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Esophageal endoscopic findings after pulmonary vein and posterior wall isolation using pulsed field ablation: results from the Eso-PFA study.

AIMS: Substrate modification, including left atrial posterior wall isolation (LAPWI), may be performed in AF patients undergoing catheter ablation. Pulsed field ablation (PFA) may protect adjacent structures like the esophagus. However, data on esophageal safety following PFA-guided LAPWI are limited. The aim is to evaluate esophageal safety during post-procedural esophagogastroduodenoscopy (EGD) and follow-up after PFA-guided LAPWI in patients with AF. METHODS AND RESULTS: This prospective observational study included consecutive AF patients who underwent PFA-guided LAPWI and post-procedural…

One-stop strategy combining pulmonary vein isolation with balloon-in-basket pulsed field ablation and left atrial appendage closure: a case report.

BACKGROUND: Concomitant pulmonary vein isolation (PVI) and left atrial appendage closure (LAAC) are increasingly performed, with substantial experience from thermal ablation and limited early reports using pulsed field ablation (PFA). This is the first reported case of a combined procedure using a balloon-in-basket PFA system. CASE SUMMARY: A 75-year-old man with symptomatic paroxysmal atrial fibrillation (AF) and recurrent macrohematuria under oral anticoagulation was referred for treatment. After a multidisciplinary team discussion, we opted for a one-stop approach combining PVI using a bal…

Comparison of the efficacy and adverse effects of long pulsed 1064 nm Nd: YAG laser and sclerotherapy in the treatment of pyogenic granuloma in children: a retrospective study.

Pyogenic granuloma (PG) is benign vascular lesions of the skin and mucous membranes that often involve the skin and mucous membranes, which often trouble patients due to its frequent bleeding. The traditional treatment is surgical removal, but its bleeding, pain, and trauma have led doctors to look for more minimally invasive methods. Between June 1, 2022 to March 1, 2024, we retrospectively analyzed 72 children with PG who were seen and treated in our department for long pulsed 1064 nm Nd: YAG laser (Gentle Nd: YAG laser) and sclerotherapy, respectively. The efficacy of the two treatments, pa…

Therapeutic efficacy and influencing factors of 5-fluorouracil combined with ultra-pulsed fractional carbon dioxide laser treatment for hypertrophic scars in burn patients.

BACKGROUND: Laser therapy is widely used in scar repair, and the use of 5-fluorouracil (5-FU) as an adjuvant treatment has also attracted attention. This study aimed to compare the therapeutic efficacy of 5-FU combined with ultra-pulsed fractional carbon dioxide laser (UFCL) treatment and UFCL treatment alone for hypertrophic scars after burns, and to analyse influencing factors to provide evidence for clinical practice. METHODS: A total of 150 patients with hypertrophic scars from burns were randomly divided into an observation group (OG) and a control group (CG). Assessments were based on t…

A preliminary study on the therapeutic potential of pulsed electric fields (PEF) in hydatid cysts: ex vivo targeted detachment of the germinal layer in daughter cysts.

Cystic echinococcosis (CE), a globally parasitic disease is primarily caused by the larval stage of Echinococcus granulosus. This zoonotic infection carries significant medical, veterinary, and economic implications. In human the disease occurs by the ingestion of parasite eggs and can create in any organ especially liver and lungs. Current therapeutic methods have some limitations. Therefore, effect of pulsed electric fields (PEF) as a non-invasive method was utilized on daughter cysts as an important part of hydatid cyst. Daughter cysts was extracted from sheep liver hydatid cyst, divided in…

Сочетание низкотемпературной радиочастотной термокоагуляции и импульсной радиочастоты двустороннего ганглиона Гассериана для двусторонней тригеминной нейронгии из-за множественного склероза: отчет о деле.

Двусторонний тригеминальный нейронный вторичный склероз является крайне редким заболеванием. Когда проводится ганглионный блок Гассериана, необходимо добиться надежного долгосрочного анальгетического эффекта, избегая при этом осложнений, связанных с лечением. КИСЛОТА: 49-летний самец с множественным склерозом продемонстрировал стойкую скучную боль и пароксисмическую электрическую боль, похожую на шоковую, в своих двусторонних максимальных миллиардных молярах и челюсти. У него был диагностирован тригеминальный нейронный диагноз, вызванный множественным склерозом. Из-за серьезных побочных эффект

Совпадение в аннотации оригинала
BACKGROUND: Bilateral trigeminal neuralgia secondary to multiple sclerosis is an extremely rare condition. When Gasserian ganglion block is … n control with medication alone. By performing low-temperature radiofrequency thermocoagulation and pulsed radiofrequency of the Gasserian ganglion while monitoring masseter muscle contraction, a satisfactory and rapid analgesic effect was obtained without masticatory atonia. CONCLUSIONS: To the best of our knowledge, this is the first case of bilatera …

Focal monopolar pulsed field ablation from within the great cardiac vein for idiopathic premature ventricular contractions after failed radiofrequency ablation.

