Результаты поиска

The incidence and relative risk of adverse events in patients treated with bisphosphonate therapy for breast cancer: a systematic review and meta-analysis.

BACKGROUND: Adjuvant bisphosphonates reduce the rate of breast cancer recurrence in the bone and improve breast cancer survival. However, the risk of adverse events associated with bisphosphonate therapy for breast cancer remains poorly defined. METHODS: A literature search was conducted using the PubMed, EMBASE, Cochrane and Web of Science libraries. Risk ratio (RR) was calculated to evaluate the adverse events of the meta-analytic results. Osteonecrosis of the jaw (ONJ) incidence was calculated using the random effect model (D+L pooled) for meta-analysis. RESULTS: A total of 47 studies com

Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications.

Given the safety and potential benefits of intravenous ascorbic acid (AA) administration in cancer patients, there is merit in further exploring this therapeutic concept. In this review, we discuss the potential benefits of intravenous AA administration on colorectal cancer and we specifically focus on its effect on glycolysis in mutant and wild type RAS. We perform a PubMed and Ovid MEDLINE search using ascorbic acid, intravenous vitamin C, KRAS mutation, BRAF mutation and colorectal cancer (CRC) as keywords. At the cellular level, colorectal cancer cells undergo a metabolic shift called the

Interventional Cardio-Oncology: Adding a New Dimension to the Cardio-Oncology Field.

The management of cardiovascular disease in patients with active cancer presents a unique challenge in interventional cardiology. Cancer patients often suffer from significant comorbidities such as thrombocytopenia and coagulopathic and/or hypercoagulable states, which complicates invasive evaluation and can specifically be associated with an increased risk for vascular access complications. Furthermore, anticancer therapies cause injury to the vascular endothelium as well as the myocardium. Meanwhile, improvements in diagnosis and treatment of various cancers have contributed to an increase i

Financial burden among older, long-term cancer survivors: Results from the LILAC study.

BackgroundIncreasing attention is being paid to financial burdens of cancer survivorship, but little is known about the prevalence and predictors of these burdens in older, long-term survivors.MethodsWe used data from 6012 participants diagnosed with cancer since enrolling in the Women's Health Initiative, and who participated in the Life and Longevity After Cancer (LILAC) ancillary study to estimate prevalence and identify predictors of financial burden. We used logistic regression to identify sociodemographic, socioeconomic, health- and cancer-related factors associated with financial burden

Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells.

Lung cancer is the leading cause of cancer death worldwide; the most common pathologic type is lung adenocarcinoma (LADC). In spite of the recent progress in targeted therapy, most LADC patients eventually expired due to the inevitable recurrence and drug resistance. New complementary agent with evidence-based molecular mechanism is urgently needed. MiR-34a is an important p53 downstream tumor suppressor, which regulates apoptosis, cell-cycle, EMT (epithelial mesenchymal transition), and so forth. Its expression is deficient in many types of cancers including LADC. Here, we show that a Chinese

Health resource utilization associated with skeletal-related events in patients with bone metastases: Results from a multinational retrospective - prospective observational study - a cohort from 4 European countries.

BackgroundSkeletal-related events (SREs; pathologic fracture, radiation or surgery to bone, spinal cord compression) frequently occur in patients with advanced cancer with bone metastases/lesions. Limited data on the associated patient and economic burden are available to aid in resource planning and evaluating treatment options.MethodsPatients with bone metastases/lesions secondary to breast, lung or prostate cancer or multiple myeloma; with at least one SRE within 97 days prior to enrollment; life expectancy of at least 6 months; and Eastern Cooperative Oncology Group performance status 0, 1

Haematological and Oncological Training Therapy With Stationary Strength and Cardio Machines (HOT) in Routine Cancer Care: A 3-Year Real-World Evaluation of Acceptance, Feasibility, Safety, and Effects.

BackgroundExercise improves physical function and health-related quality of life (HRQoL) in patients with cancer; however, nationwide structured programmes remain limited. A hospital in Germany implemented a donation-funded Haematological and Oncological Training Therapy with Stationary Strength and Cardio Machines (HOT), and a 3-year real-world data analysis aimed to evaluate its acceptance, feasibility, safety, and effects.MethodsHOT comprised 24 sessions of combined resistance and aerobic training, complemented by a sensorimotor module for patients with chemotherapy-induced peripheral neuro

Совпадение в полном тексте источника
… To clarify the relationship between an SAE and HOT, a safety board consisting of an emergency physician and two oncologists was consulted. Reasons for and timing of premature discontinuation were collected by the therapist. … Participant satisfaction was assessed during the final consultation with a haematologist/oncologist and dichotomised as yes or no. Outcome Measures Endpoints included acceptance, feasibility, safety, and effects of HOT. …

Patient Perspectives on Palliative Care Outreach to Adults Living With Homelessness.

