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Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution.

Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or by acting as a ligandin. This review collects studies that propose GSTP1-1 as a useful biomarker in different fields of application. The most relevant studies are focused on GSTP1-1 as a biosensor to detect blood toxicity in patients affected by kidney diseases. In fact, this detoxifying enzyme is over-expressed in erythrocytes when unusual amo

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… Chemical structures were designed by the software ChemDraw Ultra v8 (PerkinElmer Informatics, Cambridge, MA, USA). 3. Usefulness of GSTP1-1 Enzymatic Activity in Some Pathological Conditions 3.1. …

Clinical Outcomes of Off-Pump Coronary Artery Bypass Grafting With and Without Posterior Pericardiotomy: Impact on Pleural and Pericardial Effusions.

BACKGROUND: Posterior pericardiotomy has been proposed to prevent postoperative pericardial effusion and tamponade in coronary artery bypass grafting, but its effect on pleural fluid accumulation during off-pump CABG (OPCAB) is not well defined. OBJECTIVE: To compare intraoperative metrics and early postoperative outcomes-particularly rates of pleural and pericardial effusions-between OPCAB with and without posterior pericardiotomy. METHODS: In this retrospective cohort, 68 patients underwent OPCAB from January to March 2025 and were stratified into pericardiotomy (n = 38) and control (n = 3

Laparoscopic Subtotal Cholecystectomy for Difficult Gallbladders: Single-Center Retrospective Cohort Study.

BACKGROUND: Operating on difficult cholecystectomy with the intent to proceed with total cholecystectomy can be associated with longer postoperative time, excessive bleeding, and increased risk of intraoperative bile duct injury and other complications. Subtotal cholecystectomy is a part of bail-out procedures recommended in cases of difficult cholecystectomy. It is a convenient alternative to total cholecystectomy as it is a comparatively more manageable and safer treatment procedure. OBJECTIVE: The aim of this study was to assess the difference in outcomes between laparoscopic total cholecy

Predictive Value of High-Sensitivity Troponin I for Left Ventricular Ejection Fraction in Patients with Non-ST-Elevation Myocardial Infarction.

BACKGROUND: According to the World Health Organization's 2021 statistics, cardiovascular diseases (CVDs), particularly coronary artery disease (CAD), remain among the leading causes of global morbidity and mortality, affecting both high-income and low-income countries like Vietnam. OBJECTIVE: Acute myocardial infarction (AMI) remains a major cause of mortality and cardiovascular complications, with a poor prognosis in patients with left ventricular systolic dysfunction (LVSD). High-sensitivity cardiac troponin I (hs-cTnI) is a specific biomarker of myocardial injury linked to infarct size and

Legal Liability for AI-Assisted Radiographic Diagnosis Errors: a Comparative Review of French, Jordanian, and UAE Law.

BACKGROUND: Artificial intelligence has become an important aspect in medicine, especially in radiology. OBJECTIVE: The aim of this article was to investigate the legal liability for AI-assisted radiographic diagnosis errors in view of French, Jordanian, and UAE Law. METHODS: The authors analyze medical liability in the U.A.E, France and Jordan, focusing on how errors in diagnosis are handled, and if artificial intelligence plays a role in the diagnosis. The researchers tested many jurisdictions for demonstrating wrong doing so nothing happens to the person. RESULTS: In the United Arab Emir

Legal Frameworks for AI-driven Diagnostics and Robotic Surgery.

BACKGROUND: As technological advancements grow, so does its impact. Humans are seeing more and more computerization, a lot of it is being used for surgery. Their merger results in various legal problems relating to regulation, patient safety, and governance. OBJECTIVES: The main objectives of this article are to study and join together legal rules and systems as it pertains to the use of artificial intelligence in medical situations for all main countries. METHODS: A narrative legal review was conducted to see what's been going on since 2010. Their sources were official documents like drug a

Physicians' Knowledge and Barriers to Opioid Prescribing for Cancer Pain At a Tertiary Hospital in the Eastern Province, Saudi Arabia: a Cross-sectional Study.

