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Therapeutic Potential of Methylindoline Derivative in Ameliorating Cadmium-Induced Nephritis Experimented in Zebrafish Model.

Since kidney diseases are a major global concern, their impact on public health makes them an important area of study. The kidneys, as the p … ogenase (LDH) and malondialdehyde (MDA) while restoring the activity of antioxidant enzymes such as catalase (CAT) and superoxide dismutase (SOD). The expression of pro-inflammatory cytokine genes, including TNF-α, IL-1β, IL-6, and NF-κB, was also significantly downregulated by IC. Histopathological analysis of zebrafish kidneys demonstrated the restoratio …

Suppressive effect of topical moxifloxacin on imiquimod-induced model of psoriasis in mice.

Psoriasis is a chronic inflammatory skin disorder that is triggered by immune-mediated, genetic, and environmental factors. Moxifloxacin is … in also suppressed oxidative indicators such as MDA and elevated antioxidant enzyme levels, such as catalase. Moxifloxacin has substantial anti-psoriatic action against imiquimod-induced psoriasis through its anti-proliferative and anti-inflammatory effects. Furthermore, moxifloxacin has a restorative effect on the histopathological alterations of mice's s …

Brevibacterium Species Infections in Humans-A Narrative Review.

Brevibacterium species are Gram-positive, non-sporulating, coryneform, aerobic rods that are catalase positive and exhibit a distinctive transition from diptheroid to coccoid morphology during culture. Infections by these species are seldom identified. Objective: This narrative review aims to present all the reported cases of Brevibacterium spp. infections in humans, focusing on data about epidemiology, antimicrobial resistance, antimicrobial treatment, and mortality. A narrative review based on a literature search of PubMed/MedLine and Scopus databases was performed. In total, 41 studies prov…

Nanohybrid urate oxidase with magnetically switchable catalytic potential for precise gout therapy.

Spatiotemporal regulation of therapeutic enzymes is desirable for enhancing the efficacy and safety of enzyme-based treatments for metabolic … d (AMF). The Fe3O4 nanoring under AMF exposure functions as a nanoheater to stimulate its intrinsic catalase (CAT) activity for oxygen recycling, which in turn activates UOx/CAT cascade for controlled uric acid degradation. Through the synergistic magnetothermal and UOx/CAT cyclic cascade, NUOx exhibited greatly enhanced AMF-tunability with an ON/OFF ratio …

Additive Effects of Cu-ATSM and Radiation on Survival of Diffuse Intrinsic Pontine Glioma Cells.

Diffuse intrinsic pontine gliomas (DIPG) are highly aggressive and treatment-resistant childhood primary brainstem tumors with a median surv … acid. Cu-ATSM toxicity in DIPG cells was also inhibited by overexpression of mitochondrial-targeted catalase. These results support the hypothesis that Cu-ATSM is selectively cytotoxic to DIPGs by a mechanism involving H2O2 generation and copper and being additively cytotoxic with ionizing radiation.

Protective effect of mannose oligosaccharides on cadmium-induced hepatic oxidative damage in rats.

The objective of this study was to investigate the effect of mannose oligosaccharides (MOS) against cadmium (Cd)-induced hepatic oxidative d … ncrease in body weight gain (BWG) and thymus index. Additionally, liver superoxide dismutase (SOD), catalase (CAT) and total antioxidant capacity (T-AOC) activities were significantly improved compared to the group exposed to Cd alone. Conversely, MOS resulted in significant reductions in the liver index, liver malondialdehyde (MDA), hydrogen peroxide (H2O …

Dietary supplementation of spirulina powder (Arthrospira platensis) enhances growth, antioxidant status, immune function, and cardiac health in Japanese quails.

This study was conducted to evaluate the effects of dietary supplementation with different levels of Arthrospira platensis (Spirulina powder … d body weight gain and feed conversion ratio, enhanced antioxidant enzyme activities (SOD, GPx, and catalase) and reduced malondialdehyde (MDA) levels in serum, liver, and muscle (P < 0.001). Relative weights of immune organs (bursa of Fabricius, thymus, and spleen) increased significantly, and serum immunoglobulins (IgY, IgM, IgA) were elevated in Spiruli …

Evaluation of the Effect of Virgin Rice Bran Oil (VRBO) on Doxorubicininduced Cardiotoxicity in Wistar Rats.

