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A Focus on Relapsed Multiple Myeloma.

Multiple myeloma (MM) is a relapsing disease for many patients with multiple myeloma. At relapse, patients have many options for treatment once disease has progressed. Advanced practitioners are well suited to set expectations for ongoing therapy and underscore the importance of continued disease monitoring. Criteria for relapsed myeloma rely on biomarker and radiologic imaging, as well as physical exam and awareness of new bone pain or changes in physiologic function. The treatment of patients with relapsed MM requires a personalized approach and considers patient desires in regard to aggress

Generic Anticancer Drugs of the Jan Aushadhi Scheme in India and Their Branded Counterparts: The First Cost Comparison Study.

Introduction In India, the costs of cancer drugs are exorbitant and cause significant financial toxicity to the affected patient and their family members. Considering this, Jan Aushadhi pharmacy stores were established across the country by the government of India with the objective of providing cheap generic medicines to patients. The objective of this study was to perform a cost comparison study of generic chemotherapeutic drugs provided through Jan Aushadhi pharmacies versus their branded counterparts. This will help patients and physicians get first-hand information on the cost variation b

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… proposed treatment strongly advocates judicious use of surgery, chemotherapy, and radiotherapy depending on the stage and general health of the individual and that the sequence of treatment modality to be adopted should be arrived at through detailed discussion in the tumor board consisting of experienced oncologists … The Jan Aushadhi Kendra also dispenses chemotherapeutic drugs on a validated prescription of an oncologist. …

A multicenter observational study on Medication-Related Osteonecrosis of the Jaw (MRONJ) in advanced cancer and myeloma patients of a cancer network in North-Western Italy.

BACKGROUND: Incidence of Medication-Related Osteonecrosis of the Jaw (MRONJ) related to cancer and myeloma treatments is undetermined, with scarce data varying from 2 to 7.8/million/year in limited investigated populations. A 9-years [2009-2018] regional-wide survey was conducted, deploying the North-Western Italy Cancer Network ("Rete Oncologica Piemonte e Valle d'Aosta"), to assess number and main characteristics of MRONJ cases among myeloma/cancer patients, within a population of 4.5 million inhabitants. MATERIAL AND METHODS: MRONJ cases were collected retrospectively from January 2009 to

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… In summary, the present series aligns with the findings of our previous paper ( 11 ) and recent literature ( 7 - 13 , 25 - 27 ): MRONJ is not a rare adverse event in cancer and myeloma patients, and should require continuous attention and awareness by prescribers (oncologists, hematologists), oral and … Oncologist. 2011;16:121–32. doi: 10.1634/theoncologist.2010-0183. 3. Otto S, Marx RE, Tröltzsch M, Ristow O, Ziebart T, Al-Nawas B. Comments on "diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus". …

Targeted Radionuclide Therapy: Practical Applications and Future Prospects.

In recent years, there has been a proliferation in the development of targeted radionuclide cancer therapy. It is now possible to use baseline clinical and imaging assessments to determine the most effective therapy and to tailor this therapy during the course of treatment based on radiation dosimetry and tumor response. Although this personalized approach to medicine has the advantage of maximizing therapeutic effect while limiting toxicity, it can be challenging to implement and expensive. Further, in order to use targeted radionuclide therapy effectively, there is a need for multidisciplina

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… It is thought that the limited use of Zevalin has been, at least in part, due to lack of expertise and collaboration between oncologists and nuclear medicine physicians, poor patient access, concerns about radiation safety, and issues related to reimbursement. 6 , 9 Bexxar (tositumomab) is a monoclonal … rational use of tositumomab and iodine-131 tositumomb radioimmunotherapy for the treatment of non-Hodgkin’s lymphoma Onco Targets Ther 2009 2 229 242 20616910 10.2147/ott.s4456 PMC2886324 8 Schaefer NG Ma J Huang P Buchanan J Wahl RL Radioimmunotherapy in non-Hodgkin lymphoma: opinions of U.S. medical oncologists …

Twitter Social Media is an Effective Tool for Breast Cancer Patient Education and Support: Patient-Reported Outcomes by Survey.

BackgroundDespite reported benefits, many women do not attend breast cancer support groups. Abundant online resources for support exist, but information regarding the effectiveness of participation is lacking. We report the results of a Twitter breast cancer support community participant survey.ObjectiveThe aim was to determine the effectiveness of social media as a tool for breast cancer patient education and decreasing anxiety.MethodsThe Breast Cancer Social Media Twitter support community (#BCSM) began in July 2011. Institutional review board approval with a waiver of informed consent was o

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… Other respondents included family, friends, advocates, surgeons, medical oncologists, radiation oncologists, clinical psychiatrists, genetic counselors, and physical therapists. …

RANK/RANK-L/OPG in patients with bone metastases treated with anticancer agents and zoledronic acid: a prospective study.