BACKGROUND: Idiopathic epicardial premature ventricular contractions (PVCs) originating from the left ventricular summit are difficult to eliminate. OBJECTIVE: The purpose of this study was to describe the feasibility and procedural safety of monopolar biphasic focal pulsed field ablation (F-PFA) from within the great cardiac vein (GCV) for treatment of idiopathic epicardial PVCs. METHODS: In 4 pigs, F-PFA (Centauri, CardioFocus) was applied from within the GCV followed by macroscopic gross analysis. In 4 patients with previously failed radiofrequency ablation, electroanatomic mapping was us…

A 595 nm pulsed dye laser as an adjuvant intervention for post-comedone extraction erythema and comedone reduction: A randomized, split-face controlled trial.

BACKGROUND: Comedone extraction provides greater satisfaction for acne treatment than conventional treatment alone; however, post-comedone extraction erythema (PCEE) remains a concern for patients. OBJECTIVES: To evaluate the efficacy of pulsed-dye laser (PDL) in PCEE and comedone reduction. METHODS: Mild-to-moderate acne patients were randomly allocated in split-face fashion. Three comedones were extracted on each facial side. On the PDL-treated side, 595-nm PDL was delivered to the entire side with an additional shot on three comedone-extracted sites. Erythema index (EI) and total acne les…

The efficacy of combined Intense pulsed light plus high-intensity focussed ultrasound with two different powers in the treatment of atrophic and Icepick acne scars.

OBJECTIVE: To determine the clinical efficacy and suitable power of high-intensity focussed ultrasound combined with intense pulsed light to treat acne scarring. METHODS: The prospective study was conducted at the College of Medicine, Mustansiriyah University, Baghdad, Iraq, from September 2020 to March 2021, and comprised patients of either gender with atrophic or icepick scars. They were divided into atrophic scar group A and icepick scar group B. Both groups were first treated with intense pulsed light and then with high-intensity focussed ultrasound using 30J/cm2 and 40J/cm2 power. There …

Comparing pulsed field electroporation and radiofrequency ablation for the treatment of paroxysmal atrial fibrillation: design and rationale of the BEAT PAROX-AF randomized clinical trial.

AIMS: Using thermal-based energy sources [radiofrequency (RF) energy/cryo energy] for catheter ablation is considered effective and safe when performing pulmonary vein isolation (PVI) in patients with paroxysmal atrial fibrillation (AF). However, treatment success remains limited and complications can occur due to the propagation of thermal energy into non-target tissues. We aim to compare pulsed field ablation (PFA) with RF ablation in terms of efficacy and safety for patients with drug-resistant paroxysmal AF. METHODS AND RESULTS: The BEAT PAROX-AF trial is a European multicentre, superiori…

Evaluation of the efficacy of ultrasound-guided maxillary and mandibular nerve pulsed radiofrequency treatment for trigeminal neuralgia and factors associated with successful response: a retrospective study.

BACKGROUND: This study aimed to investigate the treatment efficacy and clinical and demographic characteristics affecting treatment success in patients who underwent ultrasound (US)-guided pulsed radiofrequency (PRF) to the maxillary and/or mandibular nerves for trigeminal neuralgia. METHODS: The data of patients with trigeminal neuralgia who underwent US-guided maxillary and/or mandibular nerve PRF between September 2022 and December 2023 were reviewed and the study was retrospectively designed. Good analgesia was defined as ≥ 50% reduction in pain score at 3 months after the procedure, and …

General anaesthesia and deep sedation for monopolar pulsed field ablation using a lattice-tip catheter combined with a novel three-dimensional mapping system.

AIMS: A novel three-dimensional mapping platform combined with a lattice-tip catheter that can toggle between monopolar pulsed field ablation (PFA) and radiofrequency energy delivery was recently launched. So far, the system was predominantly applied in general anaesthesia (GA), not in deep sedation. METHODS AND RESULTS: Patients with symptomatic paroxysmal or persistent atrial fibrillation (AF) were enrolled, and pulmonary vein isolation (PVI) and ablation of additional linear lesion sets were performed either in GA or in deep sedation. Pulsed field ablation was applied exclusively to perfor…

The Cardiac Pulsed Wave Doppler Pattern of the Common Femoral Vein in Diagnosing the Likelihood of Severe Pulmonary Hypertension: Results from a Prospective Multicentric Study.