BACKGROUND: Cancer pain is common and often undertreated. Although opioids are effective when prescribed appropriately, clinical practice remains cautious and variable. OBJECTIVE: The aim of this study was to assess physicians' knowledge and identify barriers to opioid prescribing for cancer pain in a tertiary hospital in Saudi Arabia's Eastern Province. METHODS: A cross-sectional survey was conducted during March-April 2025 among physicians managing cancer pain. An anonymous REDCap questionnaire, adapted from Ayoub et al. (2022), collected data on demographics, practice patterns, guideline

IOL Power Calculation Formulas in Post-LASIK Eyes Using Two Biometry Systems in Vietnam.

BACKGROUND: Cataract surgery aims to restore clear vision by replacing the clouded crystalline lens with an intraocular lens (IOL). Accurate IOL power calculation is crucial to achieve desirable postoperative refractive outcomes. OBJECTIVE: The aim of this study was to compare the predictive accuracy of multiple intraocular lens (IOL) power calculation formulas in eyes with prior LASIK surgery using two biometric devices, LenStar 900 and IOLMaster 500, combined with immersion ultrasound (US). METHODS: This retrospective observational study included 37 eyes of 29 patients who underwent previo

MRI-Derived Radiomics For Classifying Breast Cancer Molecular Subtypes: a Modeling Approach.

BACKGROUND: Breast cancer is a biologically heterogeneous disease with four major molecular subtypes that determine prognosis and treatment strategies. MRI-based radiomics provides a non-invasive method to predict these subtypes by quantifying tumor heterogeneity. OBJECTIVE: To develop and validate a logistic-regression model using MRI-derived radiomic features to predict four molecular subtypes of invasive breast cancer: luminal A (LA), luminal B (LB), HER2-enriched (HER2), and triple-negative breast cancer (TNBC). METHODS: A retrospective cohort of 169 patients with histologically proven i

Access Site and Pacemaker Outcomes After TAVR in HFrEF Patients: Axillary vs Femoral Approach.

BACKGROUND: Aortic stenosis is a prevalent disease affecting approximately 10% of the population by the eighth decade, it is a fatal disease without treatment, with an annual mortality rate reaching 25%. Valve replacement, either through surgical or transcatheter approach, is the only therapeutic option. Over the last 15 years, the indications for transcatheter aortic valve replacement (TAVR) have spread to include young and low surgical risk patients. OBJECTIVE: Our study aims to address this gap in the literature by comparing the adverse outcome after TAVR through axillary versus femoral ac

Effectiveness of Interventional Pain Management on Disc Herniation Resorption: Radiological Evidence.

BACKGROUND: The purpose of this study is to evaluate the change in disc herniation over time, as assessed on MRI images, in those patients who are receiving epidural steroid injections. The concept of reduction in the size of the disc, in other words, spontaneous resorption/regression will be explored and whether it has any link with administration of epidural steroid injections. OBJECTIVE: The purpose of this study is to evaluate the change in disc herniation over time, as assessed on MRI images, in those patients who are receiving epidural steroid injections. The concept of reduction in the

Correlation Between Vitamin D and TSH Levels in Healthy Controls and Individuals with Hypothyroidism According to Age and Sex.

BACKGROUND: Elevated levels of circulating 25-hydroxyvitamin D (25 (OH) D) are correlated with reduced levels of circulating thyroid-stimulating hormone (TSH). OBJECTIVE: The aim of this study was to evaluate the relationship between vitamin D and circulating TSH levels based on sex and age, with a focus on thyroid autoimmunity and thyroid hormone levels. METHODS: Fifty samples were obtained from patients with hypothyroidism (Hashimoto's thyroiditis, HT) aged 18-59 years (49.4% men, 50.6% women). The samples were tested for serum vitamin D and TSH levels using the enzyme-linked immunosorbent

Laparoscopic Completion Cholecystectomy for Symptomatic Remnant Gallbladder Following Subtotal Cholecystectomy: a Report of Two Cases.

BACKGROUND: Subtotal cholecystectomy (SC) is considered a safe option for a bailout in the presence of a difficult laparoscopic cholecystectomy with a low incidence of complications. OBJECTIVE: This report aims to describe the challenges in diagnosing and managing remnant gallbladder. CASE PRESENTATION: Case 1 is a 31-year-old male who presented with right upper quadrant abdominal pain ten years following SC. Abdominal ultrasound (US) and computed tomography (CT) scan confirmed a ruminant gallbladder. He underwent successful completion of laparoscopic cholecystectomy. Case 2 is a 40-year-old

In Silico Screening of Secondary Metabolites from Scorodocarpus Borneensis as Hepatitis B Virus Inhibitors.

