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Stabilization of DEPTOR sensitizes hypopharyngeal cancer to radiotherapy via targeting degradation.

The use of radiotherapy for hypopharyngeal cancer (HC) treatment is increasing, and it is currently the primary treatment option for this cancer. However, radioresistance occurs in a proportion of patients. Here, we found that radiation increased proteasomal gene expression and that proteasome assembly was dependent on the induction of transcription factor NRF1 in HC. Through screening assays, we identified a mechanism by which proteasome-mediated degradation of DEP domain-containing mTOR-interacting protein (DEPTOR) contributes to the elevation of mTORC1 signaling after radiation. Therefore,

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… After collecting cells, genomic DNA was extracted with a DNA Extraction Kit (Tiangen, Beijing, China). Sanger sequencing was performed across the sgRNA target sites following PCR amplification, and successful gene KO was identified following sequence analysis. … RNA sequencing was performed by Novogene Bioinformatics Institute (Beijing, China) on an Illumina HiSeq 4000 platform. …

Expert consensus on the clinical application of antibody-drug conjugates in the treatment of malignant tumors (2021 edition).

Antibody-drug conjugates (ADCs) are targeted biological agents composed of a cytotoxic drug linked to a monoclonal antibody through a linker. The monoclonal antibody targets tumor cells and transports small-molecule cytotoxic drugs for specific delivery and minimal off-target side effects. It is necessary for clinicians to understand the molecular characteristics and mechanisms of ADCs. Patients' survival mainly depends on the appropriate dose and course of treatment and also on proper management of adverse reactions. This consensus provides a systematic review of commercially available ADCs a

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… Committee on Clinical Research of Oncology Drugs, Chinese Anticancer Association; Expert Committee for Monitoring the Clinical Application of Antitumor Drugs; Breast Cancer Expert Committee of National Cancer Quality Control Center in conjunction with Cancer Chemotherapy Quality Control Expert Committee of Beijing … Yi Ba (Department of Digestive Oncology, Tianjin Medical University Cancer Institute and Hospital), Jinfei Chen (Cancer Center, Taikang Xianlin Drum Tower Hospital, Nanjing University School of Medicine), Xia Chen (Clinical Medicine Research Center, Beijing Tiantan Hospital, Capital Medical University …

Устные доклады

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… A015: One-Stage Posterior Multiple-Level Asymmetrical Ponte Osteotomies Versus Single-Level Posterior Vertebral Column Resection for Severe and Rigid Adult Idiopathic Scoliosis: A Minimum 2-Year Follow-up Comparative Study Yangpu Zhang 1 and Yong Hai 1 1 Capital Medical University of China, Beijing … A028: Single-Level Cervical Arthroplasty With ProDisc-C Artificial Disc: 10-Year Follow-up Results in One Center Yanbin Zhao 1 , Feifei Zhou 1 , and Yu Sun 1 1 Peking University Third Hospital, Beijing, China Introduction: The aim of this study was to evaluate the clinical and radiographic outcomes …

Сравнительная активность диметилфумаратных производных IDMF в трех моделях, имеющих отношение к множественному склерозу и псориазу.

Диметилфумарат (DMF) — антивоспалительное и иммунорегулирующее лекарство, используемое для лечения множественных склерозов (MS) и псориаза. Его сенсационно-информационная собственность исключает его тематическое использование, что вызывает сожаление в связи с лечением псориаза. Изосорбид ди(метилфумарат) (ИДМФ) (новая производная ДМФ) был синтезирован для того, чтобы обойти эту негативную реакцию и раскрыть потенциал тематических родов, которые могли бы быть полезными для лечения псориаза в субпопуляции псориатических пациентов, страдающих МЗ, а также в целом. Здесь мы сравнили его терапевтиче

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… Quantitative PCR ( qPCR ) assay Total RNA of BV‐2 cells was extracted using the High Pure RNA Isolation Kit (Tiangen Biotech, Beijing, China). Isolated RNA was then reverse‐transcribed into cDNA using the Evo M‐MLV RT Premix for qPCR Kit (Accurate Biology, Shandong, China). …

Вакцино-инкорпоративное и клеточное реагирование на SARS-COV-2 у пациентов с множественным склерозом на Окрелизумабе.