INTRODUCTION: The usage of doxorubicin (DOX), an antineoplastic drug that is frequently used for the cure of cancer, is restricted to maxima … Antioxidant markers showed notable recovery, with MDA levels reduced by 66.1%, while GSH, SOD, and catalase levels increased by 129.4%, 158.2%, and 84.8%, respectively. CONCLUSION: A cardioprotective benefit was found at middle and higher VRBO dosages. In order to demonstrate the effectiveness of VRBO as a cardioprotective medication, further research on …

Neurotoxic Effects of Tramadol Administration on the Cerebellar and Cerebral Cortices of Adult Male Wistar Rats.

Background Tramadol, a widely prescribed synthetic opioid, is commonly used for managing moderate to severe pain due to its dual mechanism o … Oxidative stress markers showed no changes in the antioxidant enzymes assayed with the exception of catalase. Histopathological examination of the cerebellum showed intact cerebellar layers at the cortex with normal cellular structure and orientations for the control and treated group, while that of the cerebrum revealed mild morphological alterations in t …

Наночастицы, являющиеся наночастицой кухонной пропитки, смягчают когнитивное расстройство, вызванное капризоной, с помощью антиоксидантов и противовоспалительных механизмов.

ЦЕЛЬ: Нейроинфламмация является одним из основных факторов, способствующих возникновению многих нейродегенеративных заболеваний. Cuprizone, медный агент, широко используется в исследованиях для того, чтобы вызвать нейротоксичность и демиелионацию, имитируя патологию множественного склероза. В рамках этого исследования изучаются защитные и терапевтические последствия наноформулирования куркумина и трубчатой системы, подготовленные в семенном масле Зантоксилам Ретса, для нейротоксичности мышей, вызванной купризоной. МЕТОДЫ: Семьдесят пять швейцарских мышей альбиноса были разделены на пять групп:

Совпадение в аннотации оригинала
OBJECTIVE: Neuroinflammation is a key contributor to many neurodegenerative diseases. Cuprizone, a copper-chelating agent, is widely used in … tion and induced oxidative stress, as evidenced by decreased levels of key antioxidant enzymes like catalase, superoxide dismutase, glutathione and glutathione peroxidases. Additionally, increased levels of neuroinflammatory markers such as GFAP, MCP-1, MIP-1, and CCL-5 were observed. Treatment with curcumin and piperine nanoformulations mitigated these ef …

Protective effects of ghrelin on pancreas in fructose diet and streptozotocin-induced diabetic rats.

Ghrelin, which is widely expressed in central and peripheral tissues, has several metabolic effects. It has been suggested that these effect … tochemistry in diabetic rats. Malondialdehyde, glutathione, and protein carbonyl levels, as well as catalase, glutathione-S-transferase, and superoxide dismutase (SOD) activities, were measured spectrophotometrically to detect the ghrelin effect on OS. Homeostasis model assessment for insulin resistance (HOMA-IR) and pancreatic insulin levels were assessed …

Protective effect of dental pulp stem cells' conditioned medium against cisplatin-induced testicular damage in rats.

Cisplatin is a highly effective chemotherapy drug used to treat most solid tumors. However, one of its side effects is testicular toxicity, … testosterone and IL-6 serum levels, as well as a decrease in IL-6 and TNFα levels, the activity of catalase and SOD enzymes, and an increase in MDA in testicular tissue were detected. Testicular tissue damage was associated with a significant decrease in tube diameter, germinal epithelium height, number of spermatogonia and Sertoli cells, along with a not …

Ameliorative action of eugenol on nitrate induced reproductive toxicity in male rats.

There is a great concern for studies to prevent nitrate (NO3) induced male reproductive toxicity as it might lead to infertility. Therefore, … dehydrogenase activity, serum concentration of testosterone, activities of superoxide dismutase and catalase in testis and spermatozoa and different categories of germ cells in stage VII of spermatogenesis. Further, there was significant increase in sperm abnormality and levels of nitrite (NO2) and malondialdehyde in testis and spermatozoa of NO3 treated r …

Hepatoprotective effect of date fruit extract against ethanol-induced apoptosis in human hepatoma (HepG2) cells.

