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Changes in platelet-activating factor, catecholamine, and serotonin concentrations in brain, cerebrospinal fluid, and plasma of pichinde virus-infected guinea pigs.

Brain concentrations of platelet-activating factor (PAF), catecholamines, and serotonin were measured in control and Pichinde virus-infected … with stress and may be partially responsible for the development of cardiovascular dysfunction and pulmonary edema during this viral disease.

[Hospital morbidity and mortality of acute opiate intoxication].

The records of 188 consecutive patients admitted for acute opiate intoxication were analyzed retrospectively to evaluate the morbidity and m … of gastric contents (n = 24), rhabdomyolysis (n = 22), often associated with myocarditis (n = 13), pulmonary edema (n = 16), convulsions (n = 10), left ventricular dysfunction (n = 5) and lesions of the peripheral nervous system (n = 4). All patients survived, except one who died of cardiac arrest before admission. It is concluded that acute opiate intoxication …

Reversal of advanced left ventricular dysfunction following aortic valve replacement for aortic stenosis.

A series of 12 consecutive patients who underwent aortic valve replacement (AVR) for aortic stenosis complicated by severe left ventricular dysfunction was reviewed. Ventricular dysfunction was reflected by pulmonary congestion, edema, renal and hepatic dysfunction, and by severely depressed ejection fractions (mean, 13%; range equal to 0-20%). Aortic valve replacement was accompanied by mitral commissurotomy in 1 patient and aortocoronary bypass in 5. Three of 5 patients with greater than 50% coronary obstruction died without reversal of heart failure, and 1 of the 5 died after a stroke. The

Metformin as a potential therapeutic agent in broken heart syndrome: Targeting AMPK-dependent cardio-protection and microvascular function.

Broken heart syndrome (Takotsubo or stress cardiomyopathy) is a transient form of acute left ventricular dysfunction commonly triggered by emotional or physical stress. Despite its reversible nature, it may lead to severe complications such as pulmonary edema, arrhythmias, or cardiac arrest. Current management remains largely supportive, with no established pharmacological therapy. Metformin, a well-known anti-diabetic drug, has emerged as a potential cardioprotective agent due to its multifaceted actions on cellular metabolism, vascular function, and neuro-hormonal balance. By activating the …

Dyspnea Induced by Alpha 2-Adrenergic Agonists and Dissociative Anesthetics Combination in Dogs and Cats.

This case report describes the potential adverse effects of the combination of alpha 2-adrenergic agonists and dissociative anesthetics and … asoconstrictive alpha 2-adrenergic agonists can cause transient hypertension, which can precipitate pulmonary edema and hemorrhage, leading to dyspnea. Either juvenile or atropine-premedicated patients may be at an increased risk, warranting dose adjustment, route selection, and careful monitoring during anesthesia.

Renal artery stenting for atherosclerotic renal artery stenosis: A review of contemporary data.

Renal artery stenting has been less frequently performed following the results of the Cardiovascular Outcomes in Renal Atherosclerotic Lesio … pressure, diastolic hypertension, worsening kidney function, greater antihypertensive burden, flash pulmonary edema, and mild-range proteinuria. Many of these variables illustrate a clinical picture of a patient with severe ischemic kidney disease leading to problems with hypertension and volume regulation that has not yet irreparably damaged the renal parenchyma …

Birdshot Chorioretinopathy with Cystoid Macular Oedema.

We report the case of a 48-year-old Caucasian male who presented with progressive bilateral visual decline over more than three months. He was diagnosed with birdshot chorioretinopathy (BSCR) according to the Standardization of Uveitis Nomenclature (SUN) criteria, based on characteristic fundus findings and HLA-A29 positivity. Laboratory investigations, including angiotensin-converting enzyme (ACE) and soluble IL-2 receptor levels, were within normal limits and infectious serologies were negative. Thoracic imaging by computed tomography showed no signs suggestive of sarcoidosis or infection, a

The Role of Systemic Inflammation in Paracetamol Poisoning-An Experimental Model.

