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Арбовирусные исследования в Луанде, Ангола. 2. Вирологические и серологические исследования во время вспышки заболевания, похожего на денге, вызванного вирусом Чикунгунья.

В конце 1970 года и начале 1971 года в Луанде, Ангола, была отмечена вспышка заболевания, похожего на денге. Вирус Чикунгунья был изолирован от крови пациента с типичными симптомами денге и из бассейна комаров эгипти Эйдеса. Обследование, проведенное с целью выявления антител к арбовирусам в сере людей, проживающих в Луанде, показало, что причиной этой вспышки действительно является вирус Чикунгунья. Тот факт, что эта вспышка непосредственно предшествовала эпидемии желтой лихорадки в Луанде и продолжалась одновременно с ней, свидетельствует о том, что два арбовируса из различных антигенных гру

Совпадение в аннотации оригинала
An outbreak of dengue-like disease was observed in Luanda, Angola, at the end of 1970 and beginning of 1971. Chikungunya virus was isolated from the blood of a patient with typical symptoms of dengue and from a pool of Aedes aegypti mosquitos. A survey for antibodies to arboviruses in the sera of persons living in Luanda showed that the Chikungunya virus was…

Acute-on-Chronic Liver Failure in a 13-Year-Old Patient With Wilson's Disease Due to Dengue Virus Infection: A Case Report.

Acute-on-chronic liver failure (ACLF) is characterized by acute hepatic decompensation in patients with chronic liver disease and is a clinical syndrome associated with high short-term mortality. Most commonly, the underlying cause of chronic liver disease is known prior to the acute decompensation, which is precipitated by another factor. We present the case of a 13-year-old male with previously undiagnosed Wilson's disease (WD) who developed rapidly progressive ACLF precipitated by dengue virus infection, culminating in multiorgan failure and death. This case highlights the diagnostic challe…

Clinical profile and predictors of adverse outcomes in pediatric dengue fever presenting with febrile illness: a prospective observational study in Burao, Somaliland.

BACKGROUND: Dengue fever is a growing public health concern globally, and there is limited pediatric-focused data available in Somaliland. This study aimed to prospectively characterize the clinical profile and identify predictors of adverse outcomes among children presenting with febrile illness, suspected of dengue, in Burao, Somaliland. METHODS: This prospective observational study was conducted between September 2025 and April 2026 in pediatric outpatient and inpatient departments of hospitals in Burao. Children aged 0-18 years with acute febrile illness were consecutively enrolled. Clini…

Dengue-Associated Encephalopathy With Multiple Cranial Neuropathies and Multisystem Involvement in a Patient With Epilepsy: A Comprehensive Case Report With Longitudinal Multimodality Imaging.

Dengue fever is a common arboviral infection in tropical and subtropical regions. Neurological involvement is uncommon but increasingly recognized, and may mimic stroke, post-ictal deficits, thrombotic thrombocytopenic purpura, or sepsis-associated encephalopathy. We report a 45-year-old Lebanese woman with epilepsy who presented after a short febrile illness with dysuria initially treated as a urinary tract infection. She was later found in a post-ictal state with frothy oral secretions and urinary incontinence, febrile to 40°C and hypotensive to 70/50 mmHg. Neurological examination revealed …

Application of a Temporal Fusion Transformer and Long-Term Climate and Disease Data to Assess the Predictive Power and Understand the Drivers for Malaria and Dengue.

Vector-borne diseases are strongly influenced by climate, yet the magnitude and temporal variability of climate-disease relationships remain poorly quantified. Outbreaks occur abruptly, and responses are typically delayed, underscoring the need for predictive tools that can support proactive interventions. This study applies Temporal Fusion Transformers (TFTs) to long-term, high-resolution climate datasets and to weekly malaria and dengue case records from South Africa and Vietnam to assess predictive performance and identify key environmental drivers. The models incorporated diverse climatic …

Hemophagocytic Lymphohystiocytosis in a Patient With Suspected Acute Myeloid Leukemia and Recent Viral Illness Compatible With Dengue: A Case Report and Literature Review.

BACKGROUND: Hemophagocytic lymphohistiocytosis, or HLH, is a very rare and aggressive disorder of the immune system, for which the trigger may be an infection, malignancy, or autoimmune disease. It has predominantly been described as triggered by T/NK lymphomas, but acute myeloid leukemia-induced HLH is a very rare occurrence. Viral infections like dengue fever may act as potential triggering factors. CASE PRESENTATION: A 24-year-old male developed persistent high fever, weakness, and pancytopenia a few days after recovery following a recent febrile illness clinically compatible with dengue i…

A descriptive assessment of mitochondrial COI genetic diversity and dengue and chikungunya RNA detection in Aedes aegypti across eight provinces in Thailand.

