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The use of virtual nominal groups in healthcare research: An extended scoping review.

IntroductionThe Nominal Group Technique (NGT) is a consensus group method used to synthesize expert opinions. Given the global shift to virtual meetings, the extent to which researchers leveraged virtual platforms is unclear. This scoping review explores the use of the vNGT in healthcare research during the COVID-19 pandemic.MethodsFollowing the Arksey and O'Malley's framework, eight cross-disciplinary databases were searched (January 2020-July 2022). Research articles that reported all four vNGT stages (idea generation, round robin sharing, clarification, voting) were included. Media Synchron

Acceptability and appropriateness of a clinical pathway for managing anxiety and depression in cancer patients: a mixed methods study of staff perspectives.

BackgroundClinical pathways (CPs) can improve health outcomes, but to be sustainable, must be deemed acceptable and appropriate by staff. A CP for screening and management of anxiety and depression in cancer patients (the ADAPT CP) was implemented in 12 Australian oncology services for 12 months, within a cluster randomised controlled trial of core versus enhanced implementation strategies. This paper compares staff-perceived acceptability and appropriateness of the ADAPT CP across study arms.MethodsMulti-disciplinary lead teams at each service tailored, planned, championed and implemented the

Accuracy and Reliability of Internet Resources for Information on Monoclonal Gammopathy of Undetermined Significance-What Information Is out There for Our Patients?

BACKGROUND: Online information gathering can increase patients' engagement in decision-making. The quality of online resources available for monoclonal gammopathy of undetermined significance (MGUS) was evaluated. METHODS: 900 websites from Google, Bing, Yahoo, and 150 YouTube videos were assessed. RESULTS: The websites did not differ regarding their search rank or between the search engines. The median time since last update was 24 months. The 86 unique websites showed a medium to poor general quality (JAMA score 3/4, only 8.1% websites with a valid HON certificate). The patient- (user-) fo

Systemic Sclerosis Associated Interstitial Lung Disease: New Directions in Disease Management.

A subgroup of patients with systemic sclerosis (SSc) develop interstitial lung disease (ILD), characterized by inflammation and progressive scarring of the lungs that can lead to respiratory failure. Although ILD remains the major cause of death in these individuals, there is no consensus statement regarding the classification and characterization of SSc-related ILD (SSc-ILD). Recent clinical trials address the treatment of SSc-ILD and the results may lead to new disease-altering therapies. In this review, we provide an update to the diagnosis, management and treatment of SSc-ILD.

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… East Asians have the longest median survival time (43.3 years) and Arabs the shortest median survival time (15 years) ( 12 ). Independent of race, lower median household income predicted increased mortality ( 11 ). …

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Pathogenesis and kidney prognosis of renal amyloidosis.

Light chain (AL), serum amyloid A (AA), transthyretin (ATTR), leukocyte cell derived chemotaxin 2 (ALECT2), and fibrinogen Aa (AFib) amyloidosis are some of the most common types of protein-deposition disorders involving the kidney. Each amyloidogenic protein differs in its origin and little is known about the exact mechanisms that govern renal tropism and tissue injury for each amyloid subtype. While amyloidogenic precursor protein is different in each subtype of amyloidosis, its aggregation into fibrils depositing in target organs and leading to disruption of tissue architecture and progress

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… Additional groups include Punjabis, First Nations people in British Columbia, Arabs, Israelis, and Native Americans. [ 4 , 144 ] Incompletely studied: Literature predominantes in western countries (white population) and Asians [ 15 , 17 , 159 , 165 ] Classic Etiology Plasma cell dyscrasias or B cell … Additional groups include Punjabis, First Nations people in British Columbia, Arabs, Israelis, and Native Americans. [ 4 , 144 ] | Incompletely studied: Literature predominantes in western countries (white population) and Asians [ 15 , 17 , 159 , 165 ] Classic Etiology | Plasma cell dyscrasias or B cell …

Выборочные связи между когнитивной практикой и реактивной адаптацией в множестве склерозов.

