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Oncology distress screening within predominately Black Veterans: Outcomes on supportive care utilization, hospitalizations, and mortality.

BackgroundWe evaluated whether patients' initial screening symptoms were related to subsequent utilization of supportive care services and hospitalizations, and whether patient-level demographics, symptoms, hospitalizations, and supportive care service utilization were associated with mortality in primarily low-income, older, Black Veterans with cancer.MethodsThis quality improvement project created collaborative clinics to conduct cancer distress screenings and refer to supportive care services at an urban, VA medical center. All patients completed a distress screen with follow-up screening e

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… Allsop: Methodology (equal); writing – original draft (supporting); writing – review and editing (supporting). Subrina Farah: Formal analysis (lead); methodology (supporting); writing – review and editing (equal). … Joanna Martin: Conceptualization (equal); data curation (equal); funding acquisition (lead); project administration (equal); resources (equal); writing – original draft (supporting); writing – review and editing (supporting). …

Эффективность и безопасность БКМА- или GPRC5D-directed CD3 - биконкретные антитела в повторной/редактированной миеломе: систематический обзор и метаанализ перспективных клинических испытаний и исследований в реальном мире.

ЦЕЛЬ: БКМА- или GPRC5D-directed CD3 - биконкретные антитела являются важными средствами Т-перенаправления клеток для повторной/извлеченной многократной миеломы (RRMM). Мы оценили их эффективность, безопасность и достоверность доказательств. Мы обыскали библиотеку Кокрана, Эмбазу, Пубмед, Скопус и веб - сайт науки с момента создания по февраль. 5, 2026. Были включены перспективные клинические испытания и исследования в реальном мире BCMAxCD3 или GPRC5D×CD3 по биконкретным антителам в RRMM с данными об эффективности и безопасности извлечения. Основными результатами эффективности были: беспрогрес

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… DL: Methodology, Investigation, Writing – review & editing, Conceptualization. YaZ: Data curation, Investigation, Writing – review & editing, Conceptualization. PW: Writing – review & editing, Investigation. MM: Writing – review & editing. SQ: Validation, Investigation, Writing – review & editing. … YuZ: Supervision, Writing – review & editing. YA: Supervision, Writing – review & editing. WW: Validation, Writing – review & editing. LShi: Writing – review & editing, Validation. MY: Project administration, Writing – review & editing, Funding acquisition, Resources. …

Recognition and management of persistent chylomicronemia: A Joint Expert Clinical Consensus by the National Lipid Association and the American Society for Preventive Cardiology.

Extreme hypertriglyceridemia, defined as triglyceride (TG) levels ≥1000 mg/dL, is almost always indicative of chylomicronemia. The current diagnostic approach categorizes individuals with chylomicronemia into familial chylomicronemia syndrome (FCS; prevalence 1-10 per million), caused by the biallelic combination of pathogenic variants that impair the lipolytic action of lipoprotein lipase (LPL), or multifactorial chylomicronemia syndrome (MCS, 1 in 500). A pragmatic framework should emphasize the severity of the phenotype and the risk of complications. Therefore, we endorse the term "persiste

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… Kullo: Writing – review & editing. P. Barton Duell: Writing – review & editing. Erin D. Michos: Writing – review & editing. Michael D. Shapiro: Writing – review & editing. Gerald F. Watts: Writing – review & editing. Daniel Gaudet: Writing – original draft, Writing – review & editing. Christie M. … Ballantyne: Writing – original draft, Writing – review & editing. …

Type 1 diabetes is associated with higher plasma levels of biomarkers of neurodegeneration and neuroinflammation.

