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Cannabis, One Health, and Veterinary Medicine: Cannabinoids' Role in Public Health, Food Safety, and Translational Medicine.

Public health is connected to cannabis with regard to food, animal feed (feed), and pharmaceuticals. Therefore, the use of phytocannabinoids should be examined from a One Health perspective. Current knowledge on medical cannabis treatment (MCT) does not address sufficiently diseases which are of epidemiological and of zoonotic concern. The use of cannabinoids in veterinary medicine is illegal in most countries, mostly due to lack of evidence-based medicine. To answer the growing need of scientific evidence-based applicable medicine in both human and veterinary medicine, a new approach for the

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… FOOD SAFETY REQUIREMENTS During the 1990s, major food safety adverse events (such as the bovine spongiform encephalopathy, 81 dioxin, 82 and Listeria 83 outbreaks) led to establishment of the Global Food Safety Initiative. 84 The Food Safety System Certification FSSC22000, 85 which is a set of controls … The Foundation Food Safety System Certification 22000. [accessed November 11, 2019]. Published 2018. Available at: https://www.fssc22000.com/ 86. US Food & Drug Administration. Full Text of the Food Safety Modernization Act (FSMA) FDA; [accessed November 10, 2019]. …

Risk of Atrial Fibrillation in Patients with Different Cancer Types in Taiwan.

Atrial fibrillation (AF) commonly occurs in approximately 2% of cancer patients, and the incidence of AF among cancer patients is greater than in the general population. This observational study presented the incidence risk of AF among cancer patients, including specific cancer types, using a population database. The Taiwan Cancer Registry was used to identify cancer patients between 2008 and 2017. The diagnosis of AF was based on the International Classification of Diseases codes (ICD-9-CM: 427.31 or ICD-10-CM: I48.0, I48.1, I48.2, and I48.91) in Taiwan national health insurance research data

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… Moreover, under the scheme of National Health Insurance (NHI) in Taiwan, cancer patients have access to catastrophic illness certification, exempting them from specific NHI charges and copayments for healthcare visits. … Every request for this certification undergoes expert review, ensuring a high level of diagnostic precision [ 16 ]. Thus, the potential for misclassification bias is minimized. …

Data Resource Profile: The Cancer Public Library Database in South Korea.

This paper provides a comprehensive overview of the Cancer Public Library Database (CPLD), established under the Korean Clinical Data Utilization for Research Excellence project (K-CURE). The CPLD links data from four major population-based public sources: the Korea National Cancer Incidence Database in the Korea Central Cancer Registry, cause-of-death data in Statistics Korea, the National Health Information Database in the National Health Insurance Service, and the National Health Insurance Research Database in the Health Insurance Review & Assessment Service. These databases are linked usin

Immunomodulatory drugs in multiple myeloma: Impact of the SCARMET (Self CARe and MEdication Toxicity) educational intervention on outpatients' knowledge to manage adverse effects.

Long-term multiple myeloma therapy by immunomodulatory drugs (IMiDs) raises the question of management of adverse effects. The aim of this study is to assess the impact of an educational session for patients on the acquisition of knowledge to manage hematologic and thromboembolic adverse effects of IMiDs. In this prospective single-center study, patients attended an educational session with a hospital clinical pharmacist and a nurse. The primary endpoint was the patient's level of knowledge for the management of IMiDs adverse effects, assess with a dedicated questionnaire administered before t

The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer.

BackgroundFatigue is a prevalent and complex condition with significant impacts on well-being. Existing fatigue assessments often lack comprehensiveness or practicality for general population studies.MethodsThis study validated the REST Questionnaire, a novel fatigue assessment tool, in a sample of 268 adults. Psychometric properties, including internal consistency and construct validity, were evaluated. REST scores were correlated with WHO-5 well-being, BMI, self-rated health, and chronic conditions. Exploratory factor analysis identified underlying dimensions of fatigue.ResultsThe REST Quest

Baseline Characteristics of Participants in the Alberta Cancer Exercise Hybrid Effectiveness-Implementation Study: A Wake-Up Call for Action.

Background: Alberta Cancer Exercise (ACE) is a hybrid effectiveness-implementation study evaluating a cancer-specific community-based exercise program across urban sites in Alberta, Canada. The purpose of this paper is to describe the baseline characteristics of participants. Methods: Adults with any type and stage of cancer, who were undergoing cancer treatment or up to three years post treatment completion, were eligible. ACE was delivered in person at 18 sites across 7 cities in Alberta, with video conferencing introduced during the COVID-19 pandemic. Participants took part in 60 min of mil

Surveillance of the current situation regarding influenza vaccination according to medical oncologists in Japan.

