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Clinical utility and patient consideration in the use of lenalidomide for multiple myeloma in Chinese patients.

Multiple myeloma (MM) is an incurable hematologic malignancy caused by the autonomous growth of malignant plasma cells. In the last decade, the introduction of novel targeted agents such as thalidomide, bortezomib, and lenalidomide has dramatically improved the clinical outcome of MM patients in both the frontline and recurrent settings. Lenalidomide is a synthetic derivative of thalidomide, which has been shown to significantly improve overall survival, time to progression, and overall response rates in patients with MM. The China Food and Drug Administration approved the use of lenalidomide

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… National Data [homepage on the Internet] Beijing: National Bureau of Statistics of China; [Accessed October 8, 2014]. Available from: http://data.stats.gov.cn/workspace/index?a=q&type=global&dbcode=hgnd&m=hgnd&dimension=zb&code=A020108&region=000000&time=2013,2013 . …

NSFC health research funding and burden of disease in China.

BackgroundAllocation of health research funds among diseases has never been evaluated in China. This study aimed to examine the relationship between disease-specific funding levels of National Nature Science Foundation of China (NSFC), the main governmental resource for health research in China, and burden of disease.MethodsFunding magnitudes for 53 diseases or conditions were obtained from the website of NSFC. Measures of disease burden, mortality, years of life lost (YLLs) and disability-adjusted life years (DALYs), were derived from the Global Burden of Disease Study 2010. The relationship

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… Beijing. …

Electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy in multiple myeloma: a feasibility study.

BackgroundThis single-arm study evaluated feasibility, safety, and initial efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy (PN) in cancer patients with multiple myeloma.MethodsPatients with neuropathy ≥ grade 2 received 20 acupuncture treatments over 9 weeks.ResultsFor the 19 evaluable patients, Functional Assessment of Cancer Therapy/Gynecological Oncology Group-Neurotoxicity (FACT/GOG/NTX) mean (SD) scores improved significantly between baseline and week 13 (20.8 [9.6] vs 13.2 [8.5], p = 0.0002). Moderate effect size differences began on week 4, with t

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… Beijing: Foreign Languages Press; 1997. Buschbacher RM, Prahlow ND. Manual of Nerve Conduction Studies. 2. New York: Demos Medical Publishing; 2005. …

Резюме книги для 27th Конгресс Европейской ассоциации гематологии

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Recent advances in tumor immunotherapy based on NK cells.

Immunotherapy has emerged as the established fourth pillar of cancer treatment following surgery, radiotherapy, and chemotherapy, representing a cutting-edge research domain in translational medicine and clinical oncology. Natural killer (NK) cells, a type of innate cytotoxic lymphocyte, possess unique antitumor properties that are independent of major histocompatibility complex (MHC) restrictions, making them promising candidates for "off-the-shelf" therapeutic products. NK cells can eliminate tumor cells through various mechanisms. Genetic engineering of NK cells can enhance their activation

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… cond=NCT06358430&rank=1 19 | NCT06773091 | A Phase I Study of NK042 Cell Injection in Advanced Solid Tumors | Recruiting | Phase1 | Advanced Solid Tumors | Bioloigcal: NK042|Drug: Fludarabine (FLU)|Drug: Cyclophosphamide (CTX) | Beijing, China | 2025 | https://www.clinicaltrials.gov/study/NCT06773091 … cond=NCT05703854&rank=1 22 | NCT03692637 | Study of Anti-Mesothelin Car NK Cells in Epithelial Ovarian Cancer | Unknown | Early Phase1 | Epithelial Ovarian Cancer | Biological: anti-Mesothelin Car NK Cells | Beijing, China | 2019 | https://www.clinicaltrials.gov/study/NCT03692637? …

A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health.

Curcumin is the most important active component in turmeric extracts. Curcumin, a natural monomer from plants has received a considerable attention as a dietary supplement, exhibiting evident activity in a wide range of human pathological conditions. In general, curcumin is beneficial to human health, demonstrating pharmacological activities of anti-inflammation and antioxidation, as well as antitumor and immune regulation activities. Curcumin also presents therapeutic potential in neurodegenerative, cardiovascular and cerebrovascular diseases. In this review article, we summarize the advancem

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… Thesis Beijing University of Technology Beijing, China 2020 34. Liu H. Ren P. Liu F.L. Effects of curcumin on autophagy of prostate cancer cells J. Qiannan Natl. Med. Coll. 2021 34 1 5 35. Liu L.-D. Pang Y.-X. Zhao X.-R. Li R. Jin C.-J. Xue J. Dong R.-Y. Liu P.-S. …

Exosomes and organ-specific metastasis.

