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Evaluation of Hospital-Acquired Anemia and Contributing Factors in ICU Patients: A Retrospective Cohort Study.

Objectives: Hospital-acquired anemia (HAA) is an important clinical problem that can adversely affect outcomes, particularly in critically ill patients. This study aimed to determine the incidence of hospital-acquired anemia in adult ICU patients and to evaluate its relation with diagnostic phlebotomy procedures and other etiologic factors. Methods: Data from 1170 adult ICU admissions between 1 January and 31 December 2024 were retrospectively reviewed and 321 patients were included in the analysis. The median age of the study cohort was 72 years (range: 18-102), with 45.2% females (n = 145) a…

Carbimazole-Induced Severe Acquired Aplastic Anemia in a Patient with Graves' Disease: A Case Report.

Background and Clinical Significance: Carbimazole is a widely used medication to treat Graves' disease, although it can rarely cause acquired aplastic anemia, a complication that happens in less than 0.01% of people. Case Presentation: We report a 36-year-old woman treated with supratherapeutic dose carbimazole who, after approximately six months of treatment, developed high grade fever, severe menorrhagia, spontaneous epistaxis, and pancytopenia. Her bone marrow biopsy showed severe bone marrow failure with only 5% cellularity and trilineage hypoplasia. Other potential causes were ruled out. …

Differential diagnosis of microcytic hypochromic anemia in dogs: the role of hepcidin and reticulocyte hemoglobin indices.

Microcytic hypochromic anemia in dogs represents a persistent diagnostic challenge, particularly when differentiating between absolute iron deficiency and inflammation-driven functional iron restriction. Conventional biomarkers, including serum iron and ferritin, present important limitations in terms of sensitivity, specificity, and temporal resolution, restricting their ability to accurately reflect dynamic changes in iron metabolism. This review critically evaluates the diagnostic performance and clinical relevance of hepcidin and reticulocyte hemoglobin indices (CHr/RET-He) as advanced bio…

Fatal Presumed Rhino-Orbito-Sinus Mucormycosis in a Child With Fanconi Anemia: A Case Report.

We report the case of a 10-year-old male patient with bone marrow aplasia secondary to Fanconi anemia who was initially admitted for febrile purulent tonsillitis (no throat culture was performed before antibiotic initiation). Despite several courses of broad-spectrum antibiotic therapy, the clinical course was marked by persistent fever and progressive right-sided orbitofacial cellulitis. Imaging revealed extensive involvement of the right maxillary sinus with orbital extension. The appearance of a necrotic black palatal lesion (eschar) in the setting of profound immunosuppression is highly ch…

Severe Chronic Anemia and Tumor-Mimicking Colonic Lesions as an Atypical Presentation of Crohn's Colitis.

Crohn's colitis may rarely present with severe bleeding and tumor-mimicking colonic lesions, creating concern for malignancy. A 20-year-old bedridden man with cerebral palsy had recurrent hematochezia and transfusion-dependent microcytic anemia, with hemoglobin 2.8 g/dL. Colonoscopy showed diffuse raised island-like plaques with vascular-pattern loss, rectal sparing, edematous ileocecal valve, and an oozing transverse-colon lesion requiring clipping. Multisite biopsies showed chronic active colitis with crypt distortion, cryptitis, and crypt abscesses, without granulomas, dysplasia, or maligna…

The association between the degree of social vulnerability and maternal anemia and other adverse perinatal outcomes.

OBJECTIVE: Maternal anemia in pregnancy is associated with many adverse maternal, fetal, and neonatal outcomes. The role of social determinants of health (SDOH) in the development of maternal anemia and other adverse outcomes is continually evolving. One such newer tool, the Social Vulnerability Index (SVI), measures an individual's community-level SDOH, with higher SVI denoting higher vulnerability. Our objective was to evaluate the association between SVI, maternal anemia, and other adverse perinatal outcomes. METHODS: Retrospective cohort study of pregnant individuals delivering singletons…

Acute hemolytic anemia and methemoglobinemia in a pediatric oncology patient with G6PD deficiency: a case report.

BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzymatic disorder that is often asymptomatic until exposure to oxidative stress, such as certain medications. Rasburicase, used for tumor lysis syndrome (TLS) prophylaxis, can trigger hemolysis in G6PD-deficient patients. CASE PRESENTATION: We report a nine-year-old Asian boy with acute myeloid leukemia (AML) and hyperleukocytosis who developed severe hemolytic anemia and methemoglobinemia shortly after receiving rasburicase for TLS. Enzymatic testing suggested G6PD deficiency but was unreliable due to hyperleukocyto…

Nutritional anemia is associated with increased risk of severe COPD exacerbations: a prospective cohort study.

BACKGROUND: Anemia prevalence in chronic obstructive pulmonary disease (COPD) varies widely across studies, and data on anemia subtypes and their association with mortality or COPD exacerbation readmission are limited. OBJECTIVES: We aimed to investigate anemia subtypes and their association with mortality and readmission for acute exacerbation of COPD (AECOPD) in patients hospitalized for AECOPD. METHODS: In this prospective observational cohort study, patients with COPD aged ≥45 y hospitalized for severe exacerbations in a Belgian nationwide database were included. Cox regression models in…

Febrile neutropenia in pediatric acquired aplastic anemia: a 20-year analysis of infections and mortality.

Acquired aplastic anemia (AA) is a life-threatening bone marrow failure disorder, and febrile neutropenia (FN) episodes in children with AA pose significant risks due to infections. The study aimed to investigate the incidence, types, and outcomes of infections during FN episodes in pediatric AA patients. This single-centre retrospective cohort study included 39 pediatric patients with AA diagnosed between January 2004 and January 2024. Data from medical records, including clinical characteristics, laboratory findings, immunosuppressive therapy details, microbiological results, and infection o…

The curious case of aplastic anemia: a fatal triple co-infection with Aspergillus, Mucorales, and Nocardia.

BACKGROUND: Concurrent opportunistic infections are rare but can lead to life-threatening complications in patients with hematologic disorders. Immunosuppression, particularly severe neutropenia, significantly increases the risk of invasive fungal and bacterial infections. We report a 34-year-old female with chronic hepatitis B initially presented with pancytopenia. Subsequent bone marrow evaluation revealed aplastic anemia, and she subsequently received immunosuppressive therapy. During hospitalization, she developed multiple infectious episodes, including fever, pulmonary nodular lesions, an…

Распространение и риск анемии у людей с множественным склерозом (MS): систематический обзор и мета-анализ.

ВВЕДЕНИЕ: Анемия проявляется как общая коморбида в другом времени и лежащем в основе патофизиологии у людей с MS (PwMS) и предлагается в качестве продрома в MS. Этот систематический обзор и метаанализ направлены на удовлетворение потребности в уточнении некоторых характеристик анемии в PwMS. МЕТОДЫ: Систематический поиск литературы проводился с использованием баз данных MedLINE PubMed, Scopus и Google Scientific. Соответствующие исследования прошли оценку качества с использованием " Робинз-Е " , и был проведен метаанализ пропорциональности. Риск анемии в PwMS в сравнении со здоровыми

Совпадение в аннотации оригинала
INTRODUCTION: Anemia appears as a common comorbidity in a different timing and underlying pathophysiology in people with MS (PwMS) and has been proposed as a prodrome finding in MS. This systematic review and meta-analysis aims to fulfill the need to clarify some characteristics of anemia in PwMS. METHODS: A systematic literature search was performed using …

Efficacy and safety of thalidomide with hydroxyurea in sickle cell anemia: a quasi-experimental clinical trial.

BACKGROUND: The clinical course of sickle cell anemia (SCA) is variable, with chronic hemolysis and end-organ damage caused by microvascular occlusion. We evaluated the efficacy and safety of thalidomide plus hydroxyurea (HU) compared with HU alone to determine whether the combination provides a superior clinical benefit and safety profile. METHODS: This was an open-label quasi-experimental clinical trial (Clinical Trials Registry of India, CTRI Registration Number 2023/04/065682). Patients with SCA aged > 12 years and postmenopausal females aged > 45 years were allocated 1:1 to receive eithe…

Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age.