Patients with solid cancer frequently develop bone metastases (BM). Zoledronic acid (Zometa®, ZA), routinely used to treat patients with BM, acts on osteoclasts and also has antitumor properties. We aimed to assess the effect of ZA over time in novel bone turnover markers (RANK/receptor activator of nuclear factor-k B ligand (RANK-L)/ Osteoprotegerin (OPG)) and to correlate these with serum N-terminal telopeptide (NTX). The study prospectively evaluated levels of RANK, RANK-L and OPG transcripts by real-time PCR and NTX expression by ELISA in the peripheral blood of 49 consecutive patients wit

Patient-reported outcome measures of the impact of cancer on patients' everyday lives: a systematic review.

PurposePatients with advanced disease are living longer and commonly used patient-reported outcome measures (PROMs) may miss relevant elements of the quality of extended survival. This systematic review examines the measures used to capture aspects of the quality of survival including impact on patients' everyday lives such as finances, work and family roles.MethodsSearches were conducted in MEDLINE, EMBASE, CINAHL and PsycINFO restricted to English language articles. Information on study characteristics, instruments and outcomes was systematically extracted and synthesised. A predefined set o

"I didn't really fit into any boxes": understanding the experiences of women affected by cancer in pregnancy and up to one-year postpartum-a mixed-method systematic review.

PurposeLittle is known about women's experiences of cancer during pregnancy and up to one-year postpartum. As the incidence of gestational cancer rises parallel to increasing rates of early onset cancers there is an imperative need to understand their experiences. The aim of this research is to understand women's experiences of gestational cancer during pregnancy and up to one-year postpartum.MethodsThis systematic integrative review followed the JBI methodology for mixed method systematic reviews (MMSR) which integrates empirical data from qualitative and quantitative primary studies. The sea

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… Women mostly reported ongoing communication with their “cancer team” which was inclusive of oncologists, surgeons and cancer nurses, throughout their care. … “I know that I’d been discussed at both meetings, so the doctors have all spoken to one another and I’ve seen the letters that have been going back and forward between the oncologist and the radiation oncologist, and my GP has been kept in the loop the whole time. …

The unseen symptom: A longitudinal qualitative interview study exploring mobility loss in people with advanced cancer.

BACKGROUND: Mobility loss is a common symptom in people with advanced cancer and is associated with reduced function and quality of life. While its physical consequences are well documented, less is known about how individuals and their families experience and adapt to these changes over time. AIM: To explore how individuals with advanced cancer and their caregivers experience and respond to mobility loss. DESIGN: A qualitative longitudinal study using Interpretative Phenomenological Analysis. Participants completed two semi-structured interviews, with follow-ups prompted by changes in mobil

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… They were focussed on the cancer, but I was struggling just to get to the bathroom ” – Kristen “ I don’t think anyone [oncologists] has ever asked about my walking ” – Elizabeth “ We only got help once when we hit breaking point. … Oncologist 2021; 26: e1058–e1065. 2. Funch A, Kruse NB, la Cour K, et al. The association between having assistive devices and activities of daily living ability and health-related quality of life: an exploratory cross-sectional study among people with advanced cancer. …

Frequency of Topical Immunomodulatory and Immunosuppressive Therapies for Ocular Chronic Graft-versus-Host Disease.

Introduction: The purpose of the study was to evaluate the frequency of topical immunomodulatory and immunosuppressive therapies in patients with ocular chronic graft-versus-host disease (cGVHD) in consideration of inflammatory activity and systemic immunosuppressive therapies in a tertiary care university hospital setting. Methods: We included 95 adult patients (48 male, 47 female) with ocular chronic graft-versus-host disease (cGVHD) after alloHSCT (median age 49.5 years). Clinical ophthalmological findings and the grade of ocular cGVHD according to the NIH eye score and the German-Austrian-

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… Patients were referred either by the treating hemato-oncologists or ophthalmologists, either from the same region or from other regions of the country. All patients were seen and graded by a senior ophthalmologist with more than 20 years’ experience in ocular cGVHD (TDN). … In March 2019, the patient stopped Ikervis ® by herself and continued only systemic immunosuppression with ibrutinib according to the treating hemato-oncologists. …

Qualitative Analysis of Colorectal Cancer Screening in Rural Nebraska.

