Результаты поиска

Geriatric Assessment in Patients Aged 70 Years and Older Considered for CAR T-Cell Therapy: A Retrospective Study.

Background/Objectives: Population aging has increased the incidence of non-Hodgkin lymphoma in older adults, who often receive suboptimal treatment. Geriatric assessment is a key tool to evaluate frailty and guide therapeutic decisions. CAR T-cell therapy is effective but associated with significant toxicities, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), which may be more severe in older patients. This study evaluated the role of geriatric assessments in patients aged 70 years and older referred for CAR T-cell therapy, focusing

Практическое руководство по клиническому управлению белантамбом мафодотином-ассоциированными окулярными событиями.

Важная бентанамб-мафодотин (беламаф) - это эффективные методы лечения пациентов с рецидивной и/или рефрактной множественной миеломой. Цель заключается в разработке клинических рекомендаций по выявлению, мониторингу и регулированию окулярных явлений, связанных с терапией беналама, и рекомендаций по любой требуемой модификации дозы. Был проведен систематический обзор литературы, и международная группа гематологов и офтальмологи проанализировала данные клинических испытаний, реальные данные и опубликованную литературу о о окулярных событиях, связанных с беламафом. Этот обзор литературы и коллекти

Совпадение в полном тексте источника
… Ongoing collaboration and communication between hematologists/oncologists and eye‐care professionals is essential to manage ocular events and ensure patients receive optimal treatment [ 10 ]. … When hematologists/oncologists prescribe belamaf, they should educate themselves and the wider MM patient‐care team on the risks of ocular events and how to manage these [ 10 ]. …

Bedside implications of the use of surrogate endpoints in solid and haematological cancers: implications for our reliance on PFS, DFS, ORR, MRD and more.

Clinical endpoints, such as overall survival, directly measure relevant outcomes. Surrogate endpoints, in contrast, are intermediate, stand-in measures of various tumour-related metrics and include tumour growth, tumour shrinkage, blood results, etc. Surrogates may be a time point measurement, that is, tumour shrinkage at some point (eg, response rate) or biomarker-assessed disease status, measured at given time points (eg, circulating tumour DNA, ctDNA). They can also be measured over time, as with progression-free survival, which is the time until a patient presents with either disease progr

Stereotactic Body radiotherapy and pedicLE screw fixatioN During one hospital visit for patients with symptomatic unstable spinal metastases: a randomized trial (BLEND RCT) using the Trials within Cohorts (TwiCs) design.

BackgroundSpinal metastases can lead to unremitting pain and neurological deficits, which substantially impair daily functioning and quality of life. Patients with unstable spinal metastases receive surgical stabilization followed by palliative radiotherapy as soon as wound healing allows. The time between surgery and radiotherapy delays improvement of mobility, radiotherapy-induced pain relief, local tumor control, and restart of systemic oncological therapy. Stereotactic body radiotherapy (SBRT) enables delivery of preoperative high-dose radiotherapy while dose-sparing the surgical field, al

How should multiple myeloma research change in a patient-oriented world? Findings and lessons from the pan-Canadian myeloma priority setting partnership.

BACKGROUND: Over the last decade there has been considerable research into the treatment, management, and quality of life of people living with multiple myeloma. However, there has been limited investigation into topics deemed important to patients and caregivers within this community. We conducted a James Lind Alliance Priority Setting Partnership to establish the 'Top 10 Priorities for Myeloma Research', informed by patient and public partners. METHODS: A research team and steering group were established in 2019 to conduct the myeloma priority setting partnership. Steering group members inc

Successful Pregnancies, Births, and Children Development Following Oocyte Cryostorage in Female Cancer Patients During 25 Years of Fertility Preservation.

The preservation of fertility in cancer patients is a crucial aspect of modern reproductive medicine. Amenorrhea and infertility often occur after cancer therapy, worsening the quality of life. Cryopreservation of oocytes in young cancer patients is a therapeutic option for preserving fertility. A prospective study was conducted on 508 cancer patients who underwent oocyte cryopreservation to preserve fertility between 1996 and 2021 including the COVID-19 pandemic period. Patients underwent ovarian stimulation, followed by egg retrieval, and oocytes were cryopreserved by slow freezing or vitrif

Совпадение в полном тексте источника
… Centers offering a fertility preservation program should ensure close cooperation between reproductive gynecologists and oncologists to take care of the oncology patient as quickly as possible. … Collaboration among reproductive physicians, biologists, endocrinologists, oncologists, surgeons, psychologists, and gynecologists is necessary to ensure the best fertility preservation program for each patient. …

The advantages, disadvantages, threats, and opportunities of electronic patient-reported outcome systems in cancer: A systematic review.