BACKGROUND: Aedes aegypti is the principal vector of several medically important arboviruses, including dengue virus (DENV) and chikungunya virus (CHIKV), both of which remain endemic in Thailand. However, studies on arbovirus surveillance and mitochondrial genetic diversity of Ae. aegypti populations across broad geographic scales remain limited. This study aimed to assess the detection of DENV and CHIKV and characterize the mitochondrial genetic diversity of Ae. aegypti across multiple regions of Thailand. METHODS: A total of 303 adult Ae. aegypti mosquitoes collected from eight provinces a…

Strengthening public understanding and prevention of dengue in Malaysia: insights and recommendations based on knowledge, attitudes, and practices toward vector control and vaccination.

OBJECTIVES: Malaysia continues to experience a high dengue burden, despite long-standing national education and control efforts. This study aimed to examine public Knowledge, Attitudes, and Practices related to dengue prevention, with a focus on informing more targeted education, vector control, and vaccination strategies. METHODS: This study analysed Malaysia-specific data from the publication Knowledge, Attitudes and Practices toward Dengue Fever, Vector Control, and Vaccine Acceptance Among the General Population in Countries from Latin America and Asia-Pacific: A Cross-Sectional Study (Gr…

Study of the circulation of dengue, yellow fever, and West Nile viruses in Guinea: implications for achieving the health objectives of the Simandou 2040 program.

BACKGROUND: Diseases such as dengue, yellow fever and West Nile virus, which are transmitted by arthropods, pose public health problems in tropical and subtropical regions. Like many West African countries, Guinea possesses all the conditions conducive to the circulation of these viruses. These include local ecology and climate, as well as the presence of vectors that transmit these viruses. Despite their medical importance, these viruses have received limited study, and up-to-date information on their circulation remains scarce. In this context, the present study examined the prevalence of th…

Diagnosis and Management of Dengue Fever in a Nonendemic Country: Lessons From an Acute Febrile Illness in Iran During the COVID-19 Outbreak.

Dengue fever is a tropical arboviral disease that presents with a broad spectrum of clinical manifestations and can occasionally emerge in nonendemic regions due to factors such as international travel. This case report details a 47-year-old Iranian man who had recently returned from Jakarta, Indonesia, presenting with fever, diarrhea, vomiting, and myalgia during the COVID-19 outbreak. Despite initial misdiagnoses, dengue fever was confirmed through polymerase chain reaction (PCR) testing. Moreover, the serological analysis using enzyme-linked immunosorbent assay (ELISA) further demonstrated …

Identification and computational analysis of conserved YXXΦ motifs in the pan-serotypes of dengue virus NS5 protein and their implications in host-virus interactions.

Dengue is a major global health challenge, caused by the dengue virus (DENV) and transmitted through the Aedes aegypti mosquito. The four DENV serotypes (DENV1-4) infect about 400 million people annually. The non-structural protein 5 (NS5) is the most conserved DENV protein, crucial for viral replication. This study aims to elucidate the replication and pathogenesis mechanisms of DENV by targeting tyrosine-based motifs and YXXΦ-like tetrapeptides in the NS5 protein across all serotypes. We employed computational tools to identify and analyze tyrosine-based motifs (TM) and YXXΦ-like tetrapeptid…

Integrated rapid risk assessment for dengue fever in settings with limited diagnostic capacity and uncertain exposure: Development of a methodological framework for Tanzania.

BACKGROUND: Dengue fever is one of the world's most important re-emerging but neglected infectious diseases. We aimed to develop and evaluate an integrated risk assessment framework to enhance early detection and risk assessment of potential dengue outbreaks in settings with limited routine surveillance and diagnostic capacity. METHODS: Our risk assessment framework utilizes the combination of various methodological components: We first focused on (I) identifying relevant clinical signals based on a case definition for suspected dengue, (II) refining the signal for potential dengue diagnosis …

Exploring community willingness and barriers to digital solutions and training for dengue prevention: a cross-sectional study in major urban areas of Malaysia.

BACKGROUND: Dengue fever is a significant public health concern in urban Malaysia, driven by high population density and rapid urbanization. Effective prevention requires community engagement in both digital and training-based interventions. This study aims to evaluate the sociodemographic and perception-based factors associated with the willingness to adopt a dengue prevention application and participate in dengue prevention training programs in major urban areas of Malaysia. METHODS: A cross-sectional study was conducted from February to May 2024 in four major urban areas of Malaysia; Selan…

Knowledge, Attitudes, Practices and Perceptions of the Eco-Bio-Social Determinants of Dengue Transmission in São Paulo, Brazil: A Mixed-Methods Study.

