Результаты поиска

[Imaging methods in rheumatology: imaging in psoriasis arthritis (PsA)].

Conventional radiography is still the standard method of imaging in PsA since it displays many joints at the same time, thereby allowing dif … ory spots. The relatively frequent spinal (axial) involvement is similar to that seen in ankylosing spondylitis. However, unilateral sacroiliitis, asymmetry of syndesmophytes and development of parsyndesmophytes may distinguish PsA from ankylosing spondylitis. While conventional radiography demonstrates the bony consequences of inflammation in the spine, MRI …

Relationship of psoriatic arthritis with the other spondyloarthropathies.

PURPOSE OF REVIEW: The seronegative spondyloarthropathies are a group of disorders sharing common clinical features, the hallmark of which i … rthritis. Spinal involvement in psoriatic arthritis can be asymptomatic, as in classical ankylosing spondylitis. Importantly, psoriatic spondylitis has been observed in the absence of sacroiliitis. SUMMARY: Clinicians generally agree that psoriatic arthritis constitutes a discreet subset within the spondyloarthropathy group, but the demarcation continues to …

[MR imaging in seronegative spondyloarthritis].

In twenty-five patients with a clinical diagnosis of suspected sacroiliitis conventional radiography, CT and MRI were performed. In ten patients no abnormalities were demonstrated. In thirteen cases CT and MRI revealed sacroiliitis. In two patients with normal plain films and CT para- and intraarticular changes of signal intensity suggested suspicious sacroiliitis. MRI can be considered as an important imaging modality for early diagnosis of sacroiliitis. In eighteen patients with a firm diagnosis of ankylosing spondylitis and plain films of the thoracolumbar junction suggesting destructive Ro…

Uncovering Heterogeneous Health Burden in Axial Spondyloarthritis Through Latent Class Analysis of the Assessment of SpondyloArthritis International Society Health Index.

OBJECTIVE: To identify and characterize unobserved subgroups of patients with axial spondyloarthritis (axSpA) based on response patterns to … item endorsement probabilities. Construct validity analyses included comparisons of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Axial Spondyloarthritis Disease Activity Score (ASDAS), and total ASAS HI scores. Internal validation was performed using bootstrap resampling. Secondary multinom …

Validation of the Dudley inflammatory bowel symptom questionnaire for assessing gastrointestinal symptom burden in axial spondyloarthritis.

Subclinical and overt inflammatory bowel disease (IBD) is frequently observed in patients with axial spondyloarthritis (ax-SpA), traditional … ty was assessed by examining correlations between DISQ scores and disease activity (Bath Ankylosing Spondylitis Disease Activity Index [BASDAI]), functional status (Bath Ankylosing Spondylitis Functional Index [BASFI]), and health-related quality of life (Short Form-36 [SF-36]). Discriminant validity was evaluated by comparing DISQ scores in patients with and …

Exploratory MRI and Clinical Marker Analysis of Pustulotic Arthro-Osteitis Disease Activity From a Phase 3 Brodalumab Trial.

Pustulotic arthro-osteitis (PAO) is a clinically important osteoarticular comorbidity affecting approximately 9%-28% of patients with palmop … lled in a previous phase 3 trial. Correlations were assessed between clinical indicators-Ankylosing Spondylitis Disease Activity Score, Assessment of SpondyloArthritis international Society Health Index score, physicians' Numeric Rating Scale-PAO (NRS-PAO) activity score, and patients' NRS-PAO pain score-and MRI indicators, including active lesions such as bo …

Риск системных ревматических заболеваний у людей с раздражающим синдромом кишечника: когортный анализ с глобальной федерацией.

Синдром кишечника (IBS) — широко распространенное расстройство взаимодействия кишечника и мозга, все больше связанное с иммунным и подстрекательским регулированием. Остается неясным, предрасположена ли IBS к системным ревматическим болезням. Methods Мы провели ретроспективное когортное исследование с использованием Глобальной сети сотрудничества TriNetX, которая объединяет анонимные электронные медицинские записи, полученные от более, чем 150 Организации здравоохранения и 150 million Пациенты по всему миру. Взрослые≥18 год) с диагнозом IBS≥2 посещения) между 2015 и 2023 были сопоставлены с соо

Совпадение в аннотации оригинала
BackgroundIrritable bowel syndrome (IBS) is a prevalent disorder of gut-brain interaction increasingly linked to immune and inflammatory dys … utcome was incident systemic rheumatic disease, categorized into inflammatory arthritis (ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, gout) and connective tissue disorders (systemic lupus erythematosus, systemic sclerosis, Sjögren syndrome, dermatomyositis/polymyositis). Risk estimates were generated using the TriNetX analytic function, …

Case Report: Diagnostic and therapeutic challenges of secondary spinal tuberculosis following percutaneous vertebroplasty: a case of staged surgery with bone cement retention report.