ObjectiveElectronic patient-reported outcome (ePRO) systems hold promise for revolutionizing communication between cancer patients and healthcare providers across various care settings. This systematic review explores the multifaceted landscape of ePROs in cancer care, encompassing their advantages, disadvantages, potential risks, and opportunities for improvement.MethodsIn our systematic review, we conducted a rigorous search in Scopus, Web of Science, and PubMed, employing comprehensive medical subject heading terms for ePRO and cancer, with no date limitations up to 2024. Studies were criti

Совпадение в полном тексте источника
… The intervention may not have been adequately tailored to detect certain types of adverse events, such as laboratory abnormalities. | Metastatic melanoma patients receiving immunotherapy. 51. | Sahil Sandhu, et al. 52 | 2020 | United States | To gain insights into oncologists’ perspectives regarding … the incorporation of ePROs into routine cancer care at an academic center | 16 oncologists with diverse subspecialties and experience in various cancer types | - Improved patient outcomes. …

Guarding the heart in the era of immunotherapies: insights for cardio-oncology practice.

The advent of cancer immunotherapies, including immune checkpoint inhibitors (ICI), Chimeric antigen receptor (CAR-T) cell therapies, and bispecific antibodies and other immune-activating platforms such as therapeutic vaccines and oncolytic viruses (often used in combination regimens) has revolutionized oncology by improving patient outcomes across diverse malignancies. However, these therapies are increasingly linked to cardiovascular toxicities such as myocarditis, arrhythmias, and heart failure, posing significant clinical challenges. Here we review current evidence on the mechanisms, clini

Совпадение в полном тексте источника
… By integrating existing data and recent advancements, this review aims to provide clinicians, oncologists, cardiologists, and researchers with a cohesive framework to navigate the complexities associated with immunotherapy-induced cardiovascular complications. … As ICIs become standard components of first-line cancer therapy, recognition of their cardiovascular immune-related adverse events (irAEs) has become critical for oncologists and cardiology teams worldwide. …

Cannabis stigma and symptom management considerations in cancer survivors: a mixed-methods exploration of patient perspectives.

PurposeThis study aims to assess for indications of stigma and attitudes toward cannabis among cancer survivors (CS) who use or consider the use of cannabis.MethodsThis study employed a convergent, parallel mixed methods design utilizing focus group and questionnaire data to assess the presence of stigma among a sample of CS (n = 23) who use (n = 10) and do not use (n = 13) cannabis to manage symptoms. CS were recruited from a multi-site observational study in the Northeast U.S. region that assesses cannabis use among oncology patients.ResultsA total of 23 CS participated in this study. In gen

Effectiveness of and implementation requirements for telehealth in palliative care patients with advanced cancer: A systematic review and meta-analysis.

BackgroundTelehealth is being integrated with palliative care for patients with advanced cancer to improve access to specialized palliative care. However, its effectiveness and implementation requirements in palliative care remain unclear.AimThis study evaluates the effectiveness of and implementation requirements for telehealth in palliative care patients with advanced cancer.DesignThis was designed as a systematic review and meta-analysis with narrative synthesis (registered; CRD42024581786). The effects on patients' quality of life, symptom burden, and depression were analyzed using a rando

Has the development of cancer biomarkers to guide treatment improved health outcomes?

During the last decade, testing the patient's biomarker status prior to the administration of corresponding co-dependent therapies has been emerging in clinical practice. These biomarker-guided therapies have promoted the promise of more personalized medicine, with the prescription of the right treatment to the right patient, while avoiding expensive ineffective drugs and adverse drug reactions. Cancer treatments have especially taken advantage of this technology. We assess how the introduction of biomarker tests guiding cancer therapy have affected the premature mortality and survival of canc

Совпадение в полном тексте источника
… Instead, oncologists can prescribe nonguided therapies to speed up the treatment process. … However, more diagnoses and more treatment options increase the complexity of healthcare, and it is challenging for oncologists to prioritize correctly [ 7 ]. …

Oral Presentation

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Discussion and Conclusion: The study reveals the need for more openness in prognosis communication from oncologists. In depth knowledge on parent preferences will aid the process. … The oncologist that started her relapse treatment referred her to our palliative care centre for symptoms management and overall care. …

Drug Utilization Study and Safety Pattern of Biologicals in a Tertiary Care Hospital at Eastern India.

Background Biological agents have revolutionized cancer treatment by offering targeted therapeutic effects with improved selectivity over conventional chemotherapy. However, real-world data on their utilization and safety in Indian tertiary care settings remain limited. This study aimed to evaluate the drug utilization pattern and safety profile of biologics in cancer patients. Methods A prospective, observational study was conducted over 18 months (July 2022-December 2023) at a tertiary care oncology center in eastern India. A total of 373 prescriptions were analyzed, of which 100 included bi

Совпадение в полном тексте источника
… Oncologists increasingly emphasize that conventional cytotoxic chemotherapy has reached the limits of its utility. Its nonspecific mechanism, coupled with cumulative toxicity, renders it less tolerable, particularly in elderly cohorts who constitute the majority of cancer patients [ 3 ]. … Oncologists' preference for conventional drugs or biological drugs could be affected by the type and location of cancer, but this study gives an overall comparison and highlights the need for further comparative studies in a specific type and location of malignancy. …

Use of Oral Antivirals Ritonavir-Nirmatrelvir and Molnupiravir in Patients with Multiple Myeloma Is Associated with Low Rates of Severe COVID-19: A Single-Center, Prospective Study.