BACKGROUND: The Hepatitis B Virus (HBV) is a major global health concern, primarily due to its potential to cause chronic liver disease and cancer. The HBV core protein (HBc) is essential for the viral life cycle, specifically in the assembly of the viral capsid, making it a prime target for antiviral drug development. Scorodocarpus borneensis, a plant native to Southeast Asia, is rich in diverse phytochemicals but its potential as a source for antiviral agents against HBV remains largely unexplored. OBJECTIVE: This study aimed to identify and evaluate secondary metabolites from S. borneensis

Laboratory Parameters and Clinical Presentation of Children with Measles on Hospital Admission: Single-center Study from Sarajevo, Bosnia and Herzegovina.

BACKGROUND: T Measles is a viral, highly contagious disease from the group of rash fevers, which mainly affects children. Persons suffering from measles are considered contagious four days before and four days during the period of the appearance of measles, which favors its faster spread. Clinical observation and laboratory diagnostics are essential for monitoring the course of the disease in order to prevent complications. OBJECTIVE: Our study aimed to analyze the significance and usefulness of laboratory tests on admission to hospital in pediatric patients with measles. METHODS: This prosp

Assessement of Radiological Anatomy of Prostatic Artery on 3D DECT in Symptomatic Benign Prostatic Hypertrophy.

BACKGROUND: Benign prostatic hyperplasia (BHP) is a common disease in the urinary system and often appears in old male patients with the incidence increasing proportionally to age. OBJECTIVE: The study aimed to describe the anatomy and imaging findings of the prostatic artery (PAs) on 3D rendering dual-energy multi-sequence computed tomography (DECT) in patients with symptomatic benign prostatic hypertrophy (BPH) treated by prostatic artery embolisation (PAE). METHODS: The study was conducted on 64 patients with BPH who underwent DECT scans with 3D rendering of the pelvic artery before inter

IVF/ICSI Outcomes on Hyperthyroidism - Treated Patients at Hanoi Medical University Hospital.

BACKGROUND: The relationship between the thyroid hormones and reproductive function is complex. Increased thyroid function can directly affect ovarian function and can lead to infertility. After treatment to achieve a euthyroid state, symptoms such as menstrual disorders, shakiness, or rapid heartbeat are resolved, but the question is whether fertility problems can persist even when thyroid function is improved or restored to normal. OBJECTIVE: Our study aimed to initially evaluate the impact of women's hyperthyroid status on the outcome of in vitro fertilization/intracytoplasmic sperm inject

The First Original Medical Professional Printed Book in Southeast Europe.

BACKGROUND: The author of the first Croatian medical book, also the first in Southeast Europe, was Dr.John the Baptist Lalangue. He is the one who is most responsible for the fact that in the second half of the 18th century. OBJECTIVE: The aim of thiis article was to describe important facts abot the first original medical professional printed books in the Croatian language. METHODS: The authors searched imprtant information abot the book of the author Lalangue's titled "Medicina ruralis iliti Vrachtva ladanyszka, za potrebochu musev, y sziromakov. Horvatczkoga orszaga y okolu nyega, blisnes

Spigelian Hernia in Cirrhotic Patients: When and How to Repair?

BACKGROUND: Spigelian hernia, also known as spontaneous lateral ventral hernia, is defined as a protrusion of abdominal contents through an abdominal wall defect within the transversus aponeurosis. The entity was first reported in 1742 and named after Adrian van der Spieghel. It is recognized as a rare condition, accounting for 1 to 2% of all abdominal wall hernias. Cirrhotic patients, in particular, are more predisposed to hernias of all types. When Spigelian hernia is accompanied by hepatic cirrhosis, the decision to repair gets into a controversial aspect. Herein, we present the emergency m

Cardiac Arrest Caused by Amniotic Fluid Embolism: a Report of Two Clinical Cases.

BACKGROUND: Amniotic fluid embolism (AFE) is a rare and catastrophic obstetric complication that can lead to sudden cardiac arrest, respiratory distress, and disseminated intravascular coagulation. Recognizing and managing this condition promptly is crucial for improving maternal and neonatal outcomes. OBJECTIVE: This report includes two case studies describing the timely detection, prompt delivery of medical treatment, and the interdisciplinary approach essential for achieving better outcomes for mothers and children confronting with this catastrophic condition. CASE PRESENTATION: Case 1: A