IntroductionType 1 diabetes (T1D) is associated with increased risk of dementias and other neurodegenerative diseases. Plasma biomarkers of neurodegeneration and neuroinflammation hold utility in risk prediction and diagnosis of neurodegenerative disease and other neuropathology, but there remains a paucity of data in the T1D population. This study quantified plasma levels of biomarkers of neurodegeneration and neuroinflammation [phosphorylated tau-181 (pTau-181), total tau (Tau), amyloid beta 42/amyloid beta 40 (Aβ42/40), glial fibrillary acidic protein (GFAP), and neurofilament light chain (

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… Author contributions MP: Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing, Data curation, Investigation, Methodology. … BB: Data curation, Investigation, Methodology, Project administration, Resources, Writing – review & editing. BT: Data curation, Project administration, Writing – review & editing, Software. CC-L: Data curation, Project administration, Resources, Writing – review & editing. …

Moments of deep connection between clinicians and patients in oncology: a mixed-methods study of sacred moments.

PurposeSacred moments are periods of deep connection between clinicians and patients, associated with increased clinician career fulfillment and stronger therapeutic alliances in radiation oncology and internal medicine. Our study is the first to investigate sacred moments in medical oncology.MethodsWe conducted semi-structured qualitative interviews with clinicians and patients at an NCI-designated Comprehensive Cancer Center. Interviews were recorded, transcribed, and analyzed using inductive coding. Participants completed a closed-ended (Likert-style) questionnaire that assessed demographic

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… LP: Methodology, Conceptualization, Software, Investigation, Data curation, Writing – review & editing, Writing – original draft, Formal analysis. MQ: Writing – review & editing, Methodology, Writing – original draft. … KN: Supervision, Writing – review & editing, Formal analysis, Methodology, Data curation. SS: Formal analysis, Supervision, Writing – review & editing, Writing – original draft, Methodology, Data curation. …

Муриновая корреляция саркомы Эпштейна-Барра и саркомы Капози (MHV-68) представляет собой ценную модель для оценки чувствительности к антивирусным препаратам и взаимодействия в комбинаторных наркотиках.

Человеческие герпесвирусы представляют собой основные человеческие патогены. Особый интерес представляют члены подсемейства < < Герпесвирина > > , поскольку они вызывают хронические заболевания, такие, как рак, изменяя клеточные процессы и вводя клетки отдыха в непрерывно расширяющуюся фазу. Кроме того, в центре внимания постоянно находятся аутоиммунные заболевания, такие, как множественный склероз. Прототипический вирус человека - герпесвирус - вирус Эпштейна - Барра (ЭБВ) оказался трудно проанализировать в целях развития противовирусной терапии из-за проблем, связанных с распрост

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… Debora Obergfäll: Writing – review & editing, Writing – original draft, Supervision, Methodology, Investigation, Formal analysis, Data curation. Katarína Briestenská: Writing – review & editing, Writing – original draft, Resources, Methodology. … Jela Mistríková: Writing – original draft, Supervision, Resources, Methodology. William D. Rawlinson: Writing – review & editing, Writing – original draft, Supervision, Resources, Methodology, Formal analysis. …

CAR-T cell therapy clinical trials: global progress, challenges, and future directions from ClinicalTrials.gov insights.

Chimeric antigen receptor T (CAR-T) cell therapy has undergone vigorous development in recent years, yet it still faces significant challenges and difficulties in its clinical application and further development. A systematic synthesis of global trends in CAR-T clinical trials is essential to identify knowledge gaps, optimize treatment strategies, and guide future research directions. This review analyzed 1,580 CAR-T clinical trials registered at ClinicalTrials.gov as of April 2024, and extracted characteristic data in multiple dimensions, including target specificity, treatment indication, an

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… YC: Formal analysis, Software, Writing – review & editing. PM: Data curation, Writing – review & editing. JX: Data curation, Writing – review & editing. XP: Data curation, Validation, Writing – review & editing. XZ: Data curation, Validation, Writing – review & editing. … YC: Methodology, Supervision, Writing – review & editing. QW: Methodology, Supervision, Writing – review & editing. LX: Supervision, Writing – review & editing, Investigation, Validation. …

Предлагаемый рабочий поток для тщательного анализа бактериальных стенограмм в данных RNAseq из внеклеточных везеиклов.