In patients with multiple myeloma (MM), SARS-CoV-2 infection has been associated with a severe clinical course and high mortality rates due to the concomitant disease- and treatment-related immunosuppression. Specific antiviral treatment involves viral replication control with monoclonal antibodies and antivirals, including molnupiravir and the ritonavir-boosted nirmatrelvir. This prospective study investigated the effect of these two agents on SARS-CoV-2 infection severity and mortality in patients with MM. Patients received either ritonavir-nirmatrelvir or molnupiravir. Baseline demographic

Palestinian Patients with Cancer at King Hussein Cancer Center.

BackgroundThe Palestinian Ministry of Health (MoH) routinely refers Palestinian patients with cancer to King Hussein Cancer Center (KHCC), the largest cancer center in the Middle East.AimsWe aimed to describe the characteristics of Palestinian patients with cancer.MethodsWe performed a retrospective chart review of all Palestinian patients with cancer who were treated at KHCC during 2018 and 2019, of which demographic and clinical characteristics were presented.ResultsWe initially started with 521 cases, out of which 41 (7.9%) cases were excluded due to misdiagnosis as malignant on pathology r

Совпадение в полном тексте источника
… There are only one radiation oncologist and two medical oncologists per one million population ( 5 ). Moreover, to our knowledge, palliative care is generally not available to date in the Palestinian territories. …

Infection rate and clinical management of cancer patients during the COVID-19 pandemic: experience from a tertiary care hospital in northern Italy.

BackgroundOptimal management of patients with cancer during COVID-19 pandemic is still pending.MethodsOur patients were advised to maintain their scheduled appointments, and planned cancer treatment was continued without unnecessary delays in an outpatient setting. Additional strict preventive infection measures were rapidly implemented at our outpatient department. When COVID-19 test became widely available, universal testing of healthcare workers and vigorous screening of all patients coming to our facility for COVID-19 infection were performed by SARS-CoV-2 real-time reverse transcription P

Совпадение в полном тексте источника
… Oncologist. 2020 doi: 10.1634/theoncologist.2020-0213. doi:10.1634/theoncologist.2020-0213 10. Chen N., Zhou M., Dong X., et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. … Cancer care during the spread of coronavirus disease 2019 (COVID-19) in Italy: young oncologists' perspective. ESMO Open. 2020;5 doi: 10.1136/esmoopen-2020-000759. http://www.ncbi.nlm.nih.gov/pubmed/32229501 doi:10.1136/5-e000810-F1.jpg-gr1-2020-000759 e000759. 18. …

Summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation.

The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as access to transplantation, patient demographic and health status factors, immunological and psychosocial assessment. The roles of various risk factors and comorbid conditions governing an individual's suitability for transpla

Совпадение в полном тексте источника
… Decisions about transplantation for candidates in remission from cancer should be made collaboratively with oncologists, transplant nephrologists, patients, and their caregivers Previous guidelines vary in their recommendations for candidates with cancer, most of which are based upon observational registry … multiple myeloma, respectively, should be considered and discussed with the patient ✓ Patients with leukemia or lymphoma should avoid transplantation until they have received potentially curative therapy, achieved remission and remained cancer free for a period to be determined with their hematologist/oncologist …

A new tool for comprehensive geriatric assessment in elderly patients with acute myeloid leukemia: a pilot study from China.

BackgroundAcute myeloid leukemia (AML) is a common type of hematological malignancy in elderly people. Geriatricians have developed comprehensive geriatric assessment (CGA) methods for elderly patients; however, the tools used for CGA in AML are not uniform. Thus, we aimed to validate the instrumental activities of daily living (IADL) scales, age, comorbidities (Charlson Comorbidity Index), and albumin (IACA) index, which is a new tool for CGA, in elderly patients with AML.MethodsPatients aged ≥60 years who had been diagnosed with AML were screened for eligibility. Among the IACA low-, interme

P1690: SHARED DECISION-MAKING IN MULTIPLE MYELOMA: DO PATIENTS, CAREGIVERS, AND PHYSICIANS SHARE THE SAME GOALS AND PREFERENCES?

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

P1729: COMPARING THE PSYCHOSOCIAL IMPACTS OF THE COVID-19 PANDEMIC BETWEEN HAEMATOLOGICAL CANCER AND MYELOMA PATIENTS: FINDINGS FROM AN ONLINE SURVEY

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.