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Oral health, dental treatment, and medication related osteonecrosis of the jaw in multiple myeloma - a longitudinal cohort study.

OBJECTIVE: The objective of the present study was to investigate oral health status, oral health related quality of life, and identify risk factors associated with invasive dental treatment and medication related osteonecrosis of the jaw in patients with multiple myeloma. MATERIAL AND METHODS: Patients newly diagnosed with multiple myeloma (n = 144) referred between January 2015 and September 2022 were retrospectively included. The patients underwent a thorough clinical and radiological oral examination and odontogenic infections were treated before the start of bisphosphonate treatment. The

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… The clinical examination consisted of inspection and palpation of the oral tissues, recording of present teeth, filled teeth, and decayed teeth, and periodontal status by recording of probing pocket depth, bleeding on probing, clinical attachment loss (CAL), furcation involvement, and tooth mobility. …

Predictive value of bone turnover markers and thyroid indicators for bone metabolism in GD patients after treatment.

PURPOSE: To investigate the relationship between bone turnover markers (BTMs) and thyroid indicators in Graves' disease (GD) and to further assess predictive value of changes in early stage retrospectively. METHODS: We studied 435 patients with GD and 113 healthy physical examiners retrospectively and followed up these two groups of patients after 6 months. We investigated the correlations between BTMs and other 15 observed factors, and analyzed the predictive value of FT3 and FT4 before and after treatment (FT3-P/FT3-A, FT4-P/FT4-A) on whether BTMs recovered. RESULTS: The levels of thyroid

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… .: goiter by ultrasound and palpation; signs and symptoms of hypermetabolism; decreased levels of thyroid stimulating hormone (TSH); positive autoimmune antibodies against TSH-receptors (TRAb); Increased thyroid uptake of iodine 131 (RAIU). (2) premenopausal women (aged 18 to 45) and men aged 18 to 50 …

Thalidomide upper limb embryopathy - pathogenesis, past and present management and future considerations.

This review article provides a comprehensive overview of thalidomide upper limb embryopathy including updates about its pathogenesis, a historical account of the management of the paediatric thalidomide patient, experience with management of the adult patient, as well as creating awareness about early onset age-related changes associated with limb differences. Despite its withdrawal from the market in November 1961, novel discoveries have meant thalidomide is licensed again and currently still in use to treat a variety of conditions, including inflammatory disorders and some cancers. Yet, if n

Survival Rates and Clinical Outcomes of Implant Overdentures in Old and Medically Compromised Patients.

Studies on the survival rate of implant overdentures in medically compromised patients are limited because most studies exclude patients with systemic diseases affecting implant prognosis. This retrospective study aimed to evaluate the survival rate and clinical outcomes of dental implants used for overdentures in medically compromised patients. A total of 20 patients (9 men, 11 women; mean age: 67.55 ± 6.84 years, range: 53-81 years) were included. Fourteen patients had more than two systemic diseases, and nine patients had more than three systemic diseases. The mean follow-up period was 39.0

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… The implant was indicated for removal under any of the following conditions: (1) pain on palpation, percussion, or function; (2) horizontal and/or vertical mobility; (3) uncontrolled progressive bone loss; (4) uncontrolled exudate; or (5) > 50% bone loss around the implant. …

Prospective and Multicenter Evaluation of Outcomes for Quality of Life and Activities of Daily Living for Balloon Kyphoplasty in the Treatment of Vertebral Compression Fractures: The EVOLVE Trial.

BACKGROUND: Osteoporotic and neoplastic vertebral compression fractures (VCF) are common and painful, threatening quality of life and increasing risk of morbidity and mortality. Balloon kyphoplasty is a percutaneous option for treating painful cancer- and osteoporosis-related VCFs, supported by 2 randomized trials demonstrating efficacy benefits of BKP over nonsurgical care. OBJECTIVE: To investigate 12-mo disability, quality of life, and safety outcomes specifically in a Medicare-eligible population, representing characteristic patients seen in routine clinical practice. METHODS: A total of

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… Medicare-eligible patients with 1 to 3 painful VCFs from T5 to L5 due to osteoporosis or cancer, with clinical findings (pain on palpation or percussion over the fractured vertebral body) correlating with imaging findings, were eligible. …

Diagnosis and Management of Chronic Pruritus: An Expert Consensus Review.

