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Risk evaluation of denosumab and zoledronic acid for medication-related osteonecrosis of the jaw in patients with bone metastases: a propensity score-matched analysis.

PURPOSE: This study evaluated the risk of medication-related osteonecrosis of the jaw (MRONJ) in patients with cancer who received denosumab or zoledronic acid (ZA) for treating bone metastasis. METHODS: The medical records of patients were retrospectively reviewed. Patients who did not undergo a dental examination at baseline were excluded. The primary endpoint was a comparison of the risk of developing MRONJ between the denosumab and ZA groups. Propensity score matching was used to control for baseline differences between patient characteristics and compare outcomes for both groups. RESULT

Переоценка желудочно-кишечного метаногенного археома в множестве склероза и его связь с лечением.

Роль кишечного археиального микробиома (архема) в здравоохранении и болезнях по-прежнему недостаточно понятна. Метаногенные археи были связаны с множественным склерозом (МС), однако предыдущие исследования ограничивались небольшими группами и непоследовательными методологиями. Для решения этой проблемы мы провели переоценку связи между метаногенными археями и MS с использованием метагеномических данных Международного исследования множественного склероза микробиома. Мы проанализировали микробиомные профили по 115 пациентам с НР и 115 здоровым домашним хозяйствам в Буэнос-Айресе (27,8 процента),

Fucoidan Exerts Anticancer Effects Against Head and Neck Squamous Cell Carcinoma In Vitro.

Fucoidans have been reported to exert anticancer effects with simultaneous low toxicity against healthy tissue. That correlation was observed in several cancer models, however, it has never been investigated in head and neck cancer before. To magnify the efficacy of conventional therapy, the administration of agents like fucoidan could be beneficial. The aim of this study was to evaluate the anticancer effect of Fucus vesiculosus (FV) extract alone and with co-administration of cisplatin in head and neck squamous cell carcinoma (HNSCC) in vitro. MTT assay results revealed an FV-induced inhibit

Cancer burden and risk in the Chinese population aged 55 years and above: A systematic analysis and comparison with the USA and Western Europe.

BackgroundWe analysed the cancer burden among elderly Chinese people over the age of 55 years and compared them to USA and Western Europe to explore the cancer model in China.MethodsWe retrieved data on 29 cancers with 34 risk factors from the 2019 Global Burden of Disease database to evaluate the cancer burden in Chinese elderly individuals aged 55 years and older. We then used the age-standardised incidence rate (ASIR), age-standardised death rate (ASDR), age-standardised disability-adjusted life year (DALY) rate, and average annual percentage change (AAPC) to compare the characteristics and

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… Although the Chinese government introduced its first tobacco control law in the early 1990s and signed the World Health Organization Framework Convention on Tobacco Control in 2005 [ 22 ], these efforts had little success in the Chinese population. … Mackay J.China: the tipping point in tobacco control. Br Med Bull. 2016;120:15–25. 10.1093/bmb/ldw043 23. Wang M, Luo X, Xu S, Liu W, Ding F, Zhang X, et al. Trends in smoking prevalence and implication for chronic diseases in China: serial national cross-sectional surveys from 2003 to 2013. …

Связь между аутоиммунным заболеванием и раком цвета кожи: ретроспективное тематическое исследование 120 876 Пациенты.

ЦЕЛЬ: рак цветности (КЗ) one из наиболее часто диагностируемых раковых заболеваний и одной из главных причин смертности от раковых заболеваний во всем мире. Хотя воспламенительное кишечное заболевание (ИББ) является широко распространенным фактором риска для КПР, потенциальная связь между другими аутоиммунными заболеваниями и КПР неясна. В свете растущей распространенности аутоиммунных заболеваний и их признанной связи с различными вредными явлениями в настоящем исследовании ставится задача изучить вопрос о том, связаны ли с КПР различные аутоиммунные заболевания. МЕТОДЫ: Всего 20 146 пациенто

Различия по возрасту и полу при воздействии антигипергликемических препаратов и риск вновь диагностированного множественного склероза в показателях склонности соответствуют типу 2 Фиолетовые.

СОСТОЯНИЕ: Связь между воздействием антигипергликемических препаратов (A-HgM) для типа 2 Лечение диабетом Mellitus (T2D) и множественным склерозом (MS) у пациентов T2D является неясным. МЕТОДЫ: Этот ретроспективный когортный анализ проводился с использованием базы данных о претензиях компании " Маринер " . Количество пациентов, прошедших обследование на предмет диагноза MS 12 через несколько месяцев после диагноза Т2D. Пациенты должны были быть активно зачислены в регистры претензий " Маринер " six за несколько месяцев до и по крайней мере three Через несколько лет после ди

The contribution of Cyprus to non-communicable diseases and biomedical research from 2002 to 2013: implications for evidence-based health policy.