BACKGROUND: The incidence of secondary infectious complications following percutaneous vertebroplasty is less than 1%. Among these complications, tuberculous spondylitis is particularly rare, with only a few cases reported in the literature since this condition is usually caused by the hematogenous spread of a pre-existing latent Mycobacterium tuberculosis infection rather than by direct intraoperative contamination. Misdiagnosis and improper treatment of such a condition may lead to catastrophic consequences including infection dissemination, nerve damage, and progressive kyphotic deformity. …

Exploring the genetic components and multi-omics sources of inflammatory bowel disease from the perspective of autoimmune disorders.

BACKGROUND: Inflammatory bowel disease (IBD) and autoimmune disorders result from immune system dysregulation. However, the genetic overlap … erse perspectives. RESULTS: There were significant genetic correlations between IBD and ankylosing spondylitis (rg = 0.327), rheumatoid arthritis (rg = 0.242), type 1 diabetes (rg = - 0.061), psoriasis (rg = 0.246), and ankylosing spondylitis (rg = 0.308). We identified 110 unique regions (including 5p33.3, 10q25.3, and 22q13.31) after a consistent study at …

Evaluation of instruments assessing peripheral arthritis in spondyloarthritis: an analysis of the ASAS-PerSpA study.

OBJECTIVES: To assess construct validity, including known-group discrimination, of the currently available disease activity instruments assessing peripheral arthritis in spondyloarthritis (SpA). METHODS: In this analysis from the Assessment of SpondyloArthritis International Society (ASAS)-PerSpA study, patients with a diagnosis of axial SpA, peripheral SpA, or psoriatic arthritis (PsA) were included. The disease activity instruments evaluated were the Patient Global Assessment (PGA), Bath Ankylosing Spondylitis Disease Activity Index, Axial Spondyloarthritis Disease Activity Score, Disease A…

Defining Objective BASDAI Cut-Offs for Disease Activity States and Improvement Scores in Axial Spondyloarthritis: A Multicentric Collaboration.

OBJECTIVE: To estimate objective cut-off values for Bath ankylosing Spondylitis Disease Activity Index (BASDAI) corresponding to Ankylosing Spondylitis Disease Activity Score with CRP (ASDAS) cut-off values (1.3, 2.1, and 3.5), and for interval changes (ΔBASDAI) corresponding to ΔASDAS (1.1 and 2). METHODS: In this multicentric study, adult patients with active axial spondyloarthritis (axSpA) treated with either tofacitinib 5 mg twice daily or adalimumab 40 mg subcutaneously fortnightly were recruited. Available paired data on BASDAI and ASDAS and paired interval change of these parameters (t…

Inflammatory bowel disease in axial spondyloarthritis patients. Is there any specific clinical picture? Data from the RESPONDIA and REGISPONSER registries.

BACKGROUND: Inflammatory bowel disease (IBD) affects 5%-10% of ankylosing spondylitis (AS) patients. Prior data suggest AS patients with IBD may have more severe disease and lower HLA-B27 prevalence. Yet, little is known about potential distinctions in AS with IBD compared to those without IBD. OBJECTIVE: To investigate the clinical characteristics and radiographic differences between patients with (AS) with and without concurrent IBD. DESIGN: This multicenter, observational, cross-sectional study included patients meeting European Spondyloarthropathy Study Group criteria from the Registry o…

Comparing the construct validity of measurement instruments for pain and stiffness in patients with axial spondyloartwhritis: cross-sectional analysis in the OASIS cohort.