Ethanol is a well-known hepatotoxic agent and date fruits have been associated with their biological actions. In current study, we have inve … se dependent way, induced by ethanol. Further DFE was also effective in restoring the LPO, GSH, and catalase levels towards normal altered by ethanol. Our results also revealed that ethanol-induced ROS generation was significantly inhibited by DFE. The ethanol-induced mRNA expression of apoptotic related genes (p53, caspase-3, caspase-7, Bax, and Bcl-2) we …

A meta-analysis of essential oils as a dietary additive for weaned piglets: Growth performance, antioxidant status, immune response, and intestinal morphology.

This study aimed to evaluate the effects of dietary supplementation with EOS on growth performance, blood serum antioxidant status, immune r … ) serum malondialdehyde content and higher (P < 0.05) serum concentrations of superoxide dismutase, catalase, glutathione peroxidase, and total antioxidant capacity were observed in response to the dietary inclusion of EOS. EOS supplementation increased (P < 0.001) the serum concentration of immunoglobulins A, G, and M and decreased (P < 0.05) the serum co …

Role of vitamin D3 in mitigating sodium arsenite-induced neurotoxicity in male rats.

Arsenic is associated with various neurological disorders, notably affecting memory and cognitive functions. The current study examined the … tric oxide (NO), the decrease in antioxidants (reduced glutathione; GSH, superoxide dismutase; SOD, catalase; CAT, and glutathione peroxidase; GPx), as well as the increase in pro-inflammatory markers including, tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and amyloid-beta (Aβ)1-42. Furthermore, Vit. D3 reversed the alterations in the n …

Reduced ischemia-reperfusion oxidative stress injury by melatonin and N-acetylcysteine in the male rat brain.

Middle cerebral artery occlusion (MCAO) is a model for inducing ischemic stroke in rodents, leading to devastating brain damage. Oxidative s … olume estimated and the concentrations of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and nuclear factor erythroid-2 related factor 2 (Nrf2) were analyzed by enzyme-linked immunosorbent assay (ELISA). The results indicate that the NAC + melatonin group exhibited elevated sensory-motor activity and a reduc …

Effect of galangin on oxidative stress, antioxidant defenses and mitochondrial dynamics in a rat model of focal cerebral ischemia.

Focal ischemia occurs when a cerebral artery becomes obstructed by an embolus or thrombus, leading to a rapid reduction in cerebral blood fl … malondialdehyde levels, and the density ratio of mitogen-activated protein kinase, while enhancing catalase, glutathione peroxidase and superoxide dismutase activities, and improving the density ratio of mitofusin 2 protein in the cortex and hippocampus. In conclusion, galangin showed significant in vivo potential in mitigating the pathological changes ca …

Efficacy of Standardized Yoga Asanas as Add-on Therapy in the Management of Hypothyroidism: A Randomized, Open-label, Controlled Clinical Study.

BACKGROUND: Hypothyroidism is an endocrine disorder in which the thyroid gland does not produce an adequate amount of thyroid hormones. This … to baseline (P < 0.05). There was also a positive trend of improvement in other oxidative markers (catalase, superoxide dismutase, and glutathione), and a significant reduction in interleukin-6 levels (P < 0.05) was found in the yoga group as compared to the baseline. However, there was no significant change found in the control group of subjects. CONCLU …

Enhancing farmed fish welfare: Evaluating the effectiveness of plant-based stress mitigating agents as sedatives in sea bass (Dicentrarchus labrax) following intraperitoneal vaccination.

The effectiveness of vaccines may be compromised by the stress response induced by intraperitoneal/intramuscular (IP/IM) vaccination due to … The transcription of stress (gr, hsp70, cox2), immune (il1β, il6, tnfα), and antioxidant (gpx, sod, catalase) genes confirmed the vaccination-induced stress response, with mc2r transcription indicating increased cortisol production in vaccinated groups (N.P. vaccine and FEC + vaccine). FEL reduced stress at both physiological (e.g., cortisol) and transcrip …