The aim of this study is to formulate the best clinical practice in the diagnosis and management of chronic pruritus (CP). We searched PubMed, EMBASE, Scopus, Web of Science, and the WHO's regional databases, for studies on "Diagnosis and management of chronic pruritus" from January 1, 2014, to July 31, 2015. We included programmatic reports and hand-searched references of published reviews and articles. Two independent reviewers screened articles and extracted data. We screened 87 of 95 studies that contained qualitative data. Avoid: Dry climate, heat, alcohol compress, ice packs, frequent ba

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… The distribution of primary and secondary skin lesions should be recorded together with skin signs of systemic disease General physical examination should include palpation of the liver, kidneys, spleen, and lymph nodes A solely psychological cause of pruritus should not be diagnosed without psychiatric …

Разработка и оценка мягкой одежды для обнаружения и контроля виртуальной окружающей среды на основе SEMG.

По мере увеличения числа лиц, диагностированных нейродегенеративными расстройствами (НД), возрастает потребность в повышении как количества, так и качества подходов, используемых для лечения этих изнурительных заболеваний. Прогресс ND может вызывать мышечную слабость нижних или верхних конечностей. Мы уделяем особое внимание площади верхней конечности, в частности реабилитации сцепления, путем разработки системы (VRGrip), которая может надежно регистрировать электромиографические (EGM) события ручных мышц сгибания, чтобы контролировать адаптивную и игру с помощью хватки. Цель этого исследовани

Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences.

Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes. Siltuximab is currently the only therapy approved by the FDA and EMA for idiopathic multicentric CD and is recommended as first-line therapy in treatment guidelines. Despite the extensive characterization of siltuximab treatment in clinical trials, available evidence from real-world practice is still scant. This collection of clinical experiences focuses on patients tre

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… In January 2021, the patient presented with full-body purple skin lesions, painful on palpation, intermittent, and associated with fever and night sweats. The symptoms persisted until June 2021. Laboratory tests, proteinuria and inflammation indices were normal. …

Смерть, вызванная распространением Герпеса Зостера в пациенте с множественной миеломой: Case Report and Licture Review.

Мы сообщаем о смертельном случае распространения герпеса-зостера в пациенте с множественной миеломой, иллюстрируя серьёзный риск иммунокомпромированных людей от вирусных инфекций. Путем объединения подробного доклада по делу с обширным анализом литературы в документе делается попытка пролить свет на факторы, лежащие в основе подверженности вирусной инфекции варицелла-зостр у нескольких пациентов, страдающих миэломой. Мы дополнительно оцениваем эффективные профилактические протоколы для герпеса-зостра, направленные на оснащение врачей улучшенными терапевтическими стратегиями. В данном случае по

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… Dermatological evaluation disclosed a clustered arrangement of corn-grain-sized red macules, papules, and blisters on the right inner thigh and buttocks, circumscribed by a basal red halo, with mild tenderness upon palpation. …

Malignant obstruction of the inferior vena cava: clinical experience with the self-expanding Sinus-XL stent system.

