Результаты поиска

Hypophosphatasia: Clinical Clues and Management Considerations.

This case report identifies typical manifestations of a patient with hypophosphatasia, a rare genetic condition in which mutations in tissue-non-specific alkaline phosphatase (TNSALP) enzymes cause low levels of alkaline phosphatase and defective bone mineralization. It explores common diagnostic clues from the history and laboratory evaluation, which can help clinicians identify the disorder. This case introduces a 49-year-old patient with a long history of fractures and dental abnormalities who was referred to endocrinology for evaluation of osteopenia. Further review of her laboratory data

Management of Medication-Related Osteonecrosis of the Jaws With Hyperbaric Oxygen Therapy: A Case Report.

Medication-related osteonecrosis of the jaw (MRONJ) refers to the condition where the maxillary or mandibular bone becomes exposed and necrotic as a result of bisphosphonate therapy. The number of patients on bisphosphonates is increasing and so are the MRONJ cases. Since the initial data were published in the early 2000s, research into MRONJ has expanded significantly to enhance the understanding of this emerging condition. Various treatment options are available, but none have been established as the definitive "gold standard" for managing this disease. Hyperbaric oxygen therapy (HOT) is one

Multidisciplinary Management of Morbidities Associated with Chronic Graft-Versus-Host Disease.

Chronic graft-versus-host disease (cGVHD) represents a common long-term complication after allogeneic hematopoietic stem cell transplantation (HSCT). It imposes a significant morbidity burden and is the leading cause of non-relapse mortality among long-term HSCT survivors. cGVHD can manifest in nearly any organ, severely affecting the quality of life of a transplant survivor. While the mainstay of treatment has remained systemic immunosuppression with glucocorticoids, progress has been made within the last few years with approvals of three oral agents to treat steroid-refractory cGVHD: ibrutin

Summarizing Consensus Guidelines on Obesity Management: A Joint, Multidisciplinary Venture of the International Federation for the Surgery of Obesity & Metabolic Disorders (IFSO) and World Gastroenterology Organisation (WGO).

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Molecular cytogenetic analysis of cutaneous T-cell lymphomas: identification of common genetic alterations in Sézary syndrome and mycosis fungoides.

This review summarizes current evidence on the biological, diagnostic, prognostic, and therapeutic significance of microRNAs (miRNAs/miRs) in prostate cancer (PCa). Dysregulated miRNA networks contribute to PCa initiation, progression, metastasis, and therapy resistance by regulating androgen receptor signaling, proliferation, apoptosis, epithelial-mesenchymal transition, angiogenesis, hypoxia signaling, bone tropism, and castration-resistant evolution. Oncogenic miRNAs, including miR-21, miR-93, miR-9, miR-181a, and miR-182, promote malignant phenotypes through survival, TGF-β, PI3K/AKT, MAPK

The 2024 Saudi Pharmacotherapy Didactic Curriculum Toolkit: A Modified Delphi Study.

BACKGROUND: Several pharmacy schools in Saudi Arabia (S.A.) refer to the American College of Clinical Pharmacy (ACCP) pharmacotherapy toolkit in developing their pharmacotherapy curriculum. However, the ACCP toolkit does not specifically address the healthcare needs of the Saudi population. A tailored pharmacotherapy curriculum that offers graduates the essential competencies to better serve the nation's needs is warranted. This study aims to develop a population-centered didactic pharmacotherapy toolkit for the Saudi population to assist pharmacy schools in designing pharmacotherapy course co

Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw - Prognostic factors in the treatment of BRONJ.

ObjectivesBisphosphonate-related osteonecrosis of the jaw (BRONJ) is a relatively rare but serious side effect of bisphosphonate (BP)-based treatments. This retrospective study aimed to investigate the risk factors and predictive markers in cases where patients were refractory to a recommended conservative treatment offered in our hospital.Patients and methodsThis single-center study collated the medical records of all patients treated for BRONJ between 2004 and 2011. A complete medical history, including detailed questionnaires, was collected for all patients, focusing on identifying underlyi

Changes in health in Belgium, 1990-2016: a benchmarking analysis based on the global burden of disease 2016 study.

