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Sociodemographic, Clinical, and Therapeutic Characterization of Multiple Myeloma Patients (CharisMMa Study) with Symptomatic Relapse and/or Refractory Disease: An Observational, Multicenter Study in Portugal.

OBJECTIVES: Real-world information on relapsed and/or refractory multiple myeloma (rrMM) clinical management in Portugal is scarce. The Char … ells in the bone marrow (S), light chain ratio ≥100 (Li), and MRI-detected focal lesions (M); CRAB: hypercalcemia (C), renal insufficiency (R), anemia (A), and bone lesions (B)) signs were bone lesions (59%), and 62.9% of the patients had at least one comorbidity. At study initiation, 70.5% of patients were on second-line treatment, with monoclonal antibodies a …

Primary hyperparathyroidism in pregnancy successfully treated with microwave ablation: a case report.

BACKGROUND: Primary hyperparathyroidism (PHPT) during pregnancy is rare, with an estimated prevalence of <1% among pregnant women. While oft … her second trimester, with a history of multiple miscarriages and no living children, referred for hypercalcemia discovered on routine screening. Laboratory tests revealed corrected serum calcium of 11.54 mg/dL (85-105), elevated intact parathyroid hormone (iPTH) at 100.3 pg./mL (15-65), and marked hypercalciuria. Cervical ultrasound demonstrated a vascularize …

Chest radiographic findings suggestive of possible sarcoidosis in patients with nephrolithiasis.

Renal involvement in sarcoidosis may manifest as hypercalcemia, hypercalciuria, nephrolithiasis, nephrocalcinosis, and other abnormalities, but is often underrecognized. This study investigated chest radiographic findings suggestive of possible sarcoidosis in patients with nephrolithiasis and compared available laboratory parameters between patients with and without such findings. This retrospective analytical cross-sectional study included patients undergoing PCNL or TUL for urinary stones at Razi Hospital (Guilan, Iran) from 2016 to 2021. Routine preoperative chest X-rays were reviewed; 1297…

PTH-Independent CaSR Inhibition with the Oral Calcilytic Encaleret Improves Calcium Homeostasis in Post-Surgical Hypoparathyroidism: A Phase 2 Open-Label Proof-of-Concept Trial.

The calcium-sensing receptor (CaSR) maintains calcium homeostasis by regulating parathyroid hormone (PTH) secretion and directly modulating … sions for the remainder of the study. No serious adverse events (AEs) were reported. Transient mild hypercalcemia and headache in 1 participant were the only treatment-related AEs. In PSH, encaleret reduced urinary Ca and increased serum Ca, demonstrating the PTH-independent role of CaSR signaling in renal calcium handling and supporting further study of encale …

Palopegteriparatide treatment for hypoparathyroidism in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: a case series and literature update.

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type 1, is an autos … ir brief half-lives and can result in fluctuations of serum calcium levels between hypocalcemia and hypercalcemia. Long-acting PTH analogs have recently been developed to more closely mimic physiologic PTH activity. One such agent, palopegteriparatide, a prodrug of PTH (1,34), has shown promise to be the first hormone replacement therapy for hypoPT. We report o …

Histopathological effect of hypervitaminosis D3 on the submandibular salivary gland of albino rats and the possible protective role of vitamin K "histological & ultrastructural study".

BACKGROUND: This study was designed to inspect the effects of vitamin D3 overdose on the submandibular salivary gland of Albino rats and to … . Also, co-administration of vitamin K1 diminished vitamin D3-induced histopathological changes and hypercalcemia.

Pharmacological Management of Secondary Hyperparathyroidism in Dialysis Patients: A Narrative Review of Calcimimetics, Vitamin D Analogs, and Phosphate Binders.

Secondary hyperparathyroidism (sHPT) is a prevalent complication of end-stage renal disease, driven by phosphate retention, vitamin D defici … tamin D analogs suppress PTH gene transcription but carry a narrow therapeutic window with risks of hypercalcemia and hyperphosphatemia. Phosphate binders address the primary upstream driver of sHPT; non-calcium-based agents such as sevelamer offer cardiovascular advantages but impose a pill burden contributing to nonadherence rates of 22-74%. Novel agents incl …

Intravenous Paricalcitol Versus Calcitriol for Secondary Hyperparathyroidism in Maintenance Hemodialysis: A Six-Month Single-Center Retrospective Cohort Study.

