 2005 52 710 721 10.1002/art.20932 15751074 4. Harrison J.K. Jiang Y. Chen S. Xia Y. Maciejewski D. McNamara R.K. Streit W.J. Salafranca M.N. Adhikari S. Thompson D.A. … Nephritogenic Anti-DNA Antibodies Regulate Gene Expression in Mrl/Lpr Mouse Glomerular Mesangial Cells Arthritis Rheum. 2006 54 2198 2210 10.1002/art.21934 16804897 38. Nakatani K. Yoshimoto S. Iwano M. Asai O. Samejima K. Sakan H. Terada M. Hasegawa H. Nose M. Saito Y. …

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization.

The use of nanotechnology in medicine has the potential to have a major impact on human health for the prevention, diagnosis, and treatment of diseases. One particular aspect of the nanomedicine field which has received a great deal of attention is the design and development of nanoparticulate nanomedicines (NNMs) for drug delivery (i.e., drug-containing nanoparticles). NNMs are intended to deliver drugs via various mechanisms: solubilization, passive targeting, active targeting, and triggered release. The NNM approach aims to increase therapeutic efficacy, decrease the therapeutically effecti

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… Rheum. Dis . 63 , 348 – 353 . 10.1136/ard.2003.009944 15020326 PMC1754935 Metselaar J. M. Wauben M. H. Wagenaar-Hilbers J. P. Boerman O. C. Storm G. ( 2003 ). Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes . … Arthritis Rheum . 48 , 2059 – 66 . 10.1002/art.11140 12847701 Milane L. S. Amiji M. ( 2017 ). Nanomedicine for Inflammatory Diseases. New York, NY : CRC Press Min Y. Caster J. M. Eblan M. J. Wang A. Z. ( 2015 ). Clinical translation of nanomedicine . Chem. …

CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions.

Macrophages and their monocyte precursors mediate innate immune responses and can promote a spectrum of phenotypes from pro-inflammatory to pro-resolving. Currently, there are few markers that allow for robust dissection of macrophage phenotype. We recently identified CD38 as a marker of inflammatory macrophages in murine in vitro and in vivo models. However, it is unknown whether CD38 plays a similar marker and/or functional role in human macrophages and inflammatory diseases. Here, we establish that CD38 transcript and protein are robustly induced in human macrophages exposed to LPS (±IFN-γ)

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… Arthritis Rheum (1997) 40:1725. 10.1002/art.1780400928 33. Young NA, Valiente GR, Hampton JM, Wu L-C, Burd CJ, Willis WL, et al. Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus. … Arthritis Rheum (1992) 35:630–40. 10.1002/art.1780350606 43. Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, et al. Nomenclature of monocytes and dendritic cells in blood. Blood (2010) 116:e74–80. 10.1182/blood-2010-02-258558 44. Ziegler-Heitbrock L. …

Epidemiological and economic impact of pre-exposure prophylaxis with targeted immunotherapies for COVID-19 among immunosuppressed patients in Argentina.

BACKGROUND: Some immunosuppressive disorders have shown substantially lower protection after COVID-19 vaccination against severe outcomes. Therefore, pre-exposure prophylaxis is proposed. Targeted immunotherapy with monoclonal antibodies represents an option for preventing severe COVID-19. However, there is a lack of epidemiological and economic information on pre-exposure prophylaxis with targeted immunotherapies against COVID-19 among immunosuppressed patients. Thus, this study aims to identify and estimate the size of target population and direct medical costs related to pre-exposure prophy

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… Ann Rheum Dis. 2022 Jul;81(7):1023–27. 51. Lee ARYB, Wong SY, Tay SH. Booster COVID-19 vaccines for immune-mediated inflammatory disease patients: a systematic review and meta-analysis of efficacy and safety. Vaccines (Basel) [Internet]. 2022 Apr, 22;10(5). …

A Rapid Review of Adenocarcinoma and Pulmonary Tumor Thrombotic Microangiopathy: A Deadly Duo.