Frailty is a syndrome of vulnerability to stressors linked to worse outcomes before and after lung transplantation. However, the biological basis of this association is unknown. Biological correlates of aging include epigenetic reprograming, chronic inflammation, telomere dysfunction, and anemia. We hypothesized that these aging-associated biological processes would be associated with frailty in lung transplant recipients. In a nested case-control study, we compared 43 lung transplant recipients who were frail pretransplant and posttransplant with 43 nonfrail matched controls. We quantified pe…

Indirect treatment comparisons of momelotinib vs pacritinib safety and anemia outcomes in patients with myelofibrosis.

AIM: To perform an indirect treatment comparison of safety and anemia outcomes between the Janus kinase (JAK) inhibitors momelotinib and pacritinib in patients with myelofibrosis. METHODS: Treatment-emergent adverse events (AEs) and anemia outcomes were compared in a pooled population of JAK inhibitor - experienced and - naive patients treated with momelotinib (SIMPLIFY-1/SIMPLIFY-2/MOMENTUM) or pacritinib (PERSIST-2/PAC203). RESULTS: Momelotinib had statistically significantly lower odds and risk for all grades of diarrhea, nausea, peripheral edema, and vomiting as well as grade 3/4 and ser…

Lack of association between the TMPRSS6 gene polymorphism (rs855791) and anemia: a comprehensive meta-analysis.

BACKGROUND: Anemia affects around 1.6 billion people worldwide and presents a significant challenge for healthcare providers. Despite the hemoglobin concentration being commonly used for diagnosis, identifying underlying causes remains challenging, particularly in vulnerable groups like children under five and pregnant women. Genetic factors, notably variations in the TMPRSS6 gene, are implicated in iron deficiency anemia, yet the precise relationship with anemia remains unclear. METHODS: A thorough literature search was conducted across databases, including Embase, Google Scholar, and PubMed…

Drivers of anemia reduction among women of reproductive age in Uganda: a country case study.

BACKGROUND: In Uganda, anemia prevalence among women of reproductive age (WRA) decreased from 41% in 2006 to 32% in 2016. The factors associated with this reduction are uncertain. OBJECTIVES: We conducted a systematic in-depth assessment of the quantitative and qualitative determinants of anemia among WRA in Uganda between 2006 and 2016. METHODS: Employing standard Exemplars in Global Health methodology, quantitative analyses were conducted using Uganda's Demographic and Health Surveys. Qualitative analyses included a comprehensive literature review, program analysis, and stakeholder intervi…

Analysis of prevalence, years lived with disability, and trends of anemia burden and main causes in China.

BACKGROUND: China is facing a rapidly aging population. In 2020, the number of people aged 60 and above was 264 million, accounting for 18.7% of the total population. Therefore, addressing the health issues of older adults is of great importance. This study aimed to analyze trends of anemia burden and its underlying causes in older adults aged 60 and above. METHODS: Three indicators were used to evaluate the disease burden of anemia: prevalence, Years Lived with Disability (YLDs), and Years Lived with Disability rate (YLD rate). Data on anemia prevalence were obtained from the 2002 Chinese Nu…

Exploring the association between blood donation and anemia: A cross‑sectional study based on the NHANES.

BACKGROUND: Blood donation is essential for maintaining an adequate blood supply, but repeated donation can lead to iron depletion and anemia. Evidence from nationally representative populations is limited. METHODS: We conducted a cross-sectional analysis of adults (≥18 years) from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. Blood donation within the past 12 months was self-reported. Outcomes included anemia (hemoglobin <13.0 g/dL in men, <12.0 g/dL in women), iron deficiency (serum ferritin <70 µg/L), and iron deficiency anemia (IDA, both conditions). Secondary o…