PURPOSE: To evaluate the technical and clinical outcome of Sinus-XL stent placement in patients with malignant obstruction syndrome of the inferior vena cava. METHODS: Between October 2010 and January 2021, 21 patients with different malignant primary disease causing inferior vena cava obstruction were treated with Sinus-XL stent implantation. Procedural data, technical and clinical outcome parameters were retrospectively analyzed. RESULTS: Technical success was 100%. Analysis of available manometry data revealed a significant reduction of the mean translesional pressure gradient following t

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… Lower body edema was graded as follows: 0 for absence of edema, 1 point for mild edema, 2 points for moderate edematous swelling, 3 points for severe swelling impeding the palpation of foot pulses without pain and immobility and 4 points for massive edematous swelling causing pain and immobility. …

Inpatient Medicine

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… The abdomen is mildly tender upon palpation. Creatinine is 0.8 mg/dl and total bilirubin is 2.1 mg/dl. Abdominal ultrasound is consistent with cirrhosis, splenomegaly, and large volume of ascites. Diagnostic paracentesis is scheduled. The most appropriate initial treatment is? …

Osteosarcoma of the appendicular skeleton in dogs: consensus and guidelines.

Osteosarcoma (OSA) in dogs poses a clinical challenge to veterinary practitioners across the globe. As knowledge evolves, so too do clinical practices. However, there remain uncertainties and controversies. There is value for the veterinary community at large in the generation of a contemporary wide-ranging guideline document. The aim of this project was therefore to assimilate the available published knowledge into a single accessible referenced resource and to provide expert clinical guidance to support professional colleagues as they navigate current OSA challenges and controversies. Primar

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… Metaphyseal swelling can be soft to firm and difficult to palpate in heavily muscled areas (e.g., the shoulder). Local pain is very variable. … Condition | Key features | Radiographic appearance | Prognosis and treatment Osteomas | Benign tumors, well-defined, radiodense; painless on palpation. | Radiographically dense and sharply defined. | Surgical excision is curative. …

Non-Interventional Prospective Observational Study of Platelet Rich Fibrin as a Therapy Adjunctive in Patients with Medication-Related Osteonecrosis of the Jaw.

BACKGROUND: Medication-related osteonecrosis (MRONJ) of the jaw is a severe and feared side effect of antiresorptive therapy in the oncological setting. With growing evidence that impaired angiogenesis may represent a key factor in pathogenesis, the aim of this study was to evaluate an autologous platelet concentrate as a possible additive in surgical therapy to optimize vascularization and, subsequently, resolution rates. MATERIAL AND METHODS: A non-interventional, prospective, multicenter study was conducted, and all patients with stage I-III MRONJ, undergoing antiresorptive therapy for an

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… The inflammatory phase is evaluated 35 days postoperative on the basis of bleeding (spontaneously or on palpation), granulation tissue, hematoma, tissue color, incision margins, suppuration, edema, and pain, all measured on a 9-point scale (0–8, a score of 5–8 is considered a successful inflammatory …

Hypercalcemia of Malignancy: An Update on Pathogenesis and Management.

Hypercalcemia of malignancy is a common finding typically found in patients with advanced stage cancers. We aimed to provide an updated review on the etiology, pathogenesis, clinical presentation, and management of malignancy-related hypercalcemia. We searched PubMed/Medline, Scopus, Embase, and Web of Science for original articles, case reports, and case series articles focused on hypercalcemia of malignancy published from 1950 to December 2014. Hypercalcemia of malignancy usually presents with markedly elevated calcium levels and therefore, usually severely symptomatic. Several major mechani

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… important to take a focused history (e.g., smoking history, exposure to carcinogens, family history of cancer, prior personal history of cancer, presence of cough, unintentional weight loss, etc.), and perform a thorough physical examination (e.g., breast mass in a female patient, abdominal mass on palpation …

Respiratory and Thoracic Medicine

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… Deformation of the nose or face, exophthalmia, or pain on palpation of the nasal or facial bones is most consistent with fungal disease or neoplasia. 1 Oral examination should be performed to assess for dental disease that could be causing an oronasal fistula, gingivostomatitis that could be consistent … Large polyps can be detected by palpation through the soft palate, and otic examination may reveal discoloration or bulging of the tympanum. …

Drowning the kidneys: from fluid overload to physiology-guided fluid management in onco-hematology.