Предыстория/цели: Цель нашего исследования состояла в том, чтобы изучить реакцию клеток B и T у людей с множественным склерозом (PwMS), которые лечились острелизумабом, гуманизированным антиорганизмом против CD20, которые были привиты вторым и/или ускорителем различных видов вакцин против COVID-19. Кроме того, мы обнаружили результаты, связанные с COVID-19 в PwMS после вакцинации, на основе последующих мер по крайней мере в течение 12 месяцев. Методы: В период с января 2022 года по октябрь 2024 года в клинике неврологии (СЕКС) мы зачислили 91 PwMS на орлезизумаб и 42 единицы контроля за здоров

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… cell and T cell responses in the PwMS treated with ocrelizumab who were vaccinated with second and/or third doses of various vaccines against COVID-19 [mRNA (Pfizer BioNTech, New York, NY, USA) vaccine, vector vaccines (AstraZeneca, Sputnik V, Cambridge, UK) or inactivated BBIBP vaccine (Sinopharm, Beijing …

Cancer Mortality - China, 2018.

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… Beijing: China Science and Technology Press, 1st ed, 2019. (In Chinese) 6. National Data. Tabulation on the 2010 population census of the People’s Republic of China. [2020-01-18]. http://data.stats.gov.cn/. 7. …

Е-постеры.

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… Arthroplasty-Cervical P001: Intravenous and Local Steroid Use in the Management of Dysphagia After Anterior Cervical Spine Surgery: A Systematic Review of Prospective Randomized Controlled Trials Jingwei Liu 1 and Yong Hai 1 1 Beijing Chaoyang Hospital, Capital Medical University, Beijing, China … P008: Comparison of Cervical Disc Arthroplasty Versus Dynamic Cervical Implant for the Treatment of Cervical Spondylopathy: A Clinical and Radiological Study Yong Hai 1 and Li Guan 1 1 Beijing Chaoyang Hospital, Capital Medical University, Beijing, China Introduction: To evaluate the clinical and …

2026 Приложение к резюме Международного конгресса

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… Health Systems, World Health Organization-South East Asia Regional Office, New Delhi, Delhi, India 6 All India Institute of Ayurveda, New Delhi, Delhi, India 7 Institute for TCM-X, MOE Key Laboratory of Bioinformatics, Bioinformatics Division, BNRist, Department of Automation, Tsinghua University, Beijing … , Beijing, China 8 Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States 9 Center for Comprehensive Healing, Massachusetts General Hospital, Boston, Massachusetts, United States 10 Osher Center for Integrative Health, Harvard Medical School …

Clinical characteristics and prognostic impact of Burkholderia cepacia complex colonization and infection in patients with hematologic malignancies.

ObjectiveIn recent years, there has been an increasing number of reports on infections caused by the Burkholderia cepacia complex (Bcc). However, the clinical characteristics and prognosis of Bcc infections in patients with hematological malignancies remain unreported. This study aimed to delineate the clinical trajectory from colonization to active infection and to identify prognostic factors influencing outcomes in hematologic malignancy patients with Bcc colonization.MethodsWe conducted a retrospective analysis of 185 hematological malignancy patients with Bcc colonization at the Department

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… Edited by: Fei Pan , ETH Zürich, Switzerland Reviewed by: Desiree Caselli , Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Italy Li Zhihui , Beijing Boren Hospital, China Data availability statement The original contributions presented in the study are included in the article/ …

Effect of Autologous Stem Cell Transplantation Combined with Modified VTD Regimen on Elderly Patients with Multiple Myeloma and Its Influence on miRNA Cytokines.

ObjectiveTo explore the effect of autologous stem cell transplantation combined with modified VTD regimen on elderly patients with multiple myeloma and its influence on miRNA cytokines.MethodsThe data of 42 elderly patients with multiple myeloma who were treated in our hospital from May 2010 to June 2018 were retrospectively analyzed, and they were divided into the combined group (autologous stem cell transplantation combined with improved VTD scheme, n = 25) and the control group (improved VTD scheme, n = 17) according to different treatment schemes, and the clinical efficacy of the two group

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… Beijing: Science Press; 2007. 22. Cengiz Seval G., Beksac M. The safety of bortezomib for the treatment of multiple myeloma. Expert Opinion on Drug Safety . 2018;17(9):953–962. doi: 10.1080/14740338.2018.1513487. 23. Xia J., He Y., Meng B., et al. …

Dectin-1 signaling inhibits osteoclastogenesis via IL-33-induced inhibition of NFATc1.

