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Quantitative susceptibility mapping of iron deposition in sporadic cerebral cavernous malformation-related epilepsy.

OBJECTIVE: To evaluate iron deposition patterns in patients with cerebral cavernous malformation-related epilepsy (CRE) using quantitative susceptibility mapping (QSM) for detailed analysis of iron distribution associated with a history of epilepsy and severity. METHODS: This study is part of the Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy (CRESS) cohort, a prospective multicenter study. QSM was used to quantify iron deposition in patients with sporadic cerebral cavernous malformation (CCMs). Lesions were segmented i…

Erianin Disturbs Iron and ROS Homeostasis To Trigger Ferroptosis in Colorectal Cancer Cells.

Ferroptosis is a non-apoptotic, iron-dependent death form. Ferroptosis was embedded in various disorders, including cancer. Ferroptosis induction in cancerous tissues could be an alternative treatment pathway. In this study, we studied the ferroptotic impact of the natural compound erianin, besides its apoptotic effect in colorectal adenocarcinoma cell line (Caco2). The cytotoxicity of erianin was performed in the presence and in the absence of deferoxamine (DFO) as an iron chelator. We measured reactive oxygen species (ROS), apoptosis, and cell cycle using flow cytometry. Further, the change …

Dissimilatory nitrate reduction to ammonium driven by iron tolerant Lutibacter in coastal sediments.

The processes of denitrification and dissimilatory NO3- reduction to ammonium (DNRA) occupy a competing pivotal point in the nitrogen cycle. Denitrification leads to a loss of fixed nitrogen, while DNRA recycles NO3- as bioavailable ammonium. Iron (II) is known to enhance DNRA, by acting as an electron donor, however, the organisms responsible for iron driven DNRA remain poorly understood. Here we undertook incubations of sediment with NO3- and Fe2+ additions followed by process measurements and metagenomic analysis to measure DNRA and microbial community structure. Addition of Fe2+ stimulated…

Redox properties of quercetin iron Ii complex with enhanced antioxidant and antiviral activities.

Quercetin is a naturally occurring flavonoid widely recognized for its potent antioxidant, anti-inflammatory, and anticancer effects. However, its clinical application is limited by low water solubility and poor bioavailability. In this study, the complexation of quercetin with iron (II) ions was systematically investigated through electrochemical, spectroscopic, biological, and computational techniques to improve its physicochemical and pharmacological performance. Cyclic voltammetry revealed that quercetin undergoes irreversible oxidation due to semiquinone and para-quinonemethide formation,…

Maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland China.

Iron deficiency is prevalent among pregnant women because of the increased maternal iron requirements. Uncorrected maternal iron deficiency can lead to adverse neurodevelopmental outcomes in neonates. Therefore, the aim of this study was to assess serum ferritin concentration and prevalence of iron deficiency among pregnant women in Jiangsu, China. Within a cohort study, pregnant women were followed up from 2nd trimester of pregnancy until their labour. They were assessed for iron status in 2nd and 3rd trimesters using serum ferritin. In addition, neonatal APGAR score and birth weight were ass…

Adsorptive fractionation of extracellular polymeric substances on iron oxyhydroxides: impact on copper binding.

The fractionation of extracellular polymeric substances (EPSs) on mineral surfaces alters their composition and reactivity, thereby influencing heavy metal behavior in the environment. However, the molecular-level mechanisms governing how this process affects metal-binding properties remain unclear. Hence, this study combined multispectral techniques and chemometrics to investigate the adsorptive fractionation of EPSs on minerals and its impact on heavy metal binding. Excitation-emission matrix coupled with parallel factor analysis (EEM-PARAFAC) demonstrated that aromatic and protein-like comp…

Pregnancy Outcomes Among Women with Treated Iron Deficiency Anemia: A Retrospective Cohort Study.

BACKGROUND AND OBJECTIVES: Iron deficiency anemia (IDA) is the most common cause of anemia in pregnant women and can adversely affect both maternal and fetal health. This study aimed to compare pregnancy outcomes between women with and without IDA in Northern Thailand, a region with a high prevalence of anemia. METHODS: A retrospective cohort study was conducted on all singleton pregnancies attending antenatal care (ANC) and/or delivering at Maharaj Nakorn Chiang Mai Hospital between 2003 and 2024. The study group consisted of women diagnosed with IDA in the first half of pregnancy, while the…

Otilonium bromide exhibits novel antifungal activity against Candida albicans via regulating iron homeostasis.

