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Исследование взаимосвязи между элементами сериальной трассы и уровнями MSFC в области множественного склероза: перекрестное тематическое исследование.

Воздействие микроэлементов в течение многих лет изучалось в многократной склерозовой (МС) этиологии. Однако общие результаты еще не получены в ходе предыдущих исследований. Поэтому в качестве межсекторального исследования по вопросам контроля за конкретными случаями мы стремились изучить взаимосвязь между микроэлементами и MS в провинции Конья, где загрязнение воздуха является интенсивным. Участники исследования с МЗ были исследованы в отношении расширенных показателей инвалидности (ЭДСС) и множественных функциональных склерозовых композиционных шкал (МСФК). Кроме того, была проведена оценка в

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… To avoid possible errors and confusion, a single neurologist who received training and certification from Neurostatus, an independent platform that aims to standardize the expanded disability status scale (EDSS) [ 29 ] measurement, performed EDSS and multiple sclerosis functional composite (MSFC) tests …

Прогресс, не зависящий от возобновления биологии в множестве склерозов: исследование реальных слов.

Прогресс, не зависящий от рецидивной активности (ИПРА), подразумевает развитие инвалидности у людей с повторно излучающимся множественным склерозом (RRMS) вторичного до нейродегенерации. Механистическая и биологическая ПИРА может повлиять на традиционное различие между прогрессивными и повторными СМС. В данном случае мы подсчитали прогресс, не зависящий от восстановления биологии (PIRB), в группе из 823 участников с клинически изолированным синдромом/RRMS в Калгари, Канада, с использованием модифицированного критерия [исключая рецидивы, подстрекательскую активность MRI, промежуточное ухудшение

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… In the University of Calgary MS Clinic, patients are seen annually and an EDSS is obtained by treating neurologists with an MS specialty and EDSS rating certification. …

Complex Relationships between Diagnostics and Survival in Chronic Lymphocytic Leukemia in Denmark, Finland, Norway, and Sweden.

BackgroundChronic lymphocytic leukemia (CLL) is a common hematological malignancy with highly variable clinical presentation. Many patients never require any treatment but for the others, chemotherapy, immunochemotherapy, and newer targeted therapies have changed the treatment landscape. Diagnostic age influences the applied treatment, and we thus wanted to analyze age-specific survival trends through 50 years up to 2020s.MethodsWe used 1- and 5-year relative survival from the NORDCAN database, with data from Denmark (DK), Finland (FI), Norway (NO), and Sweden (SE). Because of the variable pre

Associations Between Self-Rated Health and Mortality in the Norwegian Women and Cancer (NOWAC) Study.

PurposeWe investigated the association between self-rated health (SRH) and cancer incidence and SRH and all-cause mortality among Norwegian women.Population and methodsWe used data from 110,104 women in the Norwegian Women and Cancer (NOWAC) cohort aged 41-70 years at baseline. We used flexible parametric survival analysis with restricted cubic splines to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between SRH and mortality in the entire cohort. We employed the same method in a multistate design to assess associations between baseline SRH and 1) cancer

The Impact of Modern Bone Markers in Multiple Myeloma: Prospective Analyses Pre and Post-First Line Treatment.

Multiple myeloma, the disease characterized by the malignant proliferation of plasma cells that invades the bone marrow, produces osteolytic lesions and secretes monoclonal proteins. Several biomarkers have been shown to represent important tools in the pathogenesis of myeloma and offer insights into bone degradation and formation. The objectives of this current study were to assess the associations of modern biomarkers (TNF-α: tumor necrosis factor; IFN: Interferon; FreeRANKL: Free Receptor Activator for Nuclear Factor kappa B Ligand; RANKL: Receptor Activator for Nuclear Factor kappa B Ligan

Эксплуатация эпистила у пациентов с гематологическими отклонениями: сравнительное исследование.

ForeignEpisil () — жидкий медицинский материал, используемый для одежды и защиты сукозы у пациентов с пероральным слизистым мукозитом. В нескольких исследованиях сообщается о его эффективности у пациентов с раком головы и шеи. Однако сообщений о его применении у пациентов с гематологическими недугами мало. Таким образом, мы намеревались оценить эффективность Эписила для лечения перорального слизистого слизняка у пациентов с острой миэлогенной лейкемией, злокачественной лимфомой, острой лимфоцитной лейкемией, множественной миеломой и миэлодизпластическим синдромом. MethodsBetween May 2018 и мар

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… Episil® received European Community certification as a Class 1 medical device in May 2009 and was approved for use by the U.S. Food and Drug Administration in September 2011. As of March 2020, the use of Episil.® has been approved in 38 countries, including European countries and the U.S. [ 19 ]. …

Follicular Lymphoma in Chile in the Adult Public Cancer Program: The Impact of Chemoimmunotherapy.

