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Evaluation of Local and Systemic Melatonin Administration on Bone Healing After Tooth Extraction in Bisphosphonate-Treated Rats.

BACKGROUND: The purpose of our study was to investigate the effects of systemic and local application of melatonin after tooth extraction in bisphosphonate applied rats, on the healing of extraction socket histopathologically and immunohistochemically. METHODS: Forty four Wistar albino rats were included in the study. Subjects were divided into 4 groups: Control (C), Bisphosphonate (BIF), Bisphosphonate + Local Melatonin (BIF + LM) and Bisphosphonate + Systemic Melatonin (BIF + SM). Zoledronic acid was applied intraperitoneally once a week from the beginning of the experiment to all the groups

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… | Absence of epithelial tissue on the open surgical site | 76–100% | Severe Statistical evaluation Statistical analyses were performed using the statistical software program (WSSPAS: Web-Based Sample Size & Power Analysis Software) developed by Inonu University, Faculty of Medicine, Department of Biostatistics …

Use of Real-World Evidence to Drive Drug Development Strategy and Inform Clinical Trial Design.

Interest in real-world data (RWD) and real-world evidence (RWE) to expedite and enrich the development of new biopharmaceutical products has proliferated in recent years, spurred by the 21st Century Cures Act in the United States and similar policy efforts in other countries, willingness by regulators to consider RWE in their decisions, demands from third-party payers, and growing concerns about the limitations of traditional clinical trials. Although much of the recent literature on RWE has focused on potential regulatory uses (e.g., product approvals in oncology or rare diseases based on sin

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… Other resources required to analyze RWD include personnel with advanced training in epidemiology, biostatistics, bioinformatics, and related fields, as well data engineers, statistical programmers, data scientists, and information technology resources (e.g., servers, storage, and software) capable of …

Development and Applications of Prognostic Risk Models in the Management of Invasive Mold Disease.

Prognostic models or risk scores are frequently used to aid individualize risk assessment for diseases with multiple, complex risk factors and diagnostic challenges. However, relatively little attention has been paid to the development of risk models for invasive mold diseases encountered in patients with hematological malignancies, despite a large body of epidemiological research. Herein we review recent studies that have described the development of prognostic models for mold disease, summarize our experience with the development and clinical use of one such model (BOSCORE), and discuss the

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… Tutorial in biostatistics multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat. Med. 1996;15:361–387. doi: 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4. 11. …

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with e

Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies.

In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.

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… D.S. is shareholder at Masaryk University spinoff: Institute of Biostatistics and Analyses. Z.S. is inventor on multiple patents dealing with genetic engineering of immune cells. K.R. received honoraria from Novartis Pharma GmbH. The other authors declare no competing interests. …

Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study.

BackgroundData on patients with COVID-19 who have cancer are lacking. Here we characterise the outcomes of a cohort of patients with cancer and COVID-19 and identify potential prognostic factors for mortality and severe illness.MethodsIn this cohort study, we collected de-identified data on patients with active or previous malignancy, aged 18 years and older, with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from the USA, Canada, and Spain from the COVID-19 and Cancer Consortium (CCC19) database for whom baseline data were added between March 17 and April 16

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… MAT reports personal fees from VIA Oncology, Adaptive Advisory Board, GlaxoSmithKline, Syapse, UpToDate, Celgene, Doximity, AbbVie, Bristol-Myers Squibb, Cancer Research and Biostatistics Clinical Trials Consortium, Denovo, Hoosier Research Network, Eli Lilly, LynxBio, Strata Oncology, Takeda, and TG …

A novel approach to enhance glioblastoma multiforme treatment efficacy: non-coding RNA targeted therapy and adjuvant approaches.