OBJECTIVES: To compare the construct validity, including discrimination between known groups, of three pain and three morning stiffness (MS) measurement instruments. METHODS: Patients with radiographic axial spondyloarthritis with 8-year data from the Outcome in Ankylosing Spondylitis International Study cohort were assessed cross-sectionally. Three instruments for pain and three for MS, all self-reported and scored 0-10, were compared. Construct validity was evaluated by testing (1) hypothesis of correlations' strength and (2) discrimination between known groups using standardised mean diffe…

The effect of ixekizumab on axial manifestations in patients with psoriatic arthritis from two phase III clinical trials: SPIRIT-P1 and SPIRIT-P2.

BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory condition predominantly affecting the peripheral joints. However, some patie … ndomized, double-blind, phase III trials (SPIRIT-P1 and SPIRIT-P2), were defined as Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Question 2 (Q2; back pain)] total score ⩾4 and average of BASDAI Q5 + Q6 (morning stiffness) ⩾4 at baseline. For this post hoc analysis, the efficacy of IXE was evaluated at weeks 16, 24, and 52 using separate BASDAI …

Body Mass Index and the Risk of Rheumatic Disease: Linear and Nonlinear Mendelian Randomization Analyses.

OBJECTIVE: Although the association between obesity and risk of rheumatic disease is well established, the precise causal relation has not b … , osteoarthritis (n = 87,430), psoriatic arthropathy (n = 933), gout (n = 13,638), and inflammatory spondylitis (n = 4,328). RESULTS: Using linear MR, we found that 1 SD increase in BMI increases the incidence rate for rheumatoid arthritis (incidence rate ratio [IRR] 1.52 [95% confidence interval (95% CI) 1.36-1.69]), osteoarthritis (IRR 1.49 [95% CI 1.43-1. …

Use of external control arms in immune-mediated inflammatory diseases: a systematic review.

OBJECTIVES: External control arms (ECAs) provide useful comparisons in clinical trials when randomised control arms are limited or not feasi … lammatory bowel disease, pouchitis, rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and atopic dermatitis in which an ECA was used as the comparator. DATA EXTRACTION AND SYNTHESIS: Two authors independently screened the search results in duplicate. The characteristics of included studies, external d …

Relationship between sex and clinical and imaging features of early axial spondyloarthritis: results from a 48 month follow-up (Italian arm of the SPondyloArthritis Caught Early (SPACE) study).

OBJECTIVES: To assess the association between sex and clinical and disease activity indices, and X-rays and magnetic resonance imaging (MRI) … aders following Spondyloarthritis Research Consortium of Canada (SPARCC), modified Stoke Ankylosing Spondylitis Spinal Score, and modified New York criteria. Characteristics of axSpA patients according to sex (male/female) were compared over time using descriptive statistics. RESULTS: Ninety-one patients had axSpA (83.5% non-radiographic; 16.5% radiographic) …

Reactive Arthritis Resulting From Postoperative Complications of Third Molar Extraction: A Case Report.

The role of bacterial infections as potential triggers for chronic rheumatic diseases is well-documented. Oral infections such as periodonti … c autoimmune diseases, most notably human leukocyte antigen B27 (HLA-B27) in the case of ankylosing spondylitis as well as other rheumatic diseases. We present a case of a 23-year-old woman with reactive arthritis resulting from a postoperative infection. The patient presented with bilateral shoulder pain, decreased range of motion, worsening lower back pain, …

Safety and Effectiveness of Etanercept Biosimilar SB4 for Rheumatic Diseases in South Korea: Real-World Post-marketing Surveillance Data.

INTRODUCTION: SB4 is the first approved biosimilar of etanercept, a biologic tumor necrosis factor inhibitor, to treat various autoimmune di … (SAE). Effectiveness was assessed by the change from baseline of investigator-rated Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in patients with ankylosing spondylitis (AS) and disease activity score-28 (DAS28) in patients with RA. RESULTS: Among 316 enrolled patients, 314 were included in the safety analysis (176 with AS and 138 with RA). Th …

Psoriasis and imaging progression in early axial spondyloarthritis: results from a 48-month follow-up (Italian arm of SPACE study).

OBJECTIVES: To assess the influence of psoriasis on spinal/pelvic radiographic progression and MRI features in early-stage axial spondyloart … ed by two readers following Spondyloarthritis Research Consortium of Canada score, Stoke Ankylosing Spondylitis Spinal Score System modified by Creemers and modified New York criteria. Characteristics of axSpA patients with/without psoriasis were compared over time with descriptive statistics; multivariate logistic regression model was constructed to assess p …