Abnormal osteoclast activation contributes to osteolytic bone diseases (OBDs). It was reported that curdlan, an agonist of dectin-1, inhibits osteoclastogenesis. However, the underlying mechanisms are not fully elucidated. In this study, we found that curdlan potently inhibited RANKL-induced osteoclast differentiation and the resultant bone resorption. Curdlan inhibited the expression of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), the key transcriptional factor for osteoclastogenesis. Notably, dectin-1 activation increased the expression of MafB, an inhibitor of NFATc1, and IL

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… Samples were sent to OneArray ( http://www.OneArray.com.cn/ , Beijing, China) for transcription profiling via genome-wide microarrays, and the subsequent data analysis was also performed by OneArray. …

Экспертный консенсус в отношении многодисциплинарного подхода к лечению множественных заболеваний костей, связанных с миеломой.

Этот консенсус по множественным болезням костей, связанным с миеломой, подчеркивает важность многодисциплинарного подхода, который охватывает гематологию, радиологию, ортопедию и дополнительные специальности для решения сложных проблем. МБД, широко распространенное и изнуряющее осложнение множественной миэломы, приводит к боли в костях, переломам и событиям, связанным со скелетом, что оказывает глубокое воздействие на качество жизни пациентов. Эти руководящие принципы обеспечивают тщательную основу для диагностики, лечения и постоянной оценки с уделением особого внимания раннему обнаружению и

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… of leading scholars from various specialties, including Hematology, Orthopedic Oncology, Radiology, Pathology, Oral and Maxillofacial Surgery, Radiotherapy, and Rehabilitation, and was endorsed by the Translational Medicine Specialist Committee of the Chinese Medical Education Association and, the Beijing … Research Association for Chronic Diseases Control and Health Education, and the Hematological Committee of Beijing Perioperative Medicine Study Society. …

Association of metformin exposure with low risks of frailty and adverse outcomes in patients with diabetes.

BackgroundDiabetes is an independent risk factor of frailty, which increases adverse outcomes in patients with diabetes. Metformin is a common antidiabetic drug in clinical practice. Insulin resistance and chronic inflammation are the two common mechanisms of diabetes and frailty, as well as the main targets of metformin. Research suggested that metformin has anti-aging potential. However, few studies focus on the relationship between metformin and frailty. Thus, we aimed to explore whether metformin was associated with a low risk of frailty and other adverse outcomes in diabetic patients.Meth

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… disease Variable | OR | 95% CI | P value Frailty | 2.009 | 1.408–2.865 | < 0.001 CAD | 1.699 | 1.226–2.356 | 0.001 Metformin | 0.695 | 0.501–0.964 | 0.029 Discussion The frailty prevalence among diabetic patients in this study was 19.4%, which was close to the 19.32% for diabetic patients in the Beijing … Chhetri JK Zheng Z Xu X Ma C Chan P The prevalence and incidence of frailty in Pre-diabetic and diabetic community-dwelling older population: results from Beijing longitudinal study of aging II (BLSA-II) BMC Geriatr 2017 17 1 47 28178934 10.1186/s12877-017-0439-y PMC5299771 6. …

Молекулярная основа для человеческой митохондриальной модификации tRNA m3C с помощью альтернативной разбрызгивания METTL8.

METTL8 недавно был определен как катализатор метилпереносазы 3-methylcytidine Биогенез на месте 32 (м3С32) митохондриальных tRNA. METTL8 также потенциально участвует в мRNA метилации и R-loop Biogenesis. Как METTL8 играет многообразную роль в разных камерах, и митохондриальное образование митохондриала tRNA m3C остается неясным. Здесь мы обнаружили, что альтернативное скрещивание mRNA вызвало несколько изоформ METTL8. One (изоформ)METTL8-Iso1) был направлен на митохондрию через N-терминальную предпоследнюю последовательность, в то время как другой one (В тыс.METTL8-Iso4) в основном локализован

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… The BCA Protein Assay Kit was obtained from TIANGEN Biotech (Beijing, China). [ 3 H] SAM and [ 3 H] DMAPP were obtained from Perkin Elmer, Inc. … The band was excised and sent to BiotechPack Scientific (Beijing, China) for identification of the N-terminal sequence through the Edman degradation method. …

End-of-Life Care Practice in Dying Patients after Enforcement of Act on Decisions on Life-Sustaining Treatment For Patients in Hospice and Palliative Care or at the End of Life : A Single Center Experience

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… Concordance of preferences for end-of-life care between terminally ill cancer patients and their family caregivers in Taiwan J Pain Symptom Manage 30 510 8 10.1016/j.jpainsymman.2005.05.019 16376737 7 Holroyd EE 2003 Chinese family obligations toward chronically ill elderly members: comparing caregivers in Beijing …

Combinational Antitumor Strategies Based on the Active Ingredients of Toad Skin and Toad Venom.