ImportancePeople experiencing homelessness face higher rates of early mortality, multimorbidity, and unmet needs at the end of life, but despite these risks, they often encounter systemic barriers to accessing palliative care. Outreach-based models have emerged to address this gap, yet little is known about how these models are perceived by those receiving care.ObjectiveTo evaluate a palliative care outreach intervention, the Palliative Education and Care for the Homeless (PEACH) program, from the perspective of patients living with homelessness and life-limiting illness.Design, setting, and p

Совпадение в полном тексте источника
… From setting up the appointment to dealing with the [oncologists] to getting the transportation, making sure people are coming with me, that I’m well supported. Everything. And excellently! … From setting up the appointment to dealing with the [oncologists], to getting the transportation, making sure people are coming with me, that I’m well supported, everything. And excellently!” …

Cancer treatment-related cardiotoxicity, molecular mechanism, challenges, and research trends.

Cancer treatment-related cardiotoxicity (CTRC) encompasses a spectrum of cardiovascular complications associated with chemotherapy, targeted therapy, and radiotherapy. This review synthesizes recent mechanistic insights to delineate distinct pathological pathways: anthracyclines provoke oxidative mitochondrial damage and disrupt cardiomyocyte iron homeostasis; HER2-targeted therapies inhibit the PI3K-Akt survival pathway, compromising contractile function and calcium regulation; tyrosine kinase inhibitors impair VEGF and PDGF signaling, inducing endothelial dysfunction and microvascular rarefa

Совпадение в полном тексте источника
… Promising tools for risk stratification and treatment guidance include circulating biomarkers [ 28 , 29 ], advanced imaging techniques [ 30 ], and genetic profiling [ 31 ] Despite these advances, CTRC management remains complex and necessitates close multidisciplinary collaboration among oncologists, … This approach necessitates strengthened collaboration between oncologists and cardiologists through integrated clinical decision-making [ 3 , 85 ]. Future trends and research prospects The evolving landscape of cancer therapy demands equally advanced strategies to manage cardiotoxicity. …

Isolated Lesser Trochanter Fractures in Adults: A Systematic Review of Malignant, Infectious, and Benign Etiologies.

Isolated lesser trochanter (LT) fractures are uncommon in adults and may be the first clue to an underlying pathologic process. In contrast to adolescent apophyseal avulsions, the same finding in a skeletally mature patient has been linked to metastatic disease, primary bone tumors, hematologic malignancy, infection, and, less often, benign traumatic, stress-related, osteoporotic, or metabolic causes. This review examined the malignant, infectious, and benign etiologies, diagnostic pathways, treatments, and outcomes that have been reported in adults aged 18 years or older presenting with a rad

Совпадение в полном тексте источника
… For orthopedic surgeons, radiologists, and oncologists, the differential includes metastatic disease, primary bone tumor, infection, metabolic bone disease, benign avulsion, occult intertrochanteric extension, and mechanical instability. … Biopsy should be coordinated with the orthopedic oncologist, musculoskeletal radiologist, and pathologist so that the tract can be incorporated into any subsequent resection and that contamination of uninvolved compartments is minimized [ 34 ]. …

Availability, price and affordability of anticancer medicines in Jiangsu Province, China: a cross-sectional survey study.

BackgroundTo evaluate anticancer medicines' availability, price and affordability in nine prefecture-level cities, Jiangsu Province.MethodsBased on the standard methods recommended by the World Health Organization (WHO) and the Health Action International (HAI), a cross-sectional survey was performed to collect information about 24 essential anticancer medicines (EAMs) and 17 innovative anticancer medicines (IAMs) in hospitals and 45 community pharmacies in Jiangsu Province from July to November 2021.ResultsIn general, the availability of EAMs during the study period was higher than that of IA

Совпадение в полном тексте источника
… Selection of anticancer medicines Based on recommendations from oncologists and local health statistics, we focused on five malignancies with high morbidity and mortality in our study: lung cancer, gastric cancer, esophageal cancer, liver cancer, and colorectal cancer. … Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey. Lancet Oncol. (2021) 22:1367–77. doi: 10.1016/S1470-2045(21)00463-0, 16. Cao W, Li F, Li YQ, Yu D. …

Therapies and nanotherapies for cervical cancer (Review).