BackgroundGlioblastoma multiforme (GBM) is a lethal brain tumor. With the current gold standard chemotherapy treatment, temozolomide (TMZ), many patients do not survive beyond one year. While the urgency of researching novel treatments is understandable, the prohibitively high costs and the prolonged duration of research and clinical trials significantly delay the availability of medical advancements to the general public. This highlights the urgent need for adjuvant therapies to enhance treatment effectiveness.Main bodyRecent research has suggested the potential of repurposing FDA-approved dr

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… Biostatistics. 2019;20(2):273–86. 114. Issa NT, Stathias V, Schürer S, Dakshanamurthy S. Machine and deep learning approaches for cancer drug repurposing. Semin Cancer Biol. 2021;68:132–42. 115. Liu Y, Wu W, Cai C, Zhang H, Shen H, Han Y. …

Prevalence of symptomatic toxicities for novel therapies in adult oncology trials: a scoping review.

BackgroundPatients' self-report of their symptoms can provide important data for the evaluation of treatment benefit and tolerability of oncology drugs. Contemporary treatment approaches, including immunotherapy and molecular targeted therapies, have unique toxicities based on their novel mechanisms of action. This scoping review aimed to summarize evidence from existing reviews and clinical practice guidelines to examine the type and prevalence of toxicities including symptomatic adverse events (sympAEs) for adult cancer patients to inform clinical care and therapeutic trials.MethodsA systema

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… Yuelin Li, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, United States. Lori M Minasian, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, United States. …

Conference Proceedings - 6th International Conference on Molecular Diagnostics and Biomarker Discovery (MDBD 2022): Building Resilience in Biomedical Research : Penang, Malaysia. 11-13 October 2022.

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… Anani Aila Mat Zin 1, 4 1 Department of Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; 2 Department of Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; 3 Biostatistics …

62nd Annual Conference of the Indian Society of Gastroenterology, February 10th - 13th, 2022, Pune.

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… , Rithvik Gola 1 , Mukesh Singh 1 , Shubi Vermani 1 , Anvita Gupta 1 , Nidhi Yadav 1 , Mani Kalaivani 2 , Raju Sharma 3 , Prasenjit Das 4 , Govind Makharia 1 , Saurabh Kedia 1 , Vineet Ahuja 1 Correspondence – Vineet Ahuja – vineet.aiims@gmail.com 1 Department of Gastroenterology, 2 Department of Biostatistics … Jasvinder Singh Maras 1 , Shiv Kumar Sarin 4 , Shvetank Sharma 1 Correspondence – Sudrishti Chaudhary – sudrishti.chaudhary@gmail.com Departments of 1 Molecular and Cellular Medicine, 2 Pathology, 3 Biostatistics, and 4 Hepatology, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi …

Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy.

In the era of precision medicine, liquid biopsy is becoming increasingly important in oncology. It consists in the isolation and analysis of tumor-derived biomarkers, including extracellular vesicles (EVs), in body fluids. EVs are lipid bilayer-enclosed particles, heterogeneous in size and molecular composition, released from both normal and neoplastic cells. In tumor context, EVs are valuable carriers of cancer information; in fact, their amount, phenotype and molecular cargo, including proteins, lipids, metabolites and nucleic acids, mirror nature and origin of parental cells rendering EVs a

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of risk factor exposure and attributable burden of disease. By providing estimates over a long time series, this study can monitor risk exposure trends critical to health surveillance and inform policy debates on the importance of addressing risks in context. METHODS: We used the comparative risk assessment framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years

2026 Приложение к резюме Международного конгресса

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… Kantor 2 1 Integrative Medicine and Wellness Service, Memorial Sloan Kettering Cancer Center, New York, NY, United States 2 Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, United States 3 Departments of Nutrition and Epidemiology, Harvard T.H. … Mao 1 1 Integrative Medicine and Wellness Service, Memorial Sloan Kettering Cancer Center, New York, NY, United States 2 Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, United States Purpose : Cancer patients frequently experience treatment-related …

Материалы Международного общества по картированию раковых заболеваний (ИСИС) 18th Ежегодный учебный курс: Ментон, Франция. 7-9 октябрь 2018

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Palliative prognostic scores for survival prediction of cancer patients: a systematic review and meta-analysis.

