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Integration of Chronic Oncology Services in Noncommunicable Disease Clinic in Rural Rwanda.

BackgroundIn rural sub-Saharan Africa, access to care for severe non-communicable diseases (NCDs) is limited due to myriad delivery challenges. We describe the implementation, patient characteristics, and retention rate of an integrated NCD clinic inclusive of cancer services at a district hospital in rural Rwanda.MethodsIn 2006, the Rwandan Ministry of Health at Rwinkwavu District Hospital (RDH) and Partners In Health established an integrated NCD clinic focused on nurse-led care of severe NCDs, within a single delivery platform. Implementation modifications were made in 2011 to include cance

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… Radiotherapy required transfer to cancer centers in Uganda and Kenya [ 14 ]. …

Cali cancer registry methods.

BackgroundThe Population Cancer Registry of Cali (RPCC) has operated since 1962, disseminating high quality information to provide a framework to assess and control the burden of cancer in Cali.MethodsThe collection of new cancer cases in permanent residents of Cali is done through active search in and notification from hospitals, and public and private laboratories. The Secretary of Municipal Public Health provides individual information on general mortality and death from cancer. Tumors are coded with ICDO-3 and mortality with ICD-10. Presented rates are standardized by age and trends are as

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… Africa has the two contrasts (53.9% Uganda: Kyandono Country, 97.8% Algeria: Sétif) 37 . In low and middle income countries, a large proportion of cases diagnosed through the pathology service may suggest deficiencies in the search for cases and, therefore, evidence of incomplete registration. …

Subsidising artemisinin-based combination therapy in the private retail sector.

BACKGROUND: Malaria causes ill health and death in Africa. Treating illness promptly with artemisinin-based combination therapy (ACT) is lik … s studied people of all age groups. The studies were done in rural districts in East Africa (Kenya, Uganda and Tanzania).In this East Africa setting, these ACT subsidy programmes increased the percentage of children under five years of age receiving ACTs on the day, or following day, of fever onset by 25 percentage points (95% confidence interval (CI) 14 …

"Let him die. He caused it": A qualitative study on cancer stigma in Tanzania.

Cancer stigma presents a critical barrier to care seeking, contributing to delayed presentation and poor cancer outcomes worldwide. The burden of cancer in Tanzania is on the rise, with cancer being the third-leading cause of death in the country. Despite rising incidence and poor outcomes of cancer, cancer-related stigma interventions have received low prioritization. There is a need for sound research that focuses on understanding attitudes driving stigma, its impact on care-seeking and treatment adherence, and intervention models to reduce stigma. We used a cross-sectional qualitative study

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… Turnaround time and barriers to treatment of newly diagnosed cancer in Uganda: a mixed-methods longitudinal study. Afr Health Sci. 2022. Mar;22(1):327–37. doi: 10.4314/ahs.v22i1.40 11. Hasell J, Roser M, Ortiz-Ospina E, Arriagada P. Poverty. Our World in Data [Internet]. 2022. … Exploring stigma as a barrier to cancer service engagement with breast cancer survivors in Kampala, Uganda. Psychooncology. 2016;25[10]:1206–1211. doi: 10.1002/pon.4215 21. Flood A. Understanding phenomenology. Nurse Res. 2010;17(2):7–15. doi: 10.7748/nr2010.01.17.2.7.c7457 22. …

Network analysis of cross-income-level collaboration on multiple myeloma in sub-Saharan Africa.

Cross-income-level collaboration (CILC) is crucial for developing global health approaches that benefit low- and middle-income countries (LMICs). Multiple myeloma (MM) is a representative example of a complex, understudied disease in sub-Saharan Africa (SSA). Based on publications, we developed a network analysis tool to assess scientific collaborations. Here, we present findings from a systematic analysis of publications retrieved from PubMed between January 2002 and June 2022. We evaluated individual institutional contributions and collaboration patterns using undirected weighted networks. O

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… A great paradigm is the Men of African Descent and Carcinoma of the Prostate consortium, which presently includes multiple centres representing populations in Senegal, Ghana, Nigeria, Sudan, Uganda, Botswana and South Africa, aims to improve the prevention, screening and treatment of cancer in affected …

Изучение роли френкельских упражнений в укреплении динамического баланса и моторных функций в пожилом возрасте с неврологическими расстройствами: систематический обзор.