The transmission of information between tumor cells and other cell types in the tumor microenvironment plays an important role in tumor metastasis and is critically modulated by exosomes and other mediators. Tumor-derived exosomes can promote epithelial-mesenchymal transition, angiogenesis, immune escape, formation of the pre-metastatic microenvironment, and transmission of drug-resistant molecules, thereby promoting tumor growth, invasion, and metastasis. Integrins are important regulatory molecules on exosomes that can locate metastatic cells at the initial stage of metastasis and show good

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… This work was supported by the National Natural Science Foundation of China (grant number [no.] 81774221), Beijing Natural Science Foundation of China (no. 7212168), Capital Health Research and Development of Special (no. 2018-2-1113), and Research Foundation of Beijing Friendship Hospital, Capital Medical …

Liquid biopsy and PCR-free ultrasensitive detection systems in oncology (Review).

In oncology, liquid biopsy is used in the detection of next-generation analytes, such as tumor cells, cell-free nucleic acids and exosomes in peripheral blood and other body fluids from cancer patients. It is considered one of the most advanced non-invasive diagnostic systems to enable clinically relevant actions and implement precision medicine. Medical actions include, but are not limited to, early diagnosis, staging, prognosis, anticipation (lead time) and the prediction of therapy responses, as well as follow-up. Historically, the applications of liquid biopsy in cancer have focused on cir

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… mutation status in patients with metastatic colorectal cancer | Colorectal cancer NCT02036216 ( 196 ) | First received: January 7,2014; Last updated: January 14, 2014 | Circulating cell-free DNA as a predictive biomarker for hepatocelluar carcinoma | Sponsor: Peking Union Medical College Hospital (Beijing … , China); Collaborator: Stanford University; Principal investigator: Mao Y (Peking Union Medical College Hospital (Beijing, China) | This study is based on technologies exhibiting high sensitivity and specificity detection developed at the Stanford Genome Technology Center. …

Распространение и идентификация типа 1 диабет у взрослых китайцев с недавно диагностированным диабетом.

АИМ: Цель этого исследования заключалась в оценке распространенности скрытого аутоиммунного диабета среди взрослых (ЛАДА) и классического типа 1 Диагноз сахарного диабета (T1DM) у недавно диагностировавшегося взрослого диабета в Китае. МЕТОД: Это перекрестное исследование 17,349 вновь диагностированный диабет у взрослых ≥30 лет с 46 Больницы 31 месяцев. Демографические характеристики, клинические особенности и медицинская история были собраны квалифицированными исследователями. T1DM в целом состояли из классических T1DM и ЛАДА. Классический T1DM был определен на основе клинического фенотипа ин

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… Characteristics of COVID-19 infection in Beijing. J Infect . 2020 ; 80 : 401 – 06 . 10.1016/j.jinf.2020.02.018 32112886 PMC7102527 11 Banerjee D , Popoola J , Shah S , Ster IC , Quan V , Phanish M . COVID-19 infection in kidney transplant recipients. …

Liver resection for hepatocellular carcinoma in patients with hematological malignancies.

BACKGROUND: Improvements in antimetabolite drugs have prolonged the survival of patient with hematological malignancies. However, these drugs may have hepatotoxic side effects and may induce acute liver failure, chronic liver fibrosis, cirrhosis, or even hepatocellular carcinoma (HCC). Although liver resection remains a curative option for HCC, its role in HCC with hematological malignancies has never been fully explored. METHODS: A retrospective review of 1725 patients who underwent curative liver resection for newly diagnosed HCC between 1994 and 2016 was conducted. Among these patients, 16

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… A report from Beijing, China, in which a 26-year follow-up study was conducted, reported that the most common secondary cancers with HCC were lung cancer, colorectal cancer, and thyroid cancer. Only 1 of 40 HCC patients had a secondary site that indicated blood cancer. …

Who are the Best Candidates for Decompressive Surgery and Spine Stabilization in Patients With Metastatic Spinal Cord Compression?: A New Scoring System.

Study designA retrospective study.ObjectiveThis study aims to develop a new scoring system that can guild surgeons to select the best candidates for decompressive surgery in patients with metastatic spinal cord compression (MSCC).Summary of background dataPredicting survival and functional outcome is essential when selecting the individual treatment for patients with MSCC. The criteria for identifying MSCC patients who are most likely to benefit from decompressive surgery remain unclear.MethodsWe retrospectively analyzed 12 preoperative characteristics for postoperative survival in a series of

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… Beijing Municipal Science and Technology Commission (No. Z131107002213052) funds were received in support of this work. No relevant financial activities outside the submitted work. References 1. Shiue K Sahgal A Chow E Management of metastatic spinal cord compression . …

Электронные постеры

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The functional imperative in high-grade glioma.

