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Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme?

Most malignant brain tumours contain various numbers of cells with characteristics of activated or dysmorphic macrophages/microglia. These cells are generally considered part of the tumour stroma and are often described as TAM (tumour-associated macrophages). These types of cells are thought to either enhance or inhibit brain tumour progression. Recent evidence indicates that neoplastic cells with macrophage characteristics are found in numerous metastatic cancers of non-CNS (central nervous system) origin. Evidence is presented here suggesting that subpopulations of cells within human gliomas

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… Neuro Oncol 2010 12 49 57 20150367 10.1093/neuonc/nop007 PMC2940562 Coopman PJ Do MT Thompson EW Mueller SC Phagocytosis of cross-linked gelatin matrix by human breast carcinoma cells correlates with their invasive capacity. …

Пространственное картирование оси AA-PGE2-EP при множественных повреждениях склероза.

Биоактивные липидные посредники (ДМ), получаемые из полиненасыщенных жирных кислот (ПУФА), являются ключевыми молекулами как инициирования, так и разрешения подстрекательских реакций. Предыдущие выводы свидетельствуют о том, что дисрегулируемый баланс LM, особенно в рамках арахидонической кислоты (АА), может способствовать реакции на нарушение разрешения и последующей хронической нейроинфламмации при множественном склерозе (МС). Однако на сегодняшний день местный биосинтез и сигнализация ММ в мозге людей с MS (PwMS) остаются неисследованными. Поэтому в этом исследовании мы впервые наметили рас

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… To obtain mature microglia, the harvested myeloid precursor cells were plated in plates coated with 0.01 g/ml poly-D-lysine (Sigma, Saint Louis, MI, USA) and 0.01% gelatin type B (Sigma, Saint Louis, MI, USA) and cultured for 2 weeks in Advanced DMEM/F12 (Invitrogen, Waltham, MA, USA) supplemented with …

From Nanoparticles to Cancer Nanomedicine: Old Problems with New Solutions.

Anticancer nanomedicines have been studied over 30 years, but fewer than 10 formulations have been approved for clinical therapy today. Despite abundant options of anticancer drugs, it remains challenging to have agents specifically target cancer cells while reducing collateral toxicity to healthy tissue. Nanocompartments that can be selective toward points deeply within malignant tissues are a promising concept, but the heterogeneity of tumor tissue, inefficiency of cargo loading and releasing, and low uniformity of manufacture required from preclinical to commercialization are major obstacle

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… Polymeric and Dendrimer Nanoparticles Polymeric nanoparticles (PNPs) are structures with a diameter ranging from 10 to 100 nm, which was made from synthetic polymers (e.g., polycaprolactone and polyacrylate) or natural polymers (e.g., albumin, chitosan, and gelatin) [ 60 , 61 ]. …

Выдержка гемпта (Extractum Cannabis) в деле " Лечение кишечных расстройств и диспепсии: исторические сведения из Барселоны, Испания " .

В этом исследовании изучается траектория интереса и использования экстракта каннабиса (выдержка канабиса сативы L.) для симптоматического лечения легких желудочно-кишечных расстройств и диспепсии в Барселоне XIX и начала XX века (Каталония, Испания) 1939, на основе обзора первичных источников. Цель настоящего документа заключается в том, чтобы представить исторический фармацевтический и прикладный обзор использования гематома (Cannabis L.) в медицинских целях до его запрещения, способствуя тем самым его признанию в качестве медицинского продукта. Представленная информация свидетельствует об ис

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… Local pharmacists also embraced the technology, like Ramón Sol Roigé who patented in 1894 [ 225 ] and 1902 [ 226 ] processes for gelatine-coated “Pearl-Capsules of Indian hemp” [ 227 , 228 ]. Later on, targeted and multi-compound pills/tablets would appear ( Figure 1 a; Table 4 ) [ 229 , 230 ]. …

ESICM LIVES 2016: part two : Milan, Italy. 1–5 October 2016

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Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia.