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare paraneoplastic syndrome associated with various adenocarcinomas, most commonly gastric adenocarcinoma. This condition can progressively worsen pulmonary arterial hypertension, leading to acute or subacute pulmonary heart failure and respiratory insufficiency. This paper examines the pathogenesis, clinical presentation, diagnosis, treatment, and prognosis of PTTM. Given PTTM's poor prognosis, we emphasize treatment strategies. PTTM in adenocarcinoma patients can mimic other pulmonary diseases, causing diagnostic delays. Current PTTM tr

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… Cureus Gade AK Olariu E Douthit NT 0 12 2020 10.7759/cureus.7186 PMC7124884 32257725 11 Paraneoplastic hyperaldosteronism associated with non-Hodgkin's lymphoma N Engl J Med Mulatero P Rabbia F Veglio F 1558 1559 344 2001 11368052 10.1056/NEJM200105173442017 12 Paraneoplastic musculoskeletal syndromes Rheum …

Cardiac Amyloidosis: A Contemporary Review of Medical and Surgical Therapy.

Amyloidosis is a systemic disease initiated by deposition of misfolded proteins in the extracellular space, due to which multiple organs may be affected concomitantly. Cardiac amyloidosis, however, remains a major cause of morbidity and mortality in this population due to infiltrative /restrictive cardiomyopathy. This review attempts to focus on contemporary medical and surgical therapies for the different types of cardiac amyloidosis. Amyloidosis affecting the heart are predominantly of the transthyretin type (acquired in the older or genetic in the younger patients), and the monoclonal immun

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… Rheum. Dis. Clin. North Am. 2018;44(4):585–603. doi: 10.1016/j.rdc.2018.06.004. 45. Yilmaz A., Bauersachs J., Bengel F., et al. Diagnosis and treatment of cardiac amyloidosis: Position statement of the German Cardiac Society (DGK). Clin. Res. …

A Randomized Placebo-Controlled Trial of the Anti-Nerve Growth Factor Antibody Tanezumab in Subjects With Cancer Pain Due to Bone Metastasis.

BackgroundThis phase III, randomized, double-blind, placebo-controlled, parallel-group study assessed the efficacy and safety of tanezumab in subjects with cancer pain predominantly due to bone metastasis receiving background opioid therapy.MethodsSubjects were randomized (stratified by (1) tumor aggressiveness and (2) presence/absence of concomitant anticancer treatment) to placebo or tanezumab 20 mg. Treatment was administered by subcutaneous injection every 8 weeks for 24 weeks (3 doses) followed by a 24-week safety follow-up period. The primary outcome was change in daily average pain in t

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… Ann Rheum Dis. 2020;79(6):800-810. 10.1136/annrheumdis-2019-216296. 14. Hochberg MC, Carrino JA, Schnitzer TJ, et al. Long-term safety and efficacy of subcutaneous tanezumab versus nonsteroidal antiinflammatory drugs for hip or knee osteoarthritis: a randomized trial. …

Polymorphisms in CXCR3 ligands predict early CXCL9 recovery and severe chronic GVHD.

Chronic graft-versus-host disease (cGVHD) is a major cause of mortality and morbidity after allogeneic stem cell transplantation (alloSCT). The individual risk of severe cGVHD remains difficult to predict and may involve CXCR3 ligands. This study investigated the role of single-nucleotide polymorphisms (SNPs) of CXCL4, CXCL9, CXCL10, and CXCL11, and their day +28 serum levels, in cGVHD pathogenesis. Eighteen CXCR3 and CXCL4, CXCL9-11 SNPs as well as peri-transplant CXCL9-11 serum levels were analyzed in 688 patients without (training cohort; n = 287) or with statin-based endothelial protection

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… Arthritis Rheum. 2010;62:2073–2085. doi: 10.1002/art.27478. 50. Jameel A, et al. Statin modulation of human T-cell proliferation, IL-1beta and IL-17 production, and IFN-gamma T cell expression: synergy with conventional immunosuppressive agents. Int. J. …

Testing mapping algorithms of the cancer-specific EORTC QLQ-C30 onto EQ-5D in malignant mesothelioma.

BackgroundIn order to estimate utilities for cancer studies where the EQ-5D was not used, the EORTC QLQ-C30 can be used to estimate EQ-5D using existing mapping algorithms. Several mapping algorithms exist for this transformation, however, algorithms tend to lose accuracy in patients in poor health states. The aim of this study was to test all existing mapping algorithms of QLQ-C30 onto EQ-5D, in a dataset of patients with malignant pleural mesothelioma, an invariably fatal malignancy where no previous mapping estimation has been published.MethodsHealth related quality of life (HRQoL) data whe

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… Karlsson JA Nilsson JA Neovius M Kristensen LE Gulfe A Saxne T Geborek P National EQ-5D tariffs and quality-adjusted life-year estimation: comparison of UK, US and Danish utilities in south Swedish rheumatoid arthritis patients Ann Rheum Dis 2011 70 12 2163 2166 10.1136/ard.2011.153437 21859684 30. …

Mapping onto Eq-5 D for patients in poor health.