Traditional antifungal drugs used against Candida albicans have several drawbacks, including the emergence of drug-resistant strains. In add … ition, thus interfering with biofilm formation. Additionally, the efficacy of OB was abolished when iron ions were provided, suggesting that iron homeostasis was associated with the inhibition mechanism of OB. Interestingly, a therapeutic assay showed that OB demonstrated limited efficacy in reducing C. albicans burden in a murine systemic infection mo …

Iron deposition in ovarian endometrioma evaluated by magnetic resonance imaging R2* non-invasively.

RESEARCH QUESTION: Is surgery effective in decreasing iron deposition in the ovarian tissue surrounding an ovarian endometrioma? DESIGN: This cohort study was conducted in China between July 2023 and April 2024. Seventy-nine patients with ovarian endometriomas and 45 controls with other ovarian cyst types were enrolled. Magnetic resonance imaging using a relaxation sequence (MRI-R2*) has been proven to be a reliable method for detecting iron deposition. All participants underwent MRI-R2* preoperatively to detect the presence of iron in ovarian tissue, before surgical ovarian cystectomy. Addit…

Increased levels of systemic iron content in adult-onset interleukin-6 knockout mice.

BACKGROUND: Interleukin-6 (IL-6) is a pleiotropic cytokine that participates in multiple metabolic disorders. IL-6 is well recognized to induce hepcidin expression and decreased serum iron through the JAK2/STAT3 pathway under inflammatory conditions. Targeted inhibition of IL-6 represents a potential therapeutic regimen for multiple diseases. The current study aimed to explore the physiological concentration of IL-6 in sustaining systemic iron homeostasis. METHODS: IL-6-knockout mice (IL-6-/-) were established in the current study. Western blot measured the expression of key iron-related prot…

Iron homeostasis and health: understanding its role beyond blood health - a narrative review.

Iron is an essential trace element that plays a critical role in numerous physiological processes, including oxygen transport, cellular metabolism, immune function, and organ health. While its most well-known function is in hemoglobin synthesis for blood health, iron's regulatory mechanisms extend far beyond the bloodstream. This review examines the broader implications of iron homeostasis, focusing on its impact on cellular functions, immune responses, and the health of organs such as the liver, heart, and brain. Disruptions in iron regulation, including both deficiency and overload, can lead…

A Multifaceted Nanodrug Disrupts the Copper-Iron Homeostasis to Enhance Cancer Radiotherapeutic Effect.

Radiation therapy (RT) is a core modality in cancer treatment; however, its efficacy is often limited by tumor resistance. Studies have shown that RT induces abnormal copper ion accumulation and iron reduction, thereby inhibiting ferroptosis and exacerbating therapeutic resistance. In this study, multiomics database analysis revealed that various RT-resistant cancer cell lines and patient-derived tumor models exhibit characteristics of disrupted copper homeostasis and enhanced copper ion-binding capacity. Hence, we have created a pH-responsive nanomicelle system based on dynamic iron-coordinat…

Hearing assessment in transfusion dependent beta-thalassemia children on oral iron chelating agent.

BACKGROUND: Hearing deficit is one of the side effects of 1st generation iron chelators in β-thalassemia, however the risk of hearing deficits following 2nd generation iron chelators is not well known. AIM: To assess hearing status of Transfusion Dependent β-thalassemia children on oral iron chelating agents and detect risk factors for hearing impairment. METHODS: This is a cross-sectional study recruited sixty children and adolescent with confirmed diagnosis of transfusion dependent β-thalassemia. Demographic and clinical characteristics collected, audiological testing were performed by the…

Perspectives on Intravenous Iron Therapy Logistics and Adherence: Results from a Patient Survey.

PURPOSE: Iron deficiency anemia (IDA) affects approximately 5 million people in the United States (US), significantly impacting quality of life (QoL) and overall health. Iron stores can be replenished through oral iron or, if ineffective/poorly tolerated, through intravenous iron (IVI) therapy. Despite IVI effectiveness, patients do delay/miss infusion appointments, leading to incomplete treatment response. Here we evaluated multiple-dose IVI therapy logistics and adherence from the patient perspective. PATIENTS AND METHODS: US adult patients (≥18 years) with confirmed IDA who were currently …

Iron regulatory pathways differentially expressed during Madurella mycetomatis grain development in Galleria mellonella.