ВВЕДЕНИЕ: Микробиота однозначно связана с различными заболеваниями, однако механизмы, лежащие в основе этих ассоциаций, по-прежнему недостаточно изучены. Одним из потенциальных факторов, способствующих этой взаимосвязи, являются внеклеточные везикли, образующиеся бактериями (БЭМ). Однако обнаружение этих БЭМ сопряжено с трудностями. Поэтому мы предлагаем новый рабочий процесс для выявления бактериальной РНК, присутствующей в циркулирующих внеклеточных везиклах с использованием данных Total EV RNA-seq. В качестве доказательства концепции мы применили этот рабочий поток к набору данных от лиц с

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… AO-C: Data curation, Resources, Writing – review & editing. AA: Data curation, Resources, Writing – review & editing. RdCB-M: Funding acquisition, Methodology, Writing – review & editing. TC-T: Methodology, Resources, Writing – review & editing. LM: Methodology, Writing – review & editing. … DO: Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing. …

A machine learning framework supporting prospective clinical decisions applied to risk prediction in oncology.

We present a general framework for developing a machine learning (ML) tool that supports clinician assessment of patient risk using electronic health record-derived real-world data and apply the framework to a quality improvement use case in an oncology setting to identify patients at risk for a near-term (60 day) emergency department (ED) visit who could potentially be eligible for a home-based acute care program. Framework steps include defining clinical quality improvement goals, model development and validation, bias assessment, retrospective and prospective validation, and deployment in c

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… P.S. contributed to study design (literature, background search), data collection, data interpretation, and writing and review of paper. A.S.R. contributed to study design (literature, background search), data analysis, data interpretation, and writing and review of paper. … R.A.M. contributed to study design (literature, background search), data analysis, data interpretation, and writing and review of paper. L.C. contributed to study design (literature, background search), data collection, data interpretation, and writing and review of paper. …

Плазмоцитома в эксклюзивном манифестации Множественной миеломы: доклад по делу.

Внешняя плазменная цитома является необычным проявлением множественной миэломы (ММ) и может включать в себя широкий круг участков с мягкими тканями. Поверхностное участие спины является особенно редким и может быть ошибочно истолковано как доброкачественное повреждение мягких тканей. Мы сообщаем о случае 59-летнего мужчины с диагнозом MM, поставленным в апреле 2024 года, который лечился четырьмя циклами бортезомида, циклофосфамида и дексаметасона (ВЦД), достиг ремиссии с исчезновением сыворотки и мочи М-протеина на иммунофиксе. В октябре 2025 года, несмотря на лечение даратумумаба, болезнь вно

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… Author Contributions: Jawad Hmayed: Conceptualization, data curation, investigation and writing original draft. Doha Fadel : Imaging and writing original draft. Anthony Bayeh: Conceptualization, imaging and writing original draft. … Chris Jreij: Data curation, investigation and writing original draft. Karam Karam: Data curation, investigation and writing original draft. Lamita El Sett: Imaging, investigation and writing original draft. …

Cancer Research in the Time of COVID-19: A Colombian Narrative.

Cancer research is deficient in Colombia and efforts and resources diverted due to the COVID-19 pandemic could worsen the situation. We explore the impact of the pandemic on cancer research funding, output, and conduct. We sought information at national level and used the experience of an academic reference center to contrast the impact at institutional level. We searched databases and official documents of national governmental institutions, trial registries, hospital registries, and the Web of Science. We interviewed principal investigators (PIs) to retrieve information on the conduct of can

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… Author Contributions RM: design, data collection, data analysis, first-draft writing, and writing review and editing. GF-D: data collection, data analysis, and first-draft writing. MZ: data collection and first-draft writing. GL: design and writing review and editing. … DU-Z and IU-Z: data collection, data analysis, and writing review and editing. MM: design, data collection, data analysis, and first-draft writing. All authors contributed to the article and approved the submitted version. …

Алгоритмы машинного обучения для виртуального раннего обнаружения и выявления нейродегенеративных и нейрокогнитивных расстройств: систематический обзор.