Справочная информация: Растущая распространенность неврологических заболеваний у пожилых людей приводит к нарушению равновесия и мобильности, что повышает риск снижения риска. В рамках этого систематического обзора изучается эффективность учений < < Френкель > > в деле укрепления динамического баланса и моторных функций, при этом подчеркивается важность методов предотвращения падений, подкрепленных фактами. Методы: Этот систематический обзор проводился в соответствии с руководящими принципами, касающимися предпочтительных элементов отчетности для системных обзоров и мета-анализов (

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… Barriers to Treatment Seeking for Depression Among Elderly Service Users at Butabika National Referral and Teaching Hospital, Kampala-Uganda. Aging & Mental Health . 2025;29(5):833–843. doi: 10.1080/13607863.2025.2451101. 22. Mat Rosly M., Mat Rosly H., Davis Oam G. M., Husain R., Hasnan N. …

Внеклеточные нуклеотиды являются посредником в вирусных инфекциях центральной нервной системы: ключи от нейроинфламмации и нейродегенерации.

Недавний рост инфекционных заболеваний, затрагивающих центральную нервную систему, вызвал обеспокоенность по поводу их роли в нейроинфламмации и нейродегенерации. Вирусные патогены или их продукты могут вторгаться в центральную нервную систему и вызывать повреждения, ведущие к менингиту, энцефалиту, менингоэнцефалиту, миелиту или постинфекционным демиелинизирующим заболеваниям. Хотя изначально нейроинфламмация имеет защитную функцию, хроническое воспаление может способствовать развитию нейродегенеративных заболеваний. Такие механизмы, как агрегация белков и клеточные расстройства, связаны с ко

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… First identified in Uganda in 1947, ZIKV gained global attention during the 2015–2016 outbreak in the Americas. It is typically spread through mosquito bites but can also be sexually or transvertically transmitted (Giraldo et al., 2023). …

The Oncolytic Virotherapy Era in Cancer Management: Prospects of Applying H-1 Parvovirus to Treat Blood and Solid Cancers.

Non-Hodgkin lymphoma (NHL) and leukemia are among the most common cancers worldwide. While the treatment of NHL/leukemia of B-cell origin has much progressed with the introduction of targeted therapies, few treatment standards have been established for T-NHL/leukemia. As presentation in both B- and T-NHL/leukemia patients is often aggressive and as prognosis for relapsed disease is especially dismal, this cancer entity poses major challenges and requires innovative therapeutic approaches. In clinical trials, oncolytic viruses (OVs) have been used against refractory multiple myeloma (MM). In pr

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… This question is of general interest, since BL is mostly seen in Uganda and Nigeria and is a rare condition outside Africa ( 89 ). It prompted us to conduct further studies to assess the capacity of this virus to target cells derived from other hematological malignancies. …

Tracking health commodity inventory and notifying stock levels via mobile devices: a mixed methods systematic review.

BACKGROUND: Health systems need timely and reliable access to essential medicines and health commodities, but problems with access are commo … ies were conducted in African (Tanzania, Kenya, Malawi, Ghana, Ethiopia, Cameroon, Zambia, Liberia, Uganda, South Africa, and Rwanda) and Asian (Pakistan and India) countries. Most of the interventions aimed to make data about stock levels and potential stockouts visible to managers, who could then take corrective action to address them. We identified se …

Co-research in the development of AI and digital health tools for cancer management and care: a systematic review.

BackgroundParticipatory approaches (including co-research, co-design, Patient and Public Involvement [PPI], and Participatory Action Research [PAR]) are increasingly being incorporated into digital health innovation. However, their application in cancer-related digital and Artificial Intelligence (AI) tool lifecycle remains insufficiently synthesised, limiting understanding of how participatory approaches influence ethical outcomes, trust, and the real-world implementation of these technologies. This review moves beyond documenting participatory approaches to critically examine how far partici

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… Kabukye JK Namugga J Mpamani CJ Katumba A Nakatumba-Nabende J Nabuuma H Implementing smartphone-based telemedicine for cervical cancer screening in Uganda: qualitative study of stakeholders’ perceptions J Med Internet Res 2023 25 e45132 10.2196/45132 37782541 PMC10580134 Kabukye JK, Namugga J, Mpamani … Implementing smartphone-based telemedicine for cervical cancer screening in Uganda: qualitative study of stakeholders’ perceptions. J Med Internet Res. 2023;25:e45132. 10.2196/45132. 37782541 10.2196/45132 PMC10580134 15. …

Оценка стабильности жажды в пальчиках (Eleusine coracana L.) с использованием многовариантных подходов.