BACKGROUND: The palliative prognostic score is the most widely validated prognostic tool for cancer survival prediction, with modified versions available. A systematic evaluation of palliative prognostic score tools is lacking. This systematic review and meta-analysis aimed to evaluate the performance and prognostic utility of palliative prognostic score, delirium-palliative prognostic score, and palliative prognostic score without clinician prediction in predicting 30-day survival of cancer patients and to compare their performance. METHODS: Six databases were searched for peer-reviewed stud

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… Biostatistics primer: what a clinician ought to know—prognostic and predictive factors . J Thorac Oncol . 2013 ; 8 ( 6 ): 808 - 813 . doi: 10.1097/JTO.0b013e318292bdcd 23676560 8 Chu C , White N , Stone P. Prognostication in palliative care . …

The 11th NORDIC NUTRITION CONFERENCE NNC2016.

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The Role of IL-33/ST2 Pathway in Tumorigenesis.

Cancer is initiated by mutations in critical regulatory genes; however, its progression to malignancy is aided by non-neoplastic cells and molecules that create a permissive environment known as the tumor stroma or microenvironment (TME). Interleukin 33 (IL-33) is a dual function cytokine that also acts as a nuclear factor. IL-33 typically resides in the nucleus of the cells where it is expressed. However, upon tissue damage, necrosis, or injury, it is quickly released into extracellular space where it binds to its cognate receptor suppression of tumorigenicity 2 (ST2)L found on the membrane o

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… Using data from the Gene Expression Atlas created by the European Biostatistics Institute (Gene Expression Atlas; Available online: https://www.ebi.ac.uk/gxa/home ; access date: 30 January 2013), IL-33 expression was found to be reduced in human metastatic prostate cancer as compared to benign and primary …

Рекомендации Международной группы по работе с миеломой по диагностике и лечению изолированных плазмоклеточных опухолей.

Одиночные плазмоклеточные опухоли (СП) — редкие локализованные опухоли клоновых плазмоклеток, либо в костной ткани (одиночная костная плазмоклеточная опухоль), либо в мягких тканях/экстраоссозных (экстромедуллярные) с отсутствием или минимальным проникновением в костный мозг (КМ) (<10% клоновых плазмоклеток по иммуногистохимии) и отсутствием признаков системного вовлечения или событий, определяющих миелому. Приблизительно 50% СП прогрессируют в симптоматическую миелому в течение 5 лет после начальной определенной локальной радиотерапии. Увеличение доступности улучшенных диагностических и монит

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… Antje Hoering, Cancer Research and Biostatistics, Seattle, WA 134. James E. Hoffman, The University of Miami, Miami, FL 135. Sarah Holstein, University of Nebraska Medical Center, Omaha, NE 136. Dirk Hose, Vrije Universiteit Brussel, Brussels, Belgium 137. …

Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 2.

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… Wedderburn 1, 2, 4 and on behalf of the CLUSTER Consortium 1 UCL Great Ormond Street Institute of Child Health; 2 Centre for Adolescent Rheumatology Versus Arthritis at UCL, University College London Hospital (UCLH) and Great Ormond Street Hospital (GOSH), London; 3 MRC Biostatistics Unit, University … Kansas City; 6 Department of Pediatrics, University of Missouri-Kansas City, Kansas City; 7 Division and Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center; 8 University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati; 9 Department of Biostatistics …

Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019.

BackgroundDisability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU.MethodsEstimates were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Causes of NCDs were analysed at three different levels of the GBD 2019 hierarchy, for which mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were extracted. Estimates, with the 95% uncertainty intervals (UI), were retrieved for EU Member Stat

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… College Business School (D Kusuma DSc), Department of Primary Care and Public Health (Prof A Majeed MD, R Palladino MD, Prof S Rawaf MD), National Heart & Lung Institute (Prof D Munblit PhD), WHO Collaborating Centre for Public Health Education and Training (D L Rawaf MD), Department of Epidemiology and Biostatistics …