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Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications.

This review outlines the accomplishments and potential developments of targeted alpha (α) particle therapy (TAT). It discusses the therapeutic advantages of the short and highly ionizing path of α-particle emissions; the ability of TAT to complement and provide superior efficacy over existing forms of radiotherapy; the physical decay properties and radiochemistry of common α-emitters, including 225Ac, 213Bi, 224Ra, 212Pb, 227Th, 223Ra, 211At, and 149Tb; the production techniques and proper handling of α-emitters in a radiopharmacy; recent preclinical developments; ongoing and completed clinica

Bone Research Society 2021 Abstracts

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Characteristics of Traditional Chinese Medicine Use in Pediatric Cancer Patients: A Nationwide, Retrospective, Taiwanese-Registry, Population-Based Study.

BackgroundLarge-scale surveys of complementary traditional Chinese medicine (TCM) use in pediatric cancer patients are lacking. The aim of our study was to investigate the use of TCM in pediatric cancer patients.MethodsWe analyzed cancer patients younger than 18 years (n = 12 965) who were registered in the National Health Insurance Research Database in Taiwan between 2001 and 2011. Patients were categorized into TCM or non-TCM users based on their use of TCM.ResultsIn Taiwan, 8086 (62.4%) children with cancer sought TCM treatment at some point. Children in older age groups, including school-a

Exploring Healthcare Continuity in Pediatric-Onset Multiple Sclerosis in the United States.

OBJECTIVE: Little is known about shifting from pediatric to adult-focused multiple sclerosis (MS) care. This study aims to explore transition of care and follow-up in the US pediatric-onset MS (POMS) population. METHODS: Surveys were distributed to 10 sites in the US Network of Pediatric MS Centers (US NPMSC) about transition-of-care practices. A cohort of POMS/clinically isolated syndrome (CIS) at 12 US NPMSC sites was analyzed. The primary comparison was between < 18 and ≥ 18-years of age. The primary outcome was 1- and 2-year lapse in last follow-up visit, measured from last recorded datab

Несоразмерный небольшой форник с модифицированной микроструктурой в педиатрическом множественном склерозе, показываемом с высокой разрешающей жидкостной диффузионной трактографией.

ОКРУЖАЮЩАЯ СРЕДА: У взрослых с множественным склерозом (MS) диффузионно-тензорная съемка (DTI) выявила явные аномалии объема и диффузии форникса, основного выходного участка гиппокампа (WM). ЦЕЛЬ: Определение того, затрагивает ли форник в педиатрическом плане MS (POMS), используя те же протоколы DTI, что и для взрослых MS (AOMS), что предполагает его участие в курсе болезни на раннем этапе. МЕТОДЫ: Для выявления форников в 11 пациентах в возрасте 13-19 лет и 26 контролерах с высоким разрешением была использована инфекционная трактография с использованием флюидов. Показатели объема и диффузии с

Brief Report: Hispanic Patients' Trajectory of Cancer Symptom Burden, Depression, Anxiety, and Quality of Life.

Background: Anxiety and depression symptoms are known to increase cancer symptom burden, yet little is known about the longitudinal integrations of these among Hispanic/Latinx patients. The goal of this study was to explore the trajectory and longitudinal interactions among anxiety and depression, cancer symptom burden, and health-related quality of life in Hispanic/Latinx cancer patients undergoing chemotherapy.MethodsBaseline behavioral assessments were performed before starting chemotherapy. Follow-up behavioral assessments were performed at 3, 6, and 9 months after starting chemotherapy. D

Symptom experiences and self-management strategies of patients with haematological malignancy undergoing chemotherapy: A qualitative study.

ObjectiveTo explore symptom experiences and self-management strategies from the haematological malignancy patient's perspective.MethodsA qualitative descriptive approach was used to provide a direct and comprehensive understanding of the symptoms experienced and self-management strategies during treatment among patients with haematological malignancy. Fourteen patients with haematologic malignancies who received chemotherapy at a Chinese tertiary hospital were selected using purposeful sampling. Data were collected via semi-structured interviews and one-on-one patient sessions. The collected d

Use of complementary and alternative medicine by patients with hematological diseases experience at a university hospital in northeast Mexico.