Somatic mutations in hematopoietic stem/progenitor cells (HSPCs) can lead to clonal hematopoiesis of indeterminate potential (CHIP) and progression to myelodysplastic syndromes (MDS). Using single-cell and anatomical profiling of a large cohort of human bone marrow (BM), we show that the HSPC BM niche in CHIP and MDS is undergoing inflammatory remodeling. This includes loss of CXCL12⁺ adipogenic stromal cells and the emergence of a distinct population of inflammatory mesenchymal stromal cells (iMSCs), which arise in CHIP and become more prevalent in MDS. Functional studies in primary BM HSPC-M

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… For secretome and scRNA-seq analysis, MSCs were seeded at a density of 30,000 cells per well in gelatin-coated 12-well plates (Costar, Corning Incorporated) with 1 ml Myelocult H5100 medium (Stemcell Technologies) with 1 µM Hydroxycortisone (Sigma). … Additional control wells containing MSC mono-cultures and medium-only wells (Myelocult in gelatin-coated plates without cells) were included in each experiment. …

Stem cell revolution: bridging the gap between research and clinical application.

Stem cells are characterized by their capacity for self-renewal and their potential for multi-directional differentiation, enabling them to develop into various functional tissues and organs under specific conditions. Their applications hold considerable promise, and the market for stem cell products is progressively expanding. Internationally, several stem cell products have received approval for market release; however, in China, the field remains largely undeveloped, presenting substantial opportunities for growth. Recent years have witnessed significant advancements in stem cell research,

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… Human Mesenchymal Stem Cells on Size-Sorted Gelatin Hydrogel Microparticles Show Enhanced In Vitro Wound Healing Activities. Gels 2024, 10. 90. Shanehband N, Naghib SM. Microfluidics-assisted tumor cell separation approaches for clinical applications: an overview on emerging devices. …

Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration.

Bone regeneration is a complex biological process that relies on the orchestrated interplay of various cellular and molecular events. Bone tissue engineering is currently the most promising method for treating bone regeneration. However, the immunogenicity, stable and cell quantity of seed cells limited their application. Recently, exosomes, which are small extracellular vesicles released by cells, have been found to effectively address these problems and better induce bone regeneration. Meanwhile, a growing line of research has shown the cargos of exosomes may provide effective therapeutic an

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… Ashwin B, Abinaya B, Prasith TP, et al. 3D-poly (lactic acid) scafolds coated with gelatin and mucic acid for bone tissue engineering. Int J Biol Macromol. 2020;162:523–32. 142. Zhang Y, Huo M, Wang Y, et al. …

New insight into adiponectin role in obesity and obesity-related diseases.

Obesity is a major health problem strongly increasing the risk for various severe related complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders, diabetic retinopathy, and cancer. Adipose tissue is an endocrine organ that produces biologically active molecules defined "adipocytokines," protein hormones with pleiotropic functions involved in the regulation of energy metabolism as well as in appetite, insulin sensitivity, inflammation, atherosclerosis, cell proliferation, and so forth. In obesity, fat accumulation causes dysregulation of adipokine production tha

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… adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1) Biochemical and Biophysical Research Communications 1996 221 2 286 289 2-s2.0-0029980285 8619847 10.1006/bbrc.1996.0587 23 Nakano Y Tobe T Choi-Miura N Mazda T Tomita M Isolation and characterization of GBP28, a novel gelatin-binding …

Modeling the Bone Marrow Niche in Multiple Myeloma: From 2D Cultures to 3D Systems.

Multiple myeloma is a hematologic malignancy characterized by the clonal proliferation of plasma cells within the bone marrow. The tumor microenvironment plays a crucial role in multiple myeloma pathogenesis, progression, and drug resistance. Traditional two-dimensional cell culture models have been instrumental in multiple myeloma research. However, they fail to recapitulate the complex in vivo bone marrow microenvironment, leading to limited predictive value for clinical outcomes. Three-dimensional cell culture models emerged as more physiologically relevant systems, offering enhanced insigh

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… This dynamic 3D culture method involves the use of gelatin-based scaffolds pre-seeded with human bone marrow stromal cells (HS-5) and subsequently populated with tumor cells (MEC-1 for CLL, MM.1S for MM). …

Новые тенденции в нанобиосистемах Змей-Веном-Лоадед: всеобъемлющий обзор.