Происхождение и аналоговые расстройства (например, болезнь Альцгеймера, болезнь Паркинсона) приводят к нейронной потере; нейрокогнитивные расстройства (например, бред, слабоумие) свидетельствуют о когнитивном упадке. Раннее обнаружение имеет решающее значение для эффективного управления. Машинное обучение помогает в более точном выявлении заболеваний, потенциально преобразуя медицинское обслуживание. В рамках этого всеобъемлющего систематического обзора обсуждается вопрос о том, каким образом машинное обучение (ML) может способствовать раннему выявлению этих расстройств, превосходя при этом тр

Ожог среди врачей, которые лечат пациентов с множественным склерозом в США: подкаст.

Физический извержение, усиливающийся кризис в системе здравоохранения Соединенных Штатов Америки (США), характеризуется долгосрочным стрессом, связанным с работой, который проявляется в истощении энергии, чувстве повышенной умственной дистанции или цинизме к работе и снижении профессиональной эффективности. В частности, неврологи относятся к числу тех, у кого наиболее высокие показатели вымирания и наименьший уровень удовлетворенности сбалансированностью между работой и личной жизнью. В то же время данные об истощении среди врачей, которые лечат пациентов с множественным склерозом (МС), остают

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… Medical Writing/Editorial Assistance Medical writing assistance was provided by Gaurav Anand of Merck Specialties Pvt. Ltd., Bengaluru, India, an affiliate of Merck KGaA, and funded by EMD Serono Research & Development Institute, Inc., Billerica, MA, USA, an affiliate of Merck KGaA. … All requests should be submitted in writing to Merck’s data sharing portal https://www.merckgroup.com/en/research/our-approach-to-research-and-development/healthcare/clinical-trials/commitment-responsible-data-sharing.html . …

Acute subdural hematoma due to acute myeloid leukemia and B-cell lymphoma.

Chloroma, is an rare malignant tumor characterized by the extramedullary blast proliferation of myeloid lineages that subsequently change the normal architecture of surrounding tissues. Because this is very rare disease, primary central nervous system myeloid sarcoma has not been widely reported. Myeloid sarcoma, as a group of heterogenetic diseases, presents with differential clinical and histological pictures depending upon the primary affected site. We are presenting a 77-year-old gentleman, with past medical history of chronic lymphoblastic leukemia that was not on any treatment and who pr

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… Contributions Denis Babici: Drafting/revision of the manuscript for content, including medical writing for content; Study concept Analysis or interpretation of data. Pamraj Sharma : Drafting/revision of the manuscript for content, including medical writing for content. … Jason DeGregorio: Senior author, Histology analysis, Drafting/revision of the manuscript for content, including medical writing for content. Brian Snelling: Senior author, performed surgical procedure, Drafting/revision of the manuscript for content, including medical writing for content. …

Editorial: Challenges and strategies in the management of ER/PgR Low-expression breast cancer: exploring fundamentals, clinical insights, and treatment approaches.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… – original draft, Writing – review & editing. … VG: Writing – review & editing. S-GW: Writing – review & editing. Conflict of interest The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. …

CD200 является мощным новым фактором роста в Мультимиломе, зависящим от сигнала рецептора IGF1.

CD200 — это иммунный контрольно-пропускной пункт, безошибочно выраженный в 70% недавно диагностированных пациентов с множественной миеломой (ММ) и связанный с плохим исходом. Выражение CD200 клетками опухоли препятствует иммунной реакции через взаимодействие с CD200R и участвует в устойчивости к иммунной терапии. Однако его роль в опухоли остается слабой. В этом исследовании мы показываем, что клетки MM, перевыражающие CD200, представляют собой значительное пролиферативное преимущество в свободных культурных сыворотках, средних и клоногенных анализах. Преимущество роста клеток, опосредованное

Совпадение в полном тексте источника
… Guillaume Cartron: Writing – original draft, Investigation, Formal analysis. Laure Vincent: Writing – original draft, Investigation, Formal analysis. Charles Herbaux: Writing – original draft, Methodology, Investigation. … Caroline Bret: Writing – review & editing, Writing – original draft, Supervision, Investigation, Formal analysis, Data curation, Conceptualization. …

Recommendations for the effective use of T-cell-redirecting therapies: a Canadian consensus statement.