Compared to urban residents, rural populations are less likely to engage in colorectal cancer (CRC) screening. As part of a statewide cancer needs assessment, we aimed to elicit rural perspectives about CRC screening and resources. We conducted three focus groups with rural Nebraska cancer survivors and caregivers (N = 20) in Spring 2021 using a collective case study design. Participant awareness of and knowledge about CRC screening methods varied across focus groups; overall, 95% of participants had heard of colonoscopy. Participants were less familiar with fecal tests and had confusion about

Multisite Quality Improvement Initiative to Identify and Address Racial Disparities and Deficiencies in Delivering Equitable, Patient-Centered Care for Multiple Myeloma-Exploring the Differences between Academic and Community Oncology Centers.

Treatment of multiple myeloma (MM) is complex; however, with equal access to care, clinical outcomes for Black patients match those in other patient groups. To reveal and begin to address clinical practice barriers to equitable, patient-centered MM care, this quality improvement (QI) initiative assessed patient electronic medical records (EMRs) and surveyed patients and providers at two large hospital systems and four community-based practices. For the educational intervention, providers participated in feedback-focused grand rounds sessions to reflect on system barriers and develop action pla

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… Evidence supports that MM specialists in large academic settings may rely more on risk stratification and guidelines informed by the latest clinical evidence to guide treatment decision-making than community oncologists [ 17 ]. … | 0% Asian/Pacific Islander | 10% | 17% Mean patients with MM seen per month | 9 patients | 49 patients | 0.001 Mean years caring for patients with MM | 17 years | 9 years | 0.001 Feedback-Focused Educational Sessions | Academic Providers ( n = 58 ) | Community Providers ( n = 59 ) | Hematologist/Oncologist …

Preventing, identifying, and managing medication-related osteonecrosis of the jaw: a practical guide for nurses and other allied healthcare professionals.

BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is an infrequent, but potentially serious, adverse event that can occur after exposure to bone-modifying agents (BMAs; e.g., bisphosphonates, denosumab, and antiangiogenic therapies). BMAs are typically used at higher doses to prevent skeletal-related events in cancer patients and at lower doses for osteoporosis/bone loss. MRONJ can cause significant pain, reduce quality of life, and can be difficult to treat, requiring a multiprofessional approach to care. METHODS: We reviewed the literature and guidelines to summarize a practic

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… At the healthcare-provider level, oncologists and dentists may not be aware of all BMA-related concerns when treating their patients. … A multiprofessional approach to care and organization of the care pathway A multiprofessional team, involving nurse practitioners, dentists, physicians, oral oncologists, and oral and maxillofacial surgeons, is important to manage and treat MRONJ [ 2 , 52 ]. …

The added value of whole-body magnetic resonance imaging in the management of patients with advanced breast cancer.

This study investigates the impact of whole-body MRI (WB-MRI) in addition to CT of chest-abdomen-pelvis (CT-CAP) and 18F-FDG PET/CT (PET/CT) on systemic treatment decisions in standard clinical practice for patients with advanced breast cancer (ABC). WB-MRI examinations in ABC patients were extracted from our WB-MRI registry (2009-2017). Patients under systemic treatment who underwent WB-MRI and a control examination (CT-CAP or PET/CT) were included. Data regarding progressive disease (PD) reported either on WB-MRI or on the control examinations were collected. Data regarding eventual change i

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… This allowed the oncologists to interrupt ineffective treatments earlier, before the potential onset of acute complications of PD, such as SREs. … When oncologists in our institute program WB-MRI for an ABC patient, other imaging modalities such as CT or PET/CT are dismissed or sometimes interleaved at 3–6 months. …

Modern therapeutic approaches in cholangiocarcinoma: A narrative review of key biomarkers and clinical trials.

Cholangiocarcinoma (CCA), the second most common hepatic malignancy after hepatocellular carcinoma, presents a significant clinical challenge. This epithelial cell malignancy occurs in various anatomical subtypes, including intrahepatic, perihilar, and distal, each associated with unique genetic aberrations, clinical presentations, and treatment options. Early diagnosis is challenging, leading to poor survival rates, especially in advanced cases. Precision medicine offers hope for improved management of CCA by tailoring treatments based on molecular profiling. In recent years, the investigatio

Chinese expert consensus on the diagnosis and clinical management of medication-related osteonecrosis of the jaw.

Medication-related osteonecrosis of the jaw (MRONJ) is a side effect that occurs after treatment for systemic diseases. However, most institutions currently rely on empirical methods to make diagnosis and treatment plans, and there is a lack of consensus or guidelines for the classification, staging and treatment of MRONJ in China. To address this gap and improve prognosis, an expert panel representing 11 renowned domestic medical colleges and affiliated hospitals in China was convened. The panel made a comprehensive literature review of previous treatment experiences and research findings to

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… To decrease the risk of MRONJ development, oncologists should contact oral maxillofacial surgeons to conduct comprehensive oral examinations and treatments before prescribing medication. … For cancer patients diagnosed with MRONJ, oral maxillofacial surgeons should communicate with oncologists to understand the patient's tumor progression, overall health status and medication history. Moreover, oncologists should assess the necessity of continuing medication. …

From economic burden to patient-centered solutions: the evolving landscape of financial toxicity in oncology.