BACKGROUND: Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma (NHL) in the United States and Europe. However, data on FL from Latin America are scant. AIMS: This study aims at better understand the clinical features, treatment patterns and outcomes of patients with FL in Chile. Of special interest was to evaluate POD24 as an adverse marker. METHODS AND RESULTS: We collected retrospective data from 722 patients 15 years or older diagnosed with FL and treated in 17 cancer centers in Chile between 2000 and 2019. Time to first treatment (TTFT), progression-free survival (

Caregiver Quality of Life: Satisfaction and Burnout.

Informal caregivers (ICs) of cancer patients play a crucial role in health care. Several of the challenges they face can affect their quality of life (QoL). This cross-sectional study explored role of burnout and caregiving satisfaction in their relationship to QoL. Portuguese ICs of adult cancer patients (N = 92) answered a sociodemographic and caregiving questionnaire, the WHOQOL-SRPB BREF, assessing physical, psychological, social, environmental, and spiritual QoL domains; the Maslach Burnout Interview, assessing the dimensions of depersonalization, emotional exhaustion, and personal accomp

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… Data protection certification was conceded by the Data Protection Office of the University of Porto (A-15/2022). Figure 1 shows a flowchart of the overall study methodology. Figure 1 Flowchart of the overall study methodology. 2.4. …

Suicide after a Diagnosis of Cancer: Follow-Up of 1.4 Million Individuals, 2009-2019.

Background: The study explores whether Polish cancer patients face elevated suicide risk, emphasizing the vital need to comprehend and mitigate their unique mental health struggles. Methods: We conducted a cohort study based on Polish National Cancer Registry data (diagnosis in 2009-2019). Age-, sex-, and year-standardized mortality ratios (SMR) are presented with 95% confidence intervals (CIs) overall and by sex. Results: The study included 1.43 million individuals diagnosed with cancer. There were 830 suicide cases in this group. The overall SMR for suicide was 1.34 (95% CI 1.25-1.43). The h

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… The significant advantage of the presented research is both the good quality of the data on exposure (precision of registration of cancer cases in the PLCR and verification by trained registrars) and the outcome (accuracy of causes of death certification by the Polish Population Information System). …

Resource utilization for chimeric antigen receptor T cell therapy versus autologous hematopoietic cell transplantation in patients with B cell lymphoma.

CD19-directed chimeric antigen receptor T cells (CAR-T) have emerged as a highly efficacious treatment for patients with relapsed/refractory (r/r) B cell lymphoma (BCL). The value of CAR-T for these patients is indisputable, but one-off production costs are high, and little is known about the ancillary resource consumption associated with CAR-T treatment. Here, we compared the resource use and costs of CAR-T treatment with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) for patients with r/r BCL. Standard operating procedures were used to develop a process model

Cardiovascular-specific mortality among multiple myeloma patients: a population-based study.

IntroductionMultiple myeloma (MM) survival has greatly improved in recent decades. MM is usually diagnosed at a median age of 66-70 years. MM patients do not necessarily die from primary cancer, so cardiovascular health may be a key factor threatening long-term survival. This study was designed to explore the cardiovascular disease mortality (CVM) trends in MM patients and compare them with those in the general population.MethodsIn total, 88,328 MM patients from the Surveillance, Epidemiology, and End Results (SEER) database (1975-2016) were included. Standardized mortality ratios (SMRs) were

Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy.

ObjectiveTo investigate the prevalence of depression or anxiety in patient with multiple myeloma (MM) in China during maintenance treatment and its associated influencing factors.MethodsPatients with MM (n = 160) received maintenance therapy, and control subjects (without MM, n = 160) matched on age, sex, and BMI were recruited. Patients completed questionnaires, including the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder 7-item Scale (GAD-7), and the Verbal Pain Rating Scale (VPRS). Data on the Clinical characteristics, biochemical indicators of de novo MM were from

Immunoglobulin substitution in patients with secondary antibody deficiency in chronic lymphocytic leukemia and multiple myeloma: a representative analysis of guideline adherence and infections.

INTRODUCTION: In secondary immunodeficiency, immunoglobulin replacement therapy (IgRT) is recommended by guidelines (GL) for patients with IgG level < 4 g/l and more than 3 infections or a severe infection. IgRT may be appropriate if IgG level < 4 g/l and/or 1-3 less severe infections (≤ grade 2). METHODS: This was a retrospective sample analysis representative for practices and hospitals in Germany. The treatments and infection data were collected from patients with chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). GL adherence (GLAD) was analyzed. RESULTS: Data from 1086 patien

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… The facilities were asked to provide data on patient volume and key care parameters (clinic/office; certification). Of the centers contacted, 116 clinics and 130 medical practices responded. …

INPART - a psycho-oncological intervention for partners of patients with haemato-oncological disease - study protocol.