Background/Objectives: Secondary hyperparathyroidism is a frequent component of chronic kidney disease-mineral and bone disorder in maintena … 6.8 ± 22.4% vs. -39.5 ± 24.1%; p = 0.431), or target iPTH achievement (62.0% vs. 60.0%; p = 0.781). Hypercalcemia and hyperphosphatemia rates were also similar. In multivariable analysis, treatment type was not independently associated with target iPTH achievement, whereas higher baseline iPTH and phosphorus were associated with lower odds of achieving target i …

CNS Вовлечение нескольких серий дел Myeloma-A и наррутический литературный обзор.

Фон: участие центральной нервной системы (ЦНС) в множественной миеломе (ММ) представляет собой экстрамуллярное проявление заболевания, которое часто является весьма сложным для врачей, поскольку неврологические симптомы могут легко перекликаться с симптомами, связанными с гиперкалкемией, уремией, высокой вязкостью крови или связанной с лечением нейропатией. Цели: Это ретроспективное исследование было проведено в Клиническом институте Фундэни в Бухаресте с целью выявления и систематического анализа ряда клинических случаев, диагностированных внематочным заболеванием. Методы: В период с 2019 по

Совпадение в аннотации оригинала
Background: Central nervous system (CNS) involvement in multiple myeloma (MM) represents an extramedullary manifestation of the disease, which is often really challenging for clinicians, as the neurological symptoms could easily overlap with those related to hypercalcemia, uremia, high viscosity of the blood, or treatment-related neuropathy. Objectives: this…

Endocrinology Clinical Skills Assessment Program: A Structured Clinical Assessment Program to Enhance Clinical Reasoning in Subspecialty Training.

INTRODUCTION: The Endocrinology Clinical Skills Assessment Program (ECSAP) was developed at Wake Forest University School of Medicine to enhance history-taking, diagnostic reasoning, and personalized feedback in endocrinology fellows. Recognizing a gap in formative clinical skill evaluation, ECSAP introduces standardized case-based assessments across key endocrine topics. METHODS: ECSAP sessions occur twice yearly and include four 25-minute standardized clinical scenarios (e.g., adrenal incidentaloma, hypercalcemia). Each case is pre-assigned to faculty, who provide fellows with a one-line pr…

Bone metastasis in colorectal cancer: Pathophysiology, prognostic factors, survival outcomes, and treatment strategies - A comprehensive review.

BackgroundColorectal cancer ranks as the third most prevalent cancer globally, with over 1.9 million new cases and 930,000 deaths in 2020. W … invasion (HR: 3.457), right sided location (HR: 1.84), multiples bone metastasis sites (HR: 1.452), hypercalcemia (HR: 3.75), pathologic fracture (HR:1.91) and more than two extra-bone metastatic organs (HR: 2.357) were linked to worse prognosis. The therapeutic approach for colorectal cancer patients with bone metastasis consists of a multidisciplinary strateg …

Plasma Cell Leukemia Update on Immunophenotype, Molecular Characteristics, and Therapy. The Second Part of Plasma Cell Neoplasms with Spreading in the Blood and Tissues.

Plasma cell leukemia (PCL) is a rare and aggressive form of multiple myeloma (MM), characterized by the presence of malignant plasma cells i … ceeds 5%. PCL has a more aggressive clinical presentation than MM, involving more severe cytopenia, hypercalcemia, and renal failure. Higher tumor burden and proliferation activity in PCL are reflected by elevated levels of B2- B2-microglobulin and lactate dehydrogenase (LDH). Extramedullary localization at diagnosis is more common in pPCL and sPCL than in MM. …

Phenotypes and the Importance of Genetic Analysis in Adult Patients with Nephrolithiasis and/or Nephrocalcinosis: A Single-Center Experience.

BACKGROUND: Molecular analysis in patients with nephrolithiasis (NL) and/or nephrocalcinosis (NC) enables more accurate evaluation of underl … = 2), familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (CLDN16; n = 1), infantile hypercalcemia type 1 (CYP24A1; n = 1), primary hyperoxaluria type 1 (AGXT; n = 1), Bartter syndrome type 2 (KCNJ1; n = 1), and autosomal dominant tubulointerstitial kidney disease (UMOD; n = 1). Eight (16.3%) patients had pathogenic or likely pathogenic monoallel …

Use of Antibiotic Eluting Calcium Sulfate Beads in High-Risk Primary Total Knee Arthroplasty.