This study aimed to clarify the attitude of oncologists toward influenza vaccination and the current situation and issues regarding influenza vaccination for patients on chemotherapy in Japan. A web-based survey of medical oncologists certified by the Japanese Society of Medical Oncology was conducted between November 1 and December 31, 2019. Of the 1369 medical oncologists who were invited to participate, 415 (30.3%) responded to our survey. The questionnaire comprised 4 sections: "oncologist characteristics," "oncologist attitude toward influenza vaccines and the current status of influenza

The impact of comorbid disease history on all-cause and cancer-specific mortality in myeloid leukemia and myeloma - a Swedish population-based study.

BackgroundComorbidity increases overall mortality in patients diagnosed with hematological malignancies. The impact of comorbidity on cancer-specific mortality, taking competing risks into account, has not been evaluated.MethodsUsing the Swedish Cancer Register, we identified patients aged >18 years with a first diagnosis of acute myeloid leukemia (AML, N = 2,550), chronic myeloid leukemia (CML, N = 1,000) or myeloma (N = 4,584) 2002-2009. Comorbid disease history was assessed through in- and out-patient care as defined in the Charlson comorbidity index. Mortality rate ratios (MRR) were estima

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… Johansson LA Westerling R Comparing Swedish hospital discharge records with death certificates: implications for mortality statistics Int J Epidemiol 2000 29 3 495 502 10.1093/ije/29.3.495 10869322 31. … Johansson LA Bjorkenstam C Westerling R Unexplained differences between hospital and mortality data indicated mistakes in death certification: an investigation of 1,094 deaths in Sweden during 1995 J Clin Epidemiol 2009 62 11 1202 9 10.1016/j.jclinepi.2009.01.010 19364635 33. …

Hospital Use, Morbidity, and Cancer Risk by Age Group in Neurofibromatosis Type 1: A Nationwide Retrospective Cohort Study.

Neurofibromatosis type 1 (NF1) affects multiple organs progressively, leading to a shortened life expectancy. This study aimed to identify the complications that are prominent in each age group by comparing 28,082 patients with NF1 and 84,246 matched controls. Benign and malignant neoplasms along with neurological complications were the primary contributors to hospital use across most age groups. Respiratory and circulatory disorders were a common cause of hospital use in children and older adults, respectively. Except for soft tissue and central nervous system-originated malignancies, which a

Качество жизни, связанное со здоровьем COVID-19 Пандемия о людях, страдающих множественным склерозом, и население в целом: сравнительное исследование с использованием EQ-5D-5L с психосоциальным Болтом-Оном.

ЦЕЛИ: Исследования показали, что люди, живущие с множественным склерозом (PwMS), были серьезно затронуты COVID-19 Пандемия. Однако ни одно из исследований не сравнило общее качество жизни, связанное со здоровьем населения COVID-19 :: пандемическое воздействие на население и население в целом. Различия будут иметь последствия для политики регулирования кризисов/пандемий. Цель этого исследования заключалась в сопоставлении показателей распространенности и качества жизни, связанных со здоровьем населения COVID-19-related Неблагоприятные условия (такие, как ухудшение психического или физического з

Trends in mortality from infection among patients with hematologic malignancies: differences according to hematologic malignancy subtype.

BackgroundInfection is the most important cause of non-relapse mortality in hematologic malignancy patients, leading to increased costs and prolonged hospitalization times. However, comprehensive and comparable reports on infection-specific mortality (ISM) trends in hematologic malignancy patients are lacking.ObjectivesWe aimed to provide updated ISM trends and factors associated with ISM among hematologic malignancy patients.DesignThis is a retrospective study.MethodsPatients diagnosed with the five most common hematologic malignancies from 1983 to 2016 from the Surveillance, Epidemiology, an

A longitudinal evaluation of health-related quality of life in patients with AL amyloidosis: associations with health outcomes over time.

Light chain (AL) amyloidosis is a rare disease associated with significant, irreversible organ dysfunction and high case fatality. An observational study was conducted to assess health-related quality of life (HRQoL) in patients treated for AL amyloidosis between 1994 and 2014 with both high dose melphalan and stem cell transplantation (HDM/SCT) or non-SCT chemotherapy regimens. The SF-36v1® Health Survey (SF-36) was administered to assess HRQoL during clinic visits. Analysis of variance was used to compare pre- and post-treatment HRQoL within each treatment group to an age- and gender-adjuste

Preferred and actual place of death in haematological malignancy.

OBJECTIVES: Home is considered the preferred place of death for many, but patients with haematological malignancies (leukaemias, lymphomas and myeloma) die in hospital more often than those with other cancers and the reasons for this are not wholly understood. We examined preferred and actual place of death among people with these diseases. METHODS: The study is embedded within an established population-based cohort of patients with haematological malignancies. All patients diagnosed at two of the largest hospitals in the study area between May 2005 and April 2008 with acute myeloid leukaemia

Hepatocellular Carcinoma associated with Extra-hepatic Primary Malignancy: its Secular change, Clinical Manifestations and Survival.