BackgroundSuffering from cancer confronts both the patient and their partner with a number of psychosocial challenges in various aspects of their life. These challenges may differentially impact on quality of life, coping ability and compliance to treatment. This especially holds true for haemato-oncological diseases. To date, psychological interventions have predominantly been developed for oncological patients however specific interventions for partners of haemato-oncological patients are rare. In this study we aim to conduct a psycho-oncological group-intervention for partners of patients w

Predicting cumulative incidence of adverse events in older patients with cancer undergoing first-line palliative chemotherapy: Korean Cancer Study Group (KCSG) multicentre prospective study.

BackgroundOlder patients have increased risk of toxicity from chemotherapy. Current prediction tools do not provide information on cumulative risk.MethodsPatients aged ≥ 70 years with solid cancer were prospectively enrolled. A prediction model was developed for adverse events (AEs) ≥ Grade 3 (G3), based on geriatric assessment (GA), laboratory, and clinical variables.Results301 patients were enrolled (median age, 75 years). Median number of chemotherapy cycles was 4. During first-line chemotherapy, 53.8% of patients experienced AEs ≥ G3. Serum protein ConclusionsThis prediction tool could ide

Barriers to mental health service use among hematopoietic SCT survivors.

This study examined barriers to mental health service use and the demographic, medical and psychosocial correlates of these barriers among hematopoietic SCT (HSCT) survivors. A sample of 253 HSCT survivors who were 1 to 3 years posttransplant completed measures of demographic, physical, psychological and social characteristics as well as a newly modified measure of barriers to mental health service use. Only 50% of distressed HSCT survivors had received mental health services. An exploratory factor analysis of the barriers to mental health service use scale yielded four factors: scheduling bar

Clinical Posters From JADPRO Live 2023.

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… following principles for utilization of APPs in oncology care are particularly relevant for academic practices and apply to both individual and team-based care models. (1) Empower APPs to utilize the full extent of their education, training, and clinical expertise to practice at top of skillset and license/certification … APPs should be supported in practicing at the highest state level and certification if skillset aligns. (2) Strive to implement advanced practice leadership, allowing APPs to report to and be evaluated by APPs. …

Clinical value and cost-effectiveness analysis of conditionally approved anticancer drugs in China from 2015 to 2023.

BackgroundThe conditional approval (CA) process in China was established in 2015 to expedite access to urgently-needed drugs, however, the clinical benefits of CA drugs and potential gaps between pre-approval and confirmatory trials remain uncertain. Herein, we aim to compare the clinical values between CA and non-CA anticancer drugs from 2015 to 2023, and to explore the relationship between clinical benefit and average daily cost of treatment of drugs.MethodsThis retrospective study analyzed anticancer drugs first approved in China [2015-2023] using data from National Medical Products Adminis

Enhancing medication adherence with blister-packed oral oncolytics: A case example in chronic lymphocytic leukemia.

IntroductionMedication nonadherence is a prevalent issue in the oncology population and can be costly on the healthcare system while leading to worsened outcomes, including increased mortality. One intervention that has been shown to help promote medication adherence to oral therapies for chronic conditions is blister-packaging. However, no literature is available assessing the potential impact of blister-packaging in oncology. Therefore, we aimed to quantify the impact of blister-packaging oral oncolytics on medication adherence and healthcare costs.MethodsAn economic model was designed to as

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… drugs, special precautions and care is needed to be taken by pharmacy personnel to prevent exposure to the worker, including wearing additional personal protective equipment. 63 , 64 Additionally, if packaging machines are being used to fill medication vials or blister-packs, they must have required certification …

Tablet Acceptability in Older Outpatients Undergoing Cancer Chemotherapy.

Background/Objectives: Patient acceptability of oral anticancer drugs is a critical factor that influences treatment in older outpatients receiving cancer chemotherapy and plays a central role in enhancing adherence and treatment effectiveness. Identifying older outpatients receiving cancer chemotherapy who exhibit poor tablet acceptability before initiating oral anticancer therapy and offering alternative treatment options are beneficial. Therefore, we investigated the characteristics of patients with poor tablet acceptability by focusing on the tablet size, geriatric assessment, and polyphar

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… Patient interviews were conducted by an experienced pharmacist holding specialist certification in oncology and having extensive experience in interviewing patients with cancer. The definitions of the longest diameter and combined length, width, and thickness of the tablets are shown in Figure 1 . …