Acute kidney injury (AKI) is a frequent complication in patients with cancer. Although AKI in oncology is often multifactorial, it is frequently attributed to nephrotoxicity or intrinsic tubular injury. However, its hemodynamic mechanisms remain underrecognized. Accumulating evidence from critical care and cardiorenal medicine indicates that fluid overload, venous congestion, and increased intra-abdominal pressure are major drivers of kidney dysfunction and adverse outcomes in patients with cancer. These mechanisms are particularly relevant in onco-hematology, where protocol-driven hydration,

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… Time to add a fifth pillar to bedside physical examination: inspection, palpation, percussion, auscultation, and insonation. JAMA Cardiol. 2018;3:346–50. 10.1001/jamacardio.2018.0001 15. Díaz-Gómez JL, Mayo PH, Koenig SJ. Point-of-care ultrasonography. …

MASCC/ISOO Clinical Practice Statement: imaging and clinical laboratory tests in the diagnosis and management of medication-related osteonecrosis of the jaw.

PURPOSE: A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise resource for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS focuses on the use of imaging and clinical laboratory tests for the diagnosis, staging, monitoring, treatment decision, and prediction of medication-related osteonecrosis of the jaw (MRONJ) in cancer patients. METHODS: This CPS was developed based on a critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of

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… This is clinically relevant if the MRONJ diagnosis is based on palpation of bone through a fistula, using a hand instrument (periodontal probe). …

A Pilot Clinical Study of Hyperacute Serum Treatment in Osteoarthritic Knee Joint: Cytokine Changes and Clinical Effects.

The serum fraction of platelet-rich fibrin (hyperacute serum) has been shown to improve cartilage cell proliferation in in vitro osteoarthritic knee joint models. We hypothesize that hyperacute serum may be a potential regenerative therapeutic for osteoarthritic knees. In this study, the cytokine milieu at the synovial fluid of osteoarthritic knee joints exposed to hyperacute serum intraarticular injections was investigated. Patients with knee osteoarthritis received three injections of autologous hyperacute serum; synovial fluid was harvested before each injection and clinical monitoring was

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… Clinical signs of acute inflammation were registered by palpation and surface heat mapping. Pain (VAS) and mobility (Lysholm-Tegner and KOOS) were monitored at each office visit, e.g., before, after 1 and 2 weeks and at 3- and 6-months post-injection ( Figure 2 ). …

Percutaneous Screw Fixation of Proximal Fifth Metatarsal Fractures.

UNLABELLED: Metatarsal fractures are one of the most common injuries of the foot, accounting for approximately 5% to 6% of all fractures confronted in the outpatient setting1. Approximately 45% to 70% of these fractures involve the fifth metatarsal, which have been described using a 3 zonal approach in 1993 by Lawrence and Botte2. Zone 2 fractures are difficult to manage given their retrograde vascular supply, leading to higher rates of nonunion1,3. Jones fractures (zone 2) are primarily treated surgically, with the 2 main methods being intramedullary screw fixation and plate fixation3. Surgic

Mapping the Unmet Informational Needs of Young Portuguese Female Cancer Survivors: Psychometric Validation of a Multidimensional Scale.

Background/Objectives: Young female cancer survivors often face specific informational needs related to the physical and emotional effects of cancer and its impact on life plans, particularly fertility and parenthood. However, few tools are tailored to assess these needs during this critical life stage. This study aimed to (i) validate a multidimensional measure-the Satisfaction with Information Provided to Young Oncology Patients Scale (SIPYF-CPS)-to assess the specific informational needs of young adult female cancer survivors; and (ii) explore preferences regarding the provision of informat

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… Recommendations for surveillance (e.g., self-palpation) 19. Risk behaviors 20. Restrictions in performing daily activities after recovery 21. Implications on sexual life 22. Alternatives to building/continuing the family (e.g., adoption) [previously 23] References 1. Ferlay J. Ervik M. Lam F. …