Accumulating evidence indicates that acute, life-threatening acetaminophen (APAP) poisoning is associated with systemic inflammation (SI). I … y APAP was associated with a cytokine storm, coagulopathy (thrombocytopenia), systemic alterations, pulmonary edema, and multiorgan dysfunction. Collectively, these findings indicate that severe APAP-induced liver damage triggers SI as a characteristic pathological process.

How I treat acute myeloid leukemia with differentiation therapy.

An increasing number of acute myeloid leukemia (AML) therapeutics have been developed, not as cytotoxic therapies but rather as targeted agents able to restore the aberrant and leukemogenic "block" in normal differentiation. All-trans retinoic acid and arsenic trioxide are classic examples of differentiating agents for treatment of acute promyelocytic leukemia (APL); newer therapies functioning through differentiation include isocitrate dehydrogenase 1 and 2 inhibitors, FMS-like tyrosine kinase 3 inhibitors, and menin inhibitors. The terminal differentiation of leukemic blasts via differentiat

Rhabdomyosarcoma in adults with severe thrombocytopenia: Challenges in clinical management and therapeutic complications.

Alveolar rhabdomyosarcoma (ARMS) in adults is a rare condition with a poor prognosis compared to other subtypes. The management of this pathology is complex due to the lack of standardized guidelines and the limited response to multimodal treatments, including chemotherapy, radiotherapy, and surgery. We report the case of a 40-year-old male with stage IV ARMS and pulmonary metastasis, who underwent resection of right supraclavicular sarcoma and cervical lymph node dissection. He was later referred for palliative chemotherapy following an acute clinical presentation lasting two days, characteri

Заражение после трансплантации в Мильоме и Лимфоме: ранняя уязвимость и долгосрочные риски в получателях ASCT.

Пациенты с множественной миеломой (ММ) и лимфомой, проходящими аутологическую трансплантацию стволовых клеток (ASCT), подвержены более высокому риску инфицирования, что ведет к повышению заболеваемости и смертности. Целью этого исследования является анализ динамики и результатов инфицирования этой группы населения. Госпиталь общего профиля Кариади, Семаранг, Индонезия, 28 у пациентов с диагнозом MM и лимфома, которые прошли ACCT с января 2013 по май 2023. Данные собирались на основе медицинских записей и телефонных интервью. Были проанализированы модели заражения, бактериальные патогены и резу

Совпадение в аннотации оригинала
BackgroundPatients with multiple myeloma (MM) and lymphoma undergoing autologous stem cell transplantation (ASCT) are at a higher risk of in … in 28 days post-transplant, though these deaths were attributed to non-infectious causes, including pulmonary edema and hemorrhagic stroke. Two patients developed late-onset infections occuring more than 300 days post-transplant.ConclusionsInfections remain a significant complication following ASCT in MM and lymphoma patients, particularly within the early post-t …

Extracellular mitochondria contribute to acute lung injury via disrupting macrophages after traumatic brain injury.

Acute lung injury (ALI) is the most frequently developed complication in patients with severe traumatic brain injury (TBI), but its underlyi … × 104/µl of exMt. We further showed that non-injured mice infused with exMt intravenously developed pulmonary edema, perivascular accumulation of macrophages, inflammation, and dysfunction. Results from complementary in vitro experiments showed that exMt bound to and were phagocytosed by interstitial macrophages, resulting in autophagic flux reduction and activat …

The Deceptive Shadow: Inverted Left Atrial Appendage Mimicking Thrombus After Infant Open Heart Surgery.

Inversion of the left atrial appendage (LAA) is a rare postoperative complication following cardiac surgery, often misdiagnosed as thrombus … used progressive mitral inflow obstruction, and by postoperative day 5, the patient developed acute pulmonary edema. Although initially suspected to be a thrombus, the diagnosis of LAA inversion was confirmed intraoperatively. Given the elongated nature and prolapse of the appendage into the mitral orifice, external ligation and clipping were chosen to ensure com …

Severe Malaria Due to Plasmodium falciparum in an Immunocompetent Young Adult: Rapid Progression to Multiorgan Failure.