Clinical manifestations between hepatocellular carcinoma (HCC) and extra-hepatic primary malignancy (EHPM) are lack of large-scale study. We enrolled 14555 HCC patients between 1986 and 2013 retrospectively. The EHPM was classified as prior, synchronous and metachronous group based on before, within and after 6 months of HCC diagnosis, respectively. The incidence rate of EHPM is 3.91% (95% confidence interval [CI]: 3.60-4.23%). Urogenital cancers, kidney and bladder, were at unexpected higher ranks. Older in age, Child-Pugh A cirrhosis, negativity of HBsAg and anti-HCV, and earlier BCLC stagin

Perceived benefits and barriers to exercise for recently treated patients with multiple myeloma: a qualitative study.

BACKGROUND: Understanding the physical activity experiences of patients with multiple myeloma (MM) is essential to inform the development of evidence-based interventions and to quantify the benefits of physical activity. The aim of this study was to gain an in-depth understanding of the physical activity experiences and perceived benefits and barriers to physical activity for patients with MM. METHODS: This was a qualitative study that used a grounded theory approach. Semi-structured interviews were conducted in Victoria, Australia by telephone from December 2011-February 2012 with patients w

Декриминативный анализ пациентов, прошедших лечение с дирошимелем Фумаратом и диметилом Фумаратом - опыт реальной жизни.

КОЛИЧЕСТВО: Диметилфумарат (ДМФ) и дироксимель фумарат (ДФФ) являются двумя видами лечения, используемыми для лечения множественных склерозов (МС), которые доказали свою эффективность в деле контроля за пациентами, страдающими НР. DRF был внедрен в 2019 году с целью снижения побочного эффекта желудочно-кишечного кишечника, вызванного ДМФ. Данные, представленные в ходе клинических испытаний, проверяются лишь в нескольких исследованиях реальной жизни. МЕТОДЫ: Было проведено ретроспективное описательное исследование по пациентам-психологам в больнице Торрекарденас, которая проходит лечение с помо

Association between platelet-white cell ratio and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective cohort study.

BACKGROUND: Atrial fibrillation is common in intensive care units and portends poor prognosis. The platelet-to-white blood cell ratio is an emerging inflammatory-coagulatory biomarker with prognostic value in cardiovascular diseases. This study examines the association between platelet-white cell ratio (PWR) and all-cause mortality in this high-risk population. METHODS: In this retrospective cohort study, clinical data were obtained from the MIMIC-IV database. We included adult intensive care unit (ICU) patients with a diagnosis of atrial fibrillation. The PWR was evaluated as the primary expo

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… Author Cui passed the online training courses and exams (certification number: 59921922). The modular structure of MIMIC-IV, which supports linkage with external data, enabled the evaluation of out-of-hospital mortality. Study population Figure 1 delineates the patient selection process. … Author Cui passed the online training courses and exams (certification number: 59921922). This study was conducted in accordance with the Helsinki Declaration. All authors have read and approved the final manuscript. …

Strategies for promoting exercise adherence within a cancer exercise recovery program: a qualitative case study.

BACKGROUND: Physical activity (PA) plays an important role in physical health and well-being for cancer survivors. However, cancer survivors demonstrate low adherence to cancer PA guidelines. Research is needed to understand how to optimize delivery of cancer PA programs to enhance participation and adherence. In this study, we conducted an instrumental qualitative case study of a clinical cancer exercise recovery program (CERP) demonstrating high adherence (over 90% session completion), with the goal of understanding implementation strategies that patients link to higher program adherence. ME

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… The intervention is supervised by a trainer (exercise physiologist or technician with oncology certification through the American College of Sports Medicine). One trainer is assigned to a maximum of two patients per one-hour session, with sessions occurring two to three times per week. … For example, CERP exercise physiologists receive American College of Sports Medicine certification in cancer and exercise training. …

Trends in early-onset cancer incidence rates in the Nordic countries (2003-2022): a population-based study.

BACKGROUND: Increasing incidence rates of early-onset cancer at ages 20-49 years have been reported in several countries, especially for colorectal, kidney and breast cancer. We examined recent incidence trends of early-onset cancer in Denmark, Finland, Iceland, Norway, Sweden, Greenland, and the Faroe Islands across 18 major cancer sites and compared to trends at ages 50-84 years. METHODS: We utilised the NORDCAN database comprising incident cancer cases among individuals aged 20-84 years during 2003-2022. Age-standardised (Nordic population 2000) incidence rates (ASR) per 100,000 person-year

Estimating the shares of the value of branded pharmaceuticals accruing to manufacturers and to patients served by health systems.

Previous studies have estimated that patients served by health systems accrue 59-98% of the value generated by new pharmaceuticals. This has led to questions about whether sufficient returns accrue to manufacturers to incentivize socially optimal levels of R&D. These studies have not, however, fully reflected the health opportunity costs imposed by payments for branded pharmaceuticals. We present a framework for estimating how the value generated by new branded pharmaceuticals is shared. We quantify value in net health effects and account for benefits and health opportunity costs in the patent