BACKGROUND: Despite increasing of the Belgian health expenditures, several indicators related to population health showed poor results. The objectives of this study were to perform an in-depth analysis of the secular trend of Belgian health status using the Global Burden of Disease (GBD) 2016 study results for Belgium, and to compare these results with other European countries. METHODS: We collected results of the Global Burden of Disease 2016 study through the GBD results and visualization tools. We benchmarked Belgian GBD results with the other initial members of the European Union (EU15).

Совпадение в полном тексте источника
… Since 1990, the Belgian federal and regional governments introduced multiple measures for tobacco control [ 3 ], cancer screening [ 4 , 5 ], road injuries prevention [ 6 , 7 ], healthier nutritional habits and physical activities [ 8 ] improved air quality [ 9 ] and care accessibility [ 10 ]. …

Диабет мелитус и риск множественных склерозов: систематический обзор и метаанализ.

Множественные исследования указывают на потенциальную связь между множественным склерозом (MS) и сахарным диабетом (DM). Вместе с тем несоответствия в опубликованных публикациях, которые могут быть использованы в связи с различиями в статистических методах, размерах выборки и структуре исследования, привели к противоречивым выводам. Поэтому мы провели систематический метаанализ, с тем чтобы прояснить взаимосвязь между MS и DM и проинформировать о будущих механистических исследованиях. МЕТОДЫ: Мы провели всеобъемлющий поиск литературы в базах данных сети " Web of Science " , " Pu

Факторы, связанные с содержанием витамина D у монгольских пациентов с множественным склерозом.

ЦЕЛЬ: Множественный склероз (МС) вызывается генетическими и экологическими факторами. Витамин D был определен в качестве фактора экологического риска, причем в широтах, расположенных дальше от экватора, отмечается более высокий уровень его распространенности. В Монголии при температуре 45°N воздействие солнечного света ограничено, что повышает риск для населения в связи с дефицитом витамина D. ЦЕЛИ: Сопоставление уровней содержания витамина D среди лиц с НР (ПМК) и лиц, не имеющих НР, и выявление факторов, связанных с низким содержанием витамина D. Мы изучили связи с уровнями витамина D, испол

New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil.

The use of already-approved drugs to treat new or alternative diseases has proved to be beneficial in medicine, because it reduces both drug development costs and timelines. Most drugs can be used to treat different illnesses, due their mechanisms of action are not restricted to one molecular target, organ or illness. Diverging from its original intent offers an opportunity to repurpose previously approved drugs to treat other ailments. This is the case of sildenafil (Viagra), a phosphodiesterase-5 (PDE5) inhibitor, which was originally designed to treat systemic hypertension and angina but is

Shoulder Pain in a 33-Year-Old Male Found to Have Multiple Myeloma.

Multiple myeloma (MM) is a blood cancer involving monoclonal plasma cells, mainly diagnosed in older adults. Only a very small percentage of patients are diagnosed before age 40. A 33-year-old male presented with hip and shoulder pain and was diagnosed with Immunoglobulin G (IgG) kappa multiple myeloma. Of the CRAB (calcium elevation, renal insufficiency, anemia, and bone lesions) criteria, he only exhibited anemia and bone lesions. He was found to have extensive osseous lesions throughout his skeleton and a bone marrow biopsy showing plasma cell myeloma involving 30% of medullary cellularity.

Okay, so I need to translate this medical title into Russian. Let me start by understanding the source text. The title is "Lenalidomide-Associated Oral Pigmentation: A Case Report." First, I'll break down the components. "Lenalidomide" is a drug name. In Russian medical terminology, drug names are usually transliterated but sometimes have specific translations. Wait, but the instruction says to use international nonproprietary drug names. Lenalidomide is the nonproprietary name, so in Russian it's probably "Леналидомид" (I think that's the transliteration). Let me confirm. Yes, in Russian medical literature, lenalidomide is written as Леналидомид. Next, "Associated" here means that the pigmentation is associated with lenalidomide use. So the phrase "Lenalid. Associated Oral Pigmentation" would be "Связанная с леналидомидом оральная пигментация". Wait, but in medical terms, "associated" in this context is often translated as "связанная" or "ассоциированная". Hmm. Let me check. In Russian medical terminology,