BackgroundComplementary and alternative medicine includes a diverse group of medical and healthcare systems, practices and products not considered part of conventional medicine. Although there is information on unconventional practices in oncological diseases, specific data regarding the use of complementary and alternative medicine by hematology patients is scarce.ObjectiveThe aim of this study is to document the prevalence of this modality of unconventional therapy in patients with malignant and benign hematological diseases, particularly children with acute lymphoblastic leukemia.MethodsAn

Regorafenib (BAY 73-4506) in advanced colorectal cancer: a phase I study.

BackgroundIn a phase I dose-escalation study, regorafenib demonstrated tolerability and antitumour activity in solid tumour patients. The study was expanded to focus on patients with metastatic colorectal cancer (CRC).MethodsPatients received oral regorafenib 60-220 mg daily (160 mg daily in the extension cohort) in cycles of 21 days on, 7 days off treatment. Assessments included toxicity, response, pharmacokinetics and pharmacodynamics.ResultsThirty-eight patients with heavily pretreated CRC (median 4 prior lines of therapy, range 0-7) were enrolled in the dose-escalation and extension phases

Computational identification of salient cancer care topics and themes in oncology social work notes.

BackgroundSocial work notes provide a multifaceted narrative of a patient's cancer journey. Topic modeling is a computational technique that can be used to organize notes into thematic clusters and study topics in oncological social work at scale. In this study, we used the BERTopic framework to perform topic modeling of cancer social work notes and identify roles and themes frequently documented in oncological social work.MethodsWe collected 106 676 social work notes from 25 341 patients diagnosed with cancer at the University of California San Francisco. Notes were split at the sentence leve

The P2X7R-antagonist AFC-5128 ameliorates chronic experimental autoimmune encephalomyelitis in a preventive and therapeutic paradigm.

BACKGROUND: Multiple sclerosis (MS) is characterized by chronic inflammation driven by central nervous system (CNS)-resident immune cells such as microglia, especially during the progressive phase of the disease. The P2X7 receptor (P2X7R), a risk protein for MS, is ubiquitously expressed on immune cells. AFC-5128, a CNS-penetrating small molecule inhibitor of P2X7R, is a promising agent for the treatment of autoimmune diseases such as MS. METHODS: In vitro, the effects on the calcium influx of primary murine microglia were assessed via Fluo-4 calcium imaging. In vivo, MOG35-55 immunized C57BL

Replacement of miR-155 Elicits Tumor Suppressive Activity and Antagonizes Bortezomib Resistance in Multiple Myeloma.

Aberrant expression of microRNAs (miRNAs) has been associated to the pathogenesis of multiple myeloma (MM). While miR-155 is considered a therapeutic target in several malignancies, its role in MM is still unclear. The analysis of miR-155 expression indicates its down-regulation in MM patient-derived as compared to healthy plasma cells, thus pointing to a tumor suppressor role in this malignancy. On this finding, we investigated miR-155 replacement as a potential anti-tumor strategy in MM. The miR-155 enforced expression triggered anti-proliferative and pro-apoptotic effects in vitro. Given th

Аспекты достоинства в семьях, обеспечивающих уход за лицами, страдающими множественным склерозом.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Основное внимание в этом исследовании уделяется сохранению достоинства и посягательству на достоинство членов семьи, обеспечивающих уход за лицами, страдающими множественным склерозом. АИМ: Цель исследования заключалась в углублении понимания того, как семьи, ухаживающие за лицами, страдающими множественным склерозом, воспринимают сохранение или лишение их достоинства. Применялся герменевый подход. МЕТОДЫ ИССЛЕДОВАНИЙ: Авторы провели научные опросы в форме бесед с восемью лицами, обеспечивающими уход за членами семьи. АНАЛИЗ И МЕТОДЫ ТОЛКОВАНИЯ: Нашим компасом и руководс

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… In a study of young caregivers of single parents diagnosed with MS, Bjorgvinsdottir and Halldorsdottir ( 2013 ) found that the participants felt silent, invisible and unacknowledged as caregivers and received limited professional assistance, and their caring responsibilities led to severe restrictions …

Validity and Reliability of the CarGOQoL Questionnaire Among Informal Caregivers of Patients With Cancer.