Достижения в медицинской нанобиотехнологии в значительной степени способствовали применению ядов змеиных токсинов, облегчая разработку новых методов лечения токсинов, производимых животными. Огромное разнообразие видов змей и их ядовые сложности подчеркивают необходимость продолжения исследований. Этот обзор посвящен изучению интеграции яда змеиных ядов с наночастицами, с тем чтобы они могли использоваться в лечении человека в целях разработки методов лечения. Сложная смесь яда змей не только вызывает значительные патологические последствия, но и позволяет получить ценные знания для создания н

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… Nanosystems Containing Crotalus Snake Venom Chitosan nanoparticles were developed by Glaucia-Silva et al. [ 103 ] through an ionic gelatinization method containing Crotalus durissus cascavella crude snake venom capable of inducing murine immunization, incorporating auxiliary components to enhance the …

Rediscovering hemostasis abnormalities in multiple myeloma: The new era.

Multiple myeloma (MM) is a malignancy arisen from the abnormal proliferation of clonal plasma cells. It has a high risk of developing bleeding and thrombotic complications, which are related to poor prognosis and decreased survival. Multiple factors are involved in the breaking of the hemostasis balance, including disease specific factors, patient-specific factors, and drug factors that change pro-and anticoagulant and fibrinolysis. Recently, with the introduction of new treatments such as monoclonal antibodies, chimeric antigen receptor modified T-cell therapy, antibody-drug conjugates direct

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… They also reduce the lateral gathered to form gelatinous fragile clots, resulting in bleeding [ 27 , 28 ]. Mechanisms of thrombosis in MM Patients with MM are at a higher risk of thromboembolism than bleeding, which is a common cause of death for MM [ 6 ]. Thrombosis mainly includes VTE and ATE. …

Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions.

As the backbone of oncological treatments, systemic chemotherapy is still one of the main pawns in cancer care, alone or in combination with newer targeted agents. All chemotherapy agents can be associated with a type of adverse event called an infusion reaction, which can be characterized as unpredictable, non-dose related, and unexplained by the cytotoxic profile of the drug. For some of these events, a certain immunological mechanism can be identified by blood or skin testing. In this case, we can speak of true hypersensitivity reactions that occur as a response to an antigen/allergen. The

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… Intraoperative Anaphylaxis Following Injection of a Bleomycin-Gelatin Solution for Sclerotherapy J. Med. Cases 2022 13 159 10.14740/jmc3906 35464330 PMC8993446 86. Sung Y.-Y. Kim S.-H. Yang W.-K. Park Y.-C. Kim H.K. …

Craniovertebral Junction Instability after Oncological Resection: A Narrative Review.

The craniovertebral junction (CVJ) is a complex transition area between the skull and cervical spine. Pathologies such as chordoma, chondrosarcoma and aneurysmal bone cysts may be encountered in this anatomical area and may predispose individuals to joint instability. An adequate clinical and radiological assessment is mandatory to predict any postoperative instability and the need for fixation. There is no common consensus on the need for, timing and setting of craniovertebral fixation techniques after a craniovertebral oncological surgery. The aim of the present review is to summarize the an

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… Chordomas present as firm, pinkish gray, gelatinous masses composed of a myxoid matrix containing necrotic and hemorrhagic areas, calcifications and sequestered bone fragments. Intrinsic tumor vascularity is usually not pronounced. …

Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects.

