Результаты поиска

Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment.

Ascorbic acid has attracted substantial attention for its potential antitumor effects by acting as an antioxidant in vivo and as a cofactor in diverse enzymatic reactions. However, solid proof of its clinical efficacy against cancer and the mechanism behind its effect have not been established. Moreover, cancer forms cancer-specific microenvironments and interacts with various cells, such as cancer-associated fibroblasts (CAFs), to maintain cancer growth and progression; however, the effect of ascorbic acid on the cancer microenvironment is unclear. This review discusses the effects and mechan

Совпадение в полном тексте источника
… Vitamin c-enriched gelatin supplementation before intermittent activity augments collagen synthesis . Am J Clin Nutr ( 2017 ) 105 : 136–43 . doi: 10.3945/ajcn.116.138594 PMC5183725 27852613 109 Piersma B Wouters OY de Rond S Boersema M Gjaltema RAF Bank RA . …

Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast - A Novel Concept for Osteoporosis Treatment: Part 1.

PURPOSE: Osteoporosis results in a severe decrease in the life quality of many people worldwide. The latest data shows that the number of osteoporotic fractures is becoming an increasing international health service problem. Therefore, a new kind of controllable treatment methods for osteoporotic fractures is extensively desired. For that reason, we have manufactured and evaluated nanohydroxyapatite (nHAp)-based composite co-doped with iron oxide (IO) nanoparticles. The biomaterial was used as a matrix for the controlled delivery of miR-21-5p and miR-124-3p, which have a proven impact on bone

Совпадение в полном тексте источника
… Biosynthesis and characterization of hydroxyapatite and its composite (hydroxyapatite-gelatin-chitosan-fibrin-bone ash) for bone tissue engineering applications . Int J Biol Macromol . 2019 ; 129 : 844 – 852 . doi: 10.1016/j.ijbiomac.2019.02.058 30769044 19. …

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches.

Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge. To bridge the gap and bring effective treatment, it is important to understand the etiology of skin carcinoma, the mechanism of cell proliferation, factors affecting cell growth, and the mechanism of drug resistance. The current article focusses on understanding the structural diversity of skin cancers, tr

A Review of Recent Curcumin Analogues and Their Antioxidant, Anti-Inflammatory, and Anticancer Activities.

Curcumin, as the main active component of turmeric (Curcuma longa), has been demonstrated with various bioactivities. However, its potential therapeutic applications are hindered by challenges such as poor solubility and bioavailability, rapid metabolism, and pan-assay interference properties. Recent advancements have aimed to overcome these limitations by developing novel curcumin analogues and modifications. This brief review critically assesses recent studies on synthesising different curcumin analogues, including metal complexes, nano particulates, and other curcumin derivatives, focused o

Совпадение в полном тексте источника
… Curcumin encapsulated pH sensitive gelatin based interpenetrating polymeric network nanogels for anti cancer drug delivery. Int. J. Pharm. 2015;478:788–795. doi: 10.1016/j.ijpharm.2014.12.001. 53. Kanwar S.S., Yu Y., Nautiyal J., Patel B.B., Padhye S., Sarkar F.H., Majumdar A.P.N. …

Harnessing the Therapeutic Potential of Mesenchymal Stem Cells in Cancer Treatment.

Cancer, as a complicated disease, is considered to be one of the major leading causes of death globally. Although various cancer therapeutic strategies have been established, however, some issues confine the efficacies of the treatments. In recent decades researchers for finding efficient therapeutic solutions have extensively focused on the abilities of stem cells in cancer inhibition. Mesenchymal stem cells (MSCs) are multipotent stromal cells that can the most widely extracted from various sources such as the bone marrow (BM), placenta, umbilical cord (UC), menses blood, Wharton's jelly (WJ

Совпадение в полном тексте источника
… Mesenchymal progenitor cell-mediated inhibition of tumor growth in vivo and in vitro in gelatin matrix. Exp Mol Pathol. 2003;75(3):248–55. doi: 10.1016/j.yexmp.2003.06.001. 59. Seo SH, Kim KS, Park SH, Suh YS, Kim SJ, Jeun SS, et al. …

Nanoparticle-Based RNAi Therapeutics Targeting Cancer Stem Cells: Update and Prospective.