BackgroundT-cell-redirecting therapies, such as bispecific antibodies and chimeric antigen receptor T-cells, exploit the cytotoxic capabilities of the immune system to destroy cells expressing specific surface antigens, including malignant cells. These therapies have demonstrated unprecedented rates, depth, and duration of responses in relapsed and refractory multiple myeloma. However, there are significant challenges in implementing these therapies into practice, which require multidisciplinary and multicenter coordination and significant healthcare resources to effectively manage these patie

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… DW: Conceptualization, Investigation, Methodology, Resources, Validation, Writing – original draft, Writing – review & editing. TC: Conceptualization, Investigation, Methodology, Resources, Validation, Writing – original draft, Writing – review & editing. … MS: Conceptualization, Investigation, Methodology, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing. MEl: Resources, Supervision, Validation, Writing – original draft, Writing – review & editing. …

Mimicking urticaria: a Schnitzler syndrome case.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Daniela de Abreu e Silva Martinez: Preparation and writing of the manuscript; approval of the final version of the manuscript. Danielle Carvalho Quintella: Preparation and writing of the manuscript; approval of the final version of the manuscript. … Tullia Cuzzi: Preparation and writing of the manuscript; approval of the final version of the manuscript. …

Impact of hospital safety-net status on in-hospital and short-outcomes after hematopoietic stem cell transplantation.

Safety-net hospitals (SNHs) cater to the medical needs of underserved populations, but their impact on the outcomes of hematopoietic stem cell transplantation (HSCT) remains unclear. The aim of this study was to evaluate the relationship between safety-net status and posttransplant outcomes using the National Readmission Database (NRD), including in-hospital mortality, in-hospital complications, and readmission. This was a retrospective cohort study. Adult patients who underwent allogeneic or autologous HSCT were identified using ICD-9 and ICD-10 procedure codes. Hospitals were classified as S

Совпадение в полном тексте источника
… Data curation, formal analysis, resources, software, writing—original draft. H.W. Data curation, formal analysis, resources, software, writing—original draft. Q.C. Data curation, methodology, resources, software, writing—original draft. HJ.D. Data curation, resources, software. … QY.Y. investigation, supervision, writing—review and editing. N.L. Data curation, resources, software, writing—review and editing. W.L. methodology, writing—review and editing. N.Z. Data curation, methodology, software, writing—review and editing. …

Adefovir dipivoxil-induced hypophosphatemic osteomalacia and osteoporosis: a case report and literature review.

The nephrotoxicity of adefovir dipivoxil (ADV) can induce Fanconi syndrome, which causes hypophosphatemic osteomalacia. We report a case of a 67-year-old postmenopausal woman who had been receiving long-term adefovir dipivoxil therapy for chronic hepatitis B. She presented with severe bone pain and multiple pseudofractures, and was diagnosed with drug-induced hypophosphatemic osteomalacia. Following discontinuation of adefovir and supplementation with vitamin D and phosphate, her biochemical parameters normalized and bone pain significantly improved, indicating that osteomalacia had been essen

Совпадение в полном тексте источника
… Author contributions WY: Data curation, Methodology, Writing – original draft, Writing – review & editing. CD: Data curation, Project administration, Writing – review & editing, Writing – original draft. SC: Conceptualization, Validation, Writing – review & editing, Writing – original draft. … HJ: Methodology, Supervision, Writing – review & editing, Writing – original draft. JJ: Resources, Validation, Writing – review & editing, Writing – original draft. …