INTRODUCTION: Dengue is a mosquito-borne disease prevalent in Latin America and the Caribbean. Transmission is determined by ecological, biological and social (eco-bio-social) factors. Understanding the knowledge, attitudes, practices and perceptions of dengue's eco-bio-social factors among at-risk populations is essential for dengue prevention. We used the Ecohealth approach to investigate the socioeconomic and demographic factors associated with dengue knowledge, attitudes, practices and perceptions among residents of São Paulo. METHODS: We conducted a concurrent nested mixed-methods study …

Temporal and spatial dynamics of dengue fever in mainland China from 2004 to 2020 and the impact of COVID-19 public health interventions.

BACKGROUND: Dengue fever (DF), a mosquito-borne viral disease, presents critical public health issues worldwide, especially in tropical and subtropical areas. This study analyzed temporal and spatial patterns of DF in mainland China from 2004 to 2020 and evaluated the association between COVID-19-related public health interventions and DF incidence. METHODS: The dataset was sourced from China's Public Health Science Data Center. Joinpoint regression identified changes in incidence and mortality rates. Local Indicators of Spatial Association identified high-incidence clusters. To forecast DF i…

A Cross-Sectional Study on Bedside Abdominal Ultrasound Findings as a Diagnostic and Prognostic Tool in Dengue Fever in Manipal Hospital, Bengaluru, India.

Background Dengue fever poses a significant health burden globally, particularly in tropical and subtropical regions. Early diagnosis and effective management are crucial in reducing morbidity and mortality associated with the disease. Bedside abdominal ultrasound has emerged as a promising tool for assessing dengue patients, providing real-time imaging of abdominal organs, and aiding clinical decision-making. Materials and methods This cross-sectional study was conducted in 55 adult emergency departments of Manipal Hospital, Bengaluru, from March 2017 to March 2018. Adult patients presenting …

Clinical Picture and Risk Factors for Severity of SARS-CoV-2 and Dengue Coinfection in Children: Experience From a Tertiary Hospital in Vietnam.

Introduction Dengue is an infectious disease that is a burden in Asia-Pacific and Latin America. The COVID-19 pandemic in dengue-endemic areas has caused a "double burden" because of the possibility of coinfection, especially in children who are vulnerable to both COVID-19 and dengue. This study aimed to describe the characteristics and identify risk factors for the severity of the coinfection in Vietnamese children. Methods This was a retrospective cohort study, undertaken at Children's Hospital 1 (Ho Chi Minh City, Vietnam) during the fourth wave of the COVID-19 pandemic. All children under …

Enabling countries to manage outbreaks: statistical, operational, and contextual analysis of the early warning and response system (EWARS-csd) for dengue outbreaks.

INTRODUCTION: Dengue is currently the fastest-spreading mosquito-borne viral illness in the world, with over half of the world's population living in areas at risk of dengue. As dengue continues to spread and become more of a health burden, it is essential to have tools that can predict when and where outbreaks might occur to better prepare vector control operations and communities' responses. One such predictive tool, the Early Warning and Response System for climate-sensitive diseases (EWARS-csd), primarily uses climatic data to alert health systems of outbreaks weeks before they occur. EWAR…

Investigating the Association Between ABO Blood Groups and Rhesus Factors with Dengue and Chikungunya Virus Infections During the 2017 Outbreak in Bangladesh.

This retrospective study was conducted in 2017 during the dual dengue and chikungunya outbreak in Bangladesh. Febrile participants underwent blood tests for chikungunya, dengue, and ABO groups and rhesus (Rh) factors. Blood grouping information was gathered from healthy donors. Males and those aged between 18 and 49 years had a higher risk of contracting dengue and chikungunya. Blood group O exhibited the highest infection rates at ∼50%, whereas group AB had the lowest at ∼9% among the participants in the study. Yet, when considering the general population's blood group distribution, the combi…

First-in-human trial evaluating safety and pharmacokinetics of AT-752, a novel nucleotide prodrug with pan-serotype activity against dengue virus.

AT-752 is a novel guanosine nucleotide prodrug inhibitor of the dengue virus (DENV) polymerase with sub-micromolar, pan-serotype antiviral activity. This phase 1, double-blind, placebo-controlled, first-in-human study evaluated the safety, tolerability, and pharmacokinetics of ascending single and multiple oral doses of AT-752 in healthy subjects. AT-752 was well tolerated when administered as a single dose up to 1,500 mg or when administered as multiple doses up to 750 mg three times daily (TID). No serious adverse events occurred, and the majority of treatment-emergent adverse events were mi…