ЦЕЛЬ: Когнитивные и балансовые нарушения характерны для множественных склерозов (МС). Эффекты на практике могут отражать нейропластичность и прогнозировать реабилитацию. В ходе этого исследования были изучены когнитивные последствия и их связь с реактивной адаптацией баланса в НР. МЕТОДЫ: Twenty-seven люди, имеющие MS и 17 Нейротипичные взрослые 2 базовые когнитивные оценки по сравнению с 2 недель, за которыми следует a 2-week Программа профессиональной подготовки по вопросам сбалансированности на основе транстурбации 6 - прогрессивные сессии. Вертикальная скорость обучения и обработки была оц

Глобальные, региональные и национальные факторы метаболического риска, связанные с множественной миеломой, 1990-2021:: анализ на основе глобального исследования бремени болезней; 2021.

Цель настоящего исследования заключалась в изучении глобального бремени болезней, связанных с множественной миеломой (ММ), которая связана с метаболическими факторами. Использование данных GHDx тарирования 1990-2021, случаи MM были выявлены через ICD-10 коды (C90.0). Были проанализированы ключевые показатели, включая коэффициент смертности и коэффициент лет жизни с поправкой на инвалидность (DALY); стандартизированные по возрасту показатели (ASMR, ASDR) и расчетные годовые процентные изменения (EAPC) были рассчитаны с использованием R для сопоставления различий между регионами, полами и возрас

Структура-ориентированное исследование ДНК-аптамера, целевого PTK7, выявляет сложную 3D-составляющую, направляющую оптимизацию функции.

DNA аптамеры вышли в качестве новых молекулярных инструментов в терапевтической и диагностической медицине благодаря своей высокой аффинности и специфичности к белковым целям, что определяется их способностью сворачиваться в отличительные трехмерные (3D) структуры. Однако при проектировании и моделировании аптамеров часто игнорируются тонкие атомные взаимодействия, формирующие 3D структуры, что приводит к неэффективной оптимизации функциональных свойств. Проблемы сохраняются при определении высокоразрешающих структур комплексов аптамер-белок. Кроме того, экспериментально определенные 3D структ

Combined Immune Defect in B-Cell Lymphoproliferative Disorders Is Associated with Severe Infection and Cancer Progression.

B cell chronic lymphoproliferative diseases (B-CLPD) are associated with secondary antibody deficiency and other innate and adaptive immune defects, whose impact on infectious risk has not been systematically addressed. We performed an immunological analysis of a cohort of 83 B-CLPD patients with recurrent and/or severe infections to ascertain the clinical relevance of the immune deficiency expression. B-cell defects were present in all patients. Patients with combined immune defect had a 3.69-fold higher risk for severe infection (p = 0.001) than those with predominantly antibody defect. Inte

Rice bran arabinoxylan compound and quality of life of cancer patients (RBAC-QoL): Study protocol for a randomized pilot feasibility trial.

IntroductionRice bran arabinoxylan compound (RBAC) is a nutraceutical for enhancing a depleted immune system during and after cancer treatment. This pilot feasibility trial aims to evaluate the effects of RBAC on cancer patients' quality of life during active treatment, compared to placebo, using a validated questionnaire. Other outcome measures include changes in inflammatory and nutritional status, cytokine profile, and gut microbiota.Methods/designThe study will recruit 50 participants from a regional cancer center in Australia. Patients aged 18-70, diagnosed with solid organ cancers stage

Dural Lymphomas Unmasked: A Narrative Review of Extra-Axial Mimics and a Pragmatic Diagnostic Decision Algorithm.

Dural-based lymphomas are rare extranodal non-Hodgkin lymphomas that span from indolent primary dural entities, most commonly the extranodal marginal zone (mucosa-associated lymphoid tissue) lymphoma, to aggressive variants that are primary or represent secondary involvement from systemic lymphoma. They overlap radiologically with benign meningiomas, dural metastases, and immune-mediated pachymeningitis, creating a risk of anchoring bias, delayed diagnosis, and unnecessarily extensive resections when limited tissue sampling would be sufficient for diagnosis. We conducted a structured narrative

Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets.

Glutamine is the most abundant amino acid in human serum, and it can provide carbon and nitrogen for biosynthesis, which is crucial for proliferating cells. Moreover, it is widely known that glutamine metabolism is reprogrammed in cancer cells. Many cancer cells undergo metabolic reprogramming targeting glutamine, increasing its uptake to meet their rapid proliferation demands. An increasing amount of study is being done on the particular glutamine metabolic pathways in cancer cells.Further investigation into the function of glutamine in immune cells is warranted given the critical role these

Оценка MS MoveSmart - онлайновая структурированная тренировка, основанная на социальной когнитивной теории поведенческих тренировок и программе поддержки сверстников - по проблемам тревоги при множественном склерозе.