Plasmodium falciparum malaria remains a major cause of morbidity and mortality, particularly in endemic regions. We report the case of a 21- … progressed to multiorgan failure, including acute respiratory distress syndrome with capillary leak pulmonary edema, refractory distributive shock, acute kidney injury with severe hyperkalemia, and consumptive thrombocytopenia. Management included invasive mechanical ventilation, vasopressor support, sedation-analgesia, neuromuscular blockade, methylene blue, uns …

Asphyxiation due to obstructive fibrinous tracheal pseudomembrane after closure of repeated tracheostomy in a case of von Recklinghausen disease.

BACKGROUND: Obstructive fibrinous tracheal pseudomembrane (OFTP) is a rare but potentially fatal complication, most commonly reported after … lmonary arrest on postoperative day 14. Postmortem CT showed near-complete tracheal obstruction and pulmonary edema. Autopsy confirmed a grayish-white pseudomembrane obstructing the tracheal lumen, with only a 2-mm residual gap. Histopathology revealed fibrinous exudate with neutrophilic infiltration, consistent with OFTP. CONCLUSION: This case illustrates that …

Refractory Antiphospholipid Syndrome With Thoracic Outlet and Superior Vena Cava Syndromes: A Complex Case of Recurrent Thrombosis.

Thoracic outlet syndrome (TOS) and superior vena cava syndrome (SVCS) are rare and debilitating conditions that can cause vascular compression, hypercoagulable states, and central venous obstruction. This is the case of a 39-year-old female with treatment-resistant antiphospholipid syndrome (APS), hereditary angioedema (HAE), and mast cell activation syndrome (MCAS) complicated by SVCS and venous TOS. Her clinical course was further challenged by recurrent venous thromboembolism with treatment failure on multiple direct oral anticoagulants (DOACs), with warfarin being the only effective medica

Anesthetic Management for Giant Abdominal Paraganglioma Resection in a Patient After Extracorporeal Membrane Oxygenation: A Case Report.

Paraganglioma (PGL) is a rare neuroendocrine tumor that poses significant challenges to anesthetic management during surgical resection. In rare instances, PGL can precipitate a catecholamine crisis, potentially leading to heart failure, intracranial hemorrhage, renal failure, arrhythmias, pulmonary edema, and multisystem organ failure. We report a case of a 53-year-old male with a history of poorly controlled hypertension who was admitted for chest pain and initially diagnosed with non-ST-elevation myocardial infarction (NSTEMI). Coronary angiography revealed no abnormalities. Subsequently, t…

Fulminant Methicillin-Sensitive Staphylococcus aureus Pneumonia in a Steroid-Treated Patient With End-Stage Renal Disease: A Rapidly Fatal Case.

A man in his 50s with end-stage renal disease (ESRD) secondary to gouty nephropathy and on chronic methylprednisolone therapy presented with … the bronchial lumen and necrotic tissue. Histological findings included bronchial wall destruction, pulmonary edema, and alveolar hemorrhage. Additional findings included bilateral renal atrophy with arteriosclerosis, but no evidence of gouty tophus or urate deposition. This case illustrates the potential for MSSA to cause rapidly progressive necrotizing pneumoni …

Successful combined treatment for primary central nervous system lymphoma with massive hemorrhage: Illustrative case.

BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare tumor, accounting for only 1-2% of all primary brain tumors, with most cases being diffuse large B-cell lymphoma (DLBCL). Because these lymphomas can rapidly worsen, prompt and accurate histological diagnosis, followed by early treatment initiation, are essential for improved prognosis. Extensive surgical resection has not demonstrated a clear survival benefit, and a minimally invasive biopsy is recommended. Hemorrhage within lesions is exceedingly rare, with few reports available. CASE DESCRIPTION: A 73-year-old woman pres

Expanding the Spectrum of NR4A3 Fusion-Positive Gynecologic Leiomyosarcomas.

Recurrent gene fusions have been observed in epithelioid and myxoid variants of uterine leiomyosarcoma. PGR::NR4A3 fusions were recently des … o- and macrocysts associated with abundant myxoid matrix and hemorrhage, creating labyrinth-like or pulmonary edema-like architecture. Myogenic differentiation with frequent estrogen receptor and progesterone receptor staining and no CD10 expression characterized all tumors. All cases showed high NR4A3 RNA expression levels and NOR1 (NR4A3) nuclear staining simil …