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Coronary Artery Bypass Grafting With Mitral Annuloplasty or Replacement for Ischemic Mitral Regurgitation in Medicare Beneficiaries.

BACKGROUND: Retrospective studies of patients with ischemic mitral regurgitation (iMR) undergoing coronary artery bypass grafting (CABG) with concomitant mitral valve surgery frequently report improved survival with mitral valve repair/annuloplasty (MVr) over replacement (MVR). However, the only randomized controlled trial found no survival difference. METHODS: Medicare claims data were queried to identify beneficiaries with iMR undergoing CABG/MVr or CABG/MVR. Kaplan-Meier estimates of survival after CABG/MVr and CABG/MVR were generated, and 20-year restricted mean survival times (RMSTs) wer

Stereotactic Body Radiotherapy Reirradiation Is Safe in Patients With Lung Cancer With In-Field Enlarged Tumor Recurrence.

Introduction: Recurrence after stage III lung cancer treatment usually appears with a poor prognosis, and salvage therapy for these patients … ll survival was 66.6% for the first year and 33.3% for the second and third years. The disease-free survival rate was 46.6% for the first year and 40% for the second and third years. Nine patients who received doses of BED10 ≥ 50 Gy developed no local recurrence (P  =  .044). Discussion: In local local-regional recurrence of lung cancer, radiosurgery as reirrad …

Fertility-sparing surgery for patients with stage IC2 or IC3 epithelial ovarian carcinoma: any evidence of safety?

OBJECTIVE: Investigate the overall survival of patients with stage IC2/IC3 epithelial ovarian carcinoma undergoing fertility-sparing surgery … overall survival between the fertility-sparing and radical surgery groups (p=0.37; 5- year overall survival rates 90.2% and 85%, respectively). After controlling for tumor grade and performance of lymphadenectomy, fertility-sparing surgery was not associated with worse overall survival (HR 1.22, 95% CI 0.56, 2.62). A systematic review identified 151 patients w …

Value of Adjuvant Radiotherapy for Thymoma with Myasthenia Gravis after Extended Thymectomy.

BACKGROUND: The co-existence of myasthenia gravis (MG) and thymoma makes the surgical treatment more complicated and adjuvant radiation more … en compared the effect of the mediastinal radiation therapy across these different groups using the survival rate, the rate of postoperative myasthenic crisis, and the complete stable remission (CSR) rate as the primary endpoints. RESULTS: There was a significant difference in the occurrence of postoperative myasthenic crisis between 1-month subgroup and Group …

Long-term outcomes of combining prostate brachytherapy and metastasis-directed radiotherapy in newly diagnosed oligometastatic prostate cancer: A retrospective cohort study.

BACKGROUND: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy (STAMPEDE) trial showed the survival be … 5 months. RESULTS: Of the 40 patients, the 5-year castration-resistant prostate cancer (CRPC)-free survival rate and cancer-specific survival was 64.4% and 87.9%, respectively. Pre- or post-treatment predictive value including prostate-specific antigen (PSA) at diagnosis ≥20 ng/mL, Gleason grade group 5, positive biopsy core rate ≥51%, PSA nadir level of ≥0.02 …

Outcomes and Influence of the Pedal Arch in Below-the-Knee Angioplasty in Patients with End-Stage Renal Disease and Critical Limb Ischemia.

BACKGROUND: Management of dialysis patients with critical limb ischemia (CLI) still represents a challenge to vascular medicine, whereas the … d. A 30-day mortality rate amounted 6% with no procedure-related deaths. The 1-year amputation-free survival rate was 56% and 34% at 2 years. Two major amputations were required. Subsequent revascularization procedures were necessary in 11 patients (10 redo angioplasty, 1 pedal bypass graft). The pedal arch was classified as category I in 1 patient (3%), catego …

[Operative and long term results after diseased bowel resection for chronic radiation enteritis complicated with intestinal obstruction].