Local delivery of high-dose antibiotics via absorbable calcium sulfate beads has been investigated as a treatment of prosthetic joint infect … one patient had bilateral DVT. No cases of chronic PJI, persistent wound drainage, or postoperative hypercalcemia were identified. Prophylactic use of antibiotic-eluting calcium sulfate beads in primary TKA has resulted in low rates of early PJI in a high-risk cohort, warranting further prospective studies and investigation.

Economic evaluation of [18F]fluorocholine PET/CT in pre operative assessment of hyperfunctional parathyroids in primary hyperparathyroidism: a cost effectiveness analysis.

BACKGROUND: Primary hyperparathyroidism (PHPT) is characterized by persistent hypercalcemia caused by parathyroid adenomas. Preoperative localization of hyperfunctional parathyroids is crucial to optimize surgical outcomes. Current standard practice combines cervical ultrasound (CU), [99mTc]Tc-sestaMIBI SPECT scintigraphy (MIBI), and [18F]Fluorocholine PET/CT (PET) centered on the cervico-thoracic region. This study evaluates the cost-effectiveness of PET as a stand-alone first-line imaging strategy compared to CU + MIBI + PET and CU + PET strategies in the French healthcare system. METHODS: …

Effects of Paricalcitol on Renal Secondary Hyperparathyroidism and Proteinuria in Dogs With Chronic Kidney Disease.

BACKGROUND: Renal secondary hyperparathyroidism (RHPT) is an inevitable consequence of chronic kidney disease (CKD). Paricalcitol might safe … , p = 0.12 and 1.28, 95% CI, 1.24-1.32, p = 0.034, respectively). However, 7/13 dogs developed mild hypercalcemia. Adverse effects were not reported by the owners. CONCLUSION AND CLINICAL IMPORTANCE: Paricalcitol attenuated RHPT and stabilized renal proteinuria in dogs with CKD.

Radiation-Induced Synchronous Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Clinical, Morphological, and Genetic Insights.

The clinicopathological and molecular features of synchronous parathyroid carcinoma (PC) and thyroid carcinoma in a male patient are presented. At 11, he received mantle field radiotherapy for Hodgkin lymphoma. He had a 26-year adulthood history of recurrent nephrolithiasis treated five times with lithotripsy. At 52, he was referred to our clinic for hypercalcemia. Primary hyperparathyroidism was diagnosed (calcium: 3.46 mmol/L, parathormone: 150 pmol/L, preserved renal function, nephrolithiasis, and osteoporosis). Neck ultrasound revealed a 41 × 31 × 37 mm nodule in the left thyroid and small…

Impact of intraoperative intact PTH monitoring on reoperation rates and surgical success in primary hyperparathyroidism.

BACKGROUND: Primary hyperparathyroidism (PHPT) is caused by excessive parathormone secretion from one or more parathyroid glands. The primar … ned as calcium elevation after the 6th postoperative month. The absence of recurrence or persistent hypercalcemia was considered an indicator of surgical success. RESULTS: The mean age of the patients was 54.6 ± 12.7 years. Of the 203 patients, 40 (19.7%) were male and 163 (80.3%) were female. No correlation was found between recurrence or persistence and pati …

Impact of Genetic Polymorphisms in NF-ĸB2 and TRAF3 Genes on Response to Bortezomib-Based Therapy in Multiple Myeloma Patients.

BACKGROUND: Multiple myeloma (MM), being the second most common hematological malignancy, has garnered significant attention. The ubiquitin … he median age of participants was 55 years, with backache being the most prevalent symptom (66.3%). Hypercalcemia (22%), renal failure (8.7%), and bone fractures (45.7%) were also observed, alongside high prevalence of anemia. Notably, the frequency of the TRAF3 rs12147254 A allele was lower in cases compared to controls (31% vs. 49%, P-value=0.002). Poor respo …

Calcium phosphate deposition, tertiary hyperparathyroidism, and the long-term effect on kidney allografts.

BACKGROUND: Tertiary hyperparathyroidism adversely affects kidney allografts, with calcium phosphate deposition hypothesized to be an underlying cause. We analyzed allograft biopsies to investigate risk factors for calcium phosphate deposition and understand its impact on allograft function. METHODS: We reviewed patients who underwent kidney transplantation from 2017 to 2019. Tertiary hyperparathyroidism was defined as an elevated parathyroid hormone and hypercalcemia beyond 3 months' posttransplant or being prescribed cinacalcet. Allograft failure was defined as needing dialysis posttranspla…