Cervical cancer (CC) is a major global health concern, ranking fourth worldwide in mortality, due to its high death rate and strong link to persistent high-risk human papillomavirus infections, which drive cancer progression through cellular dysregulation. Conventional therapies used in the treatment of CC have significant disadvantages, such as adverse side effects that affect the quality of life of patients. These side effects may include nausea, vomiting, fatigue, hair loss, fertility problems, damage to nearby organs and systemic toxicity. To address these challenges, there has been an inc

Совпадение в полном тексте источника
… Moreover, in patients with advanced, recurrent, and/or persistent CC, oncologists recommend the use of combinations of paclitaxel (cell inhibitor), carboplatin (cell proliferation and division inhibitor), and bevacizumab (anti-angiogenic inhibitor) ( 26 ). … Oncologist. 2010;15:539–547. doi: 10.1634/theoncologist.2009-0274. 36. Gilbert WV, Nachtergaele S. mRNA regulation by RNA modifications. Annu Rev Biochem. 2013;92:175–198. doi: 10.1146/annurev-biochem-052521-035949. 37. Gagliardi M. Novel biodegradable nanocarriers for enhanced drug delivery. …

Factors associated with medication adherence trajectory among patients treated with oral anticancer drugs: a multicentre cohort study.

PurposeOptimal medication adherence to oral systemic anticancer therapies (SACTs) is critical for effective cancer management. However, the factors influencing adherence, particularly in relation to the longitudinal course of the disease, remain poorly understood. This study aimed to identify factors associated with medication adherence trajectories among patients initiating oral SACTs.MethodsA multicentre cohort study was conducted among patients initiating oral SACTs and enrolled in a multidisciplinary risk management programme during day hospitalisation. Medication adherence trajectories we

Does Therapeutic Repurposing in Cancer Meet the Expectations of Having Drugs at a Lower Price?

Therapeutic repurposing emerged as an alternative to the traditional drug discovery and development model (DDD) of new molecular entities (NMEs). It was anticipated that by being faster, safer, and cheaper, the development would result in lower-cost drugs. As defined in this work, a repurposed cancer drug is one approved by a health regulatory authority against a non-cancer indication that then gains new approval for cancer. With this definition, only three drugs are repurposed for cancer: Bacillus Calmette-Guerin (BCG) vaccine (superficial bladder cancer, thalidomide [multiple myeloma], and p

Совпадение в полном тексте источника
… Unfortunately, the scientific evidence from clinical trials may not be enough for oncologists to prescribe. For NMEs, massive spending from pharmaceutical companies on advertising their novel drug products and securing health regulatory authorities approval. … Once developed, it is imperative to legislate to adopt their use either on- or off-label according to treatment guidelines set by oncologists, absolutely devoid of industry ties [ 106 ]. …

What is an "early palliative care" intervention? A scoping review of controlled studies in oncology.

IntroductionEarly palliative care (EPC) has been advocated to improve cancer patients' health. However, EPC differs with regard to its elements and target groups. It is not known which parts of EPC contribute to effectiveness for which patient group. This scoping review provides a structured analysis of EPC interventions and outcome measures.DesignWe searched EMBASE, MEDLINE, CINAHL, and CENTRAL up to February 2022. We included randomized controlled trials (RCT), nonrandomized trials, cohort studies (CS), and controlled before-after studies of EPC in adult patients in English, Dutch, and Germa

Совпадение в полном тексте источника
… The palliative care physicians then gave recommendations for treatment to the oncologists and did not employ care plan changes themselves. The studies of Vanbutsele (2018) 59 and Rodin (2020) 46 are examples of an embedded approach . … Oncologist. 2021;26:157‐164. 54. Tattersall M. Early contact with palliative care services: a randomized trial in patients with newly detected incurable metastatic cancer. J Palliat Care Med. 2014;04:S309. 55. Temel JS, Greer JA, Muzikansky A, et al. …

Current and Emerging Therapeutic Targets for the Treatment of Cholangiocarcinoma: An Updated Review.