У людей с множественным склерозом (PwMS) вызывает беспокойство. Хотя известно, что участие в практической деятельности имеет ряд преимуществ, в этом контексте меньше внимания уделяется той роли, которую играет эта деятельность в снижении уровня тревоги. Понимание воздействия упражнений на состояние тревоги, предвидетелей этого изменения и опыта участников будет способствовать дальнейшей разработке программ, которые могут оказать поддержку PwMS.AIM: В этом исследовании использовалась схема оценки до/после проведения оценки (AIM):1) для оценки эффективности структурированной онлайновой программы

Advances and Challenges in Cancer Stem Cells for Onco-Therapeutics.

Six decades have passed since the foundational recognition of the primary properties of the stem cells. Research on stem cells has since remained at the forefront of efforts to combat a spectrum of diseases, most notably cancer. Despite remarkable progress in medical science, a definitive cure for cancer has remained elusive, spurring the pursuit of diverse therapeutic strategies, among which stem cell therapy is a particularly promising avenue. Moreover, the utilization of cancer stem cells as a therapeutic source holds immense potential for addressing intractable diseases. The strategy of ta

The Battlefield of Chemotherapy in Pediatric Cancers.

The survival rate for pediatric cancers has remarkably improved in recent years. Conventional chemotherapy plays a crucial role in treating pediatric cancers, especially in low- and middle-income countries where access to advanced treatments may be limited. The Food and Drug Administration (FDA) approved chemotherapy drugs that can be used in children have expanded, but patients still face numerous side effects from the treatment. In addition, multidrug resistance (MDR) continues to pose a major challenge in improving the survival rates for a significant number of patients. This review focuses

Antioxidant and Antiproliferation Activities of Lemon Verbena (Aloysia citrodora): An In Vitro and In Vivo Study.

Aloysia citrodora (Verbenaceae) is traditionally used to treat various diseases, including bronchitis, insomnia, anxiety, digestive, and heart problems. In this study, this plant's antioxidant and anti-proliferation effects were evaluated. In addition to volatiles extraction, different solvent extracts were prepared. The GC-MS, LC-MS analysis and the Foline-Ciocalteu (F-C) method were used to investigate the phytochemical components of the plant. MTT assay was used to measure the antiproliferative ability for each extract. Antioxidant activity was determined using the 2,2-diphenylpicrylhydrazy

COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network.

Patients with multiple myeloma frequently present with substantial immune impairment and an increased risk for infections and infection-related mortality. The risk for infection with SARS-CoV-2 virus and resulting mortality is also increased, emphasising the importance of protecting patients by vaccination. Available data in patients with multiple myeloma suggest a suboptimal anti-SARS-CoV-2 immune response, meaning a proportion of patients are unprotected. Factors associated with poor response are uncontrolled disease, immunosuppression, concomitant therapy, more lines of therapy, and CD38 an

Использование микробиомных средств для совершенствования методов лечения нейродегенеративных заболеваний: данные о воздействии вдоль оси микробиота-гут-мозгов.

Недавно в качестве полезной модели для понимания возникновения и развития нейродегенеративных заболеваний (НДД) появилась ось микробиота-гут-мозгов (МГБА). Меры воздействия на основе микробиома с использованием биотических добавок (пробиотики, предбиотики, синдиотики, постбиотики) могут модифицировать MGBA и служить подходящими решениями для снижения риска неврологических изменений, связанных с НИЗ, и регулирования симптомов. В настоящем описательном обзоре содержится резюме функционирования МГБС и его взаимодействия с заболеваниями, связанными с началом и развитием НИЗ. Проводится обзор мероп

The Global Obesity Epidemic: Epidemiology, Health Burden and Policy Priorities.

The global prevalence of obesity has more than tripled since 1975, now affecting nearly one billion adults and over 170 million children and adolescents. In 2025, The Lancet Diabetes & Endocrinology Commission on Clinical Obesity redefined obesity as a chronic, multisystem disease characterised by excess adiposity leading to organ dysfunction, distinguishing between preclinical obesity (excess adiposity without end-organ injury) and clinical obesity (manifest metabolic or structural complications). This framework moves beyond reliance on BMI, acknowledging that ectopic fat deposition in the li