Пальцы, как правило, выращиваются в полузасушливых тропиках, где они выращиваются главным образом фермерами-добытчиками. Однако урожайность зерна остается низкой из-за сложного количественного характера этой особенности и ее низкой наследственности. Таким образом, взаимодействие генотипа х с окружающей средой (ГЭИ) оказывает значительное влияние на производство. В этом исследовании изучается воздействие ГЭИ на качество генотипов пальца в различных средах, при этом особое внимание уделяется чувствительности урожая к изменчивости климата. Цель этого исследования заключалась в оценке воздействия

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… Farmers’ Perceptions of Finger Millet Production Constraints, Varietal Preferences and Their Implications to Finger Millet Breeding in Uganda Journal of Agricultural Science 2014 6 12 126 138 10.5539/jas.v6n12p126 5 Movahedi H. Mostafavi K. Shams M. Golparvar A. R. …

Advancing Hematopoietic Stem Cell Transplantation (HSCT) in Africa: A Pathway to Curing Hematological Disorders.

BackgroundHematopoietic stem cell transplantation (HSCT) offers a curative option for numerous hematological disorders, notably sickle cell disease and thalassemia, which are highly prevalent in Africa. Despite its potential, access to HSCT remains limited due to infrastructural, economic, and socio-cultural challenges across the continent.MethodsThis review synthesizes current literature and reports on the status of HSCT in Africa, analyzing data from existing transplant centers, national registries, and peer-reviewed studies to assess progress, challenges, and prospects for expanding HSCT se

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… Uganda has a high rate of 45%, and Gabon, and Cameroon share a rate of 20%–30% [ 8 ]. The disease cases prevail in Africa and affect up to 3% of births and it is stipulated that 6–9 million infants are born with SCD in Africa each year. …

Transforming hematology care in LMICs: strategies for enhanced diagnosis and treatment.

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… Several countries, including Nigeria, Ghana, Kenya, Uganda, and Tanzania, have introduced newborn screening programs, hydroxyurea treatment initiatives, and laboratory strengthening strategies to improve hematology services ( 11 , 20 ). …

Impact of rapid nucleic acid amplification tests for tuberculosis on patient outcomes.

RATIONALE: The World Health Organization (WHO) recommends rapid nucleic acid amplification tests (NAATs), such as Xpert MTB/RIF Ultra, as th … was cluster-randomised. Both trials were conducted in Africa (one in South Africa and the other in Uganda). One trial assessed all-cause mortality at six and 18 months, loss-to-follow-up, and the time taken to diagnose TB, while the other assessed the time taken to initiate treatment. SYNTHESIS OF RESULTS: Whether Xpert MTB/RIF Ultra or smear microscop …

Informed appropriate imaging for low back pain management: A narrative review.

Most patients with acute low back pain (LBP), with or without radiculopathy, have substantial improvements in pain and function in the first 4 weeks, and they do not require routine imaging. Imaging is considered in those patients who have had up to 6 weeks of medical management and physical therapy that resulted in little or no improvement in their LBP. It is also considered for those patients presenting with suspicion for serious underlying conditions, such as cauda equina syndrome, malignancy, fracture and infection. In western country primary care settings, the prevalence has been suggeste

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… However, a review from Uganda of 204 patients referred to a hospital orthopaedic clinic with a primary complaint of LBP showed that 4% of patients had serious spinal abnormalities due to tuberculosis, 3.5% had vertebral compression fractures, 1% brucellosis and 1% had malignancy [35] . … Aetiology of low back pain in Mulago Hospital, Uganda. Afr Health Sci. 2005;5:164–167. 36. Gardner A., Gardner E., Morley T. Cauda equina syndrome: a review of the current clinical and medico-legal position. Eur Spine J. 2011;20(5):690–697. doi: 10.1007/s00586-010-1668-3. 37. …

Causes of Moderate and Severe Anaemia in a High-HIV and TB-Prevalent Adult Population in the Eastern Cape Province, South Africa.