Cancer stem cells (CSCs) are characterized by intrinsic self-renewal and tumorigenic properties, and play important roles in tumor initiation, progression, and resistance to diverse forms of anticancer therapy. Accordingly, targeting signaling pathways that are critical for CSC maintenance and biofunctions, including the Wnt, Notch, Hippo, and Hedgehog signaling cascades, remains a promising therapeutic strategy in multiple cancer types. Furthermore, advances in various cancer omics approaches have largely increased our knowledge of the molecular basis of CSCs, and provided numerous novel targ

Совпадение в полном тексте источника
… The natural polymers used for gene-based therapy include chitosan, atelocollagen, folate (FA), HA, and gelatin, and are biocompatible, biodegradable, and generally nontoxic, even at high concentrations. Chitosan has been successfully used in gene delivery systems [ 155 , 156 , 157 ]. …

The various therapeutic applications of the medical isotope holmium-166: a narrative review.

Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which can be used for a therapeutic effect and gamma radiation which can be used for nuclear imaging purposes. Furthermore, holmium-165 can be visualized by MRI because of its paramagnetic properties and by CT because of its high density. Since holmium-165 has a natural abundance of 100%, the only by-product is metastable holmium-166 and no costly chemical purification steps are necessary for pro

Совпадение в полном тексте источника
… However, under neutral or basic conditions, it is converted into a gelatinized material enabling the retention of the complex at the administration site. The 166 Ho-labelled chitosan complex was developed as a radiopharmaceutical for cancer therapy by the Korean Atomic Energy Research Institute. …

Monoclonal Antibodies Approved for Cancer Therapy

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… After allergological testing showed that the patient had α- d -galactose-associated red meat and gelatin allergy and was skin test negative to panitumumab, intraoperative use of gelatin-derived colloids and treatment with cetuximab, both known to carry α- d -galactose residues, were prohibited and panitumumab …

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contri

Совпадение в полном тексте источника
… 1 | 300 mg solution of curcumin | ( 129 ) CuraMed | 552–578 mg of BCM-95 extracted in ethanol 99% (v/v) and 100% ethyl acetate +49–52 mg volatile oil from C. longa containing 22–23.4 mg aromatic turmerone + inactive excipients (120–140 mg) including phosphatidyl choline, medium chain TGs, glycerol, gelatin … The placebo used in this study contained calcium phosphate, FD&C yellow 5, FD&C yellow 6, gelatin, magnesium stearate, maltodextrin, silica oxide, and titanium oxide. …

Rare Diseases of the Nose, the Paranasal Sinuses, and the Anterior Skull Base.

Due to their low incidence and thus resulting limited diagnostic criteria as well as therapeutic options, rare diseases of the nose, the paranasal sinuses, and the anterior skull base are a significant challenge. The value as of which a disease has to be considered as rare amounts to a maximum of 5 patients per 10 000 people. Within these diseases, however, there are extreme differences. Some rare or orphan diseases like for example the inverted papilloma belong to regularly diagnosed and treated diseases of larger departments of oto-rhino-laryngology whereas other rare diseases and malformati

Совпадение в полном тексте источника
… Macroscopically, a polypoid, partly papillary and nodular mass with fragile consistency and ulcerating, hemorrhagic as well as rarely gelatinous or mucous parts are seen 106 250 251 . Microscopically, exophytic, papillary and tubular or mucinous growth consisting mainly of signet ring cells. …

Глубинные пространственные омики MLADI-MS, управляемые квантовой каскадной лазерной микроскопией среднего инфракрасного изображения.