A multidrug combination strategy is an important mean to improve the treatment of cancer and is the mainstream scheme of clinical cancer treatment. The active ingredients of traditional Chinese medicine, represented by toad skin and toad venom, have the advantages of high efficiency, low toxicity, wide action and multiple targets and have become ideal targets in combined treatment strategies for tumors in recent years. Toad skin and toad venom are traditional Chinese animal medicines derived from Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider that have shown excellent therapeutic

Внеклеточная ДНК и Deoxiribonuc Alternation Activity как потенциальные биомаркеры воспаления в множестве склерозов.

Нейроинфламмация играет важнейшую роль в патофизиологии множественных склерозов (MS), включая сложные взаимодействия между реактивными видами кислорода (ROS), цитокинами, хемокинами и иммунными клетками. Среди них нейтрофилы способствуют устойчивому воспалению путем обезвоживания, производства ROS и высвобождения нейтрофильных внеклеточных ловушек (NETs). Внеклеточная ДНК (ecDNA), являющаяся ключевым компонентом сетей, может выступать в качестве автоантигена, стимулирующего хроническое воспаление и повреждение тканей. Кроме того, нарушение НЕТ и деградация ecDNA в результате деоксирибонуковой

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… DNase Activity Measurement Single radial enzyme-diffusion (SRED) with GoodView Nucleic Acid Stain (SBS Genetech, Beijing, China) was used for the measurement of DNase activity in lithium-heparin plasma. …

BLAB2CancerKD: a knowledge graph database focusing on the association between lactic acid bacteria and cancer, but beyond.

In a broad sense, lactic acid bacteria (LAB) is a general term for Gram-positive bacteria that can produce lactic acid by utilizing fermentable carbohydrates. It is widely used in essential fields such as industry, agriculture, animal husbandry and medicine. At the same time, LAB are closely related to human health. They can regulate human intestinal flora and improve gastrointestinal function and body immunity. Cancer, a disease in which some cells grow out of control and spread to other body parts, is one of the leading causes of human death worldwide. In recent years, the potential of LAB i

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… In: Proceedings of the Association of Computational Linguistics (ACL) , Beijing, China, July. pp. 344–354. 27. Owens J.A., Saeedi B.J., Naudin C.R.. et al. (2021) Lactobacillus rhamnosus GG orchestrates an antitumor immune response. Cell. Mol. Gastroenterol. Hepatol. , 12, 1311–1327. 28. …

The severity of corneal nerve loss differentiates motor subtypes in patients with Parkinson's disease.

BACKGROUND: Parkinson's disease (PD) is a heterogeneous movement disorder with patients manifesting with either tremor-dominant (TD) or postural instability and gait disturbance (PIGD) motor subtypes. Small nerve fiber damage occurs in patients with PD and may predict motor progression, but it is not known whether it differs between patients with different motor subtypes. OBJECTIVE: The aim of this study was to explore whether there was an association between the extent of corneal nerve loss and different motor subtypes. METHODS: Patients with PD classified as TD, PIGD, or mixed subtype unde

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… Montreal cognitive assessment (MoCA, Beijing Version) was used to assess the cognitive status. Quality of life was evaluated with the 39-item Parkinson’s disease questionnaire (PDQ-39) with a higher score indicating a poorer quality of life. …

Protective Role of Enalapril in Anthracycline-Induced Cardiotoxicity: A Systematic Review.

BackgroundEvidence of the preventive and therapeutic effects of enalapril on cardiotoxicity caused by chemotherapy needs to be further confirmed and updated.MethodsWe performed a systematic review of studies from electronic databases that were searched from inception to January 29, 2019, and included relevant studies analyzing enalapril as a cardioprotective agent before or during the use of anthracyclines by oncology patients. Homogeneous results from different studies were pooled using RevMan 5.3 software. The Cochrane risk-of-bias tool was used to determine the quality of the studies.Result

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… Funding This study was funded by the National Natural Science Foundation of China (81822049, 81673712, 81673802), Beijing Nova program (Z171100001117028), Fok Ying Tung Education Foundation (151044), and the National Key R&D Program of China (2017YFC1700100, 2017YFC1700102), The funders had no role …