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Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe.

The consumption of immunoglobulins (Ig) is increasing due to better recognition of antibody deficiencies, an aging population, and new indications. This review aims to examine the various dosing regimens and research developments in the established and in some of the relevant off-label indications in Europe. The background to the current regulatory settings in Europe is provided as a backdrop for the latest developments in primary and secondary immunodeficiencies and in immunomodulatory indications. In these heterogeneous areas, clinical trials encompassing different routes of administration,

Совпадение в полном тексте источника
… Corticosteroids, immunosuppressants, or PE are not effective therapies for MMN, actually these treatments can even worsen the paresis ( 158 , 160 , 161 ). Optimal dose and intervals in maintenance treatment have not been established. …

High-Dose Vitamin C in Advanced-Stage Cancer Patients.

High-dose intravenously administered vitamin C (IVC) is widely used in cancer patients by complementary and alternative medicine practitioners. The most frequent indications for IVC therapy result from the belief in its effectiveness as a potent anti-cancer agent which additionally enhances chemosensitivity of cancer cells and reduces chemotherapy-related toxicities and fatigue intensity. In this narrative review, we decided to deal with this issue, trying to answer the question whether there is any scientific evidence supporting the rationale for application of high-dose IVC therapy in advanc

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… According to the authors, certain study participants also benefited from vitamin C therapy, demonstrating relief from bone pain due to metastases and from other mass effects (headache, Horner’s syndrome, laryngeal nerve paresis). …

2018 ACVIM Forum Research Report Program. Seattle, Washington, June 14 - 16, 2018.

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… They were treated by curative intent stereotactic volumetric modulated arc radiotherapy and 190, 220, 147 and 179 days after the end of irradiation they developed progressive head and neck pain with tetra‐paresis. …

Biology and Diseases of Dogs

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C

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Spinal lesions: a comprehensive radiologic overview.

Spinal lesions encompass a diverse range of pathologies, including primary and secondary tumors, infectious processes, vascular malformations, traumatic injuries, and degenerative conditions, each with distinct imaging characteristics crucial for accurate diagnosis and management. Imaging plays vital roles in assessing lesion morphology, anatomical localization, and neurological impact, guiding clinical decision-making and therapeutic planning. This review systematically explores spinal lesions based on their anatomical compartments, highlighting key radiological features and providing a compr

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… Symptoms may develop within hours to days and usually present with para- or tetra-paresis, sensory impairment, and sphincter dysfunction. Diagnosis is based on a combination of clinical evaluation, MRI, cerebrospinal fluid (CSF) analysis, and blood tests. …

Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK).

Systemic forms of amyloidosis affecting the heart are mostly light-chain (AL) and transthyretin (ATTR) amyloidoses. The latter is caused by deposition of misfolded transthyretin, either in wild-type (ATTRwt) or mutant (ATTRv) conformation. For diagnostics, specific serum biomarkers and modern non-invasive imaging techniques, such as cardiovascular magnetic resonance imaging (CMR) and scintigraphic methods, are available today. These imaging techniques do not only complement conventional echocardiography, but also allow for accurate assessment of the extent of cardiac involvement, in addition t

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… If the nervous system is affected, mixed sensomotoric peripheral neuropathies (20%) with numbness, paraesthesia, and pain up to paresis as well as autonomic neuropathies (15%) with consecutive orthostatic hypotension will occur. …

Infectious Diseases

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… as fever, maculopapular rash, mucocutaneous lesions, alopecia, lymphadenopathy, meningitis, uveitis, and cranial neuritis tertiary syphilis —develops after year(s) and may involve the heart (aortitis), eyes (iritis, Argyll Robertson pupil), bones/soft tissues (gummas), and neurologic system (general paresis …

Abstracts - IANCON 2025

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Устные доклады

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Current landscape and future directions of targeted-alpha-therapy for glioblastoma treatment.

Glioblastoma (GB) is the most aggressive malignancy of the central nervous system. Despite two decades of intensive research since the establishment of the standard of care, emerging strategies have yet to produce consistent satisfactory outcomes. Because of its specific localisation and intricate characteristics, GB is a uniquely regulated solid tumour with a strong resistance to therapy. Advances in targeted radionuclide therapy (TRT), particularly with the introduction of a-emitting radionuclides, have unveiled potential avenues for the management of GB. Recent preclinical and clinical stud

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… One experienced a brief increase in paresis. Importantly, no severe side effects were observed. The median overall survival was 23.6 months from diagnosis, while the median survival time after recurrence was 10.9 months, with a median progression-free survival of 2.7 months. …

Infectious Diseases

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Совпадение в полном тексте источника
… as fever, maculopapular rash, mucocutaneous lesions, alopecia, lymphadenopathy, meningitis, uveitis, and cranial neuritis tertiary syphilis —develops after year(s) and may involve the heart (aortitis), eyes (iritis, Argyll Robertson pupil), bones/soft tissues (gummas), and neurologic system (general paresis …

Специальный выпуск: резюме 11th Конгресс Европейской академии неврологии, Хельсинки, Финляндия.

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… While this frequently presents with concurrent neuropathic pain and sensory symptoms, both were absent in this case, broadening the clinical spectrum of this condition and highlighting Lyme disease as a rare but important differential in acute flaccid paresis. Disclosure: Nothing to disclose. …

Влияние износимой ритмической стимуляции слуха на болезнь Паркинсона, множественный склероз и инсульт: систематический обзор и метаанализ.

Движущаяся терапия с использованием рифмического стимула (RAS) оказалась полезной для болезни Паркинсона (PD). Вместе с тем необходимо провести исследования, касающиеся применения изношенных устройств во всех неврологических расстройствах. Цель этого исследования состоит в том, чтобы изучить эффективность терапии с использованием изношенных устройств при перемещении лиц с неврологическими расстройствами. Систематический обзор и метаанализ. Источники данных 27, 2024. Были проведены обыски PubMed, Web of Science, Medline, PEDro и ScienceDirect. В соответствии с руководящими принципами ПРИСМА 202

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… Furthermore, López-Ortiz et al. 20 concluded that dance and RAS provided beneficial effects in terms of balance, gait and walking for patients with Cerebral Paresis (CP). These reviews are often limited to one group of neurological disorders like PD and generally lack the use of wearable devices. …

Inpatient Medicine

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Abstracts - IANCON 2024

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Rare Diseases of the Nose, the Paranasal Sinuses, and the Anterior Skull Base.

Due to their low incidence and thus resulting limited diagnostic criteria as well as therapeutic options, rare diseases of the nose, the paranasal sinuses, and the anterior skull base are a significant challenge. The value as of which a disease has to be considered as rare amounts to a maximum of 5 patients per 10 000 people. Within these diseases, however, there are extreme differences. Some rare or orphan diseases like for example the inverted papilloma belong to regularly diagnosed and treated diseases of larger departments of oto-rhino-laryngology whereas other rare diseases and malformati

Е-постеры.

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Research Communications of the 26th ECVIM‐CA Congress

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17th Конгресс ЕВНОС: Милан, Италия, 4–6 Июнь, 2026 года

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