В пространственной "omics " высокоуверенные молекулярные идентификации необходимы для исследования сложной биологии и для пространственной биомаркировки. Однако нынешняя масс-спектрометрическая съемка (MSI) на основе пространственной "омики" должна скомпрометировать скорость получения данных и глубину биохимического профилирования. Здесь мы введём быструю, без этикеток квантовую каскадную лазерную микроскопию среднего инфракрасного изображения (QCL-MIR), чтобы направить MSI в высокоинтересные области тканей, такие маленькие, как гломерули почки, культурные многоклеточные сфероидные я

Совпадение в полном тексте источника
… For embedding, spheroids were transferred to HMPC-PVP filled channels inside a gelatin cryo-mold 68 . …

Stage-specific treatment of colorectal cancer: A microRNA-nanocomposite approach.

Colorectal cancer (CRC) is among the leading causes of cancer mortality. The lifetime risk of developing CRC is about 5% in adult males and females. CRC is usually diagnosed at an advanced stage, and at this point therapy has a limited impact on cure rates and long-term survival. Novel and/or improved CRC therapeutic options are needed. The involvement of microRNAs (miRNAs) in cancer development has been reported, and their regulation in many oncogenic pathways suggests their potent tumor suppressor action. Although miRNAs provide a promising therapeutic approach for cancer, challenges such as

Совпадение в полном тексте источника
… Gelatin-encapsulated iron oxide nanoparticles for platinum (IV) prodrug delivery, enzyme-stimulated release and MRI. Biomaterials. 2014;35:6359–6368. doi: 10.1016/j.biomaterials.2014.04.029. 125. Chandrakala V., Aruna V., Angajala G. …

Pharmacological Treatments and Therapeutic Drug Monitoring in Patients with Chronic Pain.

Pain is an unpleasant sensory and emotional experience that affects every aspect of a patient's life and which may be treated through different pharmacological and non-pharmacological approaches. Analgesics are the drugs most commonly used to treat pain, and in specific situations, the use of opioids may be considered with caution. These drugs, in fact, do not always induce optimal analgesia in patients, and several problems are associated with their use. The purpose of this narrative review is to describe the pharmacological approaches currently used for the management of chronic pain. We rev

Совпадение в полном тексте источника
… The central nervous system (CNS) includes a high concentration of ORs in the periaqueductal gray, locus coeruleus (LC), ventral rostral medulla, and the gelatinous substance of the dorsal horn of the spinal cord. …

Repositioning of drugs for Parkinson's disease and pharmaceutical nanotechnology tools for their optimization.

Parkinson's disease (PD) significantly affects patients' quality of life and represents a high economic burden for health systems. Given the lack of safe and effective treatments for PD, drug repositioning seeks to offer new medication alternatives, reducing research time and costs compared to the traditional drug development strategy. This review aimed to collect evidence of drugs proposed as candidates to be reused in PD and identify those with the potential to be reformulated into nanocarriers to optimize future repositioning trials. We conducted a detailed search in PubMed, Web of Science,

Совпадение в полном тексте источника
… Some of the most successful polymeric materials in their use are gelatin, hyaluronic acid, alginate (ALG), chitosan (CS), polylactic-co-glycolic acid (PLGA), polylactide (PLA), polyethylene glycol (PEG), polycaprolactone (PCL), and polyanionic cellulose (PAC) [ 78 ]. …

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

Совпадение в полном тексте источника
… Examples for natural polymers include polysaccharides such as chitosan (CS) [ 488 , 489 ] and proteins such as gelatine [ 490 ], Zein [ 491 ], fibroin [ 492 ], and albumin [ 493 ]. …

Integrated Engineering of CAR-T Cells for Solid Tumours.

Chimeric antigen receptor (CAR) T-cell therapy has achieved durable efficacy in hematologic malignancies but encounters persistent obstacles in solid tumours, including antigen heterogeneity, a suppressive tumour microenvironment (TME), and intrinsic T-cell dysfunction. This review examines the transition from single-axis engineering to an integrated framework that addresses these hurdles in sequence. We delineate how next-generation CAR-T cells are designed for precise spatiotemporal activation through logic-gated and pharmacologically regulatable receptors, while being reinforced by metaboli

Совпадение в полном тексте источника
… regularly interspaced short palindromic repeats cytokine release syndrome dichloroacetate diffuse intrinsic pontine glioma extra domain A of fibronectin epidermal growth factor receptor variant III electroactive nano‐injection fibroblast activation protein TME‐responsive nanoimmunomodulator gelatin … Injectable, photocurable gelatin methacrylamide (GelMA) hydrogels supported CAR‐T survival and proliferation within the TME, prolonged retention, and enabled gradual release, enhancing efficacy and survival relative to local or intravenous administration in melanoma models [ 151 ] (Figure 8B ). …

Advances in the delivery of anticancer drugs by nanoparticles and chitosan-based nanoparticles.