Cholangiocarcinoma is a malignancy of the bile ducts that is often associated with late diagnosis, poor overall survival, and limited treatment options. The standard of care therapy for cholangiocarcinoma has been cytotoxic chemotherapy with modest improvements in overall survival with the addition of immune checkpoint inhibitors. The discovery of actionable mutations has led to the advent of targeted therapies against FGFR and IDH-1, which has expanded the treatment landscape for this patient population. Significant efforts have been made in the pre-clinical space to explore novel immunothera

Do Cancer and Cancer Treatments Accelerate Aging?

Purpose of reviewThis review focuses on describing the mechanisms and clinical manifestations that underlie accelerated aging associated with cancer and its treatment.Recent findingsThe direct and indirect effects of cancer and its treatment are associated with late occurrence of comorbidities that happen earlier or more frequently in cancer survivors compared to cancer-free individuals, otherwise known as accelerated aging. Use of senolytics and dietary and exercise interventions including prehabilitation, caloric restriction, and rehabilitation are currently under investigation to reverse or

Совпадение в полном тексте источника
… Some have considered this increase to represent a 10–15-year increase in chronologic age [ 50 ], and measuring levels of this biomarker pre- and post-treatment may help oncologists predict which patients may develop treatment-associated frailty. … Yet as few as 20% of oncologists routinely discuss lifestyle guidance in survivorship [ 64 ]. Thus, chronic low physical activity, coupled with increasing chronologic age, coupled with late effects of cancer treatment can all compound to lower CRF. …

Clinicopathologic characteristics, metastasis-free survival, and skeletal-related events in 628 patients with skeletal metastases in a tertiary orthopedic and trauma center.

BACKGROUND: Skeletal-related events (SREs) due to bone metastases (BM) significantly impact the morbidity and mortality of cancer patients. The present study sought to investigate clinicopathological characteristics, metastasis-free survival (MFS), and SREs in patients referred to a tertiary orthopedic and trauma center. METHODS: Data were retrieved from electronic health records (n=628). Survival curves were estimated utilizing the Kaplan-Meier method. The Cox regression model was used to determine factors influencing MFS based on estimated hazard ratios (HRs). RESULTS: Breast (55.8%) and l

Cardiac Monitoring for Patients Undergoing Treatment With MEK Inhibitor Monotherapy.

PURPOSE OF REVIEW: Aberrant activation of the RAS-RAF-MEK-ERK signaling pathway contributes to numerous malignancies, congenital syndromes, and cardiovascular disorders, establishing MEK inhibitors (MEKi) as crucial therapeutic agents. MEKi demonstrate substantial clinical benefit as monotherapy (e.g., NF1-associated tumors) or combination therapy (e.g., melanoma, glioma, congenital RASopathies). Cardiovascular adverse events, primarily asymptomatic reductions in left ventricular ejection fraction (LVEF), have prompted intensive echocardiographic monitoring. RECENT FINDINGS: Emerging evidence

Совпадение в полном тексте источника
… We would like to introduce to this paradigm what cardio-oncologists allude to as “permissive cardiotoxicity,” or permitting some amount of abnormality in cardiac function or biomarkers to occur without change in therapy [ 85 ]. … Further, because the specialists prescribing MEKi include cardiologists, neurologists, and oncologists, in addition to general practitioners in some settings, we include relatively specific elements for assessment during a history and physical examination. …

Primary Thromboprophylaxis in Patients with Malignancies: Daily Practice Recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO), the Society of Thrombosis and Hemostasis Research (GTH), and the Austrian Society of Hematology and Oncology (ÖGHO).

Patients with cancer, both hematologic and solid malignancies, are at increased risk for thrombosis and thromboembolism. In addition to general risk factors such as immobility and major surgery, shared by non-cancer patients, cancer patients are exposed to specific thrombotic risk factors. These include, among other factors, cancer-induced hypercoagulation, and chemotherapy-mediated endothelial dysfunction as well as tumor-cell-derived microparticles. After an episode of thrombosis in a cancer patient, secondary thromboprophylaxis to prevent recurrent thromboembolism has long been established

Совпадение в полном тексте источника
… Therefore, we have generated an algorithm for such situations, to provide a means for healthcare workers, including hematologists, oncologists, and internal medicine specialists but also family practitioners and nurses caring for cancer patients in their daily practice ( Figure 1 ). … Oncologist. 2020;25:1075–1083. doi: 10.1002/onco.13540. 48. Pabinger I., van Es N., Heinze G., Posch F., Riedl J., Reitter E.-M., Di Nisio M., Cesarman-Maus G., Kraaijpoel N., Zielinski C.C., et al. …