BackgroundNon-communicable diseases (NCDs) are the leading causes of disease burden and mortality at the European level and in Cyprus. This research was conducted to map the research activities of Cypriot institutions in five NCDs, namely oncology, cardiovascular diseases, diabetes, mental health and respiratory conditions.MethodsFor the period 2002-2013, research in Cyprus was assessed on its biomedical outputs and compared to the rest of Europe relative to their GDP. The research output in the five NCDs was obtained and contrasted to their respective disease burdens. The results from each of

The DNA damage response network in the treatment of head and neck squamous cell carcinoma.

BACKGROUND: We sought to determine whether DNA damage response (DDR)-related aberrations predict therapeutic benefit in cisplatin-treated head and neck squamous cell carcinoma (HNSCC) patients and how DDR pathways are modulated after treatment with olaparib alone or in combination with cisplatin or durvalumab. PATIENTS AND METHODS: Oxidative stress, abasic sites and DDR-related parameters, including endogenous DNA damage, DNA repair mechanisms and apoptosis rates, were evaluated in HNSCC cell lines and peripheral blood mononuclear cells from 46 healthy controls (HC) and 70 HNSCC patients at b

COVID-19: The Impact in Oncology Care.

The COVID-19 pandemic has imposed a critical challenge to the current oncology care and practices including late diagnoses, delayed anti-cancer treatment, and static clinical trials. With the increasing risk of cancer patients acquiring infection during receiving the essential care, the debate ensues on how to balance the risk factors and benefits out of the oncologic emergencies in cancer patients. In this review article, we have focused on the current global re-organization of the integrity and effectiveness of the treatment modalities depending on the patient and cancer-specific urgencies w

Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis.

ObjectiveTo assess the effectiveness and safety of melatonin for perimenopausal and postmenopausal women with osteopenia.MethodsIn this meta-analysis, data from randomized controlled trials were obtained to assess the effects of melatonin versus placebo or western medicine in perimenopausal and postmenopausal women with osteopenia. The study's registration number is CRD42018086238. The primary outcomes included bone mineral density (BMD) and T-score.ResultFrom 551 articles retrieved, three trials involving 121 patients were included. Due to the high-to-substantial heterogeneity (BMD: I2=96.9%,

Exposures to IARC Carcinogenic Agents in Work Settings Not Traditionally Associated with Sinonasal Cancer Risk: The Experience of the Italian National Sinonasal Cancer Registry.

The aim of this study is to highlight tasks and jobs not commonly considered at high risk for sinonasal cancer (SNC) identified by Regional Operating Centers currently active in the Italian National Sinonasal Cancer Registry (ReNaTuNS), which retrieve occupational histories through a standardized questionnaire. Data on exposures to IARC carcinogenic agents in work settings unknown to be associated with SNC risk were collected and analyzed. Out of 2,208 SNC cases recorded in the ReNaTuNS database, 216 cases and their worked exposure periods were analyzed. Unsuspected jobs with exposure to wood

Awareness of Obesity-Related Cancers: A Complex Issue.

Cancer rates are on the rise across the world, making the illness a public health crisis, particularly in developed countries where cancer has become a leading cause of death [...].

Cancer risks in rheumatoid arthritis patients who received immunosuppressive therapies: Will immunosuppressants work?

BACKGROUND: Exploring the cancer risks of rheumatoid arthritis (RA) patients with disease-modifying anti-rheumatic drugs (DMARDs) can help detect, evaluate, and treat malignancies at an early stage for these patients. Thus, a comprehensive analysis was conducted to determine the cancer risk of RA patients using different types of DMARDs and analyze their relationship with tumor mutational burdens (TMBs) reflecting immunogenicity. METHODS: A thorough search of PubMed, EMBASE, Web of Science, and Medline was conducted up to 20 August 2022. Standardized incidence ratios (SIRs) were constructed w

A comprehensive evaluation of potentially significant drug-drug, drug-herb, and drug-food interactions among cancer patients receiving anticancer drugs.

IntroductionDuring the cancer treatment path, cancer patients use numerous drugs, including anticancer, supportive, and other prescribed medications, along with herbs and certain products. This puts them at risk of significant drug interactions (DIs). This study describes DIs in cancer patients and their prevalence and predictors.MethodsA cross-sectional study design was used to achieve the study objectives. The study was carried out in two centers in the northern West Bank, Palestine. The Lexicomp® Drug Interactions tool (Lexi-Comp, Hudson OH, USA) was applied to check the potential DIs. In a

Impact of cancer on cryopreserved sperm quality and fertility: A cohort study.