Cancer is the leading cause of death globally, and conventional treatments have limited efficacy with severe side effects. The use of nanotechnology has the potential to reduce the side effects of drugs by creating efficient and controlled anticancer drug delivery systems. Nanoparticles (NPs) used as drug carriers offer several advantages, including enhanced drug protection, biodistribution, selectivity and, pharmacokinetics. Therefore, this review is devoted to various organic (lipid, polymeric) as well as inorganic nanoparticles based on different building units and providing a wide range of

Совпадение в полном тексте источника
… Animals provide materials like chitin (CS precursor), gelatin, collagen, silk, and hyaluronic acid, while plants offer pectin, starch, and cellulose. Similarly, algae provide alginate and agar, and microorganisms provide xanthan gum, dextran, and pullulan ( Zaiki et al., 2023 ). … CS is often combined with other polymers like gelatin, cellulose, or polyvinyl alcohol, and a crosslinker is used to induce gelation ( Afra et al., 2024 ). Three-dimensional-printed multifunctional scaffolds, implants, and stents effectively treat localized and recurring tumors. …

Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy.

Spinal cord injury (SCI) is a catastrophic injury to the central nervous system (CNS) that can lead to sensory and motor dysfunction, which seriously affects patients' quality of life and imposes a major economic burden on society. The pathological process of SCI is divided into primary and secondary injury, and secondary injury is a cascade of amplified responses triggered by the primary injury. Due to the complexity of the pathological mechanisms of SCI, there is no clear and effective treatment strategy in clinical practice. Exosomes, which are extracellular vesicles of endoplasmic origin w

Совпадение в полном тексте источника
… Hydrogels currently used for SCI repair include natural hydrogels such as alginate, agarose, collagen, fibronectin, gelatine, and extracellular matrix, and synthetic hydrogels such as polylactic acid, polylactic acid-glycolic acid, and polyethylene glycol [ 174 ]. …

Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies.

The phytocannabinoid cannabidiol (CBD) is receiving increasing attention due to its pharmacological properties. Although CBD is extracted from Cannabis sativa, it lacks the psychoactive effects of Δ9-tetrahydrocannabinol (THC) and has become an attractive compound for pharmacological uses due to its anti-inflammatory, antioxidant, anticonvulsant, and anxiolytic potential. The molecular mechanisms involved in CBD's biological effects are not limited to its interaction with classical cannabinoid receptors, exerting anti-inflammatory or pain-relief effects. Several pieces of evidence demonstrate

Совпадение в полном тексте источника
… A small proof of concept study ( NCT01562314 ) using a CBD-rich botanical extract in patients with UC (starting with 50 mg of CBD extract in gelatine capsules, twice a day; dose increased to 250 mg, twice a day) revealed that, after per-protocol analysis, the primary endpoint of remission after treatment …

Current and upcoming radionuclide therapies in the direction of precision oncology: A narrative review.

As new molecular tracers are identified to target specific receptors, tissue, and tumor types, opportunities arise for the development of both diagnostic tracers and their therapeutic counterparts, termed "theranostics." While diagnostic tracers utilize positron emitters or gamma-emitting radionuclides, their theranostic counterparts are typically bound to beta and alpha emitters, which can deliver specific and localized radiation to targets with minimal collateral damage to uninvolved surrounding structures. This is an exciting time in molecular imaging and therapy and a step towards personal

Совпадение в полном тексте источника
… Single-day Gelofusine, a succinylated form of bovine gelatin which is used as a plasma expander, has also been found to reduce radiotracer uptake in the kidney but has been shown to cause allergic reactions including anaphylactoid reactions, and thus is less commonly used [44] , [51] . …