Angiogenesis and metastasis represent two challenging targets to combat cancer development in the later stages of its progression. Numerous studies have indicated the important role of natural products in blocking tumor angiogenesis signaling pathways in several advanced tumors. In recent years, the marine polysaccharides fucoidans emerged as promising anticancer compounds showing potent antitumor activity in both in vitro and in vivo models of different types of cancers. The objective of this review is to focus on the antiangiogenic and antimetastatic activities of fucoidans with special emph

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… A Fucoidan-Gelatin Wound Dressing Accelerates Wound Healing by Enhancing Antibacterial and Anti-Inflammatory Activities. Int. J. Biol. Macromol. 2022;223:36–48. doi: 10.1016/j.ijbiomac.2022.10.255. 21. Bae H., Lee J.-Y., Yang C., Song G., Lim W. …

Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery.

Biochemical components of essential oils (EOs) are an innovative but largely underexplored type of precision phytotherapy (PT) in oncology owing to their anticancer activity against many types of tumors. This article discusses the important multitargeted molecular mechanisms of EOs (apoptosis, cell cycle arrest, angiogenesis, metastasis, tumor microenvironment) and their role as antitumor agents. In particular, an effort has been made to emphasize on the most notable volatile EOs such as thymol, eugenol, limonene, β-caryophyllene, and their interaction with oncogenic signaling pathways (NF-κB,

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… Increased MMP depolarization (34.5% loss); Increased cell death (19.2% at 1.0 mM); Reduced wound closure to 8.6% (vs. 65.7% control) | ( 120 ) Bitter almond | Water/oil/water (W/O/W) dual nanoemulsion | Bitter almond oil as hydrophobic phase in dual emulsion | Graphene oxide (GO) nanocarrier coated with gelatin-polyvinylpyrrolidone …

Abstracts from the 13th International Conference for Healthcare and Medical Students (ICHAMS).

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Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders.

Precision medicine has become a cornerstone in modern therapeutic strategies, with nucleic acid aptamers emerging as pivotal tools due to their unique properties. These oligonucleotide fragments, selected through the Systematic Evolution of Ligands by Exponential Enrichment process, exhibit high affinity and specificity toward their targets, such as DNA, RNA, proteins, and other biomolecules. Nucleic acid aptamers offer significant advantages over traditional therapeutic agents, including superior biological stability, minimal immunogenicity, and the capacity for universal chemical modificatio

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… In addition, gelatin methacryloyl (GelMA) hydrogel loaded with circular bispecific synovial-meniscal aptamers has been proven to be effective for avascular meniscus repair by recruiting endogenous synovial and meniscus cells and facilitating fibrocartilage regeneration (Fig. 4a ). …

Natural anti-cancer products: insights from herbal medicine.

Herbal medicine exhibits a broad spectrum of potent anti-cancer properties, including the enhancement of tumor immune responses, reversal of multidrug resistance, regulation of autophagy and ferroptosis, as well as anti-proliferative, pro-apoptotic, and anti-metastatic effects. This review systematically explores recent advances (primarily documented since 2019) in research on key anti-cancer compounds derived from herbal medicine, such as apigenin, artemisinin, berberine, curcumin, emodin, epigallocatechin gallate (EGCG), ginsenosides, icariin, resveratrol, silibinin, triptolide, and ursolic

Exploring the role of histone deacetylase and histone deacetylase inhibitors in the context of multiple myeloma: mechanisms, therapeutic implications, and future perspectives.

Histone deacetylase inhibitors (HDACis) are a significant category of pharmaceuticals that have developed in the past two decades to treat multiple myeloma. Four drugs in this category have received approval from the U.S. Food and Drug Administration (FDA) for use: Panobinonstat (though canceled by the FDA in 2022), Vorinostat, Belinostat and Romidepsin. The efficacy of this group of drugs is attributed to the disruption of many processes involved in tumor growth through the inhibition of histone deacetylase, and this mode of action leads to significant anti-multiple myeloma (MM) activity. In

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… 100%), lymphopenia (43%), neutropenia (29%), anemia (29%), nausea (29%), dehydration (29%), pneumonia (29%), diarrhea (14%), decreased appetite (14%), fatigue (14%), hypokalemia (14%) | [ 101 ] NCT01023308 | III | n = 768 | Panobinostat/ Bortezomib/ Dexamethasone/ Placebo | Panobinostat: 20 mg (hard gelatin …