OBJECTIVE: To report operative and long-term results after surgery for chronic radiation enteritis and to evaluate the therapeutic efficacy of surgery and investigate the risk factors of postoperative survival rate. METHODS: The 120 CRE patients performed with diseased bowel resection from June 2001 to March 2011 were analyzed retrospectively and followed up by telephone. There were 22 male and 98 female patients and their age were 23-82 years (median 52 years). Their demographic data, the cancer history, the characteristics of radiotherapy received (total dose, defined as the cumulative dose…

[Clinical analysis of blood ammonia levels for predicting survival following transjugular intrahepatic portosystemic shunt in patients with cirrhosis].

Objective: To assess the blood ammonia levels value for predicting survival following transjugular intrahepatic portosystemic shunt (TIPS) t … were compared using the χ2 test between the groups. Kaplan-Meier survival curves were used to plot survival rate. Cox regression models were used for univariate and multivariate analysis. Results: AMM-ULN, CTP score, and ascites were independent risk factors affecting the liver function in surviving patients with cirrhosis following TIPS (P<0.05). The 3-year s …

Эффективность и надежность аутологической трансплантации стволовых клеток после химиотерапии при лечении злокачественной лимфомы: метаанализ.

: Автономная трансплантация стволовых клеток (AHSCT) является ценным средством лечения нескольких гематологических заболеваний, особенно в случаях рецидива или рецидива. Автономная трансплантация стволовых клеток (AHSCT) помогает улучшить показатели выживаемости отдельных пациентов, особенно больных с агрессивной лимфомой и множественной миеломой. Исследования показывают, что AHSCT может превзойти альтернативную терапию, но текущие исследования необходимы для совершенствования отбора пациентов. Многие пациенты страдают от продолжительной ремиссии и более высокого качества жизни, что свидетельс

Совпадение в аннотации оригинала
BACKGROUND: Autologous hematopoietic stem cell transplantation (AHSCT) is a valuable treatment option for several hematological malignancies, particularly in relapsed or refractory cases. Autologous hematopoietic stem cell transplantation (AHSCT) is effective in improving survival rates in selected patients, particularly those with aggressive lymphomas and m…

Mitral valve reconstruction: eight years' experience in 531 patients.

Between January 1988 and June 1996, a total of 531 patients underwent reconstruction of the mitral valve for mitral regurgitation (MR) with … followed up by physical examination and echocardiography; follow up was 93% complete. The actuarial survival rate at 84 months was 93.1% and event-free survival rate was 87.3%. We conclude that mitral valve repair in the young rheumatic population is feasible, the probability of reoperation is low, and the symptomatic relief is gratifying.

[Conservative surgery of rheumatic mitral insufficiency in children. Remote results].

Between 1977 and 1986, 38 children aged from 3.8 to 16.4 years underwent mitral valvuloplasty for symptomatic mitral valve incompetence of rheumatic origin. Two children (5.3 per cent) died in the immediate post-operative period, and 6 were lost sight of. Among the 30 children followed up for a mean period of 3.3 years, 6 were reoperated upon within 5 months of the valvuloplasty, 5 still present with a significant residual mitral valve incompetence and 9 have satisfactory clinical and echocardiographic results. Survival rate and survival rate without reoperation at 4 years were 93.8 per cent a…

Surgery in long-term dialysis patients. Experience with more than 300 cases.

Three hundred twelve surgical procedures in patients with chronic renal failure have been characterized. There is a high incidence of operation in this expanding population. Multiple procedures for each patient were found in our 10 year study. Operative mortality was 1 percent and late mortality was about 10 percent per year. The survival curve predicted an 81 percent 2 year rate and a 60 percent 5 year survival rate. The high late mortality was likely related to the underlying disease process and the high proportion of complicating associated illnesses. The gross complication rate was high (6…

Mid-term outcomes of cemented GMRS rotating-hinge knee prostheses for tumor reconstruction: A single-institution study from Japan.

BACKGROUND: This study aimed to evaluate the short-to mid-term outcomes of the Global Modular Replacement System (GMRS) rotating-hinge knee prosthesis (Stryker) used in joint function reconstruction for bone and soft-tissue tumors and metastatic bone tumors. METHODS: This study included patients who underwent lower limb joint function reconstruction using cemented GMRS rotating-hinge knee prosthesis at our hospital and were followed up for >2 years between July 2012 and December 2024. The implant and revision-free survival rates were evaluated, and complications requiring additional surgery w…

Kidney transplant in low resources countries; 6 years of successes and challenges at Benjamin Mkapa Hospital, Tanzania.