BACKGROUND: Anaemia affects one in four adults in South Africa, with a higher prevalence in persons with HIV and tuberculosis. The aim of this study is to characterise the causes of anaemia in primary care and a district hospital setting. METHODS: A cross-sectional study design investigated a purposive sample of adult males and non-pregnant females at two community health centres and a hospital casualty and outpatients. Fingerpick blood haemoglobin was measured with HemoCueHb201+. Those with moderate and severe anaemia underwent clinical examination and laboratory tests. RESULTS: Of 1327 pat

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… Measurement of kidney function in Malawi, South Africa, and Uganda: A multicentre cohort study Lancet Glob. Health 2022 10 e1159 e1169 10.1016/S2214-109X(22)00239-X 35839814 78. Niang A. Luyckx V.A. Measuring kidney function: The voice of Africa Lancet Glob. …

KSHV and cancer: understanding the oncogenic machinery for next-generation diagnostic tools and therapies.

Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV-8), is an oncogenic virus responsible for Kaposi's sarcoma (KS) and lymphoproliferative disorders like primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). This review explores KSHV's oncogenic mechanisms, focusing on its ability to manipulate host cell signaling, evade immune detection, and promote tumorigenesis through latent and lytic viral proteins. Key oncoproteins, such as LANA, vCyc, vFLIP, and vGPCR, activate cancer hallmarks, as sustained proliferation, immune evasion, angiogenesis, and re

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… The incidence and mortality rate is almost 2 times higher in men compared to women; and the worldwide geographic distribution data show that East, South and Central Africa are the endemic regions with the highest number of KS cases from both sexes (72.38% of incidence and 86.6% of mortality), with Uganda … On the African continent, the AEKS and KS-HIV forms represent 9% and 4% of all malignant pathologies in the regions of Zaire and Uganda, respectively (Forae and Obaseki 2018 ). …

Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach.

Immunotherapy is now established as a potent therapeutic paradigm engendering antitumor immune response against a wide range of malignancies and other diseases by modulating the immune system either through the stimulation or suppression of immune components such as CD4+ T cells, CD8+ T cells, B cells, monocytes, macrophages, dendritic cells, and natural killer cells. By targeting several immune checkpoint inhibitors or blockers (e.g., PD-1, PD-L1, PD-L2, CTLA-4, LAG3, and TIM-3) expressed on the surface of immune cells, several monoclonal antibodies and polyclonal antibodies have been develop

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… Three successful examples from LMICs are from Africa, Uganda—The Uganda Cancer Institute (UCI); the Middle East, Jordan—The King Hussein Cancer Center (KHCC); and Asia, India—The Tata Memorial Hospital (TMH). … murine double minute 2, KRAS—Kirsten rat sarcoma virus, NK-CART—natural killer-chimeric antigen receptor T cells, Th1 cells—Type1 T-helper cells, TILs—tumor-infiltrating lymphocytes, MDSCs—myeloid-derived suppressor cells, BCMA—B cell maturation antigen, LMIC—low-to-medium-income countries, UCI—The Uganda …

Lenacapavir as pre-exposure prophylaxis for HIV prevention.

RATIONALE: Globally, there are 1.3 million new HIV infections annually, with a disproportionate burden on young women and girls, especially … IES: We included two studies with 8660 participants. The first trial, conducted in South Africa and Uganda, included adolescent girls and young women (16 to 25 years) and compared injectable lenacapavir with daily oral PrEP consisting of F/TAF in one comparator arm and F/TDF in the other. The second trial, conducted in the USA, Brazil, Thailand, South Af …

Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care.

BACKGROUND: Digital tracking on mobile devices, combined with clinical decision support systems and targeted client communication, can facil … andomised, seven non-randomised) conducted in Bangladesh, China, Ethiopia, India, Kenya, Palestine, Uganda, and the USA. All non-randomised studies had a high risk of bias. These results are from randomised studies. 'Probably/may/uncertain' indicates 'moderate/low/very low' certainty evidence. Tracking + CDSS Relating to antenatal/ postnatal care: Provid …