Mycetoma is a chronic granulomatous infection of the subcutaneous tissue, most often caused by the fungal pathogen Madurella mycetomatis. Ch … s were differentially expressed during infection. In particular, genes encoding proteins related to iron transport were highly expressed by both G. mellonella (transferrin and ferritin) and M. mycetomatis (SidA, SidD and SidI). LC-MS/MS analysis of M. mycetomatis cultured under iron-limiting conditions revealed the presence of SidA and SidD orthologs, …

Железо во множестве склероза - от патофизиологии до развития болезней - обзор описательной литературы.

Множественный склероз (MS) — хроническое аутоиммунное заболевание, характеризующееся демиелинацией и нейродегенерацией, которое вызывает физические расстройства и серьезные изменения в неврологической системе, включая глиоз и потерю нейронов. Болезнь поражает в первую очередь миелионированные части центральной нервной системы (КНС), такие как зрительные нервы, мозжечок, мозговой ствол и спинной мозг. Т клетки играют важную роль в патогенезе MS, вызывая обезвоживание, и факторы риска включают генетическую предрасположенность, воздействие на окружающую среду и решения, касающиеся образа жизни. Р

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune illness characterized by demyelination and neurodegeneration, which causes physical disabili … e in MS pathogenesis by inducing demyelination, and risk factors include genetic predisposition, environmental effects, and lifestyle decisions. The prevalence of MS is rising, especially among women and the elderly population. Iron dysregulation is a critical element in MS pathogenesis, with excess iron causing neurodegeneration via ferroptosis and im …

Iron deposition in infants undergoing ECMO: A retrospective analysis of Postmortem tissue samples.

BackgroundInfants undergoing ECMO may have elevated serum ferritin and iron levels, raising concerns about iron overload. Recent studies question the utility of these markers for acute vs. chronic iron overload during ECMO. This study evaluates iron content and localization in autopsy tissues from deceased infants who received or were considered for ECMO.MethodsThis retrospective single-center case-control study analyzed paraffin-embedded tissues from the basal ganglia, liver, spleen, pancreas, and kidney. Tissue sections were stained to quantify iron deposition and an independent pathologist …

Iron and Magnesium Co-substituted Hydroxyapatite Nanoparticles in Orthodontic Composite: A Preliminary Assessment.

Aim The study aims to characterize Fe and Mg co-substituted hydroxyapatite nanoparticles (FeMgHAPn) and assess the antimicrobial properties of FeMgHAPn-incorporated orthodontic composite. Materials and methods FeMgHAPn was synthesized using the sol-gel method, and the prepared nanoparticle powder was characterized using Fourier Transform Infrared Spectroscopy (FTIR), energy-dispersive X-ray analysis (EDX)) and scanning electron microscopic (SEM) analysis. The FeMgHAPn was incorporated into a commercially available orthodontic composite in two concentrations (40 and 20 μL), and the structure wa

Photothermal and ferroptosis synergistic therapy for liver cancer using iron-doped polydopamine nanozymes.

An innovative nanozyme, iron-doped polydopamine (Fe-PDA), which integrates iron ions into a PDA matrix, conferred peroxidase-mimetic activity and achieved a substantial photothermal conversion efficiency of 43.5 %. Fe-PDA mediated the catalysis of H2O2 to produce toxic hydroxyl radicals (•OH), thereby facilitating lipid peroxidation in tumour cells and inducing ferroptosis. Downregulation of solute carrier family 7 no. 11 (SLC7A11) and solute carrier family 3 no. 2 (SLC3A2) in System Xc- resulted in decreased intracellular glutathione (GSH) production and inactivation of the nuclear factor ery…

Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders.

Iron overload is closely associated with metabolic dysfunction. However, the role of iron in the hypothalamus remains unclear. Here, we find that hypothalamic iron levels are increased, particularly in agouti-related peptide (AgRP)-expressing neurons in high-fat-diet-fed mice. Using pharmacological or genetic approaches, we reduce iron overload in AgRP neurons by central deferoxamine administration or transferrin receptor 1 (Tfrc) deletion, ameliorating diet-induced obesity and related metabolic dysfunction. Conversely, Tfrc-mediated iron overload in AgRP neurons leads to overeating and adipos…