BACKGROUND: An increasing amount of studies report mapping algorithms which predict EQ-5 D utility values using disease specific non-preference-based measures. Yet many mapping algorithms have been found to systematically overpredict EQ-5 D utility values for patients in poor health. Currently there are no guidelines on how to deal with this problem. This paper is concerned with the question of why overestimation of EQ-5 D utility values occurs for patients in poor health, and explores possible solutions. METHOD: Three existing datasets are used to estimate mapping algorithms and assess exist

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… Arthritis Rheum. 2008;59(10):1458. doi: 10.1002/art.24104. Segeren CM, Sonneveld P, van der Holt B, Vellenga E, Croockewit AJ, Verhoef GE. et al. …

Ход работы сессии 25th Европейский конгресс педиатрической ремуматологии (ПСР) 2018) Лиссабон, Португалия. 5-8 сентябрь 2018

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… Ann Rheum Dis. 2014;73:2168-73. 2 De Benedetti F, et al. N Engl J Med. 2018 (in press). Trial registration identifying number: NCT02059291 Disclosure of Interest I. Kone-Paut Grant / Research Support from: Novartis, SOBI, Roche, Consultant for: Novartis, SOBI, Pfizer, AbbVie, Roche, M. … oligoarthritis and polyarthritis patients from the EPOCA study; 2) 148 oligoarthritis patients from the TRIMECA trial; 3) 172 polyarthritis patients from the Abatacept trial, 4) 113 oligoarthritis and polyarthritis patients first starting methotrexate from a monocentric retrospective cohort (Swart et al, Ann Rheum …

The Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications.

Neuropathic pain, a chronic condition arising from injury or dysfunction of the somatosensory nervous system, is characterized by persistent hypersensitivity and spontaneous pain. The chemokine receptor CCR5 (C-C motif chemokine receptor 5) has recently been identified as a critical mediator in neuroinflammation and neuropathic pain signaling pathways. Expressed on immune cells and neurons, CCR5 regulates immune cell recruitment and activation, thereby contributing to neuronal sensitization and maintenance of pain states. This review examines the currently characterized molecular mechanisms th

Diagnosis and treatment of Paget's disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS).

INTRODUCTION: Paget's disease of bone is a focal skeletal disorder causing bone deformities and impairing bone quality. Despite the prevalence of asymptomatic cases is increasing, the progression of the disease can lead to invalidating complications that compromise the quality of life. Doubts on clinical and therapeutic management aspects exist, although beneficial effects of antiresorptive drugs, particularly bisphosphonates are known. However, limited information is available from randomized controlled trials on the prevention of disease complications so that somewhat contrasting positions a

Воздействие сердечного амилоида на пациентов с множественной миеломой: систематический обзор и метаанализ.

КОЛИЧЕСТВО: Иммуноглобулиновая световая цепочка (AL) амилоидоз является широко признанным осложнением множественной миеломы (ММ) с важными прогнозными последствиями. Однако воздействие сердечного амилоидоза на выживание пациентов с ММ исследовалось редко. ЦЕЛЬ: Мы намеревались проводить систематический обзор и метаанализ для количественной оценки прогноза пациентов с синдромом MM с амилоидозом и без него. Мы искали базы данных PubMed, Scopus и Kochrane для проведения исследований по сопоставлению выживаемости пациентов MM с сопутствующим амилоидозом и без него. Первостепенный результат был свя

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… Arthritis Rheum. 2006;54:2015–21. 22. Pellikka PA. Endomyocardial biopsy in 30 patients with primary amyloidosis and suspected cardiac involvement. Arch Intern Med. 1988;148:662–6. 23. …

Систематический анализ эффективности ritoximab в управлении деятельностью центральной нервной системы среди взрослых, страдающих болезнью Шёгрена.