BACKGROUND: Kidney transplantation (KT) is the optimal treatment for end-stage renal disease (ESRD), requiring multidisciplinary expertise, … ding causes of ESRD. The majority of donors were blood-related (84%), with 16% being spouses. Graft survival rates at 1, 3, and 5 years were 94%, 90%, and 90%, respectively, while patient survival rate at 1,3 and 5 were 97%, 81%, and 81%, respectively. The overall estimated mortality rate was 37.3 (95%CI: 14.0-99.4) per 1000 person per years. CONCLUSION: BMH h …

Total Hip Arthroplasty in Patients Under 30 Years Who Have Osteonecrosis of the Femoral Head: Mean Follow-Up of More than 120 Months.

BACKGROUND: Osteonecrosis of the femoral head (ONFH) primarily affects young adults, leading to femoral head collapse and secondary osteoart … r complications occurred in 13 joints: one in group A and 12 in group B (P = 0.46). Overall implant survival rate was 100% at 60 months, 98% at 120 months, and 94% at 180 months. When considering aseptic loosening as the endpoint, the 180-month survival rate was 100%. No significant differences in survival rate were found between the groups with either endpoint …

Rehabilitation of the Atrophic Edentulous Maxilla: A Retrospective Cohort Study Comparing Survival of Delayed-Loaded Implants in Grafted Bone Versus Immediately Loaded Implants in Native Bone.

OBJECTIVES: This retrospective cohort study aimed to assess the survival rate of implants placed in grafted edentulous maxillary arches following a delayed loading protocol versus a graftless approach with an immediate loading protocol. MATERIALS AND METHODS: Eighty seven patients with atrophic edentulous maxillae were included in two groups: Group-1 (GG group, n = 155 implants): 26 patients that underwent maxillary bone grafting before treatment with axially placed delayed loading implants and provided with a fixed full-arch prostheses; Group-2 (GL group; n = 244 implants): 61 patients who r…

Capecitabine plus oxaliplatin in the treatment of metastatic colorectal cancer at Tygerberg Hospital: a retrospective study.

INTRODUCTION: a capecitabine and oxaliplatin drug combination regimen has shown a survival benefit in patients with advanced colorectal cancer, yet its administration represents an attractive option for low resource settings. This study aimed to describe the therapeutic utility, efficacy and safety of a capecitabine plus oxaliplatin drug combination in patients with colorectal cancer. METHODS: a review of medical records of sixty adult patients with histological diagnosis of colorectal cancer at Tygerberg Hospital between June 2012 and June 2017 was conducted. The overall response rate was as

Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial.

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.In the primary analysis of the global phase II ELIANA trial (ClinicalTrials.gov identifier: NCT02435849), tisagenlecleucel provided an overall remission rate of 81% in pediatric

Results of the treatment of pineal tumors in children: the Lyon experience.

INTRODUCTION: Pineal tumors are rare and their incidence is of 1% among all pediatric tumors of the central nervous system. Patient survival … r medical investigation. Patients with Germ Cell Tumors have more favorable outcomes, with a global survival rate of 87 % and a pure germinoma survival rate of almost 97%. When analyzing the prognosis of pineal gland gliomas, otherwise known as tectal plate gliomas, pilocytic astrocytomas had a promising prognosis. Otherwise, prognosis of other tectal plate gli …

A Proposal for Modification of the PSOGI Classification According to the Ki-67 Proliferation Index in Pseudomyxoma Peritonei.

BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare malignancy, classified according to the Peritoneal Surface Oncology Group International (PSOGI) classification, whose response to treatment remains highly heterogeneous within the high-grade (HG) category. Molecular profiling of PMP cases might help to better categorize patients and predict treatment responses. METHODS: We studied the Ki-67 proliferation rate and P53 overexpression in tissue samples from our historical cohort of HG-PMP patients. We established as cut-off levels the third quartile of each marker to perform univariate and multi