Precision oncology has emerged as a promising strategy for treating high-grade gliomas, yet its clinical impact has been disappointing, with over 300 clinical trials on targeted therapies failing to yield substantial improvements in patient outcomes. Current approaches primarily focus on static, marker-driven tumor features, which capture only a small portion of the complex biology that governs therapeutic responses. Functional precision oncology (FPO) offers a complementary approach, enhancing treatment selection in a personalized manner by dynamically testing patient-derived tumor cells agai

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… negative breast cancer | Adults | 15 | NCT04450706 | UT, USA | Interventional | Completed | 16 February 2021 | 05 September 2024 | Nil 3D Bioprinted Models for Predicting Chemotherapy Response in Colorectal Cancer with/without Liver Metastases | Colorectal cancer | Adults (>18 years) | 120 | NCT04755907 | Beijing … glioblastoma therapies by ex vivo drug screening (ATTRACT) | Glioblastoma | Adults | 240 | NCT06512311 | Vienna, Austria | Interventional | Recruiting | 10 July 2024 | 31 December 2031 | 93 , 94 PTCs-based Precision Treatment Strategy on Recurrent HGGs | Recurrent HGGs | Adults | 30 | NCT05473923 | Beijing …

[Cross-cultural adaptation and reliability validation of a Chinese version of the Clinician-reported Submental Fat Rating Scale].

OBJECTIVE: To translate and culturally adapt the original English version of the Clinician-Reported Submental Fat Rating Scale (CR-SMFRS) into a Chinese version and to systematically evaluate its reliability for assessing submental fat severity in a Chinese population. METHODS: In this single-center, prospective, observational study, a total of 123 Chinese participants were enrolled. Standardized head and neck photographs, including frontal, left 45° oblique, and left 90° lateral views, were obtained to establish an image library. The original English version of the CR-SMFRS was translated to

[Association between different types of first-degree relatives' stroke history and the incidence risk of stroke: A prospective cohort study].

OBJECTIVE: To assess the association between different types of first-degree relatives' stroke history and the incidence risk of stroke, and to explore the familial aggregation and intergenerational transmission of stroke risk. METHODS: A prospective cohort study design was adopted, based on the data of the Fangshan Family-based Ischemic Stroke Study in China(FISSIC). The Cox proportional hazards model was used to analyze the association between different types of first-degree relatives' stroke history (paternal stroke history, maternal stroke history, parental history of stroke, and sibling

[Risk prediction of pneumonia in maintenance hemodialysis patients after severe acute respiratory syndrome coronavirus 2 infection].

OBJECTIVE: To analyze the risk factors for pneumonia after severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection in maintenance hemodialysis patients from a single center in China, and to establish a multivariate model to predict the risk of pneumonia. METHODS: A retrospective analysis was performed on maintenance hemodialysis patients with positive SARS-CoV-2 antigen or nucleic acid tests treated at Peking University Third Hospital from December 1, 2022 to January 31, 2023. Demographic data, comorbidities, dialysis-related parameters, and laboratory test results were collecte

[Prognostic value of angio-based microvascular resistance on left ventricular systolic function in patients with acute ST-segment elevation myocardial infarction].

OBJECTIVE: To investigate the correlation between angio-based microvascular resistance (AMR) and impaired left ventricular systolic function in patients with acute ST-elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PCI), and to assess its predictive value for left ventricular systolic function. METHODS: A study was conducted, enrolling consecutive STEMI patients who underwent primary PCI at the Department of Cardiology, Peking University Third Hospital from May 2023 to June 2024. Quantitative flow ratio (QFR) and AMR were calculated from coronary angi

[Impact of icariin on the differentiation towards dentinogenesis and angiogenesis, and inflammatory regulation of stem cells from human exfoliated deciduous teeth].

OBJECTIVE: To explore the effects of icariin (ICA) on the proliferation and migration of stem cells from human exfoliated deciduous teeth (SHED), as well as its impact on dentinogenic and angiogenic differentiation in vitro, and its anti-inflammatory effects. METHODS: (1) SHED cells were cultured in vitro, with a blank control group for the culture medium, a blank control group for DMSO, and different concentrations of ICA intervention groups (0.1, 1, 10, 20, 50 μmol/L), and cell viability was detected using the CCK-8 method. (2) Quantitative real-time PCR (RT-qPCR) was used to detect the gen

[Clinical characteristics and risk factors of patients with rheumatoid arthritis complicated with urinary tract infection].

OBJECTIVE: To explore the clinical characteristics of urinary tract infection (UTI) in patients with rheumatoid arthritis (RA), to evaluate the effects of different treatment regimens on the risk of UTI, and to identify independent risk factors for UTI complicated with RA. METHODS: A retrospective cohort study was conducted. RA patients hospitalized in the Department of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College from September 2020 to September 2023 were enrolled. General clinical data, laboratory indicators and medication information of the patients

[Systemic sclerosis with anti-human neutrophil cytoplasm antibody associated vasculitis: A case report].

Systemic sclerosis (SSc) is an autoimmune disease involving microvessels and a wide range of connective tissues. Anti-human neutrophil cytoplasm antibody-associated vasculitis (AAV) is a primary, systemic necrotizing small vasculitis. The coexistence of AAV and SSc is rare. We report a case of SSc combined with AAV complicated with alveolar hemorrhage, gastrointestinal hemorrhage, and cerebral hemorrhage. The patient was a 56-year-old woman with a 20-year history of Raynaud phenomenon, skin sclerosis on the fingertip and face. She developed dry cough for 1 year and shortness of breath after ac