ВВЕДЕНИЕ: Болезнь Шёгрена является аутоиммунным заболеванием, которое может иметь неврологическое отношение. Rituximab — моноколональная антитела против CD20, которая продемонстрировала потенциал в управлении центральной и периферической нейропатией в лимфомах и некоторых аутоиммунных заболеваниях. Имеются ограниченные данные об эффективности ritoximab в связи с участием центральной нервной системы (СНС) в болезни Шёгрена. Цель этого систематического обзора состояла в том, чтобы оценить воздействие ритуксимаба на участие взрослых взрослых в болезнях Шёгрена.МАТЕРИАЛЫ И МЕТОДЫ: Были проведены о

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… Ann Rheum Dis. 2024;83:1698–9. 12. Niemelä RK, Hakala M, editors. Primary Sjögren’s syndrome with severe central nervous system disease. Seminars in arthritis and rheumatism. Elsevier; 1999. 13. Ozgocmen S, Gur A. …

A Phase Ib Investigator-Initiated Trial of Filgotinib in Patients With Idiopathic Multicentric Castleman Disease.

Background Idiopathic multicentric Castleman disease (iMCD) is a chronic systemic inflammatory disease characterized by the production of in … observed. Conclusion The safety profile of filgotinib against iMCD was comparable to those against rheumatoid arthritis and ulcerative colitis over a short duration, but the efficacy of filgotinib against iMCD was not evident after eight weeks. Long-term evaluations of the safety profile and efficacy of filgotinib in the treatment of iMCD are necessary …

Involvement of Pruritus, Gut Dysbiosis and Histamine-Producing Bacteria in Paraneoplastic Syndromes.

Background/Objectives: Paraneoplastic syndromes (PNS), characterized by a large diversity of symptoms, may sometimes be the first clinical feature of a severe underlying disorder such as cancer. Methods: We report the case of a middle-aged male patient with no significant previous medical history, a nonsmoker or alcohol heavy drinker, complaining about generalized, recently onset itch. Given no reasonable explanation of pruritus after dermatological consultation and the unsatisfactory response to treatment, the patient was referred to gastroenterology with the suspicion of a cholestatic liver

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… Rheum. Dis. Clin. N. Am. 2020;46:577–586. doi: 10.1016/j.rdc.2020.04.002. 7. Rościszewska A., Tokarska K., Kośny A., Karp P., Leja W., Żebrowska A. The Importance and Challenges of Early Diagnosis of Paraneoplastic Skin Syndromes in Cancer Detection—A Review. …

Positive Anti-nuclear Antibody in Patients with Polyclonal Hypergammaglobulinemia Suggests the Presence of Multiple Distinct Comorbidities.

Objective Polyclonal hypergammaglobulinemia (PHGG) is a classic problem in internal medicine; however, its conditions and diagnostic procedures have not been well studied. We therefore conducted a retrospective study to characterize the PHGG disease spectrum. Methods We included all patients who underwent serum protein electrophoresis (SPEP) at a hematology tertiary referral center during a five-year period. For these patients, globulin clonality was determined and clinical data were extracted from the records. Results Out of 209 consecutive cases of hypergammaglobulinemia demonstrated by SPEP

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… Rheum Dis Clin North Am 34 : 935 - 947, viii-ix , 2008 . 18984413 10.1016/j.rdc.2008.08.009 …

Oral arsenic trioxide for treating acute promyelocytic leukaemia: Implications for its worldwide epidemiology and beyond.

This account describes how orally administered Arsenic-trioxide (ATO) therapy influences the epidemiology of acute promyelocytic leukaemia (APL), and how the experience that ensued may expand the indications for oral ATO as a treatment for diseases/disorders other than APL. Over the last two decades, experience with APL patients in Hong Kong treated with an oral regimen comprising ATO, all-trans retinoic acid (ATRA), and ascorbic acid (also known as "AAA") has confirmed a dramatic improvement in overall survival. Over that period, there has been an estimated 60-fold increase in the prevalence

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… Arthritis Rheum (2010) 62(6):1576–82. doi: 10.1002/art.27425 48. Almutairi KB, Nossent JC, Preen DB, Keen HI, Inderjeeth CA. The prevalence of rheumatoid arthritis: A systematic review of population-based studies. J Rheumatol (2021) 48(5):669–76. doi: 10.3899/jrheum.200367 49. …

Menorrhagia due to uterine amyloidosis in familial Mediterranean fever: case-based review.

Amyloidosis is described by the deposition of misfolded proteins in the tissues. Amyloidoses are classified into two as systemic and localized. Out of the systemic forms, AL (light chain) amyloidosis is the most prevalent type; however, amyloid A (AA) amyloidosis is more frequently encountered in the rheumatology practice. AA amyloidosis stands out as a major complication of familial Mediterranean fever (FMF). Splenic and renal involvement is more likely in FMF-associated systemic amyloidosis. The involvement of thyroid and adrenal glands has also been described, although infrequently. Amyloid…