Background and Objectives: Pulmonary hypertension (PH) is a clinical condition with high mortality rates, particularly in patients over 65. … e observational study included 175 emergency patients from three hospitals. Ultrasound assessed the pulsed wave Doppler (PW-Doppler) morphology of the CFV. This diagnostic yield for H-LPH was evaluated alongside traditional ultrasound parameters (right-to-left ventricular basal diameter ratio greater than 1 (RV > LV), septal flattening, right ventricula …

Selective Oxidation of Methanol to Methyl Formate on Gold: The Role of Low-Coordinated Sites Revealed by Isothermal Pulsed Molecular Beam Experiments and AIMD Simulations.

To elucidate the role of low-coordinated sites in the partial methanol oxidation to methyl formate (MeFo), the isothermal reactivity of flat Au(111) and stepped Au(332) in pulsed molecular beam experiments was compared for a broad range of reaction conditions. Low-coordinated step sites were found to enhance MeFo selectivity, especially at low coverage conditions, as found at higher temperatures. The analysis of the transient kinetics provides evidence for the essential role of Au x O y phases for MeFo formation and the complex interplay of different oxygen species for the observed selectivity…

Low-intensity-pulsed-ultrasound-treated menstrual-blood-derived mesenchymal stem cells repair endometrial injury by PI3K/AKT pathway inhibition.

RESEARCH QUESTION: What is the effect and underlying mechanism of low-intensity-pulsed-ultrasound (LIPUS)-treated menstrual-blood-derived mesenchymal stem cells (MenSC) on intrauterine adhesions (IUA)? DESIGN: First, MenSC were identified and exposed to LIPUS. The proliferation, migration, invasion, cytokine secretion, and ability to differentiate into human endometrial epithelial cells (HEEC) of LIPUS-treated MenSC were characterized. In vitro, human endometrial stromal cells (HESC) were treated with 10 ng/ml transforming growth factor-β1 (TGF-β1) to simulate IUA, and then co-cultured indire…

Efficacy of Paravertebral Injection of Interferon-α2b Combined with High-Voltage, Long-Term Pulsed Radiofrequency in DRG in Mitigation of Postherpetic Neuralgia: A Retrospective Study.

OBJECTIVE: This investigation aims to evaluate the effectiveness of the paravertebral injection of recombinant human interferon-α2b in conjunction with high-voltage, long-term, pulsed radiofrequency (PRF) in the dorsal root ganglion for the mitigation of postherpetic neuralgia (PHN). METHODS: This retrospective study included 84 individuals with acute PHN. The participants were divided into 3 groups. Group H was treated with interferon-α2b combined with high-voltage long-term PRF. Group C was treated with a combination of high-voltage, long-term PRF and a paravertebral injection (without reco…

Efficacy, tolerance and acceptability of pulsed dye laser on facial and neckline telangiectasias in systemic scleroderma: a prospective open-label monocentric study in 21 patients.

Facial and neckline telangiectasias have an underestimated yet important impact on quality of life of patients with systemic scleroderma (SSc). This monocentric, prospective, open-label, intra-patient comparative study was conducted in 21 consecutive patients with SSc. Patients underwent 4 sessions of PDL 8 weeks apart. A final quadruple assessment was performed by several raters 2 months after the last session, based on the following criteria: change in telangiectasia number; subjective improvement score (LINKERT scale); impact on the quality of life (QoL; SKINDEX score); visual analog pain s

Effects of combined intense pulsed light and cyclosporine 0.05% eyedrops in ocular surface matrix metalloproteinase-9 levels in patients with moderate-to-severe MGD.

To investigate the changes in meibomian gland dysfunction (MGD) and tear matrix metalloproteinase-9 (MMP-9) levels in patients with moderate-to-severe MGD after combined treatment with intense pulsed light (IPL) therapy and cyclosporine 0.05%. Thirty-six patients concurrently treated with IPL and cyclosporine 0.05% ophthalmic drops were retrospectively enrolled. Tear break up time (TBUT), corneal and conjunctival staining scores, Schirmer test, and ocular surface disease index (OSDI) questionnaire responses were recorded. Meibum quality, consistency, and eyelid margin telangiectasia were evalu…

Long-term outcomes of the pentaspline pulsed-field ablation catheter for the treatment of paroxysmal atrial fibrillation: results of the prospective, multicentre FARA-Freedom Study.

AIMS: Pulmonary vein isolation (PVI) is a well-established strategy for the treatment of paroxysmal atrial fibrillation (PAF). Despite randomized controlled trials and real-world data showing the promise of pulsed-field ablation (PFA) for this treatment, long-term efficacy and safety data demonstrating single-procedure outcomes off antiarrhythmic drugs remain limited. The aim of the FARA-Freedom Study was to evaluate the long-term efficacy and safety of PFA using the pentaspline catheter for PAF. METHODS AND RESULTS: FARA-Freedom, a prospective, non-randomized, multicentre study, enrolled pat…