Леннодомид является иммуномудулятором, широко используемым при лечении множественной миеломы, и, как правило, связан с благоприятной характеристикой безопасности. Несмотря на сообщения о таких изменениях пигментации, как резиновая гиперпигментация и перепигментация волос, оральная слизь по-прежнему плохо задокументирована. ПРЕДОСТАВЛЕНИЕ СЛУЧАИ: 80-year-old Черная самка с множественной миеломой, которая проходит курс лечения линалидомидом, имеет асимптомные коричневые макулы на языке, твердый вкус, двустороннюю буккультную слизь и ингиву. Гистопатологический анализ резной биопсии на языке пока

Fluid Shear Stress Increases Osteocyte and Inhibits Osteoclasts via Downregulating Receptor-Activator of Nuclear Factor κB (RANK)/Osteoprotegerin Expression in Myeloma Microenvironment.

BACKGROUND The aim of this study was to determine the effects of myeloma cells exposed to fluid shear stress on osteocytes and osteoclasts, and clarify the potential underlying mechanisms. MATERIAL AND METHODS A flow and a non-flow model were established using a flow fluid chamber. The myeloma cell line U266 and murine osteocytic MLO-Y4 cells were cultured in vitro. The osteocytes and osteoclasts were examined under a microscope. Osteoclasts were stained for tartrate-resistant acid phosphatase (TRAP) activity. RANKL and osteoprotegerin (OPG) gene expression were detected using reverse transcri

Keyword Index for Volume 100

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High serum level of interleukin-6 is linked with dyslipidemia in oral lichen planus.

Oral lichen planus (OLP) is a complex chronic inflammatory disorder in which autocytotoxic CD8+ T cells, locally present in the affected tissue, induce basal keratinocyte apoptosis, through the release of several cytokines, such as interleukin-6 (IL-6). IL-6 is a proinflammatory cytokine that is related to alterations in lipid metabolism in psoriasis patients. Impaired lipid metabolism together with high serum levels of triglycerides have been found in association with OLP. However, the correlation between serum levels of IL-6 and dyslipidemia has not yet been studied in this disorder. The pre

ESMO/ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2023.

The European Society for Medical Oncology (ESMO) and ASCO are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) with contributions from more than 150 authors. The purpose of the GC is to provide recommendations for the training of physicians in medical oncology and to establish a set of educational standards for trainees to qualify as medical oncologists. This edition builds on prior ones in 2004, 2010, and 2016 and incorporates scientific advances and input from an ESMO/ASCO survey on GC adoption conducted in 2019, which revealed that GC has been adopted or adapted in as many a

Potential therapeutic targets of Guggulsterone in cancer.

Natural compounds capable of inducing apoptosis in cancer cells have always been of considerable interest as potential anti-cancer agents. Many such compounds are under screening and development with their potential evolution as a clinical drug benefiting many of the cancer patients. Guggulsterone (GS), a phytosterol isolated gum resin of the tree Commiphora mukul has been widely used in Indian traditional medicine as a remedy for various diseses. GS has been shown to possess cancer chemopreventive and therapeutic potential as established by in vitro and in vivo studies. GS has been shown to t

Раскритиковать как трансдиагностический признак зависимости? Перспектива поведенческих пристрастий.

Иногда термин « зависимость » используется как в средствах массовой информации, так и в народных выступлениях для описания чрезмерного участия в повседневных действиях, таких, как потребление сахара, использование экрана или физические упражнения. Такое чрезмерное использование может отражать тот факт, что вознаграждающее поведение, как и использование приносящих пользу веществ, может приводить к многократному использованию, иногда превышающему то, что считается разумным, и иметь значительные негативные последствия. В связи с этим возникают фундаментальные вопросы: по каким критериям можно опр

Экологические и семейные факторы риска, связанные с множественным склерозом.

Предыстория и цели: Множественный склероз (MS) является хроническим аутоиммунным заболеванием, которое оказывает воздействие на центральную нервную систему и вызывает рост заболеваемости во всем мире, особенно в Саудовской Аравии. Материалы и методы: В рамках данного исследования изучаются экологические, жизненные и семейные факторы риска, связанные с MS в регионе Алжуф, на основе перекрестного анализа 155 пациентов, диагностированных по клиническим диагнозам MS. Данные собирались с помощью структурированных вопросников и медицинских обследований для оценки социально-демографических характерис