The 29-item CareGiver Oncology Quality of Life (CarGOQoL) scale measures quality of life (QoL) based on the specific characteristics of informal caregivers of patients with cancer. The 29-item CarGOQoL has been translated to numerous other languages and validated, thus confirming its validation. This study aimed to evaluate the reliability and validity of the Korean version of the 29-item CarGOQoL. We recruited 316 informal caregivers of patients with cancer. Data were collected using structured questionnaires between January 23, 2019 and November 30, 2019, and analyzed using SPSS 27.0 and Amo

A Phase II Trial of Melphalan Based Reduced-Intensity Conditioning for Transplantation of T-Replete HLA-Haploidentical Peripheral Blood Stem Cells with Posttransplant Cyclophosphamide in Patients with Hematologic Malignancies.

T-replete haploidentical donor transplants using posttransplant cyclophosphamide (haplo) have greatly expanded donor availability and are increasingly utilized. Haplo were originally performed using truly nonmyeloablative conditioning and a bone marrow graft. We have also developed myeloablative conditioning and peripheral blood stem cell (PBSC) grafts for use with haplo. However, some patients may not tolerate myeloablative conditioning but may still benefit from a more dose-intensified preparative regimen to control malignancy and diminish graft rejection. To this end, we enrolled 25 patient

Perceived social support and associations with health-related quality of life in young versus older adult patients with haematological malignancies.

BackgroundThis study compared the perceived social support of young and older adult cancer patients, examining possible influencing factors as well as associations with health-related quality of life.MethodsA total of 179 young patients (18-39 years) and 200 older adult patients (> 70 years) with haematological malignancies completed questionnaires on their perceived social support (ISSS-8, scales: Positive Support and Detrimental Interactions, range 0-16) and health-related quality of life (EORTC QLQ-C30). Tests for mean differences, correlations and regression analyses to determine associate

Gene therapy of rare diseases as a milestone in medicine - overview of the field and report on initial experiences in Slovenia.

Gene therapy has transitioned from a long-awaited promise to a clinical reality, offering transformative treatments for rare congenital diseases and certain cancers, which have a significant impact on patients' lives. Current approaches focus on gene replacement therapy, either in vivo or ex vivo, mostly utilizing viral vectors to deliver therapeutic genes into target cells. However, refining these techniques is essential to overcome challenges and complications associated with gene therapy to ensure long-term safety and efficacy. Slovenia has witnessed significant advancements in this field s

iPREFER: Опыт пациентов и предпочтение лечения множественной миеломы после нескольких линий лечения - качественное исследование.

ЦЕЛЬ: Ежегодно в Соединенном Королевстве примерно 6000 У людей диагностируется Множественная миелома (ММ) и лечатся с помощью целевых раковых препаратов. Продолжительность и периодичность такого лечения варьируются и включают пероральное, внутривенное (IV) и подкожное управление. Пациенты часто проходят несколько направлений лечения и живут в условиях неопределенности в течение многих лет и десятилетий. Данное исследование (Идентифицирующий орган Клинического производства.Государства): NCT06322927) изучает опыт лиц, проходящих курс лечения MM, то, что наиболее важно при принятии решений о лече

Ассоциация &lt; &lt; Между воздействием Солнца и риском возврата &gt; &gt; в педиатрии-посете с множественным склерозом.

ОБСТАНОВКА И ЗАДАЧИ: Облучение с низким Солнцем и ультрафиолетовым излучением (УВР) связано с повышенным риском развития педиатрического многоразового склероза (МС); однако их влияние на курс болезни не является достаточно наглядным. В первую очередь мы изучили, существует ли связь между временем, проведенным на солнце в раннем детстве, и риском рецидива в педиатрии MS. Во-вторых, мы изучали последствия воздействия солнца в последние периоды с точки зрения риска рецидива. МЕТОДЫ: Мы провели многоцентральное когортное исследование участников с педиатрической системой MS, нанятых в 18 детских кл

Results of a multicenter phase I/II trial of TCRαβ and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients.

Hematopoietic stem cell transplantation (HSCT) from haploidentical donors is a viable option for patients lacking HLA-matched donors. Here we report the results of a prospective multicenter phase I/II trial of transplantation of TCRαβ and CD19-depleted peripheral blood stem cells from haploidentical family donors after a reduced-intensity conditioning with fludarabine, thiotepa, and melphalan. Thirty pediatric and 30 adult patients with acute leukemia (n = 43), myelodysplastic or myeloproliferative syndrome (n = 6), multiple myeloma (n = 1), solid tumors (n = 6), and non-malignant disorders (n