BackgroundSperm quality at cancer diagnosis is often compromised by the disease and any given gonadotoxic treatment will further diminish fertility.ObjectivesHere, we aim to analyze the cryopreserved sperm quality according to the cancer types as well as the fertility outcomes.MethodsOur study included all cancer patients who cryopreserved sperm over 20 years at Erasme Hospital Brussels (from 1999 to 2019). First sperm samples from 111 hematologic, 104 testicular, 19 prostate, 28 gastrointestinal, and 16 neurological cancer patients were compared.ResultsOligozoo-asthenozoospermia was observed

Postoperative outcomes of multilevel versus single-level anterior cervical discectomy and fusion in patients with sarcopenia: a matched cohort study.

BACKGROUND: Anterior cervical discectomy and fusion (ACDF) remains an effective treatment for cervical degenerative pathology. However, postoperative outcomes among patients with sarcopenia following multilevel versus single-level ACDF remain poorly understood. This study compared postoperative outcomes and complications between multilevel and single-level ACDF in patients with sarcopenia. METHODS: A retrospective propensity-matched cohort study was conducted using the TriNetX database, including 2,873 patients with sarcopenia identified using International Statistical Classification of Disea

Диверсификация глобальных тенденций заболеваемости раком ранней стадии: сопоставление с тенденциями заболеваемости раком более поздней стадии и тенденциями смертности от рака ранней стадии.

Глобальное увеличение заболеваемости раком в раннем возрасте (определяемым как рак, диагностируемый на 20-49 ) является серьезной проблемой в области здравоохранения. Мы расследовали 1) отличается ли тенденция заболеваемости раком раннего зарождения от тенденции заболевания раком на более позднем этапе и 2) увеличиваются ли одновременно как частотность, так и смертность от рака раннего возраста. 2000 и 2017 от раковых заболеваний Five Базы данных о смертности на континентах и Всемирной организации здравоохранения (ВОЗ). Общенациональная распространенность ожирения среди взрослых 20-49 Годы был

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… For instance, global initiatives on comprehensive tobacco control, including taxation, warning labels, advertising bans, and smoke-free environments, have effectively reduced global smoking prevalence [ 34 ]. … The effects of tobacco control policies on global smoking prevalence. Nat Med. 2021;27(2):239–43. 35. Fontham ETH, Wolf AMD, Church TR, Etzioni R, Flowers CR, Herzig A, et al. Cervical cancer screening for individuals at average risk: 2020 guideline update from the American Cancer Society. …

Разнообразие по признаку пола 90-Day Послеоперационные осложнения у пациентов с анемической атропластикой.

Первичная анемия представляет собой фактор риска для неблагоприятных последствий после полной артропопластики (THA), что в непропорционально большой степени сказывается на женщинах и способствует заболеваемости. Хотя как анемия, так и пол независимо связаны с постоперационными осложнениями, лишь в немногих исследованиях анализировались результаты у анемических пациентов, стратифицированных по признаку пола. По сравнению с этим исследованием 90-day Коэффициент осложнений послеоперационного периода между анемическими пациентами мужского пола и анемическими пациентами женского пола, проходящими п

Seeking American Society of Clinical Oncology-Quality Oncology Practice Initiative (ASCO-QOPI) certification in a northern New England rural health system and cancer care network.

In 2006 following several years of preliminary study, the American Society of Clinical Oncology (ASCO) launched the Quality Oncology Practice Initiative (QOPI). This cancer-focused quality initiative evolved considerably over the next decade-and-a-half and is expanding globally. QOPI is undoubtedly the leading standard-bearer for quality cancer care and contemporary medical oncology practice. The program garners attention and respect among federal programs, private insurers, and medical oncology practices across the nation. The MaineHealth Cancer Care Network (MHCCN) has undergone expansive gr

Symptom Prevalence in Spanish and Colombian Oncology Patients Measured with the MSAS.

Cancer patients experience several symptoms throughout their illness and the treatments they receive. While this pathology represents a worldwide health problem, knowing the symptom prevalence in oncology patients remains a challenge; validated tools to obtain this information are essential. Furthermore, this prevalence information would help health professionals to establish appropriate treatments. The objective of this study was to ascertain the symptom prevalence in cancer patients from Spain and Colombia to improve future approaches. The frequency, severity, and distress of 32 symptoms fro