BackgroundFinancial burden has emerged as a significant challenge in oncology, adversely affecting patients' quality of life, treatment adherence, and long-term outcomes. While research on cancer-related financial toxicity (FT) has grown rapidly, a comprehensive bibliometric analysis of its knowledge structure, thematic evolution, and emerging trends remains scarce.MethodsPublications on FT among cancer patients, published from 2003 to January 19, 2026, were retrieved from the Web of Science Core Collection and Scopus databases. Bibliometric and science mapping analyses were conducted using Ci

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… In this context, multidisciplinary management and social support have emerged as prominent conceptual directions in the literature, involving collaboration among oncologists, nurses, social workers, financial navigators, and administrative personnel. … Oncologist . ( 2013 ) 18 : 381 – 90 . doi: 10.1634/theoncologist.2012-0279 , 23442307 PMC3639525 3. Wagle NS Nogueira L Devasia TP Mariotto AB Yabroff KR Islami F . Cancer treatment and survivorship statistics, 2025 . …

Surgical approaches to fertility preservation in the cancer patient: current and future directions.

Advances in oncologic therapies have markedly improved survival among reproductive-age female patients, making fertility preservation an essential component of comprehensive cancer care. Gonadotoxic treatments, including chemotherapy, radiotherapy, and surgery, can disrupt ovarian and uterine endocrine function, resulting in premature ovarian insufficiency and infertility. This narrative review summarizes current and emerging surgical approaches to fertility preservation, organized by anatomic focus on the ovary, uterus, and cervix. Ovarian transposition preserves ovarian endocrine function by

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… Additionally, radiation oncologists play a pivotal role in delineating the radiation field preoperatively to guide optimal ovarian placement ( 33 ). Ovarian transposition technique varies by individual patient anatomy and oncologic factors. … Although the effect on ovarian function is clear, oncologists and reproductive endocrinologists must weigh the benefits against the risk of incomplete cancer staging, metastatic involvement of transposed ovaries, and port-site metastases. …

Multidisciplinary Management of Morbidities Associated with Chronic Graft-Versus-Host Disease.

Chronic graft-versus-host disease (cGVHD) represents a common long-term complication after allogeneic hematopoietic stem cell transplantation (HSCT). It imposes a significant morbidity burden and is the leading cause of non-relapse mortality among long-term HSCT survivors. cGVHD can manifest in nearly any organ, severely affecting the quality of life of a transplant survivor. While the mainstay of treatment has remained systemic immunosuppression with glucocorticoids, progress has been made within the last few years with approvals of three oral agents to treat steroid-refractory cGVHD: ibrutin

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… As patients with cGVHD are more likely to be diagnosed with the components of metabolic syndrome compared to those without cGVHD, early involvement of cardio-oncologists during the transplant evaluation process and during survivorship is critical. … B., DeFilipp Z. 2022The Oncologist. 27(8):685–693. doi: 10.1093/oncolo/oyac076. doi: 10.1093/oncolo/oyac076. Ibrutinib for chronic graft-versus-host disease after failure of prior therapy. Miklos D., Cutler C. …

Гематологические болезни у пожилых пациентов: уделение особого внимания потенциальной роли управления гериатрической оценкой.

Управление гериатрической оценкой представляет собой многомерный инструмент, используемый для оценки прогнозов в отношении клинических результатов и целевых показателей в отношении мероприятий для пожилых людей, в которых рак проходит химиотерапию. В ходе этого обзора мы провели оценку возможного применения методов управления гериатрической оценкой (GAM) в гематологических паразитах. У пожилых пациентов с диффузной клеточной лимфомой B GAM может быть полезным как в прогнозировании запланированных госпитализаций, так и в улучшении качества жизни. В хронической миелоидной лейкемии индекс коморби

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… The care of frail and older adults is often complex and an approach that entails the assessment of elderly patients by geriatricians offers the advantage of enabling coordinated care with hematologic oncologists within the same clinical setting [ 56 , 57 , 58 , 59 ]. … The COACH Clinical Trial The COACH clinical trial [ 86 ], a large-scale, multicenter cluster-randomized study, showed that GAM given to oncologists along